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26 articles for “lipophilic”
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Mechanistic Studies on Aziridinyl-Benzoquinones in Cultured Tumour Cells
Abstract: This study compares the anti-tumour effects of NQO1 activated drug RH1 (2, 5-diaziridinyl-3 - hydoxymethyl-6-methyl-1, 4-benzoquinone) with a lipophilic ester derivative Es5 on the isogenic cell lines MDA 468 and MDA 468 NQO1 which differs only in expression of wtNQO1. A 39- fold enhancement of growth inhibitory activity was seen in NQO1 expressing cells compared the NQO1 null cells for the Es5 compared to the 25- fold increase seen for …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 11, Issue 2, 2023 · pp. 37–45 Read article
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Physiochemical and Formulation Factors Affecting the Absorption of Basti Dravyas
Abstract: Basti is a purificatory process by which all the three vitiated Doshas are expelled from the anal canal and is said to be the best treatment for Vata dosha. There are two main types of Basti mentioned in Ayurveda Sneha Basti and Asthapan Basti. Compared to oral and parental route, rectal drug delivery is not so much exposed in today’s era, whereas Ayurveda highlights Basti as half of the treatment, …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 6, Issue 1, 2017 · pp. 32–34 Read article
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Liposome and Its Method of Preparation: A Review
Abstract: Liposomes are spherical vesicles that self-assemble and range in size from 20 nm to 10 m. They can be used as drug carriers for lipophilic, hydrophilic, and amphiphilic medications. Lipophilic and amphiphilic drugs can be encapsulated inside the lipophilic bilayer, whereas hydrophilic drugs can be integrated into the aqueous heart. Many liposomal preparations are currently undergoing clinical trials, with some of them being accepted for clinical use. By altering the …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 2, 2025 · pp. 25–30 Read article
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Recent Advances & Prospects of Transferosomes for Transdermal Delivery: Trends in Drug Delivery
Abstract: There have been several non-invasive administrations that have emerged recently to replace conventional needle injections. With its minimal rejection rate, remarkable ease of administration, and remarkable patient comfort and perseverance, the transdermal drug delivery system (TDDS) is the most attractive of them all. The skincare industry, which includes cosmetics, may also find use for TDDS in addition to the pharmaceutical industry. As this strategy mainly entails local drug administration, it …
Published in Trends in Drug Delivery · Vol. 11, Issue 3, 2024 · pp. 01–21 Read article
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Aceclofenac and Diclofenac Sodium Conjugates with Amino Acids to Overcome Acidity
Abstract: This research work was based on a conjugate approach with some non-steroidal anti-inflammatory drugs (NSAIDs) to overcome the side effects like gastric irritation, solubility behavior, and some other effects of NSAIDs. Almost all the NSAIDs have undesirable reactions as well as they cause some types of major adverse reactions. Here the prodrugs conjugates are the approaches that increase the lipophilicity of the drug and decrease the solubility in water by …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 12, Issue 2, 2022 · pp. 19–25 Read article
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A Review on Nano-emulsion for Delivery of Anti-cancer Drugs
Abstract: Cancer disease is characterized by abnormal cell growth. Malignant growth treatments have progressed significantly, yet there is a requirement for development in particularity and feeling of dread toward foundational harmfulness. Nanotechnology is the reconciliation of nanoscience into medication by the utilization of nanoparticles. The appearance of nanoscience in disease conclusion and treatment will assist clinicians with better surveying and oversee patients and further develop the medical care framework and administrations …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 1, 2024 · pp. 7–13 Read article
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Review On: Liquid Crystal Cream for Topical Drug Delivery
Abstract: A Liquid crystal creams represent a novel approach in skincare formulations, leveraging the unique properties of liquid crystal technology to improve skin hydration and barrier function. An overview of current developments in liquid crystal cream formulations is given in this article, with an emphasis on the benefits they offer for skincare and their composition and structure. Liquid crystal creams mimic the lipid bilayers of the skin, offering enhanced compatibility and …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 1–8 Read article
