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19 articles for “cyclooxygenase (COX)”
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Effect of Olive Leaves Extract on Inflammatory Cyclooxygenase (COX) Levels in High Fat Diet (HFD) Induced Diabetic Animals
Abstract: Development of diabetes and its complications are associated with persistent inflammatory activity. It has been suggested that cyclo-oxygenase (COX)-mediated pathway involved in this inflammatory process in diabetes. For example, thromboxane A2 (TXA2) and prostaglandin E2 (PGE2) released by platelets and monocytes due to the action of COX-1 and COX-2, respectively. They are important prostanoids involved in thrombosis and atherosclerosis development in diabetic condition, this also have been proved in our …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 1, Issue 1, 2011 Read article
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In Silico Induced-Fit Molecular Docking and Pharmacokinetic Investigations of Pentacyclic Compounds as Promising Inhibitors of Cyclooxygenase-2 (COX-2) and Lipoxygenase (LOX)
Abstract: The current search involves the discovery of cyclooxygenase-2 (COX-2) (PDB ID: 3LN1) and lipoxygenase (LOX) (PDB ID: 1N8Q) inhibitory potentials of some pentacyclic macromolecules by employing the Maestro 9.1 software where Glide module was utilized for the induced-fit docking (IFD). In addition to it, the critical pharmacokinetic aspects such as QPPMDCK, QPlogPo/w, % human oral absorption, QPPCaco, and QPlogS were estimated. The study fruitfully opened the therapeutic pharmacodynamic perspectives and …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 2, 2018 · pp. 13–17 Read article
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Anti-inflammatory Potentials of Various Oxine Compound Series as Cyclooxygenase-2 (COX-2) and Lipoxygenase (LOX) Inhibitors: Induced-Fit Molecular Docking and Pharmacokinetic Prediction Studies
Abstract: The present investigation is an exploration of multiple oxine series in inhibiting crucial anti-inflammatory targets such as cyclooxygenase-2 (COX-2) (PDB ID: 3LN1) and lipoxygenase (LOX) (PDB ID: 1N8Q) by employing the Glide module of Maestro 9.1 software for induced fit docking (IFD). The study also focuses in exploration towards the essential pharmacokinetic parameters (QPlogPo/w, QPlogS, predicted aqueous solubility, QPPCaco, QPPMDCK, and percentage of human oral absorption). The study highlighted the …
Published in Research and Reviews : Journal of Computational Biology · Vol. 7, Issue 3, 2018 · pp. 16–23 Read article
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Induced-Fit Molecular Docking and Pharmacokinetic Prediction Studies of Two Phenanthrene Compound Series as Potential Cyclooxygenase-2 (COX-2) and Lipoxygenase (LOX) Inhibitors: Edema Reducing Prospects of the Emerging Candidates
Abstract: The existing explorative study involved determining the anti-inflammatory potential of two inter-linked series of phenanthrene compounds against vital targets such as cyclooxygenase-2 (COX-2) (PDB ID: 3LN1) and lipoxygenase (LOX) (PDB ID: 1N8Q) by induced fit docking (IFD) technique, employing the Glide module of Maestro 9.1 software. In addition to it, the comprehensive pharmacokinetic parameters (all 33 critical aspects) were determined using the QikProp module. The study opened avenues for developing …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 5, Issue 3, 2018 · pp. 1–8 Read article
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A Nascent Step towards the Discovery of New Generation Non-Steroidal Anti-inflammatory Agents (NSAIDs): Induced-Fit Molecular Docking and Pharmacokinetic Prediction Studies of Some Chromene Derivatives as Potential Cyclooxygenase-2 (COX-2) and Lipoxygenase (LOX) Inhibitors
Abstract: The current computational research profoundly focuses on the comprehensive based exploration of the anti-inflammatory potential of some novel chromene derivatives against major anti-inflammatory mediators by the utilization of the induced-fit docking (IFD) method of Schrodinger software along with pharmacokinetic profile exploration. The study will positively open new pharmacodynamic applications and avenues as anti-inflammatory agents in the future. Keywords: Anti-inflammatory, chromene, COX-2, docking, LOX, pharmacokineticsCite this ArticleTomy Muringayil Joseph, Debarshi Kar …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 5, Issue 2, 2018 · pp. 30–36 Read article
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In Silico Analysis and Molecular Docking Studies of COX-2 Inhibitors for Anti-Inflammatory Activity
Abstract: Although nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used to treat pain, lower fevers, and control inflammation, they frequently cause gastrointestinal side effects because they inhibit the COX-1 and COX-2 enzymes. Despite their effectiveness and lack of gastrointestinal side effects, selective COX-2 inhibitors have been linked to cardiovascular risks. To find new COX-2 inhibitors that are safer and more effective, this study uses in silico techniques, such as molecular docking and …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 38–55 Read article
