Research and Reviews: A Journal of Pharmaceutical Science

Numerical Modeling of Drug Release from HPMC Carriers with Erosion

  1. Rumiana Blagoeva
  2. Assen Georgiev Nedev

Abstract

Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Numerical modeling of drug release kinetics from hydroxypropyl methylcellulose (HPMC) carriers is investigated. Recently a comprehensive model describing the controlling processes of this kinetics (water uptake, drug diffusion and carrier swelling) was proposed [1, 2]. An appropriate Finite Element (FE) approach to solving the arisen highly nonlinear model problem with moving boundary conditions was also developed. An improved variant of the above model for quantitative prediction of drug release kinetics, accounting the effect of polymer matrix erosion, is created. The model validation is performed fitting the numerical results to experimental data for two drugs (Trimetazidine K4M and Molsidomine K15M) under different tablet dimensions, release media, initial drug loading, and carriers’ viscosity grade.

Keywords

Support