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35 articles for “drug loading”
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Comprehensive Review on Antimicrobial based Hydrogel for Wound Healing
Abstract: Chronic wounds present a significant clinical challenge due to their prolonged healing time, high risk of infection, and frequent recurrence. The development of novel wound dressings with both healing and antimicrobial properties is essential for effective wound management. This study focuses on the formulation and evaluation of an antimicrobial drug-loaded hydrogel designed to promote chronic wound healing. Chronic wounds are a growing concern in healthcare, often taking weeks or even …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 72–88 Read article
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Graphene-Polymer Nanocomposites for Drug Delivery Applications
Abstract: Graphene-polymer nanocomposites (GPNCs) have gained significant attention in drug delivery due to their exceptional physicochemical properties, including high surface area, mechanical strength, tunable functionality, and biocompatibility. These nanocomposites integrate graphene derivatives, such as graphene oxide (GO) and reduced graphene oxide (rGO), with biocompatible polymers to enhance drug loading efficiency, stability, and controlled release. Various natural (chitosan, alginate) and synthetic (PLGA, PEG, PCL) polymers are used to functionalize graphene, enabling targeted …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 362–374 Read article
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Nanotechnology: Recent Advances, Opportunities and Challenges
Abstract: Nanotechnology, the science of the minuscule, has catalysed a revolution across diverse fields, from pharmacy to veterinary science. This abstract encapsulates the dynamic interplay between nanotechnology and healthcare, unveiling its transformative impact on drug delivery, cosmeceuticals, veterinary medicine, dentistry, and biotechnology. In pharmacy, nanotechnology pioneers targeted drug delivery systems, amplifying therapeutic efficacy while mitigating adverse effects. Nano-cosmeceuticals redefine beauty standards, infusing skincare, haircare, lip care, and nail care products with …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 26, Issue 3, 2024 · pp. 44–64 Read article
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Evaluation of Polyethylene Glycol (PEG)-Based Polymers for Improving Solubility and Bioavailability of Poorly Soluble Drugs
Abstract: A significant barrier to optimizing oral bioavailability is the inadequate water solubility of numerous pharmaceutical compounds. This study examined whether polymer systems utilizing polyethylene glycol (PEG) may enhance the solubility and bioavailability of a poorly soluble model drug. Multiple PEG polymers with molecular weights between 2,000 and 10,000 Da were utilized to produce PEGylated preparations. The formulations were subsequently evaluated for dissolution efficacy, medication loading capacity, particle size, and solubility …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 489–499 Read article
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Development of Biodegradable Poly (Lactic-Co-Glycolic Acid) (PLGA) Nanoparticles for Sustained Release of Insulin
Abstract: This research outlines the creation of biodegradable composite nanoparticles made from poly (lactic-co-glycolic acid) (PLGA) designed for the sustained release of insulin. The emphasis is on the interactions between the polymer and the drug at the interface, along with the dynamics of the release matrix. The in vitro release kinetics, surface morphology, encapsulation efficiency, particle size, and polydispersity of insulin-loaded PLGA nanoparticles were analyzed following their production via a double …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1690–1699 Read article
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A Review on Nanosponges Drug Delivery System
Abstract: The main issue that the researchers are dealing with is targeted medication delivery to locations. Crosslinking polymers produce nanosponges, which are three-dimensional drug delivery systems at the nanoscale. They have the benefit of having a large capacity to carry different-sized medications. There are numerous sizes and shapes for nanosponges. Compared to alternative delivery methods, nanosponges are preferable because they may offer a regulated medication release pattern with targeted Medication administration. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 68–76 Read article
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Biodegradable Polymer Nanocarriers Composites for Biomedical Applications
Abstract: Smart polymeric nanocarriers, or SPNs, have evolved into a fascinating means of delivering medications especially to cancer cells. By improving the efficacy of chemotherapeutic treatments while lowering their negative effects, they have achieved a significant progress in exact medicine. Made to respond to certain elements in the tumours microenvironment, such as enzymes, temperature, pH, and redox conditions, these nanocarriers this reaction to triggers guarantees the release of the medicine at …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 293–305 Read article
