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24 articles for “poorly water-soluble drugs”
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Asymmetric Membrane Capsules for Delivery of Poorly Water Soluble Drugs
Abstract: After the successful implementation of asymmetric membrane in osmotic tablet preparation, it also diversified towards capsular system. The asymmetric membrane capsule is a controlled drug-delivery device widely used in controlled osmotic drug delivery. The phase-inversion technique is utilized to nurture such units. It has a relatively thin dense region supported on a thicker porous region, hence called asymmetric. In contrast to gelatin capsules, however, the walls of asymmetric membrane capsules …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 3, Issue 2, 2013 · pp. 1–5 Read article
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A Consolidated Review on Novel Liquisolid Technique to Enhance Aqueous Solubility of Poorly Water Soluble Drugs
Abstract: Liquid technique is a novel capable method that can change the dissolution rate of water insoluble drugs. Liquid preparations such as solutions or suspensions of water unsolvable drugs in suitable non-volatile liquid vechicles can be transformed into suitable flowing as well as compressible powders by blending with selected powder excipients. It has been speculated that such systems exhibit improved release profiles. In this case, even though the drug is in …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 2, 2019 · pp. 1–4 Read article
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Formulating Self Phospholipids Dispersion of Poorly Water-Soluble Drug to Enhance Oral Bioavailability
Abstract: In present study, self-nano phospholipid dispersion (SNPD) of Simvastatin (SIM) was prepared based on Phosal 53 MCT to improve the oral bioavailability. Ternary phase diagrams were constructed to evaluate the efficient nanoemulsion regions and also for the optimum concentrations of lipid (Phosal 53 MCT) and surfactant (Cremophore RH 40), co-surfactant (Gelucire 50/13) and water in the formulation. The globule size of SNPD batch A was found to be 115.7 nm, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 3, 2019 · pp. 24–33 Read article
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Advances in Solubility Enhancement Strategies for Poorly Water-soluble Drugs: A Comprehensive Review
Abstract: Solubility enhancement holds significant importance in the field of pharmaceutical research as it aims to augment the solubility and bioavailability of drugs that possess low solubility. Poorly soluble drugs pose a considerable challenge in drug development due to their tendency to display inadequate absorption, bioavailability, and therapeutic efficacy. The advancement of solubility enhancement techniques encompasses a wide range of approaches, including physical and chemical methods, as well as innovative technologies …
Published in International Journal of Vaccines · Vol. 1, Issue 1, 2024 · pp. 01–09 Read article
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An Insightful Study on SMEDDS Challenges and Potential Strategies
Abstract: Self-microemulsifying drug delivery systems (SMEDDS) have gained attention as an effective approach to enhance the bioavailability of poorly water-soluble drugs. They are innovative lipid-based formulations designed to enhance the solubility, bioavailability, and therapeutic efficacy of poorly water-soluble drugs. The development of SMEDDS involves systematic selection of components based on solubility and emulsification efficiency, followed by optimization of ratios using pseudo-ternary phase diagrams. The resulting formulations are evaluated for droplet size, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 311–334 Read article
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Solubility Enhancement of Paracetamol by Mixed Solvency Method
Abstract: The aim of this research work was to increase the solubility of poorly water soluble drugs by the mixed solvency method. This method is used for the proper pharmacological response. There are some techniques used for enhancing the solubility of poorly water soluble drugs. The recent trend possess that hydrotropic solution having high demand in industry because of some of its ideal features like easily available, having good recovery, does …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 2, 2019 · pp. 19–22 Read article
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A Review: Various Adsorbent Carriers used for Enhancing Dissolution Profile
Abstract: In recent times, a large number of studies concerning the improvement of the dissolution rate of poorly water-soluble drugs are focused on the application of various porous materials as the drug carriers. These materials have attracted the attention of researchers owing to their outstanding properties such as large surface area, high pore volumes, microporosity and possibility of surface functionalization. Fujicalin can also be used to assist flow, reduce tablet weight …
