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640 articles for “domain”
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Design and Optimization of Domain-Specific Languages for High-Performance Computing Applications
Abstract: The accelerating demand for computational power in scientific, engineering, and data-intensive domains has driven high-performance computing (HPC) systems toward unprecedented levels of parallelism and architectural complexity. Contemporary HPC platforms integrate multicore CPUs, many-core GPUs, accelerators, and deep memory hierarchies, creating significant challenges for software development and performance optimization. Traditional general-purpose programming languages and parallel programming frameworks provide low-level control over hardware resources but require extensive manual tuning, resulting in poor …
Published in Recent Trends in Parallel Computing · Vol. 13, Issue 1, 2026 · pp. 17–22 Read article
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To Improve the Efficiency of Domain Controller Server in Cyber Security
Abstract: AbstractA domain controller server responds to security authentication request a window server domain. It authenticates user, stores user account user password and user information or enforces security policy for a windows domain server. A domain control server gives access to another domain in a relationship that user logging into a domain can access resources in another domain server. If the server performing domain control role is lost, the domain control …
Published in Current Trends in Information Technology · Vol. 9, Issue 1, 2019 · pp. 7–13 Read article
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Molecular Docking Analysis of Phytocompounds from Ficus hispida Aagainst Epidermal Growth Factor Receptor Kinase Domain
Abstract: The Epidermal Growth Factor Receptor (EGFR) kinase domain plays a key role in cancer, as it promotes tumour growth and helps cancer cells survive, making it an important focus for developing treatments. Through comprehensive computational analysis, this study investigates the anticancer potential of phytocompounds from Ficus hispida, a medicinal plant renowned for its diverse bioactive compounds, as novel EGFR inhibitors. Molecular docking techniques using Py Rx software were employed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 Read article
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Molecular Docking Analysis of Phytocompounds from Ficus hispida Against Epidermal Growth Factor Receptor Kinase Domain
Abstract: The Epidermal Growth Factor Receptor (EGFR) kinase domain plays a key role in cancer, as it promotes tumour growth and helps cancer cells survive, making it an important focus for developing treatments. Through comprehensive computational analysis, this study investigates the anticancer potential of phytocompounds from Ficus hispida, a medicinal plant renowned for its diverse bioactive compounds, as novel EGFR inhibitors. Molecular docking techniques using Py Rx software were employed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 48–62 Read article
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Conceptual Modeling for Domains: Case of Logistic Terminals
Abstract: Logistics terminals in supply chains have to be designed and operated to ensure an acceptable level of service to its customers in terms of waiting times and turnaround times. Decisions problems on these issues are dealt at different managerial levels related to long term, medium term and short term planning. When performance improvement studies of different logistic terminal systems are to be conducted, many different models of the same terminal …
Published in Journal of Production Research & Management · Vol. 3, Issue 1, 2013 · pp. 1–7 Read article
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Time Domain Analysis in an On-chip High Speed RLCG Interconnection Network at 0.18 µm Technology
Abstract: In this model, the time domain waveform is evaluated for calculation of delay time, peak time, settling time, damping ratio and natural frequency for a second order RLCG interconnect network. It can also be used for multiple interconnect systems but for higher order systems it is ignored due to accurate analysis. The model is applied to a single resistance-inductance-capacitance-conductance model which can also be extended to multi-interconnect systems to analyze …
Published in Journal of VLSI Design Tools and Technology · Vol. 1, Issue 1-2-3, 2011 · pp. 57–67 Read article
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Pharmacoepigenomics of Replication Timing: How Anti- Cancer Drugs Reshape Chromatin Domains and Mutational Landscapes.
Abstract: DNA replication timing serves as a fundamental epigenetic feature that organizes genome function during the cell cycle (3), while anti-cancer drugs profoundly alter this process to disrupt tumor growth(4). These agents target chromatin architecture, shifting replication domains and reshaping mutational patterns critical for cancer evolution (1,5). DNA replication timing (RT) domains serve as dynamic epigenetic organizers, partitioning the genome into early- and late-replicating regions that correlate with chromatin states, gene …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Thevenin and Norton Resistance Using Time Domain Analyses Using Spice Simulations
Abstract: Thevenin and Norton equivalent circuits are of interest to circuit simulation designers and researchers. For the Thevenin resistance and Norton conductance determination of a network with available circuit theorems, the substitution network theorem (applied to OrCAD, SPICE, and Pspice AD simulation project) is shown to be suitable with the SPICE/ Pspice circuit simulation software. Instead of the DC option, the transient analyses option of SPICE is used to determine Thevenin/Norton …
Published in Current Trends in Signal Processing · Vol. 13, Issue 2, 2023 · pp. 8–18 Read article
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Isolation and Characterization of “Heavy Chain Antibody” Variable Domain Gene of Indian Desert Camel (Camelus dromedarius, L.)
