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45 articles for “Quantitative validation”
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RP-HPLC Analytical Method Development and Validation for Quantitative Estimation of Metoclopramide Hydrochloride in Solid Oral Formulations
Abstract: RP-HPLC technique formulated for the numerical assessment of Metoclopramide Hydrochloride in tablet formulation has been confirmed for reliability. A C18 column facilitated the chromatographic separation using a mobile phase comprising 60:40 (v/v) potassium dihydrogen phosphate buffer: meth anol mixture. Such method was used to detect, where the retained time was 6.78 minutes and Metoclo pramide Hydrochloride produced a clear peaked at 273 nm. Results were in agreement with ICH Q2 …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 07–15 Read article
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DEM Simulation of Macro and Micro-scale Behavior of Granular Materials during Loading and Unloading
Abstract: The present paper aims at comparing the simulated stress-strain behavior of granular materials quantitatively with the experiment and exploring the evolution of the micro-scale behaviors during loading and unloading using the discrete element method (DEM). A numerical sample consisting of 9826 randomly generated spheres similar to the experiment was prepared. The numerically prepared isotropic sample was subjected to loading and unloading under strain controlled condition. It is noticed that the …
Published in Journal of Geotechnical Engineering Read article
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Mechanical & Tribological Characterization of Al2024-Alumina-Graphite Reinforced Monolithic and Hybrid Composites
Abstract: This work investigates the mechanical characteristics of Al2024-Al2O3-Graphite reinforced monolithic and hybrid composites fabricated by the stir casting method. Exploratory work involved the fabrication of monolithic composites with varying Al2O3 contents (5-8 wt%) and hybrid composites with the ratios of Al2O3 (2-6 wt%) and Graphite (1-3 wt%) in matrix Al2024. For improving their dispersion, preheated reinforcement particles were introduced in matrix alloy at controlled stirring rates. A homogeneous particle distribution …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 823–836 Read article
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Bioanalytical Method Development and Validation for the Estimation of Levothyroxine in Human K₃EDTA Plasma by Using UPLC-MS/MS
Abstract: A rapid, sensitive, and highly selective UPLC-MS/MS method was developed and validated for the quantitative estimation of Levothyroxine in human plasma using Levothyroxine-D₃ as the internal standard (IS). Chromatographic separation was achieved on a Gemini NX-C18 column (50 × 3.0 mm, 3 µm) with a mobile phase consisting of acetonitrile and water (70:30, v/v) containing 0.015% formic acid at a flow rate of 0.5 mL/min. The total run time was …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 3, 2025 · pp. 32–46 Read article
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A Comprehensive Exploration of Method Validation and Development in Pharmaceutical Analysis: Focus on Vortioxetine Analysis
Abstract: The pharmaceutical industry relies on rigorous method validation to ensure the accuracy, precision, and reliability of analytical techniques employed in drug testing and quality control. This comprehensive exploration delves into the validation parameters and guidelines essential for method validation, emphasizing accuracy, precision, linearity, detection and quantitation limits, specificity, range, robustness, and ruggedness. Validation plays a pivotal role in guaranteeing high-quality products, adhering to good manufacturing practices (GMP), and optimizing manufacturing …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 1, 2024 · pp. 46–52 Read article
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Understanding of Research Bias in Herbal Medicine: A Comprehensive Review
Abstract: Background: The communication and generation of knowledge are central to research. In herbal medicine, with its deep historical roots, research must be methodologically rigorous and unbiased to validate traditional knowledge in modern contexts. Bias, defined as any tendency preventing objective evaluation of a research question, compromises validity and reliability. Objective: To highlight types of research bias in herbal medicine and discuss strategies for minimization to ensure credible and applicable findings. …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 1, 2026 · pp. 31–35 Read article
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Interfacial Bonding Efficiency in Jute-Carbon Fiber Polyester Matrix Composites Evaluated Through Short Beam Shear and Interlaminar Fracture Toughness Testing
Abstract: The natural Fiber–synthetic Fiber hybrid composites are jute–carbon Fiber hybrid in polyester matrix which could be used in semi-structural applications of automotive, construction and marine industry as an eco-friendly and cost-effective alternative of conventional carbon Fiber reinforced polymer. But the hydrophilic nature of jute Fibers and the relatively inert surface of carbon Fiber's cause weak bonding at the interface of the polyester matrix, which causes premature delamination, poor interlaminar shear …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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Quantitative Structure-activity Relationship in Computer-aided Drug Design: A Review
Abstract: Quantitative Structure-Activity Relationship stands at the forefront of Computer-Aided Drug Design, providing a systematic framework for understanding the relationship between the chemical structure of molecules and their biological activity. The present review delves into the multifaceted realm of quantitative structure-activity relationship methodologies within the landscape of drug discovery. Through an exploration of diverse quantitative structure-activity relationship models, molecular descriptors, validation techniques, and recent advancements, the present article aims to elucidate …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 55–63 Read article
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Simultaneous Determination And Stability Indicating Method For Telmisartan, Metoprolol Succinate And Cilnidipine In Tablet Dosage Form.