Published in Trends in Drug Delivery · Vol. 7, Issue 1, 2020 · pp. 5–9 Read article
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Formulation And Evaluation of Domperidone Medicated Jelly Using Solvent Deposition Method For Solubility Enhancement
Abstract: Objective: The purpose of this study is to develop and characterize medicated jelly of Domperidone. Domperidone is associated with poor aqueous solubility and dissolution rate and thus exhibit a poor bioavailability. Solvent deposition is a promising method to improve the solubility of poor water soluble drugs.Methods: Solvent depositions were prepared for optimization and evaluated for percentage drug content, invitro dissolution, solubility analysis. Optimization of Domperidone solvent deposition was done using …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 4, Issue 2, 2017 · pp. 40–53 Read article
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Formulation and Evaluation of Solid Lipid Nanoparticles of BCS Class II Drug
Abstract: In the present study, we explored the potential of antihypertensive drug loaded solid lipid nanoparticles (SLNs), as a new formulation in improving the oral bioavailability of drug, which otherwise reported with poor bioavailability. The problem of poor water-solubility has remained as a significant challenge in pharmaceutical industry. The reduction of drug particle to the nano-level increases the surface area and improves solubility and dissolution of drug and proportionate increase in …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 6, Issue 2, 2019 · pp. 32–54 Read article
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Advancements in Solubility Enhancement Through Liquisolid Compact Technology: A Comprehensive Review
Abstract: The study examines Liquisolid Compact Technology as an innovative approach for improving the bioavailability and solubility of drugs that are poorly soluble in water. Liquisolid systems, comprising solid carriers and liquid drugs, offer advantages such as improved drug release and bioavailability, reduced manufacturing costs, and controlled drug delivery. The technique involves dissolving or suspending the drug in non-volatile solvents, adding carrier materials, super disintegrants, and coating materials, and then compressing …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 2, 2024 · pp. 25–34 Read article
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Design and Development of Self Microemulsyfying Drug Delivery System of Olmesartan Medoxomil
Abstract: Olmesartan Medoxomil is poorly water soluble drug. It comes into the BCS II drug. Hence oral bioavailability of Olmesartan Medoxomil is less (26%). The purpose of this study is to develop novel dosage form of the self-microemulsifying drug delivery systems (SMEDDS) for the Olmesartan Medoxomil for enhancing its solubility hence the oral bioavailability. Before the formulation of SMEDDS, solubility study was performed in different excipients and select excipients on basis …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 3, Issue 3, 2013 · pp. 1–14 Read article
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Design and Development of Self Microemulsyfying Drug Delivery System of Olmesartan Medoxomil Smita D Patel*, M R Patel, K R Patel
Abstract: Olmesartan Medoxomil is poorly water soluble drug. It comes into the BCS II drug. Hence oral bioavailability of Olmesartan Medoxomil is less (26%). The purpose of this study is to develop novel dosage form of the self-microemulsifying drug delivery systems (SMEDDS) for the Olmesartan Medoxomil for enhancing its solubility hence the oral bioavailability. Before the formulation of SMEDDS, solubility study was performed in different excipients and select excipients on basis …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 3, Issue 3, 2013 · pp. 1–15 Read article
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Preparation and Characterization of Fenofibrate Freeze-Dried Crystals
Abstract: The present research work was aimed to prepare fenofibrate freeze-dried crystals using poloxamer by freeze-drying technique. Fenofibrate crystals containing poloxamer were prepared by freeze drying using acetone and water as solvent system. The prepared formulations containing drug and poloxamer were evaluated for solubility and in-vitro dissolution. The prepared formulations were characterized by DSC, FT-IR, XRD and SEM. Dissolution profile of the prepared freeze-dried crystals was compared with its physical mixture …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 1, 2015 · pp. 16–22 Read article
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Formulation and Evaluation of Verapamil Solid Dispersion Tablets for Solubility Enhancement
