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14 articles for “Simultaneous estimation”
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Analytical Method Development and Validation of Simultaneous Estimation of Natural Active Constituents Andrographolide and Piperine by UV Method.
Abstract: A simple, accurate, precise, and robust UV-Visible spectrophotometric method was developed and validated for the simultaneous estimation of Andrographolide and Piperine in bulk and combined pharmaceutical dosage forms. Preformulation studies confirmed favorable physicochemical properties for both drugs, including acceptable solubility profiles, melting points, pH values, and partition coefficients. The method development involved determination of λmax values at 224 nm for Andrographolide and 288 nm for Piperine using ethanol as solvent. …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 3, 2025 · pp. 33–41 Read article
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Analytical Method Development and Validation for Simultaneous Estimation of Paracetamol and Piroxicam by UV Method
Abstract: A new establishment and validation of a simple, precise, accurate and cost effective UV-Visible spectrophotometric method was developed to estimate both Paracetamol and Piroxicam simultaneously in conjoined pharmaceutical dosage forms. This technique was founded on simultaneous equation method of absorbances recorded at 252.0 nm and 282.0 nm of Paracetamol and Piroxicam in methanol respectively and an isosbestic point could be observed at 265.0 nm. It showed very good linearity over …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 3, 2025 · pp. 14–21 Read article
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Toxicology-Focused Development and Validation of an RP-HPLC Technique for Quantifying Bempefoic Acid and Rosuvastatin in a Fixed-Dose Combination
Abstract: A straightforward, precise method was developed to simultaneously assess Bempedoic acid and Rosuvastatin in both bulk and tablet forms. Utilizing a DIKMA Spursil C18 column (4.6 mm x 250 mm, 3.0 μm), chromatography was conducted with a mobile phase comprising 30% phosphate buffer and 70% acetonitrile, flowing at 1 ml/min. Operating at ambient temperature, the optimized wavelength for detection was set at 240 nm, revealing retention times of 4.418 min …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 1–9 Read article
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Lamivudine And Dolutegravir Simultaneous Dosage Forms Determined and Validated Using The RP-UPLC Method
Abstract: RP-UPLC has been used to produce a straightforward, precise, and accurate approach for the simultaneous estimation of dolutegravir and lamivudine in a pharmaceutical dose form. A HSS C18 column of 2.8 x 50 mm and featuring particles with a size of 1.6 μm was used to process the chromatogram. A mixture of 70:30 Buffer Na2HPO4 and methanol made up the mobile phase, which was pushed across the column at a …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 1, 2024 · pp. 5–13 Read article
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Development and validation of a method for simulataneous determination of tenovifir disoproxil fumarate emtriculabine and isonized in bulk and pharmaceutical dosage form using RP-HPLC with relevance to toxicological aspects
Abstract: Hence, proposed analytical methods are simple, novel, economical, rapid, sensitive, reproducible and accurate for the Simultaneous estimation of Tenofovir Disoproxil Fumarate, Emtricitabine and Isoniazid in Bulk and Phamaceutical dosage form by using RP- HPLC. This Method gives reliable assay results with short analysis time using mobile phase of Acetonitrile : 0.02M Potassium Dihydrogen Orthophosphate: water (pH 5.3) in the ratio of 60: 25: 15 respectively. Retention time was found to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 1, 2024 · pp. 17–25 Read article
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OBD-II Big Data–Driven ML and AI-Based Virtual Sensing for Fuel Economy, Component Health, and Carbon Intelligence
Abstract: The rapid growth of connected vehicles has led to the large-scale availability of high-frequency On-Board Diagnostics II (OBD-II) data; however, much of this data remains underutilised, as existing studies and commercial systems typically address fuel economy, maintenance, or emissions in isolation or rely on additional physical sensors. Such fragmented and sensor-dependent approaches limit scalability and increase system cost, particularly in high-volume and resource-constrained vehicle markets. To address this gap, this …
Published in Journal of Automobile Engineering and Applications · Vol. 13, Issue 1, 2026 · pp. 39–50 Read article
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Estimation of Alogliptin and Dapagliflozin in Synthetic Mixture by RP-HPLC Method
Abstract: The primary objective of the proposed research was to develop and validate analytical methods for the simultaneous quantification of Alogliptin and Dapagliflozin in a synthetic mixture. Alogliptin and Dapagliflozin are medications used for managing diabetes, with Alogliptin inhibiting the enzyme Dipeptidyl peptidase-4 and Dapagliflozin belonging to the class of sodium-glucose cotransporter 2 inhibitors. High-performance liquid chromatography method development was conducted using a C18 column (250 mmX4.6 mm, 5 μm particle …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 37–46 Read article
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A Concurrent Estimation of Phytoconstituents Piperine, Quercetin and Kaempferol Present in Siddha Polyherbal Formulation Kabasara Kudineer by Rp-Hplc
Abstract: A straightforward, accurate, and precise technique was developed and validated for the simultaneous determination of Quercetin, Kaempferol, and Piperine in the polyherbal formulation Kabasura Kudineer. The sample was chromatographed using a C18 column (150x4.6mm, 5u) with a mobile phase composed of Acetonitrile and Ortho phosphoric acid in a 45:55 ratio, flowing through the column at a rate of 1ml/min. The detection wavelength for Quercetin, Kaempferol, and Piperine was set at …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 1–9 Read article
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Simultaneous Determination And Stability Indicating Method For Telmisartan, Metoprolol Succinate And Cilnidipine In Tablet Dosage Form.