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Recent Trends in Ocular Drug Delivery: Challenges and Approaches
Abstract: Drug topically regulation can be accessed most easily in the eye. When given topically as eye drops, medication ocular bioavailability is quite low. Drug entry into specific ocular locations is complicated by the complex anatomy and physiology of the human eye. Research has long been interested in the topical administration of successful treatments. To provide a suitable ocular penetration and extend the duration of drug residence is their challenging task. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 3, 2024 · pp. 22–38 Read article
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Computational Analysis of Tinospora Cordifolia Phytochemicals as Potential Inhibitors of BRCA1-BRCT Domain Interaction in Breast Cancer
Abstract: Breast cancer is a leading cause of cancer-related deaths worldwide, accounting for a significant proportion of mortality rates among women. Despite current therapeutic approaches, the disease remains characterized by molecular heterogeneity, making it challenging to develop effective treatments. This study explores the potential of Tinospora cordifolia, a medicinal plant, in breast cancer therapy. Guduchi, scientifically known as Tinospora cordifolia, boasts a centuries-long history of use in traditional medicine, with a …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 27–37 Read article
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Molecular Pharmacokinetics and Structural Docking of Phenolic Acids for Targeting NF-κB Pathway Components in Inflammation and Fibrosis: A Computational Approach Toward Therapeutic Discovery
Abstract: Inflammation and Fibrosis are critical pathological processes associated with various chronic diseases, often mediated by the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. This study investigates the therapeutic potential of phenolic acids as modulators of the NF-κB pathway, aiming to identify novel ligands that can effectively interact with key components of this signaling cascade. A comprehensive computational approach was employed, utilizing molecular docking, pharmacological screening, and post-docking …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 14–31 Read article
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An Insightful Study on SMEDDS Challenges and Potential Strategies
Abstract: Self-microemulsifying drug delivery systems (SMEDDS) have gained attention as an effective approach to enhance the bioavailability of poorly water-soluble drugs. They are innovative lipid-based formulations designed to enhance the solubility, bioavailability, and therapeutic efficacy of poorly water-soluble drugs. The development of SMEDDS involves systematic selection of components based on solubility and emulsification efficiency, followed by optimization of ratios using pseudo-ternary phase diagrams. The resulting formulations are evaluated for droplet size, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 311–334 Read article
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Review on Sustained Released Matrix Tablet
Abstract: Pharmaceuticals often use sustained release dose forms to prolong the therapeutic agent’s presence in the bloodstream and maintain a consistent plasma profile. The matrix governs the drug’s release rate. Hydroxypropyl methyl cellulose, a release retardant, is a key excipient in formulations due to its ability to promote sustained release. Techniques that include wet granulation, direct compression, or the dispersion of solid particles within a porous matrix, integrating polymers, like polymethyl …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 60–69 Read article
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Pharmacokinetic Profiling and Molecular Docking of Carvacrol and Structural Analogs: Targeting Quorum Sensing Proteins to Disrupt Biofilm-Mediated Antimicrobial Resistance in Multidrug-Resistant Bacterial Pathogen
Abstract: Antibiotic resistance, particularly in Pseudomonas aeruginosa, has become a major global health threat, exacerbated by the organism's ability to form biofilms and regulate virulence through quorum sensing (QS). The LuxR and LasR receptors are key regulators in this process, influencing both pathogenicity and antibiotic resistance. This study investigates potential QS inhibitors targeting these receptors as a strategy to mitigate antibiotic resistance. The primary objective was to identify novel ligands that …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 43–61 Read article
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Development and Characterization of a Solid Dispersion of an Anti-Diabetic Drug Using Pectin as a Natural Polymer
