Search
164 articles for “drug release”
-
Role of Polymeric Composites in Controlled Drug Release Systems
Abstract: In the realm of controlled drug release systems, polymeric composites have attracted a lot of interest as they possess several diverse characteristics that enable exact control of the drug delivery rate. This lowers adverse effects and increases the efficacy of treatment. Usually composed of biocompatible polymers combined with functional fillers like nanoparticles, ceramics, or hydrogels, these composites help to get the desired drug release patterns. Stable, biodegradable, and bioactive materials …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 453–465 Read article
-
Stimuli-Responsive Polymers for Drug Release in Targeted Therapy
Abstract: SRPs, or stimuli-responsive polymers, are becoming a good way to give specific drugs. They let medicines be released in a controlled way. Some of the things that can change these polymers are pH, temperature, light, magnetic fields, and the number of ions present. Some outside signs can make SRPs respond, which helps control how drugs are released. This cuts down on side effects and improves the effectiveness of focused treatments. …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 252–265 Read article
-
Controlled Release Drug Delivery Using 3D Printing Techniques: A Current Scenario In Personalized Medicine
Abstract: Three-dimensional (3D) printing is particularly influencing the pharmaceutical manufacturing sector in the creation of controlled release drug delivery systems. This technology enables the precise fabrication of personalized medicines with tailored drug release profiles, dosages, and geometries, marking a significant advancement over traditional mass production methods. An array of 3D printing techniques, including extrusion-based, powder-based, and others, can be used to build complex dosage forms that regulate drug release through processes …
Published in Trends in Drug Delivery · Vol. 12, Issue 3, 2025 · pp. 28–43 Read article
-
Polysaccharide-Based Hydrogels for Sustained Drug Release in Pharmacology
Abstract: Polysaccharide-based hydrogels have showed great potential in medicine as materials for long-lasting, under control medication delivery systems. Natural polysaccharides include chitosan; alginate, agarose, and cellulose form these hydrogels. Among its many advantages are biocompatibility, biodegradability, and customising ability for various drug release rates. Reacting to pH, temperature, and ionic strength changes in the surroundings, polysaccharide-based hydrogels may swell. For usage requiring the release of therapeutic substances over an extended period …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 300–312 Read article
-
Effect of Polymer Crosslinking on Drug Release Kinetics
Abstract: In order to improve treatment effectiveness and minimise adverse effects, polymer-based drug delivery systems are often used to produce regulated and sustained drug release. Polymer crosslinking, which alters the structural, mechanical, and degrading characteristics of the polymer matrix, is one of the key elements affecting drug release kinetics. The porosity, swelling behaviour, and rate of degradation of the polymer are all impacted by the crosslinking process, which may be accomplished …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 636–647 Read article
-
Biodegradable Polymer Composite Materials for Long-Term Drug Release in Pharmacotherapy
Abstract: Biodegradable Polymer composite materials are a promising choice for controlled drug delivery because they let medicine be released slowly over time during treatment. These structures, which are made from safe, recyclable plastics, work well to make sure that drugs stay in the body for a long time. This means that patients will take their medicine less often and more consistently. As the body breaks down these structures, the drug inside …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 533–546 Read article
-
4D Printing in Drug Delivery: Application of Shape- Morphing Materials in Controlled Drug Release
Abstract: Four-dimensional printing technology has transformed the pharmaceutical landscape, offering unprecedented opportunities for innovation in drug development and delivery. This emerging technology enables the creation of complex geometries and customized structures, facilitating the design of personalized medications tailored to individual patient needs. Personalized dosing and drug release profiles, customized pill shapes and sizes for improved swallowability. Enhanced drug solubility and bioavailability, rapid prototyping and testing of pharmaceutical products. Development of complex …
Published in Trends in Drug Delivery · Vol. 12, Issue 3, 2025 · pp. 08–16 Read article
-
Biodegradable and Natural Fiber-Reinforced Polymer Composites for Co-Delivery of Multiple Therapeutic Agents
Abstract: The co-delivery of multiple drugs using advanced nanocarriers has revolutionized targeted therapy in various diseases, particularly in cancer, infectious diseases, and neurological disorders. Multi-layered polymeric nanocarriers (MLPNs) offer a sophisticated platform to encapsulate multiple therapeutic agents with precise control over drug release, bioavailability, and synergistic effects. These nanocarriers are designed with distinct polymer layers that enable sequential or simultaneous drug release based on stimuli-responsive mechanisms such as pH, temperature, and …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 406–419 Read article
-
3D-Printed Polymeric Drug Delivery Systems for Personalized Medicine
Abstract: Personalized medicine has revolutionized healthcare by tailoring treatments to individual patient needs. Among the emerging technologies, 3D printing has demonstrated immense potential in fabricating polymeric drug delivery systems with precise control over drug release, dosage, and bioavailability. These systems offer customized therapeutic solutions, improving efficacy while reducing adverse effects. This paper provides an overview of 3D-printed polymeric drug delivery systems, discussing the types of polymers used, fabrication techniques, applications in …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 313–325 Read article
-
Development of Sodium Alginate Beads of Telmisartan Using Emulsion Gelation Method: Formulation and In-Vitro Characterization
Abstract: Introduction: The antihypertensive medication Telmisartan (TEL) is a member of BCS class II, which is distinguished by limited oral rate and extent and water solubility. By localizing the medication release in the stomach, gastro-retentive floating bead devices may be able to address the issues related to partial absorption and the low solubility of TEL. The preparation of TEL floating alginate beads was the aim of this investigation. The current work …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 3, 2024 · pp. 13–21 Read article
