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240 articles for “binding”
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Computational Simulations in Drug Discovery: Modeling Protein Folding and Drug Binding
Abstract: Computational simulations have become essential tools in drug discovery, offering unprecedented insights into molecular behavior at the atomic level. These simulations, particularly in the domains of protein folding and drug binding, allow for the exploration of complex biological systems that are often difficult to study experimentally. Protein folding, a critical aspect of drug discovery, involves the transition of a polypeptide chain from an unfolded to a biologically active structure. Understanding …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 1, 2025 · pp. 23–29 Read article
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Comparison of High and Low Temperature Properties of Dual Modified Asphalt Binders with Polyphosphoric Acid and Polymer Modified Bitumen using Rheological Tests
Abstract: The main objective of this study was to investigate the properties of asphalt binder mixtures at both high and low temperatures. To achieve this, two types of admixtures were selected and combined, resulting in a technology known as dual modified asphalt binders. Extreme temperatures during summer and winter can lead to significant issues such as cracking and rutting in asphalt binder pavement. In order to address these problems, a comprehensive …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 23–34 Read article
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From Waste to Strength: Hybrid Binder Approach for Sustainable M25 Concrete
Abstract: The growing demand for concrete in infrastructure development has led to increased cement consumption, raising serious environmental concerns due to high energy use and carbon dioxide emissions correlated with cement manufacturing. In this context, the use of industrial residues as partial substitutions for cement has achieved deep focus as a sustainable construction strategy. The current investigations experimentally explore the strength and quality performance of concrete produced using a hybrid binder …
Published in Journal of Construction Engineering, Technology & Management · Vol. 16, Issue 1, 2026 · pp. 24–32 Read article
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Assessing Taila Bindu Pariksha as a Diagnostic and Prognostic test for Diabetes Mellitus
Abstract: Ayurveda has consistently emphasised on not just treatment of a disease but also how to diagnose it and further assess the prognosis. Ayurveda is blessed with different diagnostic tests which is broadly classified into Roga and Rogi Pariksha such as Ashtavidha Pariksha, Dashavidha Pariksha and Dwadashavidha Pariksha. These tests are used very rarely by just few Ayurvedic practioners as an important diagnostic and prognostic methods in different diseases. Taila Bindu …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 2, 2026 Read article
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Hydrolysis-Driven Optimization of Hydroxypropyl Maize Starch for Improved Micro-Pellet Binding and Quick Solubility of Spirulina-Based Micro-Pellets
Abstract: Acid hydrolysis is a well-established approach for modifying the physicochemical properties of polysaccharides & macromolecules including hydroxypropyl Maize starch (HPMS). In this study, the effect of varying concentrations of hydrochloric acid on the partial hydrolytic degradation of HPMS (Lycoat RS-780) was investigated at 85°C for 4 h, yielding polymers of different molecular weights. The Acid-mediated degradation effects on polymer characteristics were systematically assessed using capillary viscometry and gel permeation chromatography …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 3, 2026 Read article
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Exploring the Role of MAPK3 in Major Depressive Disorder: Molecular Docking, Dynamics, and Binding Free Energy Analysis of Natural Compounds as Alternatives to Conventional Drugs
Abstract: Major Depressive Disorder (MDD) is a prevalent neuropsychiatric disorder with limited treatment efficacy and significant side effects associated with conventional antidepressants. Recent studies have highlighted the role of mitogen-activated protein kinase 3 (MAPK3) in the mechanisms underlying MDD, positioning it as a potential target for the development of novel therapeutic drugs. In this study, we employed various computational approaches to explore natural compounds as viable alternatives to synthetic antidepressants. Researchers …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 53–68 Read article
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Association of Vitamin D Binding Protein BP rs2282679 Gene Polymorphism and Serum Levels of Vitamin D in Patients with Vitiligo
