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216 articles for “Insulin/IGF1-AKT-mTOR”
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Recombinant Insulin
Abstract: Recombinant insulin, a revolutionary product of biotechnology, has transformed the landscape of diabetes treatment. Developed through genetic engineering techniques, recombinant insulin offers a safer, more consistent alternative to traditional animal-derived insulin. Its production involves the insertion of the human insulin gene into host organisms such as Escherichia coli or Saccharomyces cerevisiae, which serve as efficient factories for insulin synthesis. Recombinant insulin is used to treat diabetic patients who are allergic …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 39–43 Read article
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Insulin : Comprehensive review on its Crucial Role in Metabolism and Disease Management
Abstract: Insulin's pivotal function lies in meticulously regulating blood sugar levels, thus guaranteeing cells access to the necessary energy for optimal functionality. When there is a rise in blood sugar, after a meal, the releases insulin gets released from the pancreas to facilitate the uptake of glucose by cells. Insulin primarily acts on muscle, fat, and liver cells, promoting the uptake of glucose from the blood. Another way to store glucose …
Published in International Journal of Virus Studies · Vol. 1, Issue 1, 2024 · pp. 37–43 Read article
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Knowledge, Attitude and Practices Towards Insulin Therapy Among Diabetic Patients in Jimma University Specialized Hospital, Southwest Ethiopia
Abstract: Insulin is mandatory for the treatment of type 1 diabetes mellitus (DM) and it may also be required for other types of DM as the disease progresses. Once started patients have to take the drug for lifelong and they face many problems such as problems of injections, storage of insulin, dose and how to take the injection. The aim of this study was, therefore, to assess the knowledge, attitude and …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 9, Issue 2, 2018 · pp. 1–10 Read article
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Development of Biodegradable Poly (Lactic-Co-Glycolic Acid) (PLGA) Nanoparticles for Sustained Release of Insulin
Abstract: This research outlines the creation of biodegradable composite nanoparticles made from poly (lactic-co-glycolic acid) (PLGA) designed for the sustained release of insulin. The emphasis is on the interactions between the polymer and the drug at the interface, along with the dynamics of the release matrix. The in vitro release kinetics, surface morphology, encapsulation efficiency, particle size, and polydispersity of insulin-loaded PLGA nanoparticles were analyzed following their production via a double …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1690–1699 Read article
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Computational Investigation of Phytochemicals Targeting AKT1 for Major Depressive Disorder: A Molecular Docking and ADMET Study
Abstract: Major depressive disorder (MDD) is a prevalent neuropsychiatric condition affecting approximately 280 million individuals worldwide, with women exhibiting a 50% higher likelihood of diagnosis than men. Despite significant advancements in treatment, MDD remains a chronic and relapsing disorder, necessitating the exploration of novel therapeutic interventions. This study focuses on the AKT1 gene, a key player in neuropsychiatric disorders, and investigates its interactions with natural phytochemicals as potential alternatives to conventional …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 2, 2025 Read article
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Knowledge and Practice of Self-Administration of Insulin Injections among Diabetic Patients
Abstract: High blood glucose levels are a hallmark of diabetes mellitus, a chronic and crippling illness. According to estimates from the World Health Organization (WHO), 530 million persons globally have diabetes. Diabetes management requires education, and educating patients how to administer insulin injections on their own can give them the power to take charge of their health. The purpose of this study was to evaluate diabetic patients who visited the diabetes …
Published in Journal of Nursing Science & Practice · Vol. 15, Issue 3, 2025 · pp. 29–33 Read article
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‘Betazen’ Herbal Formulation, Ameliorates Experimentally Induced Metabolic Disturbances in Insulin Resistant Rats
