Prevalence of Multidrug-Resistant Enterobacteriaceae Causing Urinary Tract Infection

Nottakaran Amanullah Fairoz Banu

Abstract

Urinary tract infections are one of the most common causes of hospital admission, high morbidity and mortality. The most common cause of urinary tract infection is Gram-negative bacteria such as Escherichia coli, Proteus spp., Pseudomonas aeruginosa, Acinetobacter spp., Klebsiella spp., Enterobacter spp., Citrobacter spp. and Gram-positive bacteria such as Enterococcus spp., Staphylococcus aureus and Coagulase-negative Staphylococci. Multidrug-resistant Enterobacteriaceae are emerging worldwide due to high empiric and injudicious use of antibiotics. The aim of our study was to evaluate the prevalence of multidrug-resistant Enterobacteriaceae causing urinary tract infection. A total of 503 urine samples (early morning clean catch midstream urine) were received from various departments. Of 186 samples, 78 strains were Escherichia coli (58.6%), 42 were Klebsiella spp. (31.5%), six were Citrobacter spp. (4.51%), five were Proteus spp. (3.75%), one was Enterobacter (0.75%) and one was Provedencia (0.75%). Of 133 isolates, 16 (12.03%) isolates were multidrug resistant. Among the multidrug resistant isolates, five were Escherichia coli, 11 were Klebsiella spp. and one was Proteus spp. Among 16 multidrug resistant isolates, all 16 isolates were sensitive to Tigecycline, 15 isolates were sensitive to Colistin, two isolates were sensitive to Amikacin, three isolates were sensitive to Chloramphenicol and one isolate was sensitive to Tetracycline.

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