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64 articles for “release kinetics”
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Effect of Polymer Crosslinking on Drug Release Kinetics
Abstract: In order to improve treatment effectiveness and minimise adverse effects, polymer-based drug delivery systems are often used to produce regulated and sustained drug release. Polymer crosslinking, which alters the structural, mechanical, and degrading characteristics of the polymer matrix, is one of the key elements affecting drug release kinetics. The porosity, swelling behaviour, and rate of degradation of the polymer are all impacted by the crosslinking process, which may be accomplished …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 636–647 Read article
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Sumatriptan Succinate Mucoadhesive Buccal Tablets: Formulation Design, Optimization and Evaluation
Abstract: The main aim of present investigation was to develop and study mucoadhesive buccal tablets of sumatriptan succinate using different bioadhesive polymer. Nine formulations were prepared by using direct compression method with varying concentration of polymer as HPMC (Metolose SR 90SH-15000), xanthan gum (XTGM) and sodium carboxy methyl cellulose (sodium CMC). Fourier transform infrared spectroscopy was used to identify drug excipient interaction. Micromeritic properties of lubricated blend, physical properties and chemical …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 13, Issue 2, 2022 · pp. 1–20 Read article
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Melanoma Skin Cancer Detection Using Deep Learning
Abstract: Cancer as one of the major diseases rank in the World is still very challenging to diagnose and treat hence need for the technological advancements. Chemotherapy, radiation, as well as surgery therapies have several drawbacks including non-selective action, damage to healthy tissues, and multi-drug resistance. Smart nano-theranostics, an advanced integration of nanotechnology with diagnostic and therapeutic modalities, offers a next-generation approach for precision oncology. Thus, the development of multifunctional nanoparticles …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 2, 2025 · pp. 1–9 Read article
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Evaluation of Polysaccharide-Based Membranes for Transdermal Drug Delivery in Chronic Pain Management
Abstract: In order to improve treatment effectiveness and patient compliance, chronic pain management is still a major challenge in modern healthcare, requiring creative medication delivery methods. The potential of polysaccharide-based membranes for transdermal drug delivery is assessed in this work, with particular attention to chitosan, alginate, and hydroxypropyl methylcellulose (HPMC). Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) were two characterization techniques used to assess the membranes' physical and chemical …
Published in International Journal of Membranes · Vol. 1, Issue 2, 2024 · pp. 28–38 Read article
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Biopolymer-Based 3D Composite Scaffolds for Bone Tissue Engineering: Photothermal-Responsive Systems with Controlled Pt (IV) Prodrug Release
Abstract: Biopolymer-based composite scaffolds have attracted significant attention as multifunctional platforms at the intersection of polymer science, regenerative medicine, and cancer nanotherapy. In this study, a dual-functional scaffold was developed for simultaneous osteosarcoma treatment and bone regeneration using poly (L-lactic acid) (PLLA) reinforced with bioactive glass (BG) and integrated with a glutathione-responsive platinum (IV) prodrug system (PDA@Pt). To improve interfacial adhesion, photothermal conversion efficiency, and tumor-specific activation, the Pt (IV) prodrug …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 351–361 Read article
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The Utilization of Oil Entrapped Floating Alginate Beads in a Gastroretentive Delivery System is Intended to Improve the Bioavailbility of Telmisartan Incorporating Principles of Bioinformatics
Abstract: Oil entrapped floating calcium alginate beads of Telmisartan were successfully prepared using sodium alginate as polymer and two different oil phases of mineral oil and olive oil by emulsion gelation method. The FT-IR spectra of final optimized formulation confirms no drug- polymer incompatibility. The floating time of beads was found to be more than 12 hrs suggesting that the method used for prepration was effective. The floating time of optimized …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 1, 2024 · pp. 21–38 Read article
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In-Vitro Evaluation of Extended Release Atorvastatin Tablets by using Natural Gums
