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51 articles for “central nervous system”
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Review on Functional and Histological Effect of Lead on the Central Nervous System
Abstract: Environmental and occupational exposure to a large number of chemicals occurs at various stages throughout human life. The nervous system is the organ that appears to be the most sensitive and chief target for lead-induced toxicity in comparison to other organs. Lead is also found in lead-glazed ceramics, and food is eaten or stored in containers painted with lead-based paint or lead-containing glaze may contain significant amounts of lead. Lead …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 9, Issue 3, 2019 · pp. 29–33 Read article
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Current Trends in Crossing the Blood–Brain Barrier: A Review
Abstract: The blood-brain barrier (BBB) is a protective barrier that protects the central nervous system (CNS) from toxins and pathogens in the blood. However, the existence of BBB challenges therapy for CNS diseases and disorders as most pharmaceuticals (drugs) are restricted to enter brain. The review article focuses on the approaches involved to cross BBB with various advanced technology such as nanoparticles, intraventricular injection, chemical modifications, virus mediated distribution, exosome mediated …
Published in Trends in Drug Delivery · Vol. 10, Issue 2, 2023 · pp. 25–38 Read article
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Comprehending and Managing Restless Leg Syndrome
Abstract: An need to move that arises during rest or is made worse by rest, that happens in the evening or at night, and that goes away or gets better with movement is the hallmark of restless legs syndrome (RLS), a frequent sensorimotor disease. The degree, frequency, and age of start of symptoms vary greatly; severe types can impair mood, quality of life, and sleep. Periodic leg movements are common in …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 1, 2025 · pp. 1–6 Read article
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Herbal Medicine in Unani Tradition: Managing Depression from A Holistic Perspective
Abstract: Depression is a prevalent mental health condition marked by persistent sadness and a loss of interest in once- enjoyed activities, often accompanied by an inability to carry out daily tasks, lasting for at least two weeks. In the field of Unani medicine, this disorder falls under the category of "Nafsiyati awamil," with its classical description referred to as "Malenkholiya" or melancholia. According to the World Health Organization (WHO), depression ranks …
Published in Research & Reviews : Journal of Herbal Science · Vol. 12, Issue 3, 2023 · pp. 1–6 Read article
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Glial Cells in Viral and Bacterial Infections
Abstract: The Central nervous system consists of neurons and glial cells. Neurons constitute about half the volume of the CNS and glial cells make up the rest. They are also known as supporting cells of the nervous system. The three types of CNS supporting cells are Astrocytes, Oligodendrocytes and microglia. The supporting cells of Peripheral Nervous System are known as Schwann cells. The main functions of glial cells are to surround …
Published in Research and Reviews : A Journal of Immunology · Vol. 10, Issue 3, 2020 · pp. 13–21 Read article
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Toxicological Profiling and Safety Assessment of NASAT 2.0: A Conceptual Framework for Adaptive Nanoparticle Therapy in Rabies
Abstract: Rabies, caused by the highly neurotropic Rabies lyssavirus, remains one of the most enigmatic and universally lethal infectious diseases known to modern medicine. Once clinical symptoms manifest following successful neuroinvasion, the fatality rate approaches absolute certainty (approximately 99.9%), a staggering statistic that has remained largely unchallenged despite massive, concurrent advances in modern virology, critical care medicine, and cellular immunology. Current late-stage therapeutic protocols, most notably the widely debated Milwaukee Protocol, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 2, 2026 · pp. 1–19 Read article
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Neurological Manifestations of COVID 19 infection-An Update
Abstract: AbstractThis article focuses on the neurological disorders related to Covid 19 infection based on studies reported from china, Italy and other countries. The virus attaches to the Angiotensin Converting enzyme Receptor which is widely distributed in the body including nervous system. Virus can effected the nervous system by direct neurotropic effects, Immune mediated damage or due to secondary involvement as a part of multi organ dysfunction. Covid 19 Infection is …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 10, Issue 2, 2020 · pp. 7–11 Read article
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pH-Triggered In-Situ Nasal Gel Systems for Migraine Therapy: A Review
Abstract: Intranasal drug delivery has gained considerable attention as a non-invasive route for delivering drugs to both systemic circulation and the central nervous system, particularly for the treatment of migraine. Traditional nasal formulations such as sprays and drops often show poor therapeutic performance due to rapid mucociliary clearance and limited retention within the nasal cavity. To overcome these challenges, in-situ gel systems have been designed, which transform from a liquid to …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 · pp. 10–25 Read article
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Smoking and Body Weight: Is There Any Relation?
