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142 articles for “Inhibitory”
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In Vitro Studies on α-Amylase Inhibitory Activity of the Leaves of Peltophorum pterocarpum (DC.) Baker ex Heyne
Abstract: AbstractThe present investigation evaluates the in vitro anti-diabetic activity of ethanolic extract of leaves of Peltophorum pterocarpum by α- amylase enzyme inhibitory activity. Besides, this qualitative phytochemical analysis of the plant was carried out. Preliminary phytochemical screening of the extract revealed that the presence of different types of compounds including flavonoids and steroids. The α-amylase inhibitory activity of ethanolic extract showed concentration dependent manner. Hence, α-amylase enzyme inhibition may be …
Published in Research & Reviews : Journal of Botany · Vol. 5, Issue 3, 2016 · pp. 16–20 Read article
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Evaluation of Antimicrobial and -Amylase Inhibitory Activity of Selected Medicinal Plants
Abstract: During this study we evaluated the a-amylase inhibitory activity and antimicrobial activity of different extracts of Psidium gujauva, Allium sativum, Withania sominfera, and Piper nigrum. Antimicrobial potential was observed against Escherichia coli and Staphylococcus aureus. The plant extracts were prepared with chloroform, ethanol, acetone and distilled water. Each extract was evaporated using rotary evaporator, under reduced pressure. Different concentrations (10, 20, 40, 60, 80, and 100 μg/ml) of each extract …
Published in Research & Reviews : Journal of Herbal Science · Vol. 4, Issue 1, 2015 · pp. 15–28 Read article
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Growth Inhibitory Effects of Centella asiatica Extracts on Escherichia coli
Abstract: Plant secondary metabolites have been known for their varying degrees of antimicrobial activity. These form important constituent of traditional medicine. The present study aims to analyze the antibacterial effects of the Centella asiatica extracts by looking into the growth inhibitory effects of organic and aqueous extracts of the leaves on Escherichia coli bacterium and to identify the secondary metabolites present in the extract by phytochemical analysis. The leaf extracts of …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 9, Issue 2, 2019 · pp. 1–7 Read article
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Chemical Constituents and Tyrosinase Inhibitory Activity of Aqueous Fraction of the Leaves of Morus alba L. from Vietnam
Abstract: The mulberry has been widely cultivated to feed silkworms. The leaves of mulberry have been used in traditional medicine as an analgesic, antitussive, cathartic, diuretic. In this study we have isolated three compounds (LC1-3) by chromatographic methods from the Mulberry leaves (Morus alba L.) collected in Thai Nguyen province, Vietnam. These compounds were identified as: Kaempferol-3,7-di-O-α-L-rhamnopyranoside (LC1), 7,4’-dihydroxy-5,3’-dimethoxyflavone (LC2), (S)-5,5’,7-trihydroxy-2’,4’-dimethoxy-6-methylflavanone (LC3). Their structures were elucidated by spectroscopic methods, including MS …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 4, Issue 3, 2017 · pp. 12–17 Read article
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5-Lipoxygenase and Phospholipase A2 Inhibitory Potentials of Alcoholic Extract of Cyperus rotundus: In vitro and In silico Study
Abstract: The literature revealed that not much reports are known for the anti-inflammatory activity of any Cyperus rotundus plant part (or extract) with respect to the molecular targets (inflammatory mediators) like cyclooxygenase-1/2 (COX-1/2), 5-lipoxygenase (5-LOX), and phospholipase A2 (pLA2). The present investigation involved exploration of in vitro inhibitory potential of alcoholic extract of C. rotundus rhizome against two important inflammatory mediators; 5-LOX and (porcine) pLA2. In addition to it, the role …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 8, Issue 2, 2018 · pp. 1–5 Read article
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In Silico Tau Protein Kinase I Inhibitory Activity of Some Commercially Available Flavonoids
Abstract: Molecular docking is a frequently used tool in computer-aided structure-based rational drug design. Flavonoids are a group of natural products which exhibits various biological and pharmacological activities. The primary objective of this study was to investigate the tau protein kinase I inhibitory activity of flavonoids using in silico docking studies. Memantine, a known neuro-receptor antagonist is currently used in the treatment of Alzheimer’s disease (AD). In silico docking studies were …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 2, Issue 1, 2015 · pp. 6–12 Read article
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Protein-Tyrosine Phosphatase-1B (PTP-1B) Inhibitory Perspectives of Hydroxylated Chalcones: Exploration through Docking Studies
Abstract: The current research emphasized on exploring the Protein-Tyrosine Phosphatase-1 B (PTP-1B) inhibitory potentials of hydroxylated chalcone derivatives against PDB ID: 4I8N (PTP-1B in complex with an inhibitor [(4-{(2s)-2-(1,3-benzoxazol-2-yl)-2-[(4-fluorophenyl)sulfamoyl]ethyl}phenyl)amino](oxo)acetic acid) by molecular docking approach using the iGEMDOCK (Genetic Evolutionary Method for Molecular Docking) software. The current molecular docking analysis of some hydroxylated chalcone derivatives have presented a profound inhibition of the antidiabetic target PTP-1B by interacting with the amino acid residues …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 6, Issue 1, 2019 · pp. 4–8 Read article