Abstract: Aim: The current study sought to improve the solubility and oral bioavailability of gliclazide by creating solid dispersions and oral dispersible tablets (ODTs) with enhanced physicochemical characteristics and maintained antidiabetic action. Methods: Preformulation studies were conducted to evaluate the physicochemical properties of gliclazide, including physical appearance, melting point, solubility, and partition coefficient. Solid dispersions were prepared using hydrophilic carriers-pectin and PVP K30, and subsequently characterized by Fourier Transform Infrared Spectroscopy …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 · pp. 01–12 Read article
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In Silico Analysis of Potential Drug Targets in E. coli as Anticancer Agents
Abstract: Escherichia coli is a bacteria which grows as symbiotic and pathogenic organism in humans that expresses with genes causing several diseases. Manipulation and control of genes of E. coli can become a solution for cure of diseases like cancer. Based on QSAR studies, Partial partial charges are neutral for all selected ligands. The surface area, mass and volume for Capsaicin is predicted more compared to other selected ligands. As the …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 2, 2019 · pp. 10–18 Read article
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Role of Nitric Oxide in Platelets of Breast Carcinoma
Abstract: Breast cancer is a disease of multifactorial origin; it is seen frequently in women of older age, having family history, affluent society, late age of marriage and first childbirth, early menarche, late menopause, and nulliparity. Oxidative stress results when balance between reactive oxygen species (ROS) production and antioxidant defence is lost which result in mutations, sister chromatid exchanges, cytotoxicity, carcinogenesis etc. Clinical, experimental and epidemiological studies suggest that free radicals …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 8, Issue 2, 2019 · pp. 25–29 Read article
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Rotenone Beyond Just An Insecticide: A Review
Abstract: Pesticides have received the most attention due to their global application and widespread implications on human health. In recent years, both epidemiological and toxicological studies have provided evidence that pesticides have the potential to act as toxicants contributing to the development of pathogenesis such as neuronal degenerations as well as may be utilized to induce signalling for reversal, suppress or prevent carcinogenic progression. Rotenone, an isoflavones naturally found in the …
Published in Research and Reviews: A Journal of Toxicology · Vol. 4, Issue 2, 2014 · pp. 8–13 Read article
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Anticancer, Bioactive, & Therapeutic Applications of Cannabinoids
Abstract: Cannabinoids, a complex class of lipophilic compounds found in Cannabis sativa L., are attracting significant clinical interest for their multifaceted therapeutic potential, particularly within oncology. This review provides a comprehensive synthesis of contemporary knowledge detailing the distinct anti-cancer properties of phytocannabinoids (such as δ-tetrahydrocannabinol and cannabidiol), endogenous endocannabinoids, and synthetic analogues. Accumulating evidence from robust in vitro and in vivo oncological models demonstrates that these compounds aggressively suppress tumor progression …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 2, 2026 · pp. 17–30 Read article
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Lipid Drug Conjugates: A Novel Approach for Drug Delivery A Systematic Review
Abstract: The lipid drug conjugates (LDCS) a novel lipid based nanoparticles which has been extensively employed for the delivery and targeting of drugs. These have been exploited for many features in the field of pharmaceutical technology. The lipid drug conjugates have a 33% drug loading capacity more than the solid lipid nanoparticles (SLNs). The lipid drug conjugates have the potential to act as a delivery system for hydrophilic and lipophilic drugs, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 3, Issue 3, 2012 · pp. 1–8 Read article
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Pharmaceutical Cocrystals of Pain Relieving Drugs
Abstract: Cocrystallisation of two components into one crystal form can enhance the solid-state properties of drug compounds. Cocrystals are considered as the next generation modified-active pharmaceutical ingredients with improved physical-chemical, (aqueous solubility, dissolution, hygroscopicity, bioavailability, stability, increase of melting point, purity of an active pharmaceutical ingredients (API), intellectual property positions) and pharmacokinetic properties. Cocrystal formation may overcome dissolution problems of highly lipophilic APIs because the new crystalline lattice being formed often …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 6, Issue 1, 2015 · pp. 16–27 Read article