Abstract: The present study was designed to evaluate anti-diabetic activity of ayurvedic formulation ‘Betazen’ in experimentally induced insulin resistant rats. Wistar rats were being rendered insulin resistant by administration of dexamethasone (2 μg/day s.c), along with high fat-high sugar (HFHS) diet (i.e. vanaspati ghee and fructose enriched) for 42 days. Animals with fasting blood glucose levels (BGL) of more than 150 mg/dl were selected, divided into different groups and administered 2.7 …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 6, Issue 2, 2016 · pp. 13–23 Read article
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Metabotropic Receptor Based Target for Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus
Abstract: G protein coupled receptors (GPCRs) moreover called as metabotropic receptor addresses the greatest gathering of film proteins in the human genome. GPCRs share a regular essential characteristic of seven hydrophobic transmembrane (TM) sections (heptahelical structure), with an extracellular amino end and an intracellular carboxyl end their assistant and valuable closeness of GPCRs stays rather than the fundamental OK assortment of the ordinary GPCR ligands. GPCRs keep on being critical revelation …
Published in Trends in Drug Delivery · Vol. 5, Issue 1, 2018 · pp. 17–27 Read article
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Epidemiology, Diagnosis, Management and Treatment of Diabetes Mellitus (DM): A Review
Abstract: Diabetes mellitus (DM), a condition caused by metabolic abnormalities, is the most common worldwide. Sometimes known as diabetes, in which a person's blood sugar levels are abnormally high, either because the body does not make enough insulin or because the insulin that is produced does not reach the cells. Polyuria (frequent urine), polydipsia (increased thirst), and polyphagia are all common indicators of elevated blood sugar (increased hunger). Type 1 diabetes, …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 10, Issue 3, 2021 · pp. 36–50 Read article
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A Case Study of Laryngeal Narrowing with Glossopharyngeal Neuritis in Insulin Dependent Diabetes Patient
Abstract: Neuritis is a very common complication met in with chronic diabetics. Commonly, peripheral nerves are involved but involvement of cranial nerves is not a common phenomenon. Involvement of cranial nerves or autonomic nerves may produce serious medical emergency that requires prompt management for life saving followed by long term control management. Such a case of insulin dependent diabetes mellitus with laryngeal narrowing and glossopharyngeal neuritis was met in a clinical …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 1, 2017 · pp. 9–14 Read article
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A Follow up Case Study of Neonatal Diabetes due to Mutation of ABCC 8 Gene: Transition from Insulin to Oral Glibenclamide was effective and safe
Abstract: Context: Neonatal diabetes is a rare condition occurring in approximately 1 in 500, 000 live births. It is occasionally due to mutations of genes which encode potassium ATP channel (KATP).Aim: The aim of this study is to identify the long term efficacy and safety of switch from insulin to oral sulfonylurea in a case of neonatal diabetes due to a mutation of ABCC 8 gene.Subject and Method: 6 years old …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 9, Issue 3, 2022 · pp. 20–22 Read article
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Hepatoprotective Role of Exogenous Melatonin and Insulin Plant (Costus IgneousNak.) Extract against the Streptozotocin Induced Diabetes in Rats
Abstract: The aim of the present study was to compare hepatoprotective efficacy of exogenous melatonin and insulin plant extract against streptozotocin induced hepatic complications. To induce diabetes adult female rat were administrated with STZ (15mg/kg) for consecutive six days. The confirmation of diabetic model was analyzed by blood glucose test. Following confirmation diabetic rat model were treated with exogenous MEL intraperitoneally and plant extract was administered orally. Administration of MEL and …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 1, 2018 · pp. 25–36 Read article
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Neuroprotective Role of Exogenous Melatonin and Insulin Plant (Costus igneus Nak.) Extract on Brain in Streptozotocin-Induced Diabetes in Female Rat
Abstract: Brain is the one of the most important coordinating and controlling system of the body, which regulates different muscular and neuromuscular activities. The current study was undertaken to explore the neuroprotective role of exogenous melatonin and insulin plant extract in diabetic female rats. Administration of melatonin and plant extract to Streptozotocin (STZ)-induced diabetic rat showed a significant decrease of lipid peroxidation (TBARS) in brain tissue comparable to the control group …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 5, Issue 1, 2018 · pp. 33–41 Read article
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Correlation of Serum Vitamin D Levels with Insulin Resistance in Young Adults
