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30 articles for “in situ forming systems”
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Formulation Challenges in Long-acting Injectable Small Molecules: Emerging Strategies and Perspectives
Abstract: Long-acting injectable (LAI) formulations represent a transformative approach in pharmacotherapy, particularly for conditions demanding sustained drug exposure over weeks to months. Although biologics have dominated this space historically, the adaptation of LAI technology to small molecules presents a distinct and complex set of challenges rooted in physicochemical properties, manufacturing scalability, and regulatory expectations. This review systematically addresses the principal formulation barriers encountered in developing LAI small-molecule products, including aqueous solubility …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article
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Revolutionizing Gastro-retentive Drug Delivery: Exploring Innovative Formulation Strategies and Mechanisms in Floating in Situ Gel Raft Forming System
Abstract: An in-depth exploration of the transformative shift underway in gastro-retentive drug delivery, spotlighting the utilization of Floating Drug Delivery Systems (FDDS) and specifically honing in on the innovative formulation strategies and mechanisms inherent in Floating In Situ Gel Raft Forming Systems. FDDS present a promising avenue for revolutionizing drug delivery efficacy by capitalizing on buoyancy to float atop the gastric fluid surface, thereby extending gastric residence time and improving drug …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 9–21 Read article
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Advances in Polymeric In Situ Drug Delivery and Soft Biosensors: Innovations in Biochemical Sensing and Personalized Healthcare
Abstract: Advanced healthcare and personalized medicine are undergoing a transformation thanks to in situ medication delivery systems and biochemical sensor technology. Polymeric in situ drug delivery systems form gels upon administration, releasing medications in a controlled manner and providing benefits such as ease of administration and enhanced patient compliance. Similarly, advancements in soft electronics, including flexible and stretchable biosensors, enable continuous, in situ biochemical monitoring, conforming to complex biological environments like …
Published in International Journal of Cheminformatics · Vol. 2, Issue 1, 2024 · pp. 27–32 Read article
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pH-Triggered In-Situ Nasal Gel Systems for Migraine Therapy: A Review
Abstract: Intranasal drug delivery has gained considerable attention as a non-invasive route for delivering drugs to both systemic circulation and the central nervous system, particularly for the treatment of migraine. Traditional nasal formulations such as sprays and drops often show poor therapeutic performance due to rapid mucociliary clearance and limited retention within the nasal cavity. To overcome these challenges, in-situ gel systems have been designed, which transform from a liquid to …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article
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Floating In-Situ Gel for Gastric Retention Delivery
Abstract: When taken orally, medications with a limited window of absorption in the gastrointestinal tract (GIT) are typically accessible to the extremities due to the partial release of the active component and the brief residence period at the absorption site. Because they prolong the duration of the drug's presence in the stomach, they are made with high density and have the capacity to swell. Because oral fluids go more quickly through …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 2, 2024 · pp. 24–32 Read article
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Universities in India: Study of Various Types of Universities Operational in India as of 2024 From Faculty Perspective
Abstract: The Indian university system, a legacy of British colonial rule, has witnessed significant growth post-independence. The recent implementation of the National Education Policy (NEP) 2020 further accelerates this expansion, aiming to dismantle the affiliation system and foster the growth of autonomous colleges and universities. This study explores the forms, traits, and difficulties of Indian universities, revealing their variegated environment. It looks at how various institutions respond to the rising demand …
Published in International Journal of Education Sciences · Vol. 2, Issue 1, 2025 · pp. 62–73 Read article
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Exploring Abies grandis phytocompounds potential by in silico analysis targeting on the 5P9J Protein