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Locomotion Inhibitory Activity of Lagerstroemia speciosa Hydroalcoholic Root Extract
Abstract: Presently, it has been found from the medical databases such as PubMed, Scopus, Google Scholar, etc. that no locomotion inhibitory activity has been explored by any research group so far for the hydroalcoholic extract of Lagerstroemia speciosa (Family: Lythraceae) root. The present study involved filling the above gap by exploring the locomotion inhibitory activity (actophotometer-based) in Swiss albino rats. The investigation showed promising therapeutic perspectives (as compared to standard drug …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 11, Issue 1, 2021 · pp. 8–11 Read article
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Chemical Constituents and Tyrosinase Inhibitory Activity of Ethyl Acetate Extract of the Leaves of Morus alba L. from Vietnam
Abstract: AbstractFour compounds (DB1–4) were isolated from the Mulberry leaves (Morus alba L.) collected in Thai Nguyen province by chromatographic methods. These compounds were identified as: Kaempferol-3-O-β-D-glucopyranoside (DB1), quercetin 3-O-α-L-rhamnopyranoside (DB2), isofraxidin-7-O-β -D-glucopyranoside (DB3), and (±) -3, 5, 6, 7, 8, 4’-hexahydroxyflavane (DB4). Their structures were elucidated by spectroscopic methods, including mass spectrometry (MS) and nuclear magnetic resonance (NMR). Compound DB4 was isolated from Mulberry leaves for the first time. Compound …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 8, Issue 1, 2018 · pp. 21–26 Read article
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Inhibitory Action of Sodium Tellurite on Uropathogenic Bacteria
Abstract: The objective of the present study was to predict the toxic properties of sodium tellurite against selected uropathogenic bacteria. A group of nine clinical isolates of different uropathogenic bacteria isolated from urine in suspected cases of urinary tracts infection Enterococcus faecalis, Staphylococcus aureus, Acinetobacter baumannii, Citrobacter freundii, Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis and Pseudomonas aeruginosa were collected and utilized for screening tests. The spectrum of toxic properties …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 8, Issue 2, 2018 · pp. 6–10 Read article
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Bacterial DNA Gyrase (Topoisomerase) Inhibitory Potentials of Heterocyclic Natural Products: Investigations through Induced-Fit Molecular Docking Approach
Abstract: The study exclusively focuses on the exploration towards the hidden potential of heterocyclic natural products against bacterial DNA gyrase (topoisomerase) through induced-fit docking (IFD) by utilizing the Glide module of Maestro 9.1 software. The study will open new doors for the antibacterial drug discovery by the inhibition of imperative biological target. Keywords: antibacterial, DNA gyrase, heterocyclic compound, molecular docking, natural product, topoisomeraseCite this ArticleTomy Muringayil Joseph, Debarshi Kar Mahapatra. Bacterial …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 2, 2018 · pp. 7–9 Read article
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Multifarious Pharmacotherapeutic Perspectives of Some Natural Bromophenol Compounds: In silico Enzyme Inhibitory Potentials
Abstract: The process of drug discovery, design, and development often designated as 3Ds has played enormous role in modern era. The present research investigation includes in silico exploration of possible pharmacological potentials of bromophenol compounds by the aid of Schrodinger Maestro 9.1 software against six pharmacotherapeutic targets; Dipeptidyl peptidase (anti-diabetic), Angiotensin-1-Converting Enzyme (anti-hypertensive), Cyclin-Dependent Kinase-5 (anti-cancer), Protein kinase C (anti-cancer), Lipoxygenase-5 (anti-inflammatory), and Cycloxygenase-2 (anti-inflammatory). The docking scores, referred to as …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 2, 2019 · pp. 24–29 Read article
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IN SILICO EVALUATION OF INHIBITORY POTENTIAL OF SOME COMMERCIALLY AVAILABLE FLAVONOIDS AGAINST BETA- SECRETASE IN THE MANAGEMENT OF ALZHIEMER’S DISEASE
Abstract: In a continuing effort to develop multitargeted compounds as potential treatment agents against Alzheimer's disease (AD), a certain commercially available flavonoids were evaluated against crystal structure of beta-secretase enzyme using in silico docking studies. In this perspective, flavonoids like apigenin, galangin, gallocatechol, genistein, luteolin, myricetin, and theaflavin were selected. AutoDock 4.2 software was used for the in-silico docking studies which possess the principle of Lamarckian genetic algorithm. In the docking …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 2, 2019 · pp. 30–35 Read article
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Inhibitory Potentials of Datura Metel to Prevent Mild Corrosion
Abstract: The resistance of mild steel to corrosion was evaluated by immersing it in well water and determining the weight it lost after being allowed to return to room temperature after the submersion. The effectiveness of mild steel's ability to withstand corrosion was evaluated using this approach. A reduction in total body mass has an influence that is connected to and helps play a role in the prevention of rusting from …
Published in Journal of Polymer & Composites Read article
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Melanogenic Inhibitory Effects of Sesamum indicum Phytocompounds Towards CDK 2, c-KIT, and BRAF.
