Search
53 articles for “Gram Negative”
-
Global Emergence of mcr-mediated Colistin Resistance in Gram-negative Bacteria: Focusing the Current Status in India Under One Health Lens
Abstract: In the global crisis of antimicrobial resistance (AMR), colistin has been revived as a last resort treatment option for multidrug-resistant (MDR) Gram-negative bacterial infections. Rapid dissemination of mobilized colistin resistance (mcr) genes among Gram-negative bacterial pathogens is alarming the healthcare fraternity throughout the world, especially in developing countries such as India compromises infection prevention practices and reduces colistin efficacy during medical emergencies.. Several developed countries have implemented strict regulations on …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 12, Issue 3, 2022 · pp. 6–18 Read article
-
A Single-domain Antibody Cross-reacts with Lipopolysaccharide from Diverse Gram-negative Bacteria
Abstract: Gram-negative bacterial sepsis and endotoxemia are the leading causes of morbidity and mortality in animals and humans worldwide, and attempts have continued to design rational therapies. Endotoxin/lipopolysaccharide (LPS)-neutralizing polyclonal and monoclonal antibodies have been produced, but are not free from problems. Single-domain antibodies (dAbs), constructed from the camelid and the shark ‘heavy chain antibodies’ by phage display technology possess favorable features for in vivo applications. The objective of this study …
Published in Research and Reviews : A Journal of Immunology · Vol. 6, Issue 2, 2016 · pp. 29–37 Read article
-
Isolation and Identification of Bacteria Causing Chronic Suppurative Otitis Media and Its Antibiogram
Abstract: Background: Chronic Suppurative Otitis Media (CSOM) is defined as chronic inflammation of middle ear and mastoid cavity, which presents with recurrent ear discharge or otorrhoea through a tympanic perforation. According to WHO, the prevalence of CSOM in India is more than 4% and it falls among those countries where urgent attention is needed. It can be caused by various bacteria, fungus and viruses. Bacterial origin of CSOM is more common …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 9, Issue 3, 2019 · pp. 1–5 Read article
-
An innovative antibiotic "Abaucin": Instigated by Artificial Intelligence
Abstract: Nosocomial Gram-negative pathogen, Acinetobacter baumannii repeatedly demonstrates multidrug resistance. Discovering novel antibiotics against A. baumannii has proven thought-provoking through conventional screening tactics. Providentially, machine learning approaches allow for the speedy exploration of chemical space, snowballing the probability of determining new antibacterial molecules. In the following research era, a neural network is accomplished with growth reserve dataset and accomplished in silico predictions for structurally unconventional molecules with commotion in divergence to …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 13, Issue 3, 2023 · pp. 29–33 Read article
-
Antibacterial Potentiality of SourSop Leaf and Fruit Extract: A Review
Abstract: SourSop is scientifically known as Annona muricata Linnaeus, which is a highly potent plant with a wide range of activities especially against cancer. The plant has many health benefits and all its parts have been utilized for treating various diseases. It is also used popularly to make various food items like ice creams and beverages. Lately, it has been explored for its antibacterial and anticancer properties by researchers worldwide. The …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 12, Issue 1, 2024 · pp. 59–64 Read article
-
Review of the Effect of Imine, Azo, and Formazan Compounds on the Cell Membrane of Bacteria, Fungi, and Their Inhibition of Activity
Abstract: The role of antibiotics is to reduce the resistance of bacterial and fungal cell membranes, thereby penetrating the cell membrane and causing bacterial death. Therefore, researchers have turned to preparing chemical compounds that mimic antibiotics in their ability to eliminate bacteria and microorganisms. Through ongoing research in the field of biological activity, recent decades have witnessed a significant increase in laboratory experiments involving imines, formazan, and other compounds in this …
Published in International Journal of Membranes · Vol. 3, Issue 2, 2026 · pp. 1–10 Read article
-
Whispers of the Microbial World: Unveiling Bacterial Dialogues through Quorum Sensing
Abstract: Quorum sensing is a special way of bacteria by which they can regulate their own gene expression as per the population density of the bacteria. It is basically a type of cell-to-cell communication pathway used by the microbes. The signal molecule which helps in this mechanism are called auto inducer(AI). As the mechanism depends by changes in the cell density, so when the cell density reaches to the threshold cell …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 3, 2024 · pp. 1–8 Read article
