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179 articles for “Phytochemical compound”
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Harnessing Nature: Formulations for Colon Cancer Prevention and
Abstract: Colon cancer, a rapidly advancing disease worldwide, involves the carcinogenesis of the distal part of the intestine. This malignancy progresses through various developmental stages necessitating diverse treatment approaches. Traditional treatments include drug therapy and chemotherapy; however, emerging methods, such as the use of phytochemical compounds offer promising mechanisms for combating this disease. Phytochemical compounds derived from natural food sources, including flavonoids, tannins, resveratrol, and epigallocatechin-3-gallate, exhibit potent anti-cancer properties. They …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 3, 2024 · pp. 11–23 Read article
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Phytochemical Screening and the Effect of Temperature Treatment on the Extraction Yield of Phenolic Compounds and the Antioxidative Activities of Two Medicinal Species Growing in Algeria: Ammi visnaga and Mentha pulegium
Abstract: The aims of this investigation are the identification of molecules of secondary metabolism and study the impact of two extraction techniques (extraction by boiling water under reflux and maceration in 70% hydroethanolic solution at ambient temperature) on the yield of phenolic compounds and the antioxidative activity on two species widely used in Algeria as medicinal plants; Ammi visnaga and Mentha pulegium. The results show that phytochemical screening indicates the presence …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 5, Issue 3, 2018 · pp. 18–25 Read article
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Targeting Homogentisate Dioxygenase Dysfunction in Alkaptonuria: Investigating Curcuma longa’s Therapeutic Potential
Abstract: Objectives: Alkaptonuria is known to have a faulty gene HGO in the metabolic process. In the present research work, the focus is towards investigating the therapeutic capabilities of the Curcuma longa upon the faulty Homogentisate dioxygenase gene using ligand-protein binding, which would assist in the corrective tyrosine metabolism. Methods: This study is based on the computational approach using different phytochemicals for evaluation of the potency against the abnormal Homogentisate dioxygenase …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 2, 2024 · pp. 1–11 Read article
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Network Pharmacological Studies in Biological Interactions of Thymoquinone
Abstract: Thymoquinone, a bioactive phytochemical compound belonging to the class of benzoquinones, is prominently present in the plant Nigella sativa. Despite its widespread use, the precise molecular mechanisms underlying its beneficial effects remain elusive. To address this gap, we employed network pharmacology to investigate the actions of Thymoquinone (TQ). Our methodology encompassed the utilization of diverse bioinformatic tools to scrutinize this molecule of interest comprehensively. Initially, we retrieved the chemical structure, …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 12, Issue 3, 2023 · pp. 18–25 Read article
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GC-MS Analysis of Boerhavia diffusa Linn. Whole Plant Extracts: An Ethno-medicinal Plant
Abstract: In the present investigation, phytochemical compounds and GC-MS analysis of Boerhavia diffusa whole plant was studied, and presence of phytochemical compounds was screened by qualitative method. The results confirmed the presence of phytochemicals namely terpenoids, saponin, flavonoids, cardiac glycosides, phlobatannins and tannin. In GC-MS analysis, 42 phytochemical compounds were identified in the methanol extract of Boerhavia diffusa, the components were identified by comparing their relation indices and mass spectra fragmentation …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 5, Issue 1, 2018 · pp. 7–12 Read article
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Phytochemical Analysis of Organic Compounds as an Indicator of Metal Uptake in Selected Plants
Abstract: Plants contain a number of potential chelating agents such as amino acids, organic acids, peptides, and proteins, etc. These chelating compounds are very important for the physiological processes in plants. In addition, these ligands are found in both hyperaccumulator and non-hyperaccumulator plants and play a vital role in metal uptake from contaminated soil. Many organic compounds have been found to bind and accumulate trace and toxic metals in hyperaccumulating plants. …
Published in Research & Reviews : Journal of Botany · Vol. 9, Issue 3, 2020 · pp. 8–12 Read article
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In silico analysis of Abrus precatorius L. as a potential agonist of PPARγ : A novel approach to the treatment of diabetes
