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313 articles for “stability-indicating”
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Stability Indicating HPLC Method for Drugs Indicated for Helicobacter Pylori-associated Ulcers
Abstract: Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 Triple therapy regimen that comprises a proton pump inhibitor likes Omeprazole, antibiotics like Doxycycline and Tinidazole can be used for treatment of peptic ulceration which is caused by H. pylori. A validated HPLC method was developed as a stability-indicating HPLC method for these drugs and its impurities. New method overcame interference between Doxycycline and its epimer on achiral column by using …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 6, Issue 1, 2015 · pp. 28–46 Read article
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Two New, Useful and Facile Stability-Indicating UV Spectrophotometric Methods for the Determination of Rosiglitazone in Pharmaceuticals
Abstract: Rosiglitazone (ROS) is an antidiabetic drug belonging to the thiozolidine class. Two simple, rapid, sensitive, accurate and reproducible UV-spectrophotometric methods were developed and subsequently validated for the determination of ROS in bulk and tablet form. The methods are based on the measurement of the absorbance of the drug solution either in 0.1 M NaOH (NaOH method) or in 0.1 M HCl (HCl method) at 316 nm in both instances. The …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 2, 2017 · pp. 8–19 Read article
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Stability-Indicating Rp-Hplc Development and Validation for the Estimation of Lercanidipine Hydrochloride Content in Tablet Dosage Form
Abstract: A sensitive, stability-revealing, and easy reverse-phase high-performance liquid chromatographic (RP-HPLC) technique was developed and rationalized to be in a position to determine Lercanidipine hydrochloride in ingested dosing preparations. It was separated by chromatography on a C 18 column using a mobile phase containing 10 mM potassium dihydrogen phosphate buffer and methanol (20:80, v/v; pH 4.0) at a flow rate of 1.0 mL/min and UV detected at 258 nm. The retention …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 1, 2026 · pp. 17–26 Read article
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Development and Validation of a New Stability-Indicating HPLC Method for the Determination of Rosiglitazone in Tablets
Abstract: Rosiglitazone (ROS) is an antidiabetic drug belonging to the thiazolidine class. A new stability-indicating high-performance chromatographic (HPLC) method was developed for the determination of ROS in pharmaceuticals, and validated for its suitability following the ICH guidelines. Chromatography was performed on a Chromatopack (250×4.6 mm; 5 µm particle size) column using phosphate buffer of pH 3.2 and methanol (70:30 v/v) as mobile phase pumped at a flow rate of 1 ml …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 1, 2017 · pp. 1–9 Read article
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Simple, Direct and Stability-Indicating UV Spectrophotometric Assay of Pioglitazone Hydrochloride in Pharmaceuticals
Abstract: Pioglitazone hydrochloride (PGH) is an antihyperglycemic agent used in the treatment of type-2 diabetes mellitus. A simple and straight forward UV-spectrophotometric method is presented for the determination of PGH in bulk drug and tablets by measuring the absorbance of drug solution in 0.1M H2SO4 at 269 nm. A plot of absorbance versus concentration obeyed Beer’s law over 2–36 µg ml-1 concentration range (r = 0.9981) with a molar absorptivity of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 3, 2017 · pp. 7–16 Read article
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Simultaneous Determination And Stability Indicating Method For Telmisartan, Metoprolol Succinate And Cilnidipine In Tablet Dosage Form.