Abstract: The present research is the formulation of extended-release tablets Atorvastatin is used as a hypoglycemic agent; it is HMG CoA Reductase inhibitor. All the formulation were prepared with using different grades of xanthan gum, guar gum, sodium alginate, then all the formulations were subjected to pre-compression and post-compression parameters such as angle of repose, bulk density, tapped density, Carr’s index, Hausner's ratio, weight variation, thickness, hardness, friability and drug content. …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 2, 2019 · pp. 55–62 Read article
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Qualitative and Quantitative Effects of Non-Thermal Atmospheric Pressure Plasma and ErCr: YSGG Laser Activation on Surface Remineralization and Fluoride Release of Three Different Fluoride Varnishes
Abstract: Dental caries remains a prevalent oral health concern worldwide, prompting ongoing research into innovative approaches for caries prevention and management. This experimental investigation endeavors to conduct a comparative assessment of the bioactivity, fluoride release kinetics, shear bond strength, and compressive strength of glass ionomer cement (GIC) augmented with three distinct types of inorganic bioactive nanoparticles. Bioactive nanoparticles have garnered interest in dental materials for their potential to enhance material properties …
Published in Journal of Polymer & Composites · Vol. 12, Issue 5, 2024 · pp. 292–303 Read article
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Numerical Modeling of Drug Release from HPMC Carriers with Erosion
Abstract: Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Numerical modeling of drug release kinetics from hydroxypropyl methylcellulose (HPMC) carriers is investigated. Recently a comprehensive model describing the controlling processes of this kinetics (water uptake, drug …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 2, Issue 1, 2011 · pp. 30–35 Read article
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Mathematical Modeling of Concentration Flux in Thermosensitive Biopolymer-assisted Drug Delivery
Abstract: A mathematical model of drug concentration flux across thermosensitive biopolymer with degradable cross-link was developed to predict the effect of the physical configuration and chemical composition of thermosensitive biopolymer on the kinetics of MK2 inhibitor peptide drug release. The overall goal of this research was to efficiently model the 3D drug release kinetics of a controlled drug from a double-shell spherical nanoparticle. The newly developed model would be used to …
Published in Journal of Thermal Engineering and Applications · Vol. 9, Issue 3, 2022 · pp. 9–15 Read article
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Development and Assessment of Levetiracetam Microspheres Utilizing Synthetic and Natural Polymers: A Biomedical Engineering Perspective
Abstract: In the present study, comparative study of Levetiracetam loaded microspheres using Ethyl cellulose as synthetic and Sodium alginate as natural polymers was done. Solvent evaporation and ionic gelation technique has been successfully employed to produce Levetiracetam loaded ethyl cellulose and sodium alginate microspheres with optimal drug encapsulation that sustained the drug release over a period of time. Based on the pre-formulation studies E1 to E4 and S1 to S4 batches …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 1–18 Read article
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Design and Evaluation Cefaclor Microspheres for Bioavailability Enhancement
Abstract: This study attempted to formulate microspheres for oral administration of Cefaclor by using different polymers like Hydroxypropyl methylcellulose (HPMC) K4M, (HPMC) K15M and Ethylcellulose (EC) which increases the gastric residence time and thereby the bioavailability. Solvent evaporation method was found to be the best due to its ease of fabrication without compromising the activity of the drug. Cefaclor is a second-generation cephalosporin antibiotic used to treat certain ear, lung, skin, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 3, 2019 · pp. 39–48 Read article
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Effect of Starch CMC Blend on the Drug Release from the Tablet
Abstract: Starch is frequently used as a binder and disintegrate for immediate release tablet formulation and is also used to prepare sustained release formulations. Starches from various sources show different functional characteristics; while combining with other excipients. When starch blend from various sources is used in the combination with carboxy methyl cellulose (CMC), it shows different release properties. The aim of the present work is to investigate the influence of starch-CMC …
Published in Trends in Drug Delivery · Vol. 5, Issue 1, 2018 · pp. 10–16 Read article
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Role of Polymeric Composites in Controlled Drug Release Systems
Abstract: In the realm of controlled drug release systems, polymeric composites have attracted a lot of interest as they possess several diverse characteristics that enable exact control of the drug delivery rate. This lowers adverse effects and increases the efficacy of treatment. Usually composed of biocompatible polymers combined with functional fillers like nanoparticles, ceramics, or hydrogels, these composites help to get the desired drug release patterns. Stable, biodegradable, and bioactive materials …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 453–465 Read article