Abstract: There are several medicinal agents available for antihypertensive activity. Telmisartan, metoprolol and cilnidipine are among them. Quantitative and qualitative analysis plays a pivotal role in safeguarding patients. Here, the estimation of these drugs was performed by using the chromatographic technique RP-HPLC. It was conducted with Phosphate buffer (pH 3.5 ± 0.01): Methanol (50:50 v/v) mobile phase. The system was operated at 1 ml/min. Drug volume to the system was 20μl. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 32–38 Read article
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Experimental Investigation and Optimization of Machining Parameters for Al6351 Alloy Using a Modified Taguchi Approach
Abstract: Machining processes encompass both conventional and non-conventional techniques and optimizing machining parameters is crucial for achieving high-quality outcomes. However, simplifying these processes remains a significant challenge. This study focuses on determining the optimal machining parameters—cutting speed, feed rate, and depth-of-cut to enhance performance characteristics in Al6351 alloy plates. The parameters evaluated include surface roughness (Ra), material removal rate (MRR), resultant forces (RF), and temperature at the tool- workpiece interface (Temp). …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1463–1481 Read article
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Hierarchical Computational Modeling of Physical Structure Across Quark, Nuclear, and Atomic Scales
Abstract: We present a modular, multi-scale computational framework that integrates physical modeling and visualization across quark, nuclear, and atomic scales within a unified pipeline. Developed to address the traditional fragmentation between sub-nucleonic, nuclear, and electronic representations, the system provides a continuous data flow and visualization bridge spanning from femtometers to ångströms. The framework consists of three primary modules: a particle-level module illustrating nucleons as confined quark-triplets with effective flux-tube geometries; a …
Published in Research & Reviews : Journal of Physics · Vol. 15, Issue 1, 2026 Read article
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Concept Design of a Simple Marine Dry Dock (Without Gate)
Abstract: This article explores various options for facilities used in underwater ship repair, including Dry Dock, Ship Lift systems, Floating Dry Docks, and Simple Slipway systems with cradle and winch. Such facilities are crucial to any ship repair operation. Among these, Dry Docks are known for their high capital cost and limited capacity to repair only one ship at a time. This makes them less appealing unless there is substantial demand …
Published in Journal of Offshore Structure and Technology · Vol. 11, Issue 3, 2024 · pp. 46–69 Read article
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Fibre Orientation and Void Distribution Analysis in Polymer Composite Structures Using Image Processing
Abstract: Fibre orientation and void distribution are critical microstructural features that govern the mechanical performance and reliability of polymer composite materials. Accurate and simultaneous characterisation of these features remains challenging due to their complex spatial interactions and dependence on processing conditions. In this work, an integrated image-processing framework is proposed for the quantitative analysis of fiber orientation and void distribution in polymer composite structures. High-resolution composite microstructure images are processed through …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 925–933 Read article
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Elemental Mobility and Provenance in Sediments: A Geochemical Study of Deccan Basalts, Bay of Bengal, and Northern China
Abstract: Twenty-eight sediment samples from seventeen rivers, including the Krishna headwaters and the west-flowing Western Ghat rivers, draining the Deccan Trap basalts, were analyzed for major elements (Na, Ca, Mg, K, Al, Ti, Fe) and trace elements (Sr, Ba, Mn, P, V, Cr, Ni, Cu, and Zn). The mobility of these elements, especially Na, Ca, Mg, and Sr, was assessed by comparing their abundances in sediments and dissolved phases. Approximately 60% …
Published in International Journal of Minerals · Vol. 1, Issue 2, 2024 · pp. 19–27 Read article