Abstract: There are several medicinal agents available for antihypertensive activity. Telmisartan, metoprolol and cilnidipine are among them. Quantitative and qualitative analysis plays a pivotal role in safeguarding patients. Here, the estimation of these drugs was performed by using the chromatographic technique RP-HPLC. It was conducted with Phosphate buffer (pH 3.5 ± 0.01): Methanol (50:50 v/v) mobile phase. The system was operated at 1 ml/min. Drug volume to the system was 20μl. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 32–38 Read article
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Photochemically Assisted LC–MS Method Development and Validation for Stability-Indicating Determination of Glasdegib in Rat Plasma
Abstract: A simple, precise, and cost-effective LC–MS method was successfully developed for the determination of Glasdegib in rat plasma. The method optimization was carried out by systematically varying key chromatographic parameters, including flow rate, injection volume, analyte concentration, and mobile phase composition, to achieve optimal sensitivity and resolution. A C18 Hypersil BDS column (150 mm × 4.6 mm, 3.5 µm particle size) was used for chromatographic separation, offering effective peak shape …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 4, Issue 1, 2026 · pp. 11–20 Read article
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Development of Validated Stability Indicating RP-HPLC Method for Amisulpride Injection
Abstract: Objective of the present work is to develop and validate a simple, cost effective, sensitive and fast RPHPLC method for the analysis of Amisulpride injection. A Waters HPLC system with Octacysilane 150 mm × 4.6 mm column is employed for the analysis using pH 4.5 phosphate buffer solution, acetonitrile and methanol in the ratio of (75:20:5 v/v) as mobile phase. Signal from Amisulpride is detected at 280 nm by UV …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 1, 2023 · pp. 24–40 Read article
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Optimization of Mobile Phase and Stability—Indicating HPTLC Method for the Determination of Prasugrel Hydrochloride in Pharmaceutical Dosage Form
Abstract: A simple and sensitive high-performance thin layer chromatographic method was developed and validated for Prasugrel hydrochloride. It was spotted on silica gel 60F254 TLC plates, developed using toluene:methanol (9.9:0.1, v/v) as mobile phase and scanned at 258 nm using a Camag TLC Scanner IV. The Rf value of Prasugrel hydrochloride were found to be 0.53±0.03. It was found to be linear in the concentration range of 300–1500 ng/band. The limit …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 2, 2018 · pp. 7–12 Read article
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Determination of the Antidiabetic Drug Miglitol in Pharmaceuticals by Ultra-Performance Liquid Chromatography
Abstract: Miglitol (MGL) is a drug used in the treatment of type-2 diabetes mellitus. A new analytical method employing ultra-performance liquid chromatography (UPLC) with UV-detection is presented for the determination of MGL in bulk drug and tablet forms. Analysis was performed in less than 3 min in isocratic mode on a reversed phase BEH C18 (100 mm × 2.1 mm; 1.7 µm particle size) column using phosphate buffer of pH 3.7-acetonitrile …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 9, Issue 2, 2018 · pp. 11–26 Read article
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Voltage Stability Assessment of Wind Integrated System for Variable Wind Speed with FACTS Devices
Abstract: Requirement of power utilization is increasing exponentially both by industrial usage as well as in our day-to-day life due to inclusion of latest developments in the technology and automation. So, increase of power generation from conventional as well as non-conventional type of energy resources to meet these challenges is also needed. This increase in power generation is not possible alone by existing methods. Wind energy and integration of wind energy …
Published in Journal of Alternate Energy Sources & Technologies · Vol. 7, Issue 3, 2016 · pp. 15–22 Read article
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An Improvement of Voltage Stability by Generator Bus Rescheduling
Abstract: This paper focuses on assessment and improvement of voltage stability by Georgeoschrin’s theorem using new evolutionary TLBO and PSO algorithm. In today’s environment, voltage stability maintained without sacrificing the power system parameters is really a herculean task. Generally, eigen value of reduced Jacobian matrix or Jacobian matrix of N-R base load flow analysis is well thought-out as voltage stability indices for weak bus identification. Here, the diagonal elements reduced Jacobian …
Published in Trends in Electrical Engineering · Vol. 7, Issue 2, 2017 · pp. 1–10 Read article
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A Comprehensive Exploration of Method Validation and Development in Pharmaceutical Analysis: Focus on Vortioxetine Analysis
Abstract: The pharmaceutical industry relies on rigorous method validation to ensure the accuracy, precision, and reliability of analytical techniques employed in drug testing and quality control. This comprehensive exploration delves into the validation parameters and guidelines essential for method validation, emphasizing accuracy, precision, linearity, detection and quantitation limits, specificity, range, robustness, and ruggedness. Validation plays a pivotal role in guaranteeing high-quality products, adhering to good manufacturing practices (GMP), and optimizing manufacturing …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 1, 2024 · pp. 46–52 Read article