Abstract: There are several medicinal agents available for antihypertensive activity. Telmisartan, metoprolol and cilnidipine are among them. Quantitative and qualitative analysis plays a pivotal role in safeguarding patients. Here, the estimation of these drugs was performed by using the chromatographic technique RP-HPLC. It was conducted with Phosphate buffer (pH 3.5 ± 0.01): Methanol (50:50 v/v) mobile phase. The system was operated at 1 ml/min. Drug volume to the system was 20μl. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 32–38 Read article
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Effects of Reels and short videos on human mind and Academic Life
Abstract: The rapid rise of short-form video platforms such as Instagram Reels, TikTok, and YouTube Shorts has fundamentally reshaped the way people consume information and entertainment. While these applications offer quick engagement and social connection, their excessive use has raised serious concerns about their psychological and academic impacts. This research investigates the relationship between short-form video addiction, mindfulness, academic anxiety, and academic engagement among university students. Drawing upon the theoretical framework …
Published in International Journal of Behavioral Sciences · Vol. 3, Issue 2, 2026 Read article
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Examining the Relationship Between Academic Stress, Maladaptive Perfectionism and Trauma-Related Responses Among University Students
Abstract: Academic stress is a significant concern among university students, frequently contributing to maladaptive perfectionism and trauma-like responses. While perfectionism can enhance performance, its maladaptive variant may be exacerbated by academic stress which can induce trauma-like responses. This study investigates the correlation between academic stress, maladaptive perfectionism and trauma-like responses. Validated self-report measures were used in a quantitative, correlational study involving 101 university students. Linear regression analysis and Kendall’s Tau-B correlation …
Published in International Journal of Education Sciences · Vol. 3, Issue 1, 2026 · pp. 145–154 Read article
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The Awareness–Behaviour Paradox: Media Literacy and Social Media Risk Behaviour Among Nigerian Undergraduates
Abstract: Background: The proliferation of internet-capable devices and social media platforms has created an intricate web of risks for Nigerian undergraduates, including cyberbullying, addiction, misinformation, and exposure to indecent content. While media literacy has been widely proposed in Western scholarship as a sustainable intervention for responsible online behaviour, its protective mechanisms remain insufficiently understood in non-Western contexts, particularly with respect to the psychological pathways through which literacy operates. Objectives: This study …
Published in International Journal of Behavioral Sciences · Vol. 3, Issue 1, 2026 · pp. 121–126 Read article
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Development and Validation of a Robust RP-HPLC Method for Rufinamide Quantification in Pharmaceutical Dosage Forms
Abstract: The creation and validation of a simple, precise, and targeted reverse phase high-performance liquid chromatographic (RP-HPLC) approach allowed for the quantification of rufinamide in pharmaceutical dosage forms. With a mobile phase of methanol and water (50:50, v/v), the technique used a gradient mode Symmetry Qualisil gold C18 column (4.6 x 150mm, 5 μm). For the detection method, a flow rate of 1 mL/min was employed at 220 nm. During a …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 1, 2024 · pp. 25–32 Read article
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Photochemically Assisted LC–MS Method Development and Validation for Stability-Indicating Determination of Glasdegib in Rat Plasma
Abstract: A simple, precise, and cost-effective LC–MS method was successfully developed for the determination of Glasdegib in rat plasma. The method optimization was carried out by systematically varying key chromatographic parameters, including flow rate, injection volume, analyte concentration, and mobile phase composition, to achieve optimal sensitivity and resolution. A C18 Hypersil BDS column (150 mm × 4.6 mm, 3.5 µm particle size) was used for chromatographic separation, offering effective peak shape …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 4, Issue 1, 2026 · pp. 11–20 Read article
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Estimation of Alogliptin and Dapagliflozin in Synthetic Mixture by RP-HPLC Method
