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50 articles for “PD-1”
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An Evaluation of the Effectiveness of a Self-Instructional Module on First Aid and Safety Measures for School Children (Aged 11–14 years) at PDR VVP Vidyalaya, Loni
Abstract: Background: School children are active youngsters. India is home to nearly 500 million young individuals, with approximately 370 million being children under 15 years old, highlighting their crucial role as the future of the country. Young children often exhibit naughty, defiant, and impulsive behavior. According to the World Health Organization’s Global report, in the South-East Asia Region, road traffic accidents, drowning, burns, and other injuries are leading causes of child …
Published in Journal of Nursing Science & Practice · Vol. 15, Issue 1, 2025 · pp. 17–22 Read article
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Molecular Docking Evaluation of Cedrus deodara Secondary Metabolites as a Potent Anti-ovarian Cancer Agent
Abstract: Objective: According to the statistics for the year 2022 it was seen that cancer total cases is 14,61,427. After breast cancer, ovarian cancer is the second most frequent cancer among women. The estrogen receptor (PDB ID: 1X7E), progesterone receptor (PDB ID: 1A28), and Phosphoinositide 3-kinases (PDB ID: 4FJY) can be considered as target protein for ovarian cancer. The plant Cedrus deodara and its phytochemicals were chosen in this study to …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 77–93 Read article
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Image-Based Crack Morphology Characterisation for Electrical Failure Analysis in Conductive Polymer Composites
Abstract: Electrical performance in conductive polymer composites is strongly governed by crack-network evolution, yet failure analysis typically relies on qualitative image inspection or electrical anomaly detection in isolation. This work proposes an end-to-end framework that converts optical/SEM crack imagery into a standardised crack morphology signature and quantitatively links it to electrical degradation indicators. A two-stage learning strategy is adopted: crack-representation pretraining using the public Concrete Crack Images for Classification dataset, followed …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1375-1386 Read article
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In-silico Approach of Few Selected Phytoconstituents on Newer Cancer Targets
Abstract: Background: Cancer’s high death rates are mainly due to, drug resistance and unmet medical demands. It necessitates novel anticancer medications. AI tools aid in efficient and faster drug discovery by analyzing data, modeling processes and optimizing pipeline stages. Aim: The aim of this present study is to evaluate phytoconstituents against novel and newer cancer targets. Methodology: The ligands Daidzein, Resveratrol and Genistein were targeted against the Glutamate dehydrogenase (PDB ID …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 3, 2024 · pp. 12–17 Read article
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An Optimize Formulation to Synthesis of size Controlled Hydrophobic Starch Acetate Nanoparticles using Box- Behnken Design
Abstract: The best way to improve the overall performance of native starch is by chemical modification. In recent years, hydrophobically modified starch has attracted considerable attention for the design and manufacture of novel nanoparticulate drug delivery carriers. The purpose of this research was to synthesize hydrophobic starch nanoparticles (NPs) and to optimize process factors through the use of response surface methodology (RSM). The corn starch acetate (CSA) NPs was synthesized using …
Published in Journal of Polymer & Composites Read article
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In-Silico Repurposing of Antipsychotic Drugs Against Novel Protein Targets in Multidrug-Resistant Mycobacterium tuberculosis
Abstract: Multidrug-resistant TB is a growing worldwide health concern, particularly in high-burden areas. Resistance to frontline drugs like isoniazid and rifampicin is caused by mutations in key Mycobacterium tuberculosis proteins. Given the difficulty of developing new antibiotics, medication repurposing offers a good alternative. The potential use of molecular docking to target resistance-associated TB proteins with FDA-approved antipsychotic drugs is investigated in this work. Three proteins were selected: InhA (PDB ID: 5W07), …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 49–63 Read article
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Exploring Potential Phytochemicals for Myasthenia Gravis Treatment: A Molecular Docking and ADME Analysis Approach
Abstract: Objective: Muscle feebleness and exhaustion derived from a disruption in neuromuscular transference are hallmarks of the crippling autoimmune disease myasthenia gravis (MG). The drawbacks of the current MG therapy options are frequently partial efficacy and adverse effects. To investigate the potential of phytochemicals in MG control, in this work we integrated molecular docking with ADME (absorption, distribution, metabolism, and excretion) analysis using a computer method. We identified molecules exhibiting favorable …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 1–13 Read article