Abstract: Camelids have “heavy chain antibodies” (HCAbs) of IgG isotype (IgG2 and IgG3 subtypes) and lack light chains and heavy chain constant domain 1 (CH1) in their structure. The molecular biological features of VHH (i.e., antigen binding variable domain of HCAbs) gene isolated from Indian desert camel were examined as a prelude to construct VHHs-phage display library. VHH cDNA was synthesized by reverse transcription-polymerase chain reaction (RT-PCR) from B lymphocyte mRNA, …
Published in Research and Reviews : A Journal of Immunology · Vol. 3, Issue 1, 2013 · pp. 22–31 Read article
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Modelling of The Viscoelastic Composite Curved Panel for The Time Domain Analysis Using TTBDF, β1 / β2−Bathe and Newmark Method
Abstract: Viscoelastic materials are extensively used in structures, especially thin-walled structures, for damping. The accurate modelling of the time domain dynamics of the viscoelastic material is essential for appropriately capturing the damping of the viscoelastic material. Various implicit and explicit time integration schemes are available to evaluate time domain response. However, the rightness of the implementation of the time integration scheme to the viscoelastic material model is very essential. In this …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 204–222 Read article
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Simulation and Analysis of Battery Pack Using the Multi Scale Multi-Domain Battery Model
Abstract: The creation of sophisticated simulation models has been made necessary by the need for reliable and effective battery packs in energy storage systems and electric vehicles. This study focuses on the simulation and analysis of battery packs using a multi-scale multi-domain battery model. The model enables a thorough knowledge of battery pack behavior across a range of operating situations by integrating the electricity, thermal, and mechanical domains. Multi-scale modeling bridges …
Published in International Journal of Electro-Mechanics and Material Behaviour · Vol. 2, Issue 2, 2024 · pp. 31–46 Read article
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Indirect Methods for Discretizing Fractional Order Differentiator in Delta Domain—A Comparative Study
Abstract: In this paper, three indirect methods are presented for discretizing fractional order differentiator in delta domain. To this aim, three extensively used discrete time approximation methods of -domains are reformulated in delta domain. As a first step of applying the indirect discretization method, rational approximation of a half order differentiator is obtained using the Oustaloup approximation method. Then, all of the proposed discretization methods are applied separately on the integer …
Published in Journal of Control & Instrumentation · Vol. 8, Issue 2, 2017 · pp. 27–34 Read article
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Comparative Performance Analysis of Inter-Domain Routing Protocols in Integrated HSDPA and WLAN Ad Hoc Networks with Streaming Traffic
Abstract: AbstractIntegration of HSDPA and WLAN Ad Hoc Networks is to increase coverage and capacity of UMTS Networks. Inter-Domain routing is new challenge for them due multiple hopes away end users. This paper presents a comparative performance analysis for Inter-domain routing in Integrated HSDPA and WLAN Ad Hoc Networks with asymmetric voice and video streaming traffic class on BellmanBGPv4, Bellman, RIPv2 and RIPv2BGPv4 routing protocols.Keywords: Integrated HSDPA and WLAN Ad Hoc …
Published in Journal of Communication Engineering & Systems · Vol. 5, Issue 3, 2015 · pp. 7–18 Read article
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Production of Single-domain Antibodies Library by Phage Display Technology
Abstract: Single-domain antibodies (dAbs) are synthesized from variable domain gene-segments of atypical camelid or shark “heavy chain antibodies” (HCAbs) by phage display technology. We have constructed a phage display library of > 5 × 107 dAb clones derived from HCAb genes in B lymphocyte repertoire of a lipopolysaccharide (LPS)-immunized Indian desert camel and isolated dAb-phage clones by panning of the library against LPS and Staphylococcus aureus exotoxins. Nucleotide and deduced amino-acid …
Published in Research and Reviews : A Journal of Immunology · Vol. 2, Issue 3, 2012 · pp. 8–13 Read article
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Metagenome-Informed Engineering of Monoclonal Antibodies: Mining Microbial Immunoglobulin-Like Domains for Ultra-Stable Therapeutics
