Development and Applications of a Simple Chalcone- Based Low Molecular Weight Ligand for Treating Nosocomial Infections due to Staphylococcus aureus and Escherichia coli

Kanhaiya M Dadure; Animeshchandra G M Haldar; Debarshi Kar Mahapatra

doi:10.37591/rrjom.v10i2.2059

Abstract

Abstract Inspired from the available biological data of several imperative therapeutic scaffolds in several medicinal chemistry databases, thiophene-containing chalcone compounds were identified and the molecule was designed for treating various nosocomial infections. In one of the recent rational exploration, (E)-3-(4-methoxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one was synthesized in a single-step reaction, characterized comprehensively by using a few sophisticated spectroscopic instruments such as FT-IR spectroscopy, mass spectroscopy, and 1H-NMR spectroscopy, as well as CHN analyzer, and ultimately screened for its anti-bacterial potentials against gram-negative microbial species (Escherichia coli) and gram-positive microbial species (Staphylococcus aureus) using the conventional procedure. The chemical structure of the proposed molecule was completely recognized by sophisticated spectroscopic instruments. The compound exhibited an incredible anti-bacterial activity against anti-E. coli and expressed a fair bacterial activity against anti-S. aureus in in-vitro anti-microbial screening model, but with a very low potency. The compound was found to be more effective towards gram-negative species. The investigation pointed towards several prospective for the development of broad-spectrum anti-microbial drugs against resistant pathogenic strains by looking insights into the unexplored class of thiophene-containing chalcone compound. Keywords: Anti-microbial, chalcone, Escherichia coli, Staphylococcus aureus, Thiophene synthesisCite this Article Kanhaiya M. Dadure, Animeshchandra G.M. Haldar, Debarshi Kar Mahapatra. Development and Applications of a Simple Chalcone-Based Low Molecular Weight Ligand for Treating Nosocomial Infections due to Staphylococcus aureus and Escherichia coli. Research & Reviews: Journal of Medicine. 2020; 10(2): 14–18p.