Abstract: Blood Cancer, also popular with name ‘Hematologic cancer’ have variety of types: Leukaemia, Lymphoma, Myeloma, uncontrolled multiplication of blood cells mainly affecting to bone marrow and blood cells (White Blood Cells). Lymphoma, originating from lymphatic system resulted in uncontrolled growth and instead of normal apoptosis development of tumor. Myeloma, uncontrolled formation of malignant plasma cells leads disrupting production of healthy blood cells. This situation creates variety of diseases like anaemia, …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 Read article
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Adoption of One-Touch Emergency Alert Apps: User Authentication, Simplicity, and Trust for Human Safety
Abstract: Quick reactions to disasters are extremely important to the safety and health of people. Nonetheless, another frequent problem with emergency cases is the time lag between reports of the incidents and the success and timely response of the concerned authorities. Mobile-based emergency alert systems have thus come in as a potential solution to this problem, given that they enable straightforward and direct communication between the citizens and the law enforcement …
Published in International Journal of Mobile Computing Technology · Vol. 4, Issue 1, 2026 · pp. 01–13 Read article
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Mind-Gut Connection: The Psychosomatic Effects of Stress and Emotions on Digestive System
Abstract: Stress, understood as an immediate disruption to bodily equilibrium, triggers an adaptive or allostatic response that impacts gastrointestinal function both in the short and long term. The enteric nervous system communicates in both directions with the brain through parasympathetic and sympathetic pathways, collectively forming what is known as the brain-gut axis. Unani scholars describe stress as a response to the loss of something valuable, such as an opportunity, a desired …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 1, 2025 · pp. 11–14 Read article
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Physiographic, Climatic, and Hydrogeological Determinants of Urban Flooding in Bhopal: A Spatial Assessment
Abstract: Bhopal, capital city of Madhya Pradesh, is uniquely shaped by hilly terrain, lake systems, and complex hydrogeological characteristics, which historically supported efficient natural drainage. However, rapid urbanization, encroachment, and alterations in land use have increasingly disrupted these natural systems, amplifying the city’s susceptibility to urban flooding. The city’s physiography, defined by five major hills, undulating slopes, and a network of natural drainage channels, directs runoff toward low-lying zones that frequently …
Published in Journal of Water Resource Engineering and Management · Vol. 13, Issue 1, 2026 · pp. 25–32 Read article
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Advances in Photocatalytic Catalysts for Wastewater Treatment
Abstract: Water is a fundamental component of the life support system and is indispensable for the survival of all living organisms. Life cannot exist without water, and human societies depend on it for drinking, agriculture, industry, and sanitation. Water resources are increasingly under pressure in terms of both quality and availability, largely due to rapid industrial development, expanding urban areas, and rising population levels. These human-driven activities have played a major …
Published in Journal of Catalyst & Catalysis · Vol. 13, Issue 1, 2026 · pp. 44–56 Read article
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Gear-Related Stress Analysis and Comparison Between the Fem and Agma Standards
Abstract: In many different devices, gears enable the efficient transfer of motion and torque. They are an essential component of modern mechanical power transmission systems. It has been demonstrated that bending and surface contact stresses at the gear tooth are the primary causes of gear failure, despite their widespread use. Too much stress can lead to tooth wear, pitting, or breakage, which can ultimately reduce the operating life and reliability of …
Published in Trends in Mechanical Engineering & Technology · Vol. 15, Issue 3, 2025 · pp. 13–18 Read article
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Advances in Polymer-Based Nanocomposites for Moisture-Sensitive Applications
Abstract: Polymer-based nanocomposites have emerged as promising materials in sensor technology due to their superior mechanical, electrical, and environmental stability. These advanced materials offer unique advantages, such as enhanced sensitivity, durability, and adaptability to various environmental conditions, making them highly suitable for sensor applications. One of the most significant breakthroughs in this field is the integration of semiconducting nanoparticles (NPs) within a polymer matrix, which has led to remarkable improvements in …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 145–152 Read article
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A Survey on Hydrogen Storage System using Composite Material and its Alloys
