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7 articles for “Muscle spasms.”
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Review On Primary Failure Adrenocortical Insufficiency
Abstract: Adisson's disease, also known as adrenal insufficiency, is an uncommon ailment that happens when the body doesn't generate enough of a number of hormones. When someone has Addison's disease, their adrenal glands typically generate too little aldosterone and too little cortisol. In industrialised nations, autoimmune attacks on the adrenal cortex are the main cause of Addison's disease; prevalence estimates in Europe range from 93-220 per million. The damage to your …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 10, Issue 1, 2023 · pp. 17–22 Read article
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Examining Thiocolchicoside from a Surgical Perspective
Abstract: Thiocolchicoside functions as a muscle relaxant, anti-inflammatory, and analgesic agent, effectively preventing and alleviating muscle spasm. It is widely recognized analgesic that effectively alleviates muscle pain and low back pain. This medication typically begins with the administration of paracetamol. For the alleviation of symptoms associated with low back pain, it is common practice to utilize a combination of non-steroidal anti-inflammatory drugs (NSAIDs), analgesic, and muscle relaxants. Low back pain (LBP), …
Published in Research and Reviews : Journal of Surgery · Vol. 12, Issue 3, 2023 · pp. 14–20 Read article
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Formulation and Characterization of Liquisolid Tablet of Skeletal Muscle Relaxants and Anti-Inflammatory Drugs
Abstract: Baclofen is a skeletal muscle relaxants and nimesulide is a Non- steroidal anti- inflammatory drug (NSAID). Baclofen is used in the treatment of muscle spasm, arthritis and spondylitis. NSAID’s are preferred to reduce the symptoms caused by muscle spasm i.e., severe pain and fever. Hence combination of drug is used to minimise the frequent use of the drug. The main objective of the present work was to enhance solubility and …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 2, 2015 · pp. 6–14 Read article
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Molecular Docking studies of Benzodiazepine Derivatives With GABA(B) Receptor
Abstract: Benzodiazepines (BZDs) are pharmacologically significant compounds that act by binding to GABA A neurotransmitter receptors, subsequently augmenting GABA-induced chloride ion flux, consequently inducing neuronal hyperpolarization. Benzodiazepines are commonly used in the treatment of sleep disorders, anxiety, muscle spasms, seizure disorders, and some forms of depression. The primary inhibitory neurotransmitter, GABA, functions on two types of receptors: the ligand-gated GABA A/C receptors and the G protein-coupled GABA B receptors. These neurotransmitters …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 2, 2024 · pp. 1–14 Read article
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Multiple Sclerosis: A Brief Overview of the Disease, Its Pharmacotherapy
Abstract: Multiple Sclerosis is an autoimmune disorder mostly affecting individuals aged between 20-40. In this disorder, the optic, vertebral, and central nervous system nerves are primarily impacted. It is a neurological condition that worsens over time and is characterized by inflammation and the breakdown of the sheath that surrounds and shields the nerve fiber. Common symptoms may include muscle weakness, numbness, tingling, fatigue, vertigo, tremor, vision complications, pain, Lhermitte sign, sexual …
Published in International Journal of Brain Sciences · Vol. 1, Issue 1, 2024 · pp. 13–18 Read article
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A Short Review on Long-Term Effects of Botox on Neuronal Sprouting: Mechanisms and Its Clinical Implications
Abstract: Botulinum toxin (Botox) is extensively used for its ability to induce temporary muscle paralysis through inhibition of acetylcholine release at neuromuscular junctions. While its short-term effects are well documented, emerging evidence suggests that chronic use of Botox may trigger neuronal sprouting, a process that could have significant long-term implications. This review synthesizes current research on the mechanisms by which Botox induces nerve sprouting and evaluates the clinical outcomes associated with …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 3, 2024 · pp. 72–87 Read article
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Stiff Person Syndrome: Advances in Understanding, Diagnosis, and Treatment of a Rare Autoimmune Disorder
Abstract: Stiff Person Syndrome (SPS) is a rare and complex autoimmune neurological disorder characterized by progressive muscle stiffness, rigidity, and painful spasms. This chapter provides a comprehensive overview of SPS, exploring its pathophysiology, clinical presentation, diagnostic challenges, and current treatment approaches. We discuss the latest research findings, including the role of autoantibodies, genetic factors, and environmental triggers in the development of SPS. The chapter examines various diagnostic methods, emphasizing the importance …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 35–43 Read article