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22 articles for “T2DM”
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Exploring The Multitarget Pharmacological Mechanism of Diabex for T2dm by Combining Network Pharmacology and Molecular Docking Techniques
Abstract: Objective: Hyperglycemia brought on by an absolute or relative absence of insulin synthesis or action characterises a set of illnesses known as diabetes mellitus. Chronic hyperglycemia in diabetes mellitus has been linked to organ damage, heart, and blood vessels. The persistent metabolic condition Diabetes is a severe global issue with negative social, health, and economic effects. It is a type of metabolism disorder that interferes with food digestion in the …
Published in International Journal of Bioinformatics and Computational Biology Read article
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Limitations to Therapeutic Approaches to T2DM in Light of Different HbA1C Values Suggested by Different Scientific Associations: A Review
Abstract: The present article provided a comprehensive review of international and national guidelines for managing Type-2 diabetes, with a focus on personalized treatment strategies. It discussed the recommended glycated haemoglobin targets and the initial treatment approach involving lifestyle modifications and the use of metformin. The present article underlined the necessity for treatment intensification due to the progressive nature of type-2 diabetes. It also emphasized the complexity of selecting additional antidiabetic medications, …
Published in Research and Reviews: A Journal of Medicine · Vol. 13, Issue 2, 2023 · pp. 13–26 Read article
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Role of Inflammatory Markers and Lipid Abnormalities in Glycemic Dysregulation Among Type 2 Diabetics
Abstract: Background: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by systemic inflammation and associated with various complications in multiple organs. Type 2 diabetes mellitus (T2DM) specifically involves insulin resistance, hyperglycemia, and inflammatory responses. This study investigates the levels of various inflammatory markers and their correlation with glycaemic control in T2DM patients.Objective: To evaluate the levels of inflammatory markers (including NLR, PLR, SII, SIRI, CRP, IL-6, TNF-α, TGF-β, MCP-1, IL-4, …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 2, 2025 Read article
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Screening of Mean Platelet Volume as a Prognostic Marker in Patients with Type 2 Diabetes Mellitus
Abstract: In this study platelets volume and its important role as a diagnostic marker was estimated in the prevalence of type 2 diabetes mellitus (T2DM) which are associated with mean platelet volume (MPV). The aim of the study was to investigate if platelets were activated in diabetes and its associated vascular complications by measuring the MPV in the diabetics compared to the non-diabetics, and to determine the correlation of MPV with …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 9, Issue 1, 2020 · pp. 47–52 Read article
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Evaluation of the Effects of Vitamin D Supplementation on Glycemic Control and Lipid Profile in Normoglycemic and STZ-Induced Type-2 Diabetic Rats
Abstract: The term diabetes mellitus describes a metabolic disorder of multiple aetiologies and is characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. The current approaches for treatment of diabetes are mostly dependent on insulin and other oral standard drugs, which have their own drawbacks. Thus, micronutrients supplementation is gaining momentum as the quest for management of diabetes …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 6, Issue 2, 2016 · pp. 24–34 Read article
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Identification of the Dietary Risk Factors of Diabetes Mellitus Type 2 among Employees of Aligarh Muslim University Aligarh: An Observational Study
Abstract: Background: Type 2 diabetes mellitus is closely related to lifestyle factors such as diet, physical activities, alcohol, smoking, calorie intake as well as obesity and positive family history. Available data suggest that diet is the main culprit and a change in dietary habits and dietetics has a greater potential to improve T2DM. Aims and Objectives: To identify the dietary risk factors of T2DM and find out the association of established …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 7, Issue 2, 2018 · pp. 20–25 Read article
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Impact of PPAR-γ2 pro12Ala Gene Polymorphism and Susceptibility of Type 2 Diabetes Mellitus in Patients Visiting Gondar University Teaching Hospital