Abstract: The transition to a carbon-neutral energy landscape hinges on the ability to store hydrogen safely, densely, and reversibly. While high-pressure tanks and cryogenic vessels dominate today’s infrastructure, solid-state storage in metallic alloys offers a compelling alternative by combining high gravimetric capacity with intrinsic safety to form a composite material. This work presents a systematic investigation of a family of reversible hydrogen-absorbing composite material alloys—principally Mg-based intermetallics (Mg₂Ni, MgFeMn) and TiV-based …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 2, 2025 Read article
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Self-Healing Structural Polymer Composites Incorporating Bio-Inspired Nanofillers
Abstract: Self-healing polymer composites become an attractive family of intelligent materials that are capable of autonomously repairing damage, which will enhance their durability, reliability and service life in extreme engineering applications. The materials are based on the principles of nature, using the nanofillers that are derived from biological systems to improve mechanical properties and self-healing capabilities by utilizing hierarchical structures and multifunctional interface interactions. The recent developments on the formulation of …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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Design and Validation of an Artificial Intelligence-Driven Digital Twin for Real-Time Monitoring and Control in Polymer Composite Manufacturing
Abstract: Polymer Matrix Composites (PMCs) have become indispensable in high-performance sectors such as aerospace and automotive engineering, offering exceptional strength-to-weight ratios that outperform traditional metals in many demanding applications. However, the reliability of manufacturing PMCs via Vacuum-Assisted Resin Transfer Molding (VARTM) is frequently undermined by stochastic process variabilities. Unpredictable fluctuations in thermal history, preform permeability, resin rheology, and ambient conditions often lead to some defects; namely voids, dry spots, and incomplete …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 224–233 Read article
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Advances in Polymer Chemistry: The Role of Polymer Composites in Modern Applications
Abstract: Polymer composites have gained immense significance in various industries due to their superior mechanical, thermal, and chemical properties, making them highly versatile materials. These composites are formed by combining polymer matrices with reinforcing agents such as fibers, nanoparticles, or other fillers to enhance specific properties. The field of polymer chemistry plays a crucial role in the development and optimization of these materials, ensuring their suitability for diverse applications. This paper …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 51–56 Read article
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Overview AI-Driven Antenna Technologies and Privacy- Preserving Methods for Next-Generation 6G Wireless Systems
Abstract: The next generation of wireless communications, 6G, will be built on the convergence of artificial intelligence (AI) and advanced antenna systems. AI-driven antennas are poised to address the unprecedented requirements for data rate, reliability, adaptability, and ubiquity in future networks. An overview of current advancements in AI-enabled antenna systems for 6G networks is provided in this study. From traditional base station deployments to distributed, cell-free, and user-centric frameworks, it examines …
Published in Journal of Telecommunication, Switching Systems and Networks · Vol. 13, Issue 1, 2026 · pp. 28–34 Read article
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Exploring Type-II Diabetes Potential of Phyto-Derived Carbon Dots
Abstract: The integration of phytoconstituents with carbon dots (C-dots) presents a novel and sustainable approach to the development of nanotherapeutics for type 2 diabetes mellitus (T2DM). C-dots, zero-dimensional carbon-based nanomaterials, exhibit unique physicochemical properties including high fluorescence, tunable surface chemistry, biocompatibility, and low toxicity. Their ability to enhance the solubility, bioavailability, and targeted delivery of poorly soluble phytochemicals renders them highly suitable for biomedical applications. This study explores the synthesis of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 08–25 Read article
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Understanding the Impact: Adult BCG Vaccination in the Fight Against Tuberculosis
Abstract: Tuberculosis (TB) remains a big global health challenge, with significant mortality rates, especially in developing nations. India holds most TB cases throughout the globe. As HIV rates, multidrug-resistant tuberculosis (MDR-TB), and extensively drug-resistant tuberculosis (XDR-TB) continue to increase, the situation is deteriorating. These all come in the way of the End TB epidemic campaign by the World Health Organization (WHO) by 2030. Immunology and vaccinology represent critical fronts in TB …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 3, 2024 · pp. 1–6 Read article