-
Development and Applications of a Simple Chalcone- Based Low Molecular Weight Ligand for Treating Nosocomial Infections due to Staphylococcus aureus and Escherichia coli
Abstract: Abstract Inspired from the available biological data of several imperative therapeutic scaffolds in several medicinal chemistry databases, thiophene-containing chalcone compounds were identified and the molecule was designed for treating various nosocomial infections. In one of the recent rational exploration, (E)-3-(4-methoxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one was synthesized in a single-step reaction, characterized comprehensively by using a few sophisticated spectroscopic instruments such as FT-IR spectroscopy, mass spectroscopy, and 1H-NMR spectroscopy, as well as CHN analyzer, and …
Published in Research and Reviews: A Journal of Medicine · Vol. 10, Issue 2, 2020 · pp. 14–18 Read article
-
Ventilator Associated Pneumonia: Prevalence of Bacteria and their Antibiogram in Tertiary Care Centre, Kota, Rajasthan, India
Abstract: Background: Mechanical ventilation is a life-saving procedure, but it is associated with a high risk of acquiring respiratory infections. Hence to prevent it and initiate empirical antimicrobial therapy, knowledge of microbial profile and their local antimicrobial sensitivity pattern are essential. The study aimed to investigate the role of endotracheal aspirate (ETA) surveillance cultures in identifying the aetiology of VAP earlier. Methods: A prospective study was carried out over a period …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 11, Issue 1, 2021 · pp. 30–34 Read article
-
Properties and antimicrobial activity of bacterial nanocellulose composite incorporated with silver nanoparticles based on green synthesis
Abstract: Green silver nanoparticles (AgNPs) synthesized using medical plant extracts as capping and reducing agents demonstrate broad applicability in addressing the threat posed by infections. In this study, we present a sustainable, low-toxicity, and cost-effective bacterial nanocellulose composite with silver nanoparticles based on green synthesis that uses Origanum vulgare as a reducing agent due to numerous biological components. The formation of AgNPs in composite and morphological properties was analyzed using scanning …
Published in Journal of Polymer & Composites · Vol. 12, Issue 1, 2024 · pp. 323–328 Read article
-
The Predatory Bacteria, Bdellovibrio and Like Organisms (BALOs): An Emerging Savior for Human Welfare
Abstract: Bdellovibrio and like organisms (BALOs) are capable of killing other Gram negative pathogenic and non-pathogenic bacteria dwelling in a diverse environmental niches such as soil, freshwater and ocean. The predatory nature of BALOs can be a viable alternative to conventional use of antibiotics to treat ocular, periodontal, respiratory and fish pathogen infections since the incessant use develops resistance against them. Unique property such as potential to survive in ecologically hazardous …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 8, Issue 3, 2018 · pp. 19–33 Read article
-
Synthesis of Copper Nanoparticles using Alternanthera Sessilis Linn Leaf Aqueous Extract and their Characterization
Abstract: The current study describes the biogenesis of Cu NPs using an aqueous extract of the leaf of Alternanthera sessilisLinn. (A.S). recently, biological synthesis of nanoparticles has gained popularity due to the fact that it is eco-friendly, simple, cost-effective, non-hazardous, and extreme conditions. The aqueous extract of Alternanthera sessilisleaf contains enoughterpenoids, carbohydrates, and flavonoids to convert metal ions into metal and thus stabilize the resulting nanoparticles. The UV-visible spectrophotometer confirmed the …
Published in Journal of Polymer & Composites · Vol. 10, Issue 2, 2022 · pp. 14–28 Read article
-
Mechanism of Action of Essential Oils and their Major Components
Abstract: The essential oil of lemongrass, palm rosa and eucalyptus were found to be good antimicrobial agents. To a large extent the results suggest their potential use as chemotherapeutic agents, food preserving agents, and disinfectants. However before considering these compounds as chemotherapeutic agents against human/animal diseases, it is important to study their cytotoxic and mutagenic effects. Studies were then carried to investigate the probable mechanism by which these compounds act against …
Published in Research & Reviews : Journal of Botany Read article
-
Synthesis, Characterization and Antibacterial Activity of Mono- and Binuclear Co(II) and Cr(III) Mixed-Ligand Complexes Derived from α-Amino Acid and 1,10- Phenanthroline with 1,3-Diaminopropan as a Spacer