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Modern Approaches in Lung Cancer Management from Herbal Nanomedicine to Artificial Intelligence
Abstract: Lung cancer continues to be a major global health concern and one of the leading causes of cancer-related mortality worldwide. Despite significant advancements in therapy, there is still a pressing need for safer and more effective therapeutic alternatives; problems such drug resistance, side effects, metastasis, and recurrence continue to impact patient outcomes and quality of life. Examining current advancements in the use of herbal drug-loaded nanoparticles as a novel approach …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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Ocular Films as a Drug Delivery System Against Fungal Infections: Current Insights and Future Directions
Abstract: Fungal infections of the eye, including keratitis, endophthalmitis, and blepharitis, represent a challenging class of ocular diseases due to their potential for vision loss and the limited efficacy of existing treatments. These infections are caused by a range of pathogenic fungi, such as Aspergillus, Candida, and Fusarium species, and often require long-term therapeutic intervention. Conventional topical antifungal therapies, such as eye drops and ointments, suffer from poor ocular bioavailability due …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 101–109 Read article
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Synthesis and Characterization of pH-Sensitive Poly (N-isopropylacrylamide-co-acrylic Acid) Hydrogels for Controlled Release of Doxorubicin
Abstract: pH-responsive polymeric hydrogels have attracted significant attention as intelligent biomaterials for site-specific and controlled drug delivery in cancer therapy due to their ability to respond to the acidic tumor microenvironment. In the present study, poly (N-isopropylacrylamide-co-acrylic acid) [P(NIPAM-co-AAc)] hydrogels were synthesized via free radical copolymerization and systematically characterized to evaluate their suitability for controlled delivery of doxorubicin, a widely used chemotherapeutic agent. The copolymer hydrogels were prepared using N-isopropylacrylamide and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 449–458 Read article
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Microneedles: A Modern Breakthrough in Drug Delivery Systems
Abstract: Microneedles (MNs) represent a revolutionary and transformative advancement in the realm of transdermal drug delivery systems, which are designed to facilitate the administration of therapeutic agents through the skin. These exceptionally small, micron-scale needles penetrate the stratum corneum, thereby enabling the direct delivery of pharmacological agents into the underlying dermis or the upper epidermis, consequently enhancing bioavailability while simultaneously circumventing the detrimental effects of first-pass metabolism and the degradation that …
Published in Trends in Drug Delivery · Vol. 12, Issue 3, 2025 · pp. 01–07 Read article
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Design and Evaluation of Thermo-Responsive Poly(N-isopropylacrylamide)-Based Polymeric Nanoparticles for Temperature-Triggered Intratumoral Release of Doxorubicin in Solid Tumors
Abstract: Thermo-responsive polymeric systems have emerged as promising platforms for targeted intratumoral drug delivery in cancer therapy. This study aimed to develop and evaluate poly(N-isopropylacrylamide) (PNIPAM)-based polymeric nanoparticles as intelligent carriers for temperature-responsive delivery of doxorubicin (DOX) to solid tumors. Nanoparticles were synthesized via free radical polymerization using N-isopropylacrylamide as a thermoresponsive monomer and N,N′-methylenebisacrylamide as a crosslinker, forming a stable network with a tunable lower critical solution temperature (LCST).The optimized …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 159–168 Read article
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Microneedles: An Innovative Drug Delivery System
Abstract: Microneedles represent a groundbreaking innovation in drug delivery systems, offering a transformative alternative to conventional hypodermic needles and transdermal patches. This advanced technology combines the precision and efficacy of needle-based delivery with the convenience and pain-free nature of patches, creating a minimally invasive platform that addresses many limitations of traditional drug administration. Microneedles are designed to penetrate the stratum corneum – the skin’s outermost layer – without reaching pain-sensitive nerves …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 60–67 Read article
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Polymeric Micelles for Medicinal Plant Solubilization and Delivery of Bioactive Compounds