Abstract: This study was mainly designed to solve the drawbacks of conventional verapamil solid dosage form, low bioavailability and limited clinical efficacy, by preparing solid dispersion. Verapamil solid dispersion was developed by kneading method, melt solvent method and co-precipitation method to modify the release and enhance solubility of the drug. The physical state of the dispersed verapamil in the polymer matrix was characterized by differential scanning calorimetry, powder X-ray diffraction, scanning …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 1, 2016 · pp. 39–54 Read article
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Swift Solutions: The Science and Innovation Behind Fast-Dissolving Tablets
Abstract: Swift solutions in the context of fast dissolving tablets (FDTs) represent an innovative breakthrough in pharmaceutical science, aiming to provide rapid and effective drug delivery for patients who face difficulty swallowing conventional dosage forms. The science and innovation behind FDTs are rooted in advanced formulation techniques, material science, and drug delivery mechanisms that prioritize speed, convenience, and patient compliance. These tablets are formulated to dissolve quickly in the mouth, removing …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 26–36 Read article
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Solid Self Nanoemulsifying Tablets: Statistical Optimization by 23 Factorial Designs
Abstract: The objective of the current research was to enhance the solubility of poorly water soluble drug i.e. atorvastatin calcium, by self nanoemulsifying drug delivery system (SES) and formulating it as tablets using 23 factorial designs. The prepared liquid SES were adsorbed onto aerosil which acts as carrier. The 23 factorial designs were employed to optimize the concentration of micro-crystalline cellulose, PVP and sodium starch glycollate. The observed values were in …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 2, 2017 · pp. 1–7 Read article
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Preparation and Characterization of Solid Dispersion of Tenoxicam
Abstract: The aim of the present study was to prepare solid dispersions of a poorly water-soluble drug Tenoxicam in Polyvinylpyrrolidone (PVP), prepared by spray-drying techniques. The physicochemical properties of the solid dispersion and drug-polymer interactions were characterized by DSC, FT-IR, XRD and SEM. Tenoxicam was found amorphously dispersed in solid dispersion systems with the drug to polymer weight ratio of 1:3. Dissolution profile of the prepared solid dispersion was compared with …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 1, 2015 · pp. 23–29 Read article
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Monophase Solution for Enhancing Solubility and Dissolution of Ezetimibe by Spray Dried Microparticle
Abstract: The aim of the present study was to improve the solubility and dissolution rate of Ezetimibe by preparing crystals by spray drying technique using Isopropyl alcohol (IPA) and water as solvent system. Ezetimibe crystals were produced by spray drying using IPA as solvent to enhance solubility and dissolution rate. The prepared crystals were evaluated for solubility and in vitro dissolution. The prepared formulations were characterized by differential scanning calorimetry (DSC), …
Published in Trends in Drug Delivery · Vol. 1, Issue 3, 2014 · pp. 30–36 Read article
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Toxicological Optimization and Assessment of Buccal Films Containing Felodipine Co-crystals to Enhance Bioavailability
Abstract: The preformulation study of felodipine was carried out and it was found that the drug is poorly water soluble. The co-crystals were prepared using three different co-formers sorbitol, ascorbic acid and oxalic acid. The solublity enhancement was observed in combination with sorbitol compared to other co-formers used. The characterization of co crystals was performed like PXRD, FTIR, SEM Analysis. XRD results indicates the amorphous form of the drug. The co-crystals …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 10–29 Read article
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Evaluation of Polyethylene Glycol (PEG)-Based Polymers for Improving Solubility and Bioavailability of Poorly Soluble Drugs
Abstract: A significant barrier to optimizing oral bioavailability is the inadequate water solubility of numerous pharmaceutical compounds. This study examined whether polymer systems utilizing polyethylene glycol (PEG) may enhance the solubility and bioavailability of a poorly soluble model drug. Multiple PEG polymers with molecular weights between 2,000 and 10,000 Da were utilized to produce PEGylated preparations. The formulations were subsequently evaluated for dissolution efficacy, medication loading capacity, particle size, and solubility …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 489–499 Read article