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Bioinformatics-based Preparation and Characterization of Silver Nanoparticles Synthesized from Pterocarpus marsupium
Abstract: Silver nanoparticles were synthesized using Pterocarpus marsupium bark extract in combination with silver nitrate solution through a green synthesis method. Silver nanoparticles formation was confirmed by the formation of dark brown from solution of silver nitrate, where the reduction of silver ion occurs which leads to the formation of silver nanoparticles. The UV–visible spectra showed a peak at 429 nm, confirming the reduction of silver ions and the subsequent synthesis …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 2, 2024 · pp. 21–34 Read article
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Microsphere-Based Drug Delivery: A Critical Review of Innovations and Applications
Abstract: Microspheres have emerged as a revolutionary approach in pharmaceutical sciences, offering controlled and targeted drug delivery with improved bioavailability, stability, and patient compliance. These spherical carriers, ranging from nanometers to micrometers in size, can encapsulate both hydrophilic and hydrophobic drugs, enabling sustained and site-specific release. The development of microspheres has been significantly driven by the need to enhance drug efficacy while minimizing systemic side effects. This review provides a comprehensive …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 52–59 Read article
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Exploring Biomedical Innovations in the Formulation and Assessment of Medicated Hard Candy Lozenges Containing Metoclopramide Hydrochloride
Abstract: The objective of this study was to formulate and evaluate metoclopramide hydrochloride medicated lozenges for antiemetic action through buccal absorption by incorporating a polymer. All formulations were developed and assessed for in-vitro drug release, physical appearance, weight variation, thickness, hardness, moisture content, mouth-dissolving time, and drug content. The prepared lozenges exhibited uniformity in weight and thickness. The hardness of all formulations ranged between 7.3–15.50 kg/cm², falling within standard limits. The …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 2, 2024 · pp. 50–62 Read article
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Hydrolysis-Driven Optimization of Hydroxypropyl Maize Starch for Improved Micro-Pellet Binding and Quick Solubility of Spirulina-Based Micro-Pellets
Abstract: Acid hydrolysis is a well-established approach for modifying the physicochemical properties of polysaccharides & macromolecules including hydroxypropyl Maize starch (HPMS). In this study, the effect of varying concentrations of hydrochloric acid on the partial hydrolytic degradation of HPMS (Lycoat RS-780) was investigated at 85°C for 4 h, yielding polymers of different molecular weights. The Acid-mediated degradation effects on polymer characteristics were systematically assessed using capillary viscometry and gel permeation chromatography …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 · pp. 41–61 Read article
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Comparative Assessment of Antibacterial Effectiveness, Bioactivity, Fluoride Release, and Microleakage of Various Bioactive Smart Composites: An In Vitro Investigation.
Abstract: The demand for dental composites with enhanced properties has led to the development of bioactive smart composites aimed at addressing multiple aspects of restorative dentistry. This in vitro investigation aimed to conduct a comparative assessment of the antibacterial effectiveness, bioactivity, fluoride release, and microleakage properties of various bioactive smart composites. Bioactive smart composites are emerging dental materials designed to promote remineralization and inhibit bacterial growth, thereby enhancing the longevity of …
Published in Journal of Polymer & Composites · Vol. 12, Issue 3, 2024 · pp. 76–86 Read article
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Gastro Retentive Drug Target System: Its Needs, Advantages, Limitation and Approaches
Abstract: Background: Gastro retentive drug delivery systems (GRDDS) address limitations of oral therapy for drugs with poor solubility, instability at intestinal pH, or narrow absorption windows by prolonging gastric residence and increasing contact with the gastric mucosa. Objectives: To review GRDDS approaches—floating systems, mucoadhesive systems, and super porous hydrogels—with emphasis on formulation strategies and polymer–excipient selection to enhance gastric retention, modulate buoyancy/swelling/adhesion, and ultimately improve oral bioavailability and therapeutic outcomes for …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 · pp. 47–58 Read article