Abstract: The primary objective of the proposed research was to develop and validate analytical methods for the simultaneous quantification of Alogliptin and Dapagliflozin in a synthetic mixture. Alogliptin and Dapagliflozin are medications used for managing diabetes, with Alogliptin inhibiting the enzyme Dipeptidyl peptidase-4 and Dapagliflozin belonging to the class of sodium-glucose cotransporter 2 inhibitors. High-performance liquid chromatography method development was conducted using a C18 column (250 mmX4.6 mm, 5 μm particle …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 37–46 Read article
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Investigating Temperature Effects on Thermal Analysis of Composite Heat Pipes with Diverse Geometrical Configurations
Abstract: As the demand for efficient heat dissipation technologies continues to surge, understanding the intricate interplay between temperature variations and the thermal performance of heat pipes assumes paramount importance. This study investigates the impact of temperature fluctuations on the thermal behaviour of heat pipes with diverse geometric configurations. A comprehensive analysis is conducted utilizing advanced computational simulations coupled with experimental validation techniques. Heat pipes are an innovative heat transfer device with …
Published in Journal of Polymer & Composites · Vol. 12, Issue 3, 2024 · pp. 20–34 Read article
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Structural Performance Evaluation of Circular Perforated Plates under Mechanical Loading
Abstract: Circular perforated plates are structurally critical components in aerospace, automotive, and marine sectors, where perforation-induced stress concentrations govern failure under mechanical loading. This study conducts a systematic finite element analysis of stress distribution, deformation, and interlaminar behavior in aluminum and glass-epoxy laminates ([−45/45/90/0]S and [−45/45/90/0]AS) under uniform transverse pressure with clamped-free boundary conditions. Four perforation configurations—no hole, central hole, single-series, and 25-hole grid—were evaluated using ANSYS Shell-181, verified against Kirchhoff–Love, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 1–20 Read article
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The Impact of Nutrition on Sports Performance and Academic Success: A Study Among University Athletes – Eastern Technical University of Sierra Leone
Abstract: University athletes operate within dual-performance environments that require simultaneous academic and athletic excellence. Nutrition plays a critical role in supporting both physiological performance and cognitive functioning; however, limited empirical work has examined its combined influence on athletic and academic outcomes within university athlete populations, particularly in low-resource contexts. This study aimed to investigate the relationship between nutritional practices, sports performance, and academic achievement among university athletes at the Eastern Technical …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 15, Issue 1, 2026 · pp. 16–27 Read article
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Assessment of Water Quality and Quantity Trends at Reuse Locations within the Bahr El- Baqar Drainage Catchment under Water Stress Reduction Scenarios
Abstract: Many countries face the pressing challenge of water scarcity, affecting around 20% of the global population in areas with water shortages. Egypt, one of the most populous countries in Africa and the Middle East, is severely impacted by this issue. To address this, Egypt is focusing on developing alternative water resources, including the reuse of agricultural drainage water for irrigation. In this study, the SIWARE model was employed to evaluate …
Published in Journal of Water Resource Engineering and Management · Vol. 12, Issue 3, 2025 · pp. 1–11 Read article
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Qualitative and Quantitative Effects of Non-Thermal Atmospheric Pressure Plasma and ErCr: YSGG Laser Activation on Surface Remineralization and Fluoride Release of Three Different Fluoride Varnishes
Abstract: Dental caries remains a prevalent oral health concern worldwide, prompting ongoing research into innovative approaches for caries prevention and management. This experimental investigation endeavors to conduct a comparative assessment of the bioactivity, fluoride release kinetics, shear bond strength, and compressive strength of glass ionomer cement (GIC) augmented with three distinct types of inorganic bioactive nanoparticles. Bioactive nanoparticles have garnered interest in dental materials for their potential to enhance material properties …
Published in Journal of Polymer & Composites · Vol. 12, Issue 5, 2024 · pp. 292–303 Read article