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Screening of Newer Phytoconstituents on Novel Enzymes for their Biological Activity
Abstract: Background: Hyperlipidemia and gout are prevalent metabolic disorders significantly impacting global health. The xanthine oxidase and HMG-CoA reductase pathways play pivotal roles in the pathophysiology of these conditions. This study explores the potential of natural phytoconstituents—daidzein, resveratrol, and genistein—as dual inhibitors for these enzymatic targets, offering insights into innovative therapeutic strategies. Aim: To evaluate the potential of natural phytoconstituents—daidzein, resveratrol, and genistein—as dual inhibitors of xanthine oxidase and HMG-CoA reductase …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 1, 2025 · pp. 81–86 Read article
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Recovery of Mycelial Biomass of Agaricus Bisporus, Pleurotus Ostreatus, Ganoderma lucidum, Hieracium Erinaceus: A comparative Study
Abstract: Mushrooms are the spore-bearing fruiting body of fungi which has a significant potential for numerous applications like pharmaceuticals, textile industry, bioremediation, soil management, alternative to toxic packaging materials and environment sustainability. Mushrooms generally belongs to the class Basidiomycota or Ascomycota. They are typically made of hyphae, the tiniest threads which comprises most fungi. Mycelia are tiny thread like structure which help in making vegetative part of fungus. In this study, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 2, 2024 · pp. 12–18 Read article
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Molecular Docking and Interaction of Anthocyanin Derivatives in Regulating Hippo-taz Pathway for Renal Injuries
Abstract: Introduction: The Hippo pathway plays a pivotal role in renal disease, with Yes-associated protein (YAP) exhibiting promise for combined treatments. The crucial evaluation of YAP-targeted drug safety and efficacy through preclinical studies is imperative. Additionally, α-SMA and SMAD3 emerge as potential therapeutic targets in renal fibrosis, driving ongoing research toward innovative interventions. Materials and Methods: In the systematic identification of therapeutic secondary metabolites, Anthocyanin derivatives were methodically retrieved from the …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 23–38 Read article
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Dasatinib Induced Pulmonary Hypertension
Abstract: Dasatinib (Das) is a second-generation tyrosine kinase inhibitor that is used in the treatment of chronic myelogenous leukemia (CML) in patients who are resistant or intolerant to imatinib, as well as in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) patients. Dasatinib-induced pulmonary arterial hypertension (PAH) is a known but rare adverse effect of dasatinib and is grouped under Group-1 PAH. The mechanism of PAH development is not fully known, but …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 92–95 Read article
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Fabrication of Polydimethylsiloxane Composites with Nickel Nanoparticles: Unification and Current–Voltage Relationship
Abstract: Polydimethylsiloxane (PDMS)–nickel nanoparticle (NiNPs) nanocomposite films were fabricated and systematically investigated to understand their electrical transport behavior through current–voltage (I–V) characterization. Nanocomposite films with varying Ni nanoparticle filler concentrations (14.88 wt%, 15.77 wt%, and 16.65 wt%) were prepared using a solution-mixing and spin-coating technique, followed by controlled thermal curing. The electrical properties of both pristine PDMS and PDMS– NiNPs nanocomposites were examined over a wide voltage range (up to 800 …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 16, Issue 1, 2026 · pp. 22–29 Read article
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An Immunohistochemical Study to Assess the Role of Myofibroblasts in Diagnosing and Predicting the Outcome of Oral Squamous Cell Carcinoma
Abstract: Background: Squamous cell carcinoma (SCC) accounts for approximately 94% of all oral malignancies, hence establishing oral squamous cell carcinoma (OSCC) as one of the top 10 most prevalent malignant tumors. Cells with several functions, such as macrophages and myofibroblasts, play a vital role in the biological behavior of tumors. This study aimed to assess and evaluate the prevalence of myofibroblasts (MF) and macrophages in SCCs occurring in the oral region. …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 1, 2024 · pp. 13–17 Read article
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Evaluating the Role of Platelet Indices, with a Focus on Immature Platelet Fraction (IPF), in Differentiating Hyper-Destructive and Hypo-Productive Thrombocytopenia: A Study from Ludhiana, Punjab, India