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Cyclooxygenase 3 Inhibition: A Probable Mechanism of Acetaminophen in Human: A Review
Abstract: The key rate-limiting step in prostanoid and thromboxane biosynthesis is catalyzed by Cyclooxygenases (COXs) and is the target of nonsteroidal anti-inflammatory drugs (NSAIDs). Until recently, the existence of only two isoforms: COX-1 and COX-2; remained under debate as the anti-pyretic and analgesic property of acetaminophen (paracetamol) could not be explained by mere COX-1 or COX-2 blockades. A novel COX-1 splice variant termed COX-3, sensitive to acetaminophen, was recently discovered in …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 6, Issue 3, 2015 · pp. 23–29 Read article
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Acetaminophen: Current Understanding and Future Directions in Pharmacology
Abstract: In this review, acetaminophen is described as one of the most widely used analgesic and antipyretic medications worldwide due to its effectiveness and reduced gastrointestinal toxicity compared with traditional NSAIDs. Its precise mode of action is still unclear despite widespread therapeutic use. Acetaminophen has little peripheral anti-inflammatory effect and largely acts within the central nervous system, in contrast to NSAIDs, which mainly block peripheral cyclooxygenase (COX) enzymes and lower inflammation. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 Read article
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Pharmacological Comparison of Turmeric and Non-Steroidal Anti-Inflammatory Drugs in Pain Relief
Abstract: Pain is one of the most frequently encountered clinical symptoms affecting millions globally and is typically treated pharmacologically with nonsteroidal anti-inflammatory drugs (NSAIDs). However, long-term use of NSAIDs is associated with adverse effects such as gastrointestinal, renal, and cardiovascular issues. In recent years, turmeric and its main active compound, curcumin, have received considerable attention for their reported anti-inflammatory, analgesic, and antioxidant properties as natural therapeutic options. This review seeks to …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 1, 2026 · pp. 19–28 Read article
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Pain Management in Rheumatoid Arthritis: Clinical Role and Therapeutic Implications of NSAIDs
Abstract: Rheumatoid arthritis (RA) is a progressive, chronic autoimmune condition that results in swelling in multiple joints. It is estimated to occur in 0.5–1% of the global population and is more common in women. India has an estimated prevalence of 0.75%. RA causes the destruction of joints and a decrease in disabilities and quality of life. It is accompanied by further manifestations and multiple co-occurring conditions that lead to a greater …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 4, Issue 1, 2026 · pp. 21–27 Read article
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Herbal Coxibs: Nature’s Aspirin
Abstract: Pain is part and parcel of most health conditions from joint disorders to cancer. This explains why several researchers were hooked on to unraveling the deep puzzle behind the pain mechanism and finding a better way to relieving it with medicines that went far beyond killing pain alone. When a landmark outcome emerged and identified prostaglandins, the body’s chemical messengers, as the cause of inflammation, or pain, and that they …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 6, Issue 3, 2015 · pp. 13–22 Read article
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A Promising Approach Towards Arthritis: Bacopa Monnieri
Abstract: Joint inflammation, pain, and a progressive loss of function are the hallmarks of arthritis, a chronic and crippling condition that frequently results in disability and a lower quality of life. The need for safer options is highlighted by the fact that while current therapy approaches, such as NSAIDs, corticosteroids, and disease-modifying antirheumatic medications, give symptomatic relief, they are usually linked to serious adverse effects. In this regard, the wellknown Ayurvedic …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 14, Issue 3, 2025 · pp. 76–91 Read article
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3′,4′-Methylenedioxy Moiety Containing Murrayanine Based Chalcone as Emerging Anti-inflammatory Agent