Abstract: Among young adults, both insulin resistance (IR)and vitamin D deficiency are common and pose the risk of complications, such as type 2 diabetes mellitus (T2DM). A few studies demonstrated that vitamin D deficiency might negatively influence insulin sensitivity, but the results of these studies have been inconsistent and/or inconclusive. This review focuses on young adults and aims to summarize and critique studies that assess the relationship between IR and serum …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 15, Issue 1, 2026 · pp. 69–74 Read article
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Role of PI3K/AKT/mTOR Signaling Pathways in Breast Cancer
Abstract: Abstract: Breast cancer is among the most commonly diagnosed cancers and remains a leading cause of mortality among women globally. Although early detection and interventions aimed at curtailing tumor progression have significantly improved breast cancer survival rates, there is an ongoing demand for more potent systemic therapies to effectively prevent metastasis. A central pathway frequently associated with the growth, survival, and motility of breast cancer cells is the PI3K/AKT/mTOR signaling …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 1, 2025 · pp. 23–34 Read article
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Effect of Nutritional Counselling on Risk Level of Glycosylated Hemoglobin (HbA1c) of Middle-aged Non-insulin Dependent Diabetics
Abstract: Glycosylated hemoglobin (HbA1c) is a form of hemoglobin that is measured primarily to identify the average plasma glucose concentration over a prolonged period of time. As the average amount of plasma glucose increases, the fraction of glycosylated hemoglobin increases in a predictable way. This serves as a marker for average blood glucose levels over the previous months prior to the measurement. Present study was conducted on diabetic patients who were …
Published in Research and Reviews: A Journal of Health Professions · Vol. 4, Issue 3, 2014 · pp. 17–23 Read article
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Evaluation of the Effects of Vitamin D Supplementation on Glycemic Control and Lipid Profile in Normoglycemic and STZ-Induced Type-2 Diabetic Rats
Abstract: The term diabetes mellitus describes a metabolic disorder of multiple aetiologies and is characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. The current approaches for treatment of diabetes are mostly dependent on insulin and other oral standard drugs, which have their own drawbacks. Thus, micronutrients supplementation is gaining momentum as the quest for management of diabetes …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 6, Issue 2, 2016 · pp. 24–34 Read article
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Multitarget Molecular Docking Using Curcuma longa Phytocompounds for Polycystic Ovary Syndrome Treatment
Abstract: Objective: The primary goal of this research is to understand and describe specific aspects of molecular interaction, it includes studying various aspects such as binding affinity, binding mode, and stability of the ligand-protein complex. Molecular docking is a computational technique used to predict the preferred orientation of one molecule to a second when bound together to form a stable complex. In this study, molecular docking will be employed to stimulate …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 1, 2024 · pp. 15–28 Read article
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Modeling of Valveless Piezoelectric Micropump for Insulin Delivery System
Abstract: In order to cope up with the rising needs of micro-electro-mechanical systems (MEMS) in the fields of biological and medical applications, important progress of the micropump as one of the essential fluid handling devices to deliver precise amounts of fluids is considered. The micropump consists of two fluid diffuser/nozzle elements on each side of a chamber volume with an oscillating diaphragm. The vibrating diaphragm produces an oscillating chamber volume, which …
Published in Journal of Mechatronics and Automation · Vol. 2, Issue 1, 2015 · pp. 50–59 Read article
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Application of Probiotic Diet on Rats and its Effect on Lipid Profile: A Case-control Study
Abstract: Lipid profile and cholesterol level play an important role in cardiovascular and other life style diseases. A case-control study was designed on 16 rats to observe the effects of probiotic diet for controlling lipid and cholesterol level. Probiotic bacteria culture (Danisco freeze drying culture) was collected from Denmark. The isolation and identification of the strains was carried out at Industrial Food Microbiology laboratory, Institute of Food science and Technology of …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 7, Issue 2, 2017 · pp. 7–11 Read article