Abstract: Tobacco is a tall, green leafy plant, originally grown in South and Central America, but now cultivated throughout the world. The link between smoking and body weight is evident as early as adolescence. Nicotine acts on nicotinic cholinergic receptors in the brain and autonomic ganglia. The binding of nicotine to the nicotinic receptors opens ion channels, allowing entry of sodium and calcium, thereby; augment the release of various neurotransmitters. This …
Published in Research and Reviews: A Journal of Health Professions · Vol. 3, Issue 3, 2013 · pp. 33–36 Read article
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Review on Histological Effect of Lead on Liver and Kidney
Abstract: Our environment can be polluted by environmental toxins which are chemicals and other materials produced largely from industry and its products. There are large numbers of environmental toxicants which are potentially harmful to health. These large numbers of environmental toxicants can be divided into three major categories (heavy metals, air pollutants, and pesticides) and they are commonly studied environmental toxicants. Environmental toxins can be entered into the body by various …
Published in Research and Reviews: A Journal of Toxicology · Vol. 10, Issue 1, 2020 · pp. 8–29 Read article
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Sudden Natural Deaths in and around Guwahati: An Autopsy Based Study
Abstract: Death occurring within 24 h of the onset of terminal symptoms is defined as sudden death. It is frequently associated with allegations of foul play. A retrospective study of sudden natural deaths in an around Guwahati from 2016 to 2018 was conducted from the medico-legal autopsy cases done at Guwahati Medical College and Hospital Guwahati. A total of 9835 autopsy cases were done during those 3 years. Out of a …
Published in Research and Reviews: A Journal of Toxicology · Vol. 9, Issue 3, 2019 · pp. 29–33 Read article
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An Expected Cardiovascular Disease Detection Using Deep Learning Techniques
Abstract: Many avoidable deaths globally are caused by CVD, often due to individuals remaining unaware of their risk factors until severe symptoms, such as heart attacks or strokes, appear. This study utilizes retinal images as the dataset to explore the potential of retinal imaging as a non-invasive diagnostic tool for early detection of cardiovascular diseases (CVD). The delay in diagnosis and treatment highlights the need for sophisticated diagnostic instruments that can …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 2, 2024 Read article
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Kisspeptin Modulates Reproduction in Ruminants
Abstract: AbstractKisspeptin, a neuropeptide encoded by the KiSS1 gene and its cognate, KiSS1R are the key regulators of reproduction in animals. Kisspeptin, also known as metastin, is a potent secretagogue of gonadotropin-releasing hormone (GnRH). It stimulates the GnRH neurons in the brain and generates pulses for GnRH thereby its secretion and release, and this in turn stimulates the release of LH and FSH. Owing to its importance in reproductive biology, the …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 5, Issue 1, 2016 · pp. 7–12 Read article
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A Review on Natural Radio-protective Agents
Abstract: AbstractRadioprotectors play crucial role in safeguarding biological system from various damages to DNA (Deoxyribonucleic acid), protein molecules, lipids by peroxidation as well as hematopoietic, gastrointestinal, reproductive and central nervous system exposed to radiation dose especially against radiation injury in cancer survival patients undergoing radiotherapy. As over 40% patients require this therapy, during the treatment where ionizing radiation is used to shrivel tumors and exterminate cancer cells by disrupting their DNA. …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 10, Issue 2, 2020 · pp. 20–31 Read article
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A Critical Appraisal on VastiKarma—A Healing Therapy in Pediatric Age Group w.s.r. to Enteric Nervous System
Abstract: Vasti is the most important therapy among Panchakarma therapies. Acharya Kashyapa said Vasti as Shishu-sneha and also said that Vasti works like Amrita for both children and adults. Vasti is the best and authentic treatment for Vata Vikara’s and also said as Ardha-Chikitsha. Nervous system disorders especially motor system disorders are considered as Vata Vikara’s, as “Vagati-gandhanyoiti Vata” means gatior movement function is maintained by Vata. Vasti gives significant results …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 7, Issue 3, 2017 · pp. 1–7 Read article
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Enhancing Patient Safety: A Study On Adr Monitoring In Tertiary Care Hospitals
Abstract: Background: Adverse drug reactions (ADRs) are a major concern in healthcare, causing patient morbidity and mortality. The objective of this study was to investigate the adverse drug reactions in a tertiary care hospital. Methods: From January to July 2024, an observational study was carried out at Bangalore's Akash Super Specialty Hospital. 51 individuals had their demographics, medications, and suspected adverse drug reactions (ADRs) gathered. The Naranjo scale was used to …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 1–7 Read article
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CB₁ Reverse Agonists: A Cheminformatic and Patent Landscape Study
Abstract: The endocannabinoid system plays a crucial role in numerous physiological functions, making cannabinoid receptor 1 (CB1) an attractive target for therapeutic development. This review provides a systematic analysis of patent filings from 2019 to 2023 that focus on small-molecule CB1 reverse agonists. It begins with an overview of the endocannabinoid system, highlighting CB1’s involvement in energy balance, pain regulation, and neuroinflammatory processes The main section of the review examines fifteen …
Published in International Journal of Cheminformatics · Vol. 3, Issue 2, 2025 · pp. 33–36 Read article
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Effect of Conventional Physiotherapy and Modified Constraint Induced Movement Therapy through Play way Method to Improve the Upper Extremity Motor Skills among the Children with Hemi paretic Cerebral Palsy
Abstract: There is a tendency in children with unilateral involvement to use their non-affected hand as the dominant hand, even when the actual functional loss is mild. The potential use of the affected upper extremity of children with hemiparetic CP often fails due to “developmental non-use”, and this leads to increased muscle tone, and decreased active and passive range of motion of the joints of the limb, poor motor control, generalized …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 2, Issue 2, 2013 · pp. 1–9 Read article
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Immunomodulation in Viral Infections
Abstract: Several studies conducted over a period of two decades established that hypothalamic-pituitary-adrenocortical axis is activated during systemic viral diseases. Modulation of the Th1/Th2 balance may affect the susceptibility to or the course of infections. Reduction of T and B lymphocytes are reported during influenza virus infection. This modulation leads to limited immune response. The brain areas involved in the regulation of hypothalamic-pituitary-adrenocortical axis are affected during viral infection. Human immunodeficiency …
Published in Research and Reviews : A Journal of Immunology · Vol. 7, Issue 2, 2017 · pp. 5–8 Read article
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Acetaminophen: Current Understanding and Future Directions in Pharmacology
Abstract: In this review, acetaminophen is described as one of the most widely used analgesic and antipyretic medications worldwide due to its effectiveness and reduced gastrointestinal toxicity compared with traditional NSAIDs. Its precise mode of action is still unclear despite widespread therapeutic use. Acetaminophen has little peripheral anti-inflammatory effect and largely acts within the central nervous system, in contrast to NSAIDs, which mainly block peripheral cyclooxygenase (COX) enzymes and lower inflammation. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 Read article