Abstract: Natural products are the emerging compounds for treating a wide variety of ailments. In a recent trend, rational semi-synthesis remained an impressive approach for developing inhibitors with pronounced activity. 3′,4′-methylenedioxy have been found to be present in a variety of compounds expressing anti-mycobacterial, anti-inflammatory, anti-cancer, analgesic, anti-pyretic, etc. The present study focuses on the rational development of (E)-3-(benzo[d][1,3]dioxol-5-yl)-1-(1-methoxy-9H-carbazol-3-yl)prop-2-en-1-one from murrayanine and 3′,4′-(methylenedioxy)acetophenone and investigating the anti-inflammatory activity of the fabricated …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 9, Issue 1, 2018 · pp. 12–16 Read article
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A Review on Anti-Inflammatory Activity of Benzthiazole Derivatives
Abstract: Benzothiazoles are an important biologically active heterocyclic compounds which contain six membered benzene rings fused with five membered thiazole rings at 1,4 positions. They possess various biological activities like Anti-microbial, Anti-fungal, Anthelmintic, Antioxidant and Anti-inflammatory activities. Benzothiazoles nucleus is believed to produce it’s Anti-inflammatory activity either by inhibiting Beta-2 receptors of Bradykinin or by inhibiting cox₂ enzymes (cyclooxygenase). The present review focuses on some methods of benzothiazoles synthesis and its …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 9, Issue 1, 2022 · pp. 1–13 Read article
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The Therapeutic vade mecum of Green Tea
Abstract: Green tea has achieved a remarkably impressive healing, or curative reputation in the West —more so, in recent times. The herb is replete with a historical legacy as a safe, effective anti-inflammatory, analgesic, and antioxidant agent. Research has shown that green tea has the ability to reduce arthritic pain, including the risk of certain forms of cancer. Other studies suggest that green tea has the ability to stabilise blood lipids—this …
Published in Trends in Drug Delivery · Vol. 5, Issue 3, 2018 · pp. 22–30 Read article
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5-Lipoxygenase and Phospholipase A2 Inhibitory Potentials of Alcoholic Extract of Cyperus rotundus: In vitro and In silico Study
Abstract: The literature revealed that not much reports are known for the anti-inflammatory activity of any Cyperus rotundus plant part (or extract) with respect to the molecular targets (inflammatory mediators) like cyclooxygenase-1/2 (COX-1/2), 5-lipoxygenase (5-LOX), and phospholipase A2 (pLA2). The present investigation involved exploration of in vitro inhibitory potential of alcoholic extract of C. rotundus rhizome against two important inflammatory mediators; 5-LOX and (porcine) pLA2. In addition to it, the role …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 8, Issue 2, 2018 · pp. 1–5 Read article
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Grid based docking study of some 2-(4-methylsulfonyl phenyl) pyrimidine derivatives (designed after QSAR studies) with Cyclooxygenase
Abstract: Molecular docking helps in studying drug/ligand or receptor/ protein interactions by identifying the suitable active sites in protein, obtaining the best geometry of ligand-receptor complex and calculating the energy of interaction for different ligands to design more effective ligands. In Grid based docking, after unique conformers of the ligand are generated, the receptor cavity of interest is chosen and a grid is generated around the cavity. Cavity points are found …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 23–41 Read article
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Computational Exploration of Bhrijraj-derived Phytochemicals as Potential Anti-inflammatory Agents: A Molecular Docking Study with Cyclooxygenase-II Complex
Abstract: The molecular docking analysis was meticulously conducted using state-of-the-art computational tools, notably Chimera and Python. These tools were employed to unravel the complex interactions between the identified phytochemicals from Bhrijraj and the target protein, COX-II. The 3D structures of the phytochemicals were prepared with precision using ChemSketch, ensuring accuracy in the subsequent molecular docking simulations. This rigorous approach enhances the reliability and validity of the findings. This research aims to …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 31–37 Read article
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Candida albicans: In vitro Inhibition of Morphological Transition by Analgesic Compounds
Abstract: This study aimed to investigate, in vitro, the effect of some analgesic compounds, which inhibit the activity of cyclooxygenase isoenzymes, on the morphological transition of Candida albicans from unicellular budding yeast to a filamentous form. C. albicans ATCC 10231 cultured in Sabouraud’s dextrose broth supplemented with 20% human serum for 72 h at 30 °C in the presence or absence of tramadol of HCl, ketorlac tromethamine, piroxicam and acetaminophen at …
Published in Research and Reviews: A Journal of Medicine · Vol. 3, Issue 3, 2013 · pp. 11–15 Read article