Abstract: Background: Thrombocytopenia, characterized by a reduction in platelet count, is commonly observed in clinical settings. Its etiology can be broadly classified into hyper-destructive thrombocytopenia, where platelets are destroyed at an accelerated rate, and hypo-productive thrombocytopenia, where platelet production is impaired. Differentiating between these two causes is essential for effective management. The Immature Platelet Fraction (IPF) has emerged as a promising non-invasive diagnostic tool to distinguish these causes. Objectives: The primary …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 2, 2025 Read article
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Evaluation of Tectona Grandis Leaf Extract As A Green Corrosion Inhibitor for Aluminium in 1M NaOH
Abstract: A kind of tropical hardwood tree called the Tectona grandis tree that is indigenous to India. The name "teak tree" is another common name for this kind of tree. It is a member of the plant family that is referred to as Lamiaceae. The primary purpose of this research is to investigate whether or not the plant extract has a corrosion-inhibiting quality. In this study, an aqueous extract of Tectona …
Published in Journal of Polymer & Composites · Vol. 2, Issue 2, 2023 · pp. 41–50 Read article
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Effect of Different Incubation Times on the Effectiveness of Oyster Mushrooms Towards the Growth of Some Fungal Isolates
Abstract: The study was conducted by preparing the filtrate of the oyster mushroom Pleurotus ostreatus, where the effectiveness of the fungal filtrate prepared from growing the fungus in the liquid Potato Dextrose Broth (PDB) medium was selected for two different periods (14, 28 days) in inhibiting some types of fungi (Aspergillus Spp : Aspergillus niger ،Aspergillus flavus, Aspergillus terreus) and some types of fungi (Candida Spp: Candida albicans, Candida tropicalis, Candida …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 2, 2025 · pp. 1–8 Read article
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A Survey on Hydrogen Storage System using Composite Material and its Alloys
Abstract: The transition to a carbon-neutral energy landscape hinges on the ability to store hydrogen safely, densely, and reversibly. While high-pressure tanks and cryogenic vessels dominate today’s infrastructure, solid-state storage in metallic alloys offers a compelling alternative by combining high gravimetric capacity with intrinsic safety to form a composite material. This work presents a systematic investigation of a family of reversible hydrogen-absorbing composite material alloys—principally Mg-based intermetallics (Mg₂Ni, MgFeMn) and TiV-based …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 2, 2025 Read article
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Stretchable Elastomer–Phase Change Composites for Passive Thermal Management in Wearable Electronics
Abstract: Elastomer-embedded phase change material (EPCM) composites are developed as stretchable, leakage-free, and electrically insulating thermal regulation layers for wearable electronics operating under stringent skin-safety requirements. The EPCM architecture comprises microencapsulated organic phase change materials (μPCM, 30–70 wt%) uniformly dispersed within soft elastomer matrices based on PDMS or SEBS-type thermoplastic elastomers, together with low loadings (1–8 wt%) of electrically insulating hexagonal boron nitride (h-BN) fillers to enhance lateral heat transport. Differential …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 30–41 Read article
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Computational Screening of Vitex negundo Compounds for Potential Arthritis Therapies in India
Abstract: Objective: Arthritis is a pervasive medical condition that manifests as inflammation and discomfort within the joints. As of September 2021, arthritis has affected an estimated 180 million people in India, making it a substantial public health concern with a considerable impact on individuals' quality of life and healthcare systems. Therefore, using molecular docking, drug-likeness prediction, and ADME analysis, an effort was made to identify natural compounds from Vitex negundo, which …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 01–18 Read article
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Comparative Analysis of CMOS CNFET and Memristor Based Full Adder Circuits and CMOS Memristor Based Multiplexer Circuits
Abstract: Continued developments in microelectronics technology have led to a myriad of new compute- intensive applications at the micro-edge, such as artificial intelligence and signal and image processing. Multiplication is a crucial arithmetic process in such applications. However, large logic complexities typically seen in traditional multipliers generate combinatorial blocks with long chains of cascaded carry addition. As such, energy efficiency has remained a primary design challenge for these applications, when powered …
Published in Journal of VLSI Design Tools and Technology Read article