Abstract: Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia that can occur through mechanisms such as; impaired insulin secretion, insulin resistance in peripheral tissues and increased glucose output by liver. Type 2 diabetes clearly represents a multifactorial disease, and several findings indicate that multiple genetic and environmental factors are important contributing factor involved in the pathogenesis of this disease. Recently great emphasis has been given to genetical factors to combat …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 5, Issue 2, 2015 · pp. 21–28 Read article
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Frequency of Physical Activities by Type 2 Diabetes Mellitus Patients in Kashmir Valley
Abstract: The therapeutic regimen which is useful in the management of Type 2 diabetes (T2DM) profoundly includes physical activity and exercise. The paper focuses on the extent and type of physical exercise indulged by T2DM patients in Kashmir valley. The study was carried out in the major hospitals (both government and private) having Endocrinology department situated in Srinagar district as well as private health clinics. A total of 1000 diabetic adults …
Published in Research and Reviews: A Journal of Health Professions · Vol. 7, Issue 2, 2017 · pp. 41–46 Read article
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Evaluation of the Effect of Zinc Supplementation on Glycemic Control and Lipid Profile in Normoglycemic and Streptozotocin-induced Type-2 Diabetic Rats
Abstract: Diabetes mellitus is a chronic, progressive disease, which is accompanied by multiple complications. Hyperglycemia and dyslipidemia are common complications of diabetes mellitus. The current approaches for treatment of diabetes are mostly dependent on insulin and other oral standard drugs, which have their own put falls. Thus, micronutrients supplementation is gaining momentum as the quest for management of diabetes continues. Certain micronutrients increase insulin synthesis secretion and insulin sensitivity thereby improve …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 5, Issue 2, 2016 · pp. 41–51 Read article
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Recent Advances in Diabetes Management: A Gendered Approach in North India
Abstract: Background: Diabetes Mellitus remains a major public health issue in India, with disproportionate burdens observed in North India and among women. Objectives: To examine gender and residence-based disparities in glycemic control, medication adherence, and healthcare access among adults with Type 2 Diabetes Mellitus (T2DM) in North India. Page 2 of 7 Methods: A cross-sectional study was conducted among 800 adults with T2DM across five North Indian states. Data on clinical …
Published in Research and Reviews: A Journal of Health Professions · Vol. 16, Issue 2, 2026 Read article
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Metabotropic Receptor Based Target for Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus
Abstract: G protein coupled receptors (GPCRs) moreover called as metabotropic receptor addresses the greatest gathering of film proteins in the human genome. GPCRs share a regular essential characteristic of seven hydrophobic transmembrane (TM) sections (heptahelical structure), with an extracellular amino end and an intracellular carboxyl end their assistant and valuable closeness of GPCRs stays rather than the fundamental OK assortment of the ordinary GPCR ligands. GPCRs keep on being critical revelation …
Published in Trends in Drug Delivery · Vol. 5, Issue 1, 2018 · pp. 17–27 Read article
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IMPACT OF DIET AND CERTAIN FUNCTIONAL FOODS IN TYPE-II DIABETES MANAGEMENT
Abstract: Global health is greatly challenged by type 2 diabetes mellitus (T2DM), whose management mostly depends on dietary and lifestyle changes. This review study looks at how important diet and certain functional items are for managing type 2 diabetes. It offers a thorough summary of current scientific discoveries and clinical investigations that emphasize the contribution of dietary decisions and functional foods to better glycemic control, increased insulin sensitivity, and decreased risk …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 13, Issue 1, 2024 · pp. 9–15 Read article
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Practical approach for Type 2 Diabetes: Role of DPP4 Inhibitors
Abstract: Dipeptidyl peptidase-4 inhibitors (DPP-4Is) have become essential in managing type 2 diabetes mellitus (T2DM) due to their ability to enhance incretin hormone activity, which promotes insulin secretion and inhibits glucagon release. These agents effectively lower HbA1c levels by 0.5–1.0%, are weight-neutral, and have a low risk of hypoglycemia, making them suitable for a broad patient population, including the elderly. The antidiabetic market in India is vast. Gliptin as group row …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 2, 2024 · pp. 20–26 Read article
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Evaluation of Medication Adherence in Patients with Type 2 Diabetes Mellitus: A Mixed- Methods Approach