Abstract: Diabetes mellitus is a chronic disorder that is characterized by a lack of insulin secretion by the pancreas or a defect in insulin action, or both. If diabetes is not controlled, over time it can cause damage to blood vessels and nerves, leading to life-threatening complications such as, kidney damage, heart disease and vision impairment. It can also weaken the immune system, making patients more prone to infection. Although treatments …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 · pp. 13–24 Read article
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Phytochemical and Solubility Test of Guava, Jambolan, Ber & Lakshmi Taru Leaves
Abstract: The current research study aimed to conduct a comprehensive phytochemical screening of four distinct plant leaves, namely Guava, Jambolan, Ber, and Lakshmitaru, all of which are found in the Madan Mohan Herbal Garden located at JNCHRC in Bhopal. This screening process involved the preparation of ethanolic extracts from the plant leaves. The analysis revealed the presence of various phytoconstituents, including tannins, phenolic compounds, flavonoids, saponins, alkaloids, terpenoids, steroids, carbohydrates, and …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 10, Issue 1, 2023 · pp. 23–32 Read article
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Exploring the Role of Ginkgo biloba in Investigating 7L1X in Triple-Negative Breast Cancer Through Integrative Bioinformatics
Abstract: Objectives: Triple-negative breast cancer is a very dangerous form of cancer that affects mostly Hispanic and African American women above the age of 40. It represents approximately 15–20% of the global cancer incidence. This experiment aims to investigate the use of Gingko biloba in the treatment of the disease triple-negative breast cancer. Methods: We use a variety of online tools, and websites, including the Indian Medicinal Plants, Phytochemistry, and Therapeutics …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 2, 2024 · pp. 1–10 Read article
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Therapeutic Prospects and Comparative Bioactive Evaluation of Fenugreek Seed Extracts
Abstract: A medicinal plant with substantial therapeutic potential, fenugreek (Trigonella foenum-graecum L.) is rich in bioactive phytoconstituents. The phytochemical makeup and antioxidant properties of aqueous and methanolic fenugreek seed extracts were compared in this study. Phenolics, flavonoids, terpenoids, alkaloids, tannins, and saponins were found in both extracts, with the methanolic fraction showing greater intensity, according to preliminary phytochemical screening. The methanolic extract has higher levels of phenolic, flavonoid, and terpenoid content, …
Published in Research & Reviews : Journal of Botany · Vol. 15, Issue 2, 2026 · pp. 64–75 Read article
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Antimicrobial Potential of Methanolic Extract of Barringtonia acutangula (L.) Gaertn Fruits
Abstract: Barringtonia acutangula is a middle-sized plant which is distributed in Meghalaya, Assam, West Bengal, Madhya Pradesh, Bihar and Odisha, used in treatment of various ailments. The present work has investigated the antimicrobial activity of methanol extract of Barringtonia acutangula fruit against six resistance bacterial strains such as Enterococcus faecalis, Staphylococcus aureus, Acinetobacter bumannii (Gram positive) and Citrobacter freundii, Enterobacter aerogenes, Escherichia coli (Gram negative). The antibacterial activity was evaluated by …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 3, Issue 3, 2016 · pp. 13–18 Read article
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Unveiling Nature’s Potential: In Silico Exploration and Identification of Herbal Remedies for Major Depressive Disorder Through Molecular Interaction Studies
Abstract: Major depressive disorder (MDD), a globally discussed mental health condition, has drawn significant attention because of its unique and intricate nature. This is marked by the enduring presence of negative emotions stemming from a lack of interest, diminished self-esteem, and excessive rumination. Despite the widespread availability of various antidepressant medications, their effectiveness is hindered by low response rates, prolonged treatment durations, and the prevalence of side effects, such as headaches, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 54–62 Read article
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Paeonia emodi: An Ethnopharmacological and Phytochemical Review
Abstract: This review is an attempt to evaluate the phytochemical potential of the Paeonia emodi and covers the pharmacological and ethnopharmacological activities of its chemical constituents, newly isolated chemical compounds and their medicinal importance. P. emodi is used in several traditional medicinal systems in China, Korea, Pakistan, India and Thailand. Different isolated natural products like anthraquinones, terpenoids, tannins, carbohydrates, phenolics and tannins, glycosides, paeoniflorin, lactiflorin, oxypaeoniflorin, cycloartenol, cholesterol, sitosterol, campesterol, emodinol, …
Published in Research & Reviews : Journal of Herbal Science · Vol. 6, Issue 2, 2017 · pp. 11–20 Read article