-
Controlled Release of Anti-Inflammatory Drugs from Biopolymer Matrices
Abstract: Carefully releasing anti-inflammatory drugs from natural materials is a new way to make treatments work better and cut down on the side effects of current drug delivery methods. To slowly release drugs, this method uses safe, reusable materials. It's a good alternative to pills or shots. Anti-inflammatory drugs that are used to treat long-term conditions like gout and inflammatory bowel disease work better when they are made in a controlled …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 388–399 Read article
-
Biodegradable Polymer Nano Composites for Enhanced Drug Bioavailability
Abstract: Polymer-based nanoparticles have emerged as a revolutionary approach in drug delivery systems, particularly in enhancing the bioavailability of poorly soluble and unstable drugs. These nanoparticles, composed of both natural and synthetic polymers, serve as effective vehicles for encapsulating a wide range of therapeutic agents. Their surface characteristics can also be modified to enable targeted drug delivery, increasing the concentration of drugs at the site of action while minimizing side effects. …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 433–443 Read article
-
Design and Evaluation of Extended-Release Tablet Compositions Containing Oxaprozin: Integrating Concepts from Bioinformatics
Abstract: The procured sample of Oxaprozin was tested for its identification. The manufacturer also was confirmed of quality and purity of sample. The sustained release tablets of Oxaprozin were prepared by wet granulation method, They were evaluated for weight variation, drug content, friability, hardness, and thickness for all batches (T-1 – T-10). The release of Oxaprozin from sustained release tablet of various formulations varied according to the ratio and degree of …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 1, 2024 · pp. 39–45 Read article
-
Design and Evaluation of Extended-Release Tablet Compositions Containing Oxaprozin: Integrating Concepts from Bioinformatics
Abstract: The procured sample of Oxaprozin was tested for its identification. The manufacturer also was confirmed of quality and purity of sample. The sustained release tablets of Oxaprozin were prepared by wet granulation method, They were evaluated for weight variation, drug content, friability, hardness, and thickness for all batches (T-1 – T-10). The release of Oxaprozin from sustained release tablet of various formulations varied according to the ratio and degree of …
Published in Research and Reviews: A Journal of Toxicology · Vol. 11, Issue 1, 2024 · pp. 39–45 Read article
-
Formulation and Evaluation of Betel Leaf and Clove Based Herbal Gel
Abstract: This study developed and assessed a herbal gel comprising extracts of betel leaf (Piper betle) and clove (Syzygium aromaticum) for topical use. Herbal extracts were prepared by Soxhlet extraction and analyzed for yield, phytochemical profile and total phenolic content (TPC). The phytochemicals present were alkaloids, flavonoids, tannins and phenols, and glycosides, with a greater phenolic content for clove extract. Herbal gels were prepared using Carbopol 934 and assessed for properties, …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 2, 2026 Read article
-
Polymer-Based Film Coatings for Enhancing Drug Stability and Shelf-Life
Abstract: Pharmaceutical stability is a crucial factor in ensuring drug efficacy and safety throughout its shelf-life. Polymer-based film coatings have emerged as an effective strategy to enhance drug stability by protecting active pharmaceutical ingredients (APIs) from environmental stressors such as moisture, oxygen, temperature fluctuations, and light exposure. These coatings act as physical barriers that prevent degradation, improve mechanical integrity, and enable controlled drug release. Various types of polymers are employed for …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 558–570 Read article
-
Review on Sustained Released Matrix Tablet
Abstract: Pharmaceuticals often use sustained release dose forms to prolong the therapeutic agent’s presence in the bloodstream and maintain a consistent plasma profile. The matrix governs the drug’s release rate. Hydroxypropyl methyl cellulose, a release retardant, is a key excipient in formulations due to its ability to promote sustained release. Techniques that include wet granulation, direct compression, or the dispersion of solid particles within a porous matrix, integrating polymers, like polymethyl …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 60–69 Read article
-
Evaluation of Polysaccharide-Based Membranes for Transdermal Drug Delivery in Chronic Pain Management
Abstract: In order to improve treatment effectiveness and patient compliance, chronic pain management is still a major challenge in modern healthcare, requiring creative medication delivery methods. The potential of polysaccharide-based membranes for transdermal drug delivery is assessed in this work, with particular attention to chitosan, alginate, and hydroxypropyl methylcellulose (HPMC). Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) were two characterization techniques used to assess the membranes' physical and chemical …
Published in International Journal of Membranes · Vol. 1, Issue 2, 2024 · pp. 28–38 Read article
-
Synthesis and Characterization of pH-Sensitive Poly (N-isopropylacrylamide-co-acrylic Acid) Hydrogels for Controlled Release of Doxorubicin
Abstract: pH-responsive polymeric hydrogels have attracted significant attention as intelligent biomaterials for site-specific and controlled drug delivery in cancer therapy due to their ability to respond to the acidic tumor microenvironment. In the present study, poly (N-isopropylacrylamide-co-acrylic acid) [P(NIPAM-co-AAc)] hydrogels were synthesized via free radical copolymerization and systematically characterized to evaluate their suitability for controlled delivery of doxorubicin, a widely used chemotherapeutic agent. The copolymer hydrogels were prepared using N-isopropylacrylamide and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 449–458 Read article
-
Development and Assessment of Levetiracetam Microspheres Utilizing Synthetic and Natural Polymers: A Biomedical Engineering Perspective
Abstract: In the present study, comparative study of Levetiracetam loaded microspheres using Ethyl cellulose as synthetic and Sodium alginate as natural polymers was done. Solvent evaporation and ionic gelation technique has been successfully employed to produce Levetiracetam loaded ethyl cellulose and sodium alginate microspheres with optimal drug encapsulation that sustained the drug release over a period of time. Based on the pre-formulation studies E1 to E4 and S1 to S4 batches …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 1–18 Read article