Abstract: Objective: Melanoma is thought to be the fifth most frequent cancer in the US population, despite cancer being the most common cause of death in the globe. BRAF, CDK2, and c-KIT proteins are regarded as potential therapeutic agents since mutations in these proteins are the primary cause of melanoma. For the investigation of their pharmacological properties and therapeutic activities against the target proteins, Sesamum indicum L. and its phytocompounds were …
Published in International Journal of Bioinformatics and Computational Biology Read article
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Effect of Temperature on Inhibitory Efficacy of Tamarindus indica fruit extract on acid corrosion of Aluminium
Abstract: An attempt has been made to investigate the anti-corrosive propensity of ethanolic extract of Tamarindus indica fruit at elevated temperature between 303 to 343 K, so as to replace the exploitation of toxic chemicals as corrosion inhibitors. Inhibition efficiency has been observed significantly high (84.06%) at room temperature at concentration 0.45 %. The inhibition efficiency is found to increase with increasing concentration of extract and decrease with rise in temperature. …
Published in Recent Trends in Fluid Mechanics · Vol. 10, Issue 3, 2023 · pp. 42–50 Read article
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Comparative Evaluation of Hibiscus Cannabinus and Solanum Trilobatum Extracts as Inhibitors for C- Steel Corrosion protection in Acidic Medium
Abstract: This study analyzed the efficacy of various inhibitors in safeguarding carbon steel against corrosion in hydrochloric acid. The compounds that were subjected to testing included Acalypha indica root extract (AIRE), Hibiscus cannabinus (HC), and Solanum trilobatum (ST) leaf extracts. The investigation focused on the inhibitory efficacy through the application of gravimetric and electrochemical impedance methods. GC-MS and FTIR were employed to investigate the features of the inhibitors and co-inhibitors. Tafel …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 555–565 Read article
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Promising Antimicrobial Compounds from an Endophytic Fungus Penicillium daleae EF 4 Isolated from the Seaweed Enteromorpha flexuosa Linn.
Abstract: AbstractThe present aim of the study is to isolate the endophytic fungi from various seaweeds and to screen their bioactivity, to analyze the β-lactamase inactivator and to evaluate the interactions between the crude extract of Endophytic fungi Penicillium daleae EF 4 and two antibiotics (penicillin G and tetracycline), against some antibiotic resistant bacterial strains. Seaweeds collected from various places of Bay of Bengal coast was subjected to Endophytic fungal isolation. …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 9, Issue 1, 2019 · pp. 26–39 Read article
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Antimicrobial Resistance Pattern of Streptococcus Pneumoniae with Reference of Penicillin Resistance
Abstract: Streptococcus pneumoniae (pneumococcus) is the leading bacterial cause of infection worldwide, ranging from common infections such as otitis media to life threatening invasive infections such as Sepsis, Meningitis and Pneumonia. For many years Penicillin provided very effective treatment for pneumococcal infections. However, the last two decades have seen the emergence of pneumococcal strains with resistance to Penicillin. AST with special reference to Penicillin was determined along with the minimum inhibitory …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 3, Issue 3, 2013 · pp. 1–4 Read article
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Allelopathic Effect of Lantana camara L. on Moong Germination
Abstract: Allelopathy is a biological process where plants inhibit the growth and germination of surrounding species. This study examined the allelopathic effects of Lantana camara L. leaf extracts using concentrations of 25%, 50%, 75%, and 100% on Vigna radiata L., compared to a control group. Results showed that L. camara L. extracts significantly inhibited both growth and germination of Vigna radiata L., with increasing effects at higher concentrations. On the 10th …
Published in Research & Reviews : Journal of Botany · Vol. 15, Issue 1, 2026 · pp. 36–41 Read article