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Development and Applications of a Simple Chalcone- Based Low Molecular Weight Ligand for Treating Nosocomial Infections due to Staphylococcus aureus and Escherichia coliBy Kanhaiya M Dadure, Animeshchandra G M Haldar, Debarshi Kar Mahapatra
Abstract: Abstract Inspired from the available biological data of several imperative therapeutic scaffolds in several medicinal chemistry databases, thiophene-containing chalcone compounds were identified and the molecule was designed for treating various nosocomial infections. In one of the recent rational exploration, (E)-3-(4-methoxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one was synthesized in a single-step reaction, characterized comprehensively by using a few sophisticated spectroscopic instruments such as FT-IR spectroscopy, mass spectroscopy, and 1H-NMR spectroscopy, as well as CHN analyzer, and …
Published in Research and Reviews: A Journal of Medicine · Vol. 10, Issue 2, 2020 · pp. 14–18 Read article →