Abstract: Background: Medication adherence refers to how closely an individual follows the prescribed medication regimen. It is essential for achieving desired therapeutic outcomes and improving patient health. Inadequate adherence can result in the deterioration of health conditions, higher mortality rates, and increased healthcare expenses. Diabetes mellitus, being a chronic condition, demands ongoing medical care not only to prevent the onset of serious complications but also to manage them effectively once they …
Published in International Journal of Community Health Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 28–35 Read article
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Exploring Type-II Diabetes Potential of Phyto-Derived Carbon Dots
Abstract: The integration of phytoconstituents with carbon dots (C-dots) presents a novel and sustainable approach to the development of nanotherapeutics for type 2 diabetes mellitus (T2DM). C-dots, zero-dimensional carbon-based nanomaterials, exhibit unique physicochemical properties including high fluorescence, tunable surface chemistry, biocompatibility, and low toxicity. Their ability to enhance the solubility, bioavailability, and targeted delivery of poorly soluble phytochemicals renders them highly suitable for biomedical applications. This study explores the synthesis of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 08–25 Read article
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GLP-1 Receptor Agonists: A Dual Therapeutic Strategy for the Management of Type 2 Diabetes Mellitus and Obesity
Abstract: For the treatment of obesity and type 2 diabetes mellitus (T2DM), glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become a revolutionary class of pharmaceutical drugs. These drugs were first created as glucose-lowering treatments, but they have now shown other advantages, such as notable weight loss, better cardiovascular results, and general metabolic control. The objective of this narrative review is to assess the pharmacological mechanisms, clinical efficacy, safety profile, and therapeutic …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 69–75 Read article
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SGLT2 Inhibitors in Heart Failure and Chronic Kidney Disease: Expanding Therapeutic Horizons beyond Glycemic Control
Abstract: Heart failure (HF) and chronic kidney disease (CKD) are closely related clinical diseases that significantly increase morbidity and death worldwide. The co-occurrence of both conditions is frequently referred to as the "cardio-renal syndrome," in which the failure of one organ hastens the decline of the other. The original purpose of sodium–glucose cotransporter-2 (SGLT2) inhibitors was to treat type 2 diabetic mellitus (T2DM) by reducing blood sugar levels. Nevertheless, new data …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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Correlation of Serum Vitamin D Levels with Insulin Resistance in Young Adults
Abstract: Among young adults, both insulin resistance (IR)and vitamin D deficiency are common and pose the risk of complications, such as type 2 diabetes mellitus (T2DM). A few studies demonstrated that vitamin D deficiency might negatively influence insulin sensitivity, but the results of these studies have been inconsistent and/or inconclusive. This review focuses on young adults and aims to summarize and critique studies that assess the relationship between IR and serum …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 15, Issue 1, 2026 · pp. 69–74 Read article
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Lipid Profile Analysis in Type 2 Diabetes Mellitus Patients Belonging to Kota South
Abstract: Background: Diabetes mellitus is a category of metabolic disorders marked by persistently high blood sugar levels and abnormalities in the metabolism of fats, proteins, and carbohydrates as a result of deficiencies in the secretion or action of insulin, or both. Diabetic dyslipidemia is characterized by elevated low-density lipoprotein cholesterol (LDL-C), reduced high-density lipoprotein cholesterol (HDL-C), and increased triglyceride (TG) levels. The objective of this study is to assess the lipid …
Published in Research and Reviews : A Journal of Immunology · Vol. 13, Issue 2, 2023 · pp. 38–41 Read article
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PREVENTION AND CONTROL OF DIABETES MELLITUS (DM) WITH DIETOTHERAPY: A REVIEW
Abstract: Prevalence of type II diabetes mellitus (T2DM) have been increasing throughout the world day by day, to an extent that the condition has reached the epidemic proportions in many countries. One of the main reasons for increasing diabetic cases is the sedentary lifestyle, intake of junk food and obesity. Unhealthy eating with profound dependence on junk food, is the major reason for increasing lifestyle diseases like Diabetes Mellitus. Greco-Arab and …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 7, Issue 2, 2020 · pp. 10–19 Read article