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Preparation of an Indicator Dye from Tender Coconut Husk and Analysis of its Stability
Abstract: India is eminent in its production and usage of tender coconuts. The aim of this paper was to develop a useful product from tender coconut waste. It focuses on the utilization of coconut husk to produce an indicator dye for the detection of the approximate pH of any solution. A concentrated dye was first prepared in aqueous form. When stored, it was stable and functional at room temperature as well …
Published in Research & Reviews : Journal of Botany · Vol. 9, Issue 3, 2020 · pp. 17–23 Read article
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Radiosonde Data Analysis for Predicting the Thunderstorm Potential Instabilities in Tropics
Abstract: The Gangetic belt of West Bengal of India is one of the most effective zones of atmospheric instabilities. The formation of the instabilities follows complex method whose clear understanding is very essential. The present work reports a model for its prediction system. The instabilities at the thunderstorms in the pre-monsoon and monsoon seasons for a period of two years exhibit interesting findings. Taking support of different meteorological parameters as derived …
Published in Research & Reviews : Journal of Space Science & Technology · Vol. 10, Issue 2, 2021 · pp. 11–21 Read article
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Artificial Intelligence–Assisted Reduced-Order Modeling and Stability Control in Granular Couette Flow
Abstract: This study develops a reduced-order and stability-aware modeling framework for dense granular Couette flow by integrating continuum mechanics, bifurcation analysis, and data-driven stability estimation. Starting from coupled governing equations for momentum, granular temperature, and microstructural evolution, the system is nondimensionalized and reduced using a Galerkin projection consistent with shear-driven boundary conditions. This yields a low-dimensional nonlinear dynamical system that preserves the essential coupling between velocity, fluctuation energy, and structural relaxation. …
Published in Emerging Trends in Chemical Engineering · Vol. 13, Issue 3, 2026 Read article
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Development of an Innovative Nanotransdermal Formulation Utilizing an Optimal Combination of Acyclovir and Omeprazole to Improve Antiviral Efficacy
Abstract: The study effectively created nanogel formulations of Acyclovir and Omeprazole using the solvent diffusion technique. Among the various formulations (F1–F9), F9 was identified as the most suitable for gel preparation based on its pH evaluation. Drug content analysis, performed using UV-spectroscopy, confirmed the homogeneity of the prepared nanogels, which appeared opaque, free of lumps, particles, or aggregates. The spreadability assessment of F9 demonstrated excellent spreadability, while viscosity values for all …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 19–35 Read article
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Mechanical Properties, Viscoelastic and Water Absorption Properties of Biocarbon-Reinforced Composites
Abstract: Biocarbon-reinforced polymer composites have emerged as a sustainable alternative to conventional composites, combining environmental benefits with promising material properties. This study explores the effect of varying biocarbon content (0%, 10%, 20%, and 30% by weight) on the mechanical, viscoelastic, and water absorption properties of a polypropylene (PP) matrix. Tensile strength tests reveal that incorporating 10% biocarbon yields the highest strength at 35 MPa, attributed to enhanced interfacial bonding. However, at …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 145–157 Read article
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HPLC Method Development and Validation for Simultaneous Estimation of Succinic Acid and Succinylmonocholine in Succinylcholine Chloride Injection
Abstract: Succinylcholine chloride injection USP is a sterile, non-pyrogenic solution to be used as a short-acting, depolarizing, skeletal muscle relaxant. The injection is administered as IM or IV use. Succinylcholine chloride, USP is chemically designated C14H30N2O4 and its molecular weight is 290.399. Succinylcholine chloride has three known impurities: (1) Doublet peak, (2) Succinic acid and (3) Succinylmonocholine chloride. Out of these impurities, succinic acid and succinylmonocholine chloride are degradation impurities, whereas …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 3, 2015 · pp. 52–60 Read article
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Development and Validation of RP-HPLC Method for Determination of Thermal Degradation Impurity in Macrolide Immunosuppressant Substance and Drug Product
Abstract: The present study describes a simple and stability-indicating reverse phase high-performance liquid chromatography (RP-HPLC) method for the quantification of the thermal degradation impurities of Tacrolimus (FK506) namely Ally ester rearrangement impurity (Impurity R) in Tacrolimus capsules and drug substances. Successful separation of impurity R from Tacrolimus, its other related substances and its tautomers were achieved on a Zorbax XDB C8 (150×4.6 mm, 5 μm) and detector of UV at 210 …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 3, Issue 1, 2016 · pp. 14–19 Read article