Abstract: Mixed-ligand complexes of Co(II) and Cr(III) ions were synthesized from the reaction of metals chloride salts with α-amino acid (H2L1) as a primary ligand and 1,10-phenanthroline (L2) as secondary ligand. The ligand 2-(benzo[d]thiazol-2-ylamino)-2-(2-hydroxynaphthalen-1-yl) acetic acid (H2L1) has been synthesized from the condensation reaction of inobenzothiazol with 2-hydroxy-1-naphthaldehyde in the presence of HCN as three components–one pot reaction. H2L1 considered as a tridentate chelater of ONO-coordination binding type toward the metals, …
Published in Journal of Polymer & Composites · Vol. 11, Issue 2, 2023 · pp. 107–120 Read article
-
A Screening Study on Occurrence and Distribution of Urinary Tract Infections Among Suspected Cases (Pyuria, With or Without Symptoms) During Pregnancy
Abstract: Background: Urinary tract infection is one of the most frequently seen medical complications in pregnancy. Methods: Ethical approval was granted for this research. The study employed a time-bound prospective design; total pregnant women (900) were categorized into those suspected of having UTI (pyuria, with or without symptoms) and those not suspected. Asymptomatic bacteriuria is diagnosed through a urine specimen with an appropriate microscopic examination, followed by culture. Results: The occurrence …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 3, 2024 · pp. 13–20 Read article
-
Prevalence of Multidrug-Resistant Enterobacteriaceae Causing Urinary Tract Infection
Abstract: Urinary tract infections are one of the most common causes of hospital admission, high morbidity and mortality. The most common cause of urinary tract infection is Gram-negative bacteria such as Escherichia coli, Proteus spp., Pseudomonas aeruginosa, Acinetobacter spp., Klebsiella spp., Enterobacter spp., Citrobacter spp. and Gram-positive bacteria such as Enterococcus spp., Staphylococcus aureus and Coagulase-negative Staphylococci. Multidrug-resistant Enterobacteriaceae are emerging worldwide due to high empiric and injudicious use of antibiotics. …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 11, Issue 2, 2021 · pp. 13–18 Read article
-
Study The Effect of The Alcoholic and Hot Aqueous Extract of Costus specious on Some Bacterial Species
Abstract: Plant extracts are among the methods that have been used since ancient times in alternative medicine and are still developing until recently with the progress of science and modern technologies. These materials can be used in the composition of many pharmaceutical drugs. The current research aimed to evaluate the inhibitory effect of alcoholic and hot aqueous extract of the roots of Costus specious on some gram-positive and gram-negative bacteria (Enterococcus …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 3, 2024 · pp. 13–18 Read article
-
Molecular Docking and Pharmacokinetic Profiling of the Phytocompounds of Jatropha curcas as Antagonist for Salmonella typhi
Abstract: Background: Typhoid is an infection caused by the Gram-negative bacterium, Salmonella enterica serovar typhi. The study assessed the potential use of Jatropha curcas as a typhoid fever therapy alternative to traditional medications. The ability to uncover novel drug indications for currently available medications using in silico methods has increased thanks to the wealth of pharmacological and biological knowledge that is available. Objective: In this study, we assessed the potential inhibitory …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 1, 2023 · pp. 67–81 Read article
-
Evaluation of Inhibition Effect of Nanohybrid Curcumin (Cur-ZnO) and Cur-free Against Some Types of Bacteria
Abstract: This study aimed to prepare an efficient nanohybrid food preservative by loading curcumin on zinc oxide. The prepared compound was characterized using microscopy and spectral methods. Fourier transform infrared spectrum of the nanohybrid curcumin showed a shift in the frequencies of some chemical groups towards high and low frequencies. X-ray diffraction (XRS) spectrum also revealed the emergence of new diffraction planes in the nanohybrid compound, Compared with the carrier spectrum …
Published in Journal of Polymer & Composites · Vol. 11, Issue 2, 2023 · pp. 68–79 Read article
-
A review on antibacterial properties of eucalyptus oil and different eucalyptus species used in pharmaceuticals
Abstract: Medicinal plants with antimicrobial compounds play a crucial role in combating various pathogens. Eucalyptus, belonging to the myrtle family, is notable for its diverse antimicrobial compounds. This fast-growing plant thrives in many countries and its various parts offer significant medicinal value, including timber, pulpwood, and essential oils. The leaves, often considered forest harvesting waste, contain essential oils with potential medicinal benefits. Members of the genus Eucalyptus are highly valued for …
Published in International Journal of Antibiotics · Vol. 1, Issue 2, 2024 · pp. 10–19 Read article