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A Review on Phytochemistry and Pharmacology of Macaranga peltata
Abstract: Macaranga peltata, categorized within the Euphorbiaceae family, represents a prevalent pioneer arboreal species across Southeast Asia, specifically in regions such as India and Sri Lanka. This review scrutinizes the phytochemical properties and pharmacological profiles of Macaranga peltata, underscoring both its historical medicinal applications and prospective therapeutic roles. The plant exhibits a rich composition of secondary metabolites, encompassing flavonoids, stilbenes, tannins, and terpenes, with the majority of these compounds being extracted …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 50–59 Read article
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Targeting Vasopressin 2 Receptor (V2R) in Renal Cystogenesis by Exploring the Nephroprotective Potential of “Terminalia arjuna”
Abstract: Objectives: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder, leading to the formation of multiple cysts in the kidneys. It is a major cause of end-stage renal disease (ESRD), which often requires dialysis or a kidney transplant for survival. This research focuses on identifying potential bioactive compounds derived from natural sources that show promise for drug development targeting the V2R gene. Methods: The naturally occurred …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 14–24 Read article
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A review on the effects of Indian medicinal spices on age related molecular and cellular pathways in light of geriatric muscle loss
Abstract: Biological aging is an enigmatic and progressive process, which can be affected by various mechanisms - genetic alteration, deregulated nutrient sensing, proteostasis, cellular degeneration and stem cell dysfunctioning. Indian spices are an underexplored repository of phytoactives with a medicinal potential. Especially spices like cumin (Cuminum-cyminum) and fennel seeds (Foeniculum vulgare) are central to the Indian diet as well as a part of numerous traditional recipes and formulations with medicinal implications. …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 12, Issue 3, 2024 · pp. 1–10 Read article
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Rauwolfia Serpentina: A Comprehensive Phytochemical Study of Its Bioactive Metabolites
Abstract: Rauwolfia Serpentina is an important medicinal plant used in Ayurveda, Unani, and folk medicine system of medicine. This plant grew as a bush in company of other plants as an evergreen structure. It is commonly known as ‘Sarpaghanda’. in Ayurvedic and Unani medicine system. It is safe and effective for the treatment of snakebites and various types of disease like malaria, breast cancer, prostate cancer, high blood pressure, insomnia, epilepsy, …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 2, 2024 · pp. 25–50 Read article
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Targeting PTPN22 in Arthritis: Molecular Docking and Pharmacokinetic Evaluation of Artemisia vestita Compounds
Abstract: Rheumatoid arthritis (RA) is a long-term autoimmune condition characterized by inflammation of the synovial membrane, commonly resulting in swelling, pain, stiffness, and overall fatigue. Protein tyrosine phosphatase non-receptor type 22 (PTPN22) has been identified as a risk factor linked to various autoimmune diseases, including RA. In the PTPN22 gene, two missense Single nucleotide polymorphisms (SNPs) are associated with autoimmune conditions. The R620W (C1858T, rs247660) variant in exon 14 has been …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 20–31 Read article
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Molecular Docking of Nigella Sativa Phytocompound as Inhibitors of Transcription Factors NF-KB Implicated in Rheumatoid Arthritis
Abstract: Objectives: Nigella sativa, a plant considered around the world as the most treasured nutrient-rich herb for centuries together in different civilizations, is exceptionally known for its high levels of antioxidant properties. Free radical intensification due to oxidative stress plays a key role in the pathogenesis of rheumatoid arthritis by activating the NF-KB protein that regulates the expression of the genes involved in inflammation. Methods: This study involves in-silico approach to …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 42–55 Read article
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Natural Products: A Prospective Tactic to Unite Nature and Disease
Abstract: The most primitive and effective method from pre-historic time to heal injuries, cure disease and relieve suffering; is treatment with the help of plants extract. Resistance to anti microbial agents has lead to treatment failure and the shift of medical care from orthodox to herbal medicine. Most of the herbal medicines in use await validation of their claimed effects and possibly the development of novel antimicrobial drugs from them. Every …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 5, Issue 3, 2015 · pp. 35–38 Read article