Abstract: Metagenome-informed engineering represents an emerging strategy for improving the stability and functionality of monoclonal antibodies (mAbs) by leveraging the vast diversity of microbial immunoglobulin-like (Ig-like) domains (10,24). These domains, derived from uncultured bacteria and bacteriophages, exhibit exceptional thermostability, protease resistance, and structural resilience due to adaptation to extreme environments (29,30). This review highlights advances in metagenomic mining, structural characterization, and protein engineering that enable the integration of microbial Ig-like scaffolds …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 · pp. 70–83 Read article
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On The Time-Domain Analysis of the Electromagnetic Transients in High-Voltage Line Towers
Abstract: This paper presents an efficient and direct method for the time-domain transient analysis of high voltage power line towers. A Mathematica-based numerical solution of the governing set of simultaneous partial differential and algebraic equations is proposed. The results of a corresponding computer code are presented and discussed. A comparison with other more sophisticated analytical time-and Laplace-domain approaches is presented. In addition to the possible use of the EMTP transients’ program, …
Published in Journal of Nuclear Engineering & Technology · Vol. 13, Issue 2, 2023 · pp. 12–20 Read article
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Background Service QoS in Integrated UMTS-HSDPA and WLAN Ad Hoc Networks with Various Inter-Domain Routing Protocols
Abstract: AbstractThe Next Generation Network (NGN) allows the service providers to extend the coverage and capacity of existing network towards rural and hot spots area with large variety of services. Integrated UMTS-HSDPA and WLAN Ad Hoc Networks is most eligible NGN’s under this category. The integrated network offers a large variety of services e.g. conversational, streaming, interactive, and background class. This paper focuses on asymmetric best-effort service belonging to the background …
Published in Journal of Computer Technology & Applications · Vol. 6, Issue 3, 2015 · pp. 31–59 Read article
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Characterization of a Broadly Specific LPS-Neutralizing Single Domain Antibody
Abstract: Gram negative endotoxaemia or sepsis remains a lethal challenge to humans and animals, globally. Single domain antibodies (dAbs) have emerged as therapeutic biologics for challenging antigens such as lipopolysachharide (LPS). The present study characterized a broadly specific LPS-neutralising dAb produced from phage display library from LPS-immunized Indian desert camel, for its sequence validation with mass spectrometry. Also, the dAb clone 26 was subjected to co-crystallisation with LPS, extracted from E. …
Published in Research and Reviews : A Journal of Immunology · Vol. 7, Issue 1, 2017 · pp. 1–7 Read article
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Cloning and Expression of LPS-Binding Single Domain Antibody Clones Selected from Phage Display Library of Indian Desert Camel
Abstract: Despite the absence of light chains in their structure, camelid and shark “heavy chain antibodies” (HCAbs) variable domains (designated as VHH) are able to make functional paratopes. The authors have selected lipopolysaccharide (LPS)-binder “single-domain antibodies” (dAb) clones from the previously constructed phage display library of (LPS)-immunized Indian desert camel. This study was undertaken to make available large amounts of some LPS-binder dAb clones by using a suitable expression vector-host system …
Published in Research and Reviews : A Journal of Immunology · Vol. 4, Issue 1, 2014 · pp. 1–7 Read article
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A Single-domain Antibody Cross-reacts with Lipopolysaccharide from Diverse Gram-negative Bacteria
Abstract: Gram-negative bacterial sepsis and endotoxemia are the leading causes of morbidity and mortality in animals and humans worldwide, and attempts have continued to design rational therapies. Endotoxin/lipopolysaccharide (LPS)-neutralizing polyclonal and monoclonal antibodies have been produced, but are not free from problems. Single-domain antibodies (dAbs), constructed from the camelid and the shark ‘heavy chain antibodies’ by phage display technology possess favorable features for in vivo applications. The objective of this study …
Published in Research and Reviews : A Journal of Immunology · Vol. 6, Issue 2, 2016 · pp. 29–37 Read article