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506 articles for “Degradation studies.”
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Validation and Forced Degradation Studies for the Determination of Erlotinib in Bulk and Pharmaceutical Dosage Forms by RP-HPLC
Abstract: A new reverse phase-high performance liquid chromatography (RP-HPLC) have been developed and validated for the determination of Erlotinib in bulk drug and pharmaceutical dosage form. The developed method is rapid, accurate, precise, simple and economical. The separation was carried out using column Hypersil ODS C-18 (150 mm x 4.6 mm 5 μm particle size) in isocratic mode, using mobile phase composition of 0.1% orthophosphoric acid: Acetonitrile in the ratio of …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 3, Issue 2, 2016 · pp. 44–53 Read article
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COMPOSITION, RADIATION DOSE AND TEMPERATURE DEPENDENT DEGRADATION STUDIES OF POLYAMIDE 6 HOMOPOLYMER AND COPOLYMERS
Abstract: Composition radiation dose temperature dependency on free radicals generated in PA6, PA6/ PA12 copolymer, has been investigated by electron spin resonance (ESR) and FTIR techniques. ESR spectra of -irradiated PA6 has shown complex shaped and number of hyperfine lines is observed to be in between 6-10. This complex spectrum is assigned to macro-radicals of the type ~CH2CHCH2~, which in principle has to give a ten line ESR spectrum. However, due …
Published in Journal of Catalyst & Catalysis · Vol. 5, Issue 1, 2018 · pp. 25–37 Read article
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New RP-HPLC Method Development and Validation for Simultanious Estimation and Forced Degradation Studies of Gallic acid and Curcumin in Solid Dosage Form
Abstract: Objective: A New method was established for simultaneous estimation of Gallic acid and curcumin by RP-HPLC method. Methods: Chromatographic separations were performed on an Inspire (4.6 x 150mm, 5m) column with a mobile phase composition of 0.1 percent OPA buffer and Acetonitrile (30:70) delivered at a flow rate of 1 ml/min, and detection was performed on a waters HPLC auto sampler, separation module 2695 with PDA detector 2996 at wavelength …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 13, Issue 1, 2022 · pp. 7–15 Read article
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Electron Beam and Gamma Radiation Dose Dependency on the Degradation Products of Polytetrafluoroethylene (PTFE)
Abstract: AbstractGamma radiation induced degradation phenomena of polytetrafluoroethylene (PTFE) in the form of granules has