Abstract: This study involved the design, fabrication, and characterization of polymeric micellar nanocomposites utilizing amphiphilic block copolymers to effectively encapsulate and transport hydrophobic phytoconstituents. The selected bioactive molecule is curcumin, a polyphenol with limited water solubility. A polymeric system known as PEG-PCL was utilized to fabricate core-shell nanostructures by a solvent evaporation-induced self-assembly method. The resulting nanocomposites exhibited homogeneity and colloidal stability, characterized by a zeta potential of −18.7 ± 1.4 …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 208–219 Read article
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Carboxymethyl Cellulose-Based Spray-Dried Microspheres: Recent Advances and Applications in Targeted Drug Delivery Systems
Abstract: Microspheres are spherical particles ranging from 1 to 1000 μm, made from natural or synthetic polymers and inorganic materials. Their structure allows precise drug delivery, improving targeted release and minimizing off-target effects. Natural polymers such as starch, chitosan, and alginate are favored for their biodegradability, adhesion, and compatibility, enhancing mucosal interaction and residence time. Microspheres are widely used in site-specific drug delivery, gene therapy, and vaccine administration, improving immunogenicity, extending …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 251–268 Read article
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Microsphere and Nanoparticle Drug Delivery Systems: Role of Polymers in Pharmacology
Abstract: Microsphere and nanoscale drug delivery methods have changed the field of pharmacology by making treatment agents more bioavailable, more targeted, and easier to manage. These delivery systems, which are mostly made up of polymers, look like a good way to get around the problems that traditional drug formulations have, like not dissolving well, clearing quickly, and spreading in different places. Plastics are very important in the creation of these improved …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 420–432 Read article
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Polymer Chemistry-Driven Approaches for Improved Therapeutic Delivery
Abstract: Polymer chemistry has revolutionized pharmaceutical technology by enabling the development of advanced drug delivery systems with improved precision, stability, and therapeutic outcomes. This review explores the role of polymer design, synthesis, and functionalization in the development of responsive and targeted drug carriers. Emphasis is placed on various types of polymers—biodegradable, synthetic, natural, and stimuli-responsive—and their suitability for drug delivery platforms such as nanoparticles, micelles, hydrogels, dendrimers, and implants. The physicochemical …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 Read article
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DEVELOPMENT OF POLYMERSOMES AS MACROMOLECULAR PLATFORMS FOR NANOMEDICINE
Abstract: The conventional method of drug delivery is plagued with instability, low targeting and low bioavailability. A solution to these shortcomings is the use of polymer Somes, artificial vesicles that are produced through self-assembly of amphiphilic block copolymer, and they are suggested as universal nanoscale carriers. They have stiff, tunable membranes (thickness = 2-50 nm) due to accurate control of polymer chemistry, chain length, and hydrophilic mass fraction (f), which allows …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 Read article
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A Review on: Oral Thin Films: A New Approach to Effective and Easy Drug Delivery
Abstract: Oral Thin Film (OTF) is an advance drug delivery system in which drug is incorporated into dissolvable strip and place in oral cavity for rapid absorption. OTF is useful for patient such as pediatric and geriatric who have difficulty swallowing pills. It provides rapid action, precise dosage and improved bioavailability. OTFs consist of fast-dissolving films, extended-release films, and mucoadhesive films for various therapeutic applications. The manufacturing processes of OTFs such …
Published in Trends in Drug Delivery · Vol. 11, Issue 3, 2024 · pp. 22–41 Read article
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Formulation and development of Lamivudine Nanoemulsion by using Emulsifying Polymers and It’s Evaluation
Abstract: Nanoemulsion is a novel approach to medicine delivery that helps to increase the bioavailability of drugs that aren’t particularly soluble in water. In this research work, nanoemulsion of Lamivudine was formulated by using polymers such as SPAN 80, TWEEN 80 and Whey protein concentrate with the help of Ultrasonication technology. The formulation was optimized. It was evaluated by assessing pH, viscosity, turbidity, in vitro franz diffusion study, particle size distribution, …
Published in Journal of Polymer & Composites · Vol. 12, Issue 6, 2024 · pp. 22–35 Read article