Abstract: For vitamin D to have an impact, the vitamin D receptor (VDR) must be expressed and activated in the nucleus. The VDR has several known genetic variants. Biological impacts can be caused by changes in DNA sequences known as "polymorphisms" that are common in the population. Vitiligo is a disease that causes loss of skin color in patches, and it is a chronic (long-lasting) autoimmune disorder loss of color. The …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 2, 2024 · pp. 45–52 Read article
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An Exploratory Study on the Application of Locust Bean Pod Extract as a Natural Binder in the Manufacture of Laterite Blocks for Affordable Housing Construction
Abstract: This study investigates the potential application of locust bean pod extract as an alternative binding material in the production of laterite blocks for local building construction. It also examines the availability and distribution of locust bean pod resources across Nigeria and other parts of Africa. Locust bean pods are typically treated as agricultural waste and discarded after the seeds are removed, creating an opportunity to convert this underutilized by-product into …
Published in Journal of Industrial Safety Engineering · Vol. 13, Issue 1, 2026 · pp. 36–45 Read article
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Polymer Chemistry in Nutraceutical Composites: Exploring Natural Polymers and Binding Systems in a Bamboo-Enhanced Formulation
Abstract: Polymer chemistry underpins the development of advanced nutraceutical composites, blending natural polymers with functional ingredients for health benefits. This study examines a novel nutraceutical formulation comprising ragi (16.39 g/100g), wheat (12.29 g/100g), soybean (12.29 g/100g), buffalo milk (16.39 g/100g), buffalo butter (4.13 g/100g), bamboo extract (0.90 g/100g), and auxiliary components (37.61 g/100g, including fats, sugars, and proteins). Natural polymers—proteins from soybean and milk, polysaccharides from ragi and wheat—form a macromolecular …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 878–884 Read article
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Targeting Homogentisate Dioxygenase Dysfunction in Alkaptonuria: Investigating Curcuma longa’s Therapeutic Potential
Abstract: Objectives: Alkaptonuria is known to have a faulty gene HGO in the metabolic process. In the present research work, the focus is towards investigating the therapeutic capabilities of the Curcuma longa upon the faulty Homogentisate dioxygenase gene using ligand-protein binding, which would assist in the corrective tyrosine metabolism. Methods: This study is based on the computational approach using different phytochemicals for evaluation of the potency against the abnormal Homogentisate dioxygenase …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 2, 2024 · pp. 1–11 Read article
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Hemoglobin is the Breath of Life within Our Cells: An Update
Abstract: Hemoglobin is a fascinating protein found in human red blood cells. This specialist protein carries oxygen from your lungs to every cell in your body, functioning as a little delivery system. While hemoglobin’s stronghold on oxygen is necessary, releasing it at the right time is a delicate challenge. This adaptable protein masterfully balances holding on to its oxygen cargo or releasing it swiftly. This article explores how hemoglobin achieves this …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 1, 2024 · pp. 25–31 Read article
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Interaction of Bioactive Component of Aframomum melegueta on Molecular Docking
Abstract: Computational mimicry of the structure of large complexes created by di- and poly-interaction of molecules has been termed molecular docking. The purpose of molecular docking is the prediction of the three-dimensional structures of interest, this is due to that docking only produces plausible candidate structures. The docking was carried out between the bioactive compounds against 5α-reductase, 3β-hydroxy-steroid dehydrogenase, and 17β-hydroxy-steroid dehydrogenase of returned binding energy, BE (kcal/mol) between -5.9 and …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 51–60 Read article
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Targeting Vasopressin 2 Receptor (V2R) in Renal Cystogenesis by Exploring the Nephroprotective Potential of “Terminalia arjuna”
Abstract: Objectives: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder, leading to the formation of multiple cysts in the kidneys. It is a major cause of end-stage renal disease (ESRD), which often requires dialysis or a kidney transplant for survival. This research focuses on identifying potential bioactive compounds derived from natural sources that show promise for drug development targeting the V2R gene. Methods: The naturally occurred …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 14–24 Read article
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In Silico Pharmacological Evaluation of Certain Commercially Available Terpenoids As Αlpha-Amylase Inhibitors for The Management of Diabetes Mellitus.
Abstract: The objective of this study was to investigate the α-amylase inhibitory activity of certain commercially available terpenoids using in silico docking studies. In this perspective, terpenoids like Abietane, Artemisinin, Carvone, Cucurbitane, Ferruginol, Lupeol, Nerolidol, Retinol, Sabinene, and Zingiberene were selected. Glibenclamide, a well-known antidiabetic drug was used as the standard. In silico docking studies were carried out using AutoDock 4.2, based on the Lamarckian genetic algorithm as the working principle. …
Published in Research and Reviews : Journal of Computational Biology Read article
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Study The Effect of Metakaolin Powder in Hot Mix Asphalt as Mineral Filler
Abstract: Mineral fillers are crucial for bridging the spaces between the internal particles of the asphalt matrix. The purpose of this study is to investigate the mechanical properties of hot mix asphalt as well as the impact of utilising Metakaolin (MK) as a mineral filler. Coarse aggregate, fine aggregate, and filler are the main components of hot mix asphalt (HM). With or without modifiers, materials and asphalt binders. HMA components have …
Published in Journal of Polymer & Composites · Vol. 11, Issue 10, 2023 · pp. 9–15 Read article
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Exploring The Multitarget Pharmacological Mechanism of Diabex for T2dm by Combining Network Pharmacology and Molecular Docking Techniques
Abstract: Objective: Hyperglycemia brought on by an absolute or relative absence of insulin synthesis or action characterises a set of illnesses known as diabetes mellitus. Chronic hyperglycemia in diabetes mellitus has been linked to organ damage, heart, and blood vessels. The persistent metabolic condition Diabetes is a severe global issue with negative social, health, and economic effects. It is a type of metabolism disorder that interferes with food digestion in the …
Published in International Journal of Bioinformatics and Computational Biology Read article
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Molecular Docking and Pharmacokinetic Profiling of the Phytocompounds of Jatropha curcas as Antagonist for Salmonella typhi
Abstract: Background: Typhoid is an infection caused by the Gram-negative bacterium, Salmonella enterica serovar typhi. The study assessed the potential use of Jatropha curcas as a typhoid fever therapy alternative to traditional medications. The ability to uncover novel drug indications for currently available medications using in silico methods has increased thanks to the wealth of pharmacological and biological knowledge that is available. Objective: In this study, we assessed the potential inhibitory …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 · pp. 67–81 Read article
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A Review of Properties of Geopolymer Concrete
Abstract: The growing need for concrete around the world has led to both more concrete being made and more of it being used. Carbon dioxide is released into the atmosphere when regular Portland cement is made, which contributes to global warming (OPC). because concrete that is good for the environment needs new kinds of binders. Using different binders could cut down on the energy needed to make traditional concrete and the …
Published in Journal of Polymer & Composites · Vol. 11, Issue 4, 2023 · pp. 60–69 Read article
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Detecting the Failure Stages in Asphalt Concrete Through the Fatigue Life
Abstract: The signs of failure initiation in asphalt concrete through its service life may appear as cracking, rutting, or other types of distress after practicing dynamic stresses from vehicular loading. This work is concerned with detecting the failure initiation in asphalt concrete in the laboratory, and the role of binder content and constant strain level through a comprehensive testing program. Asphalt concrete mixtures were formulated with the optimal binder content, as …
Published in Trends in Transport Engineering and Applications · Vol. 11, Issue 1, 2024 · pp. 21–27 Read article
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Characterization of Thermochemical Properties and Combustion Behavior In AP/HTPB Polymer Composite Solid Propellant for Enhanced Performance
Abstract: The thermal decomposition of solid propellants containing hydroxyl-terminated polybutadiene (HTPB) binder is a complex process, driven by multiple interacting chemical and physical factors. Solid propellant combustion characteristics are profoundly influenced by the composition of the propellant, the conditions of pressure, the starting temperature, and a range of aero-thermochemical parameters. The paper explores the influence of polymeric structure in the HTPB binder on thermal decomposition characteristics of the AP/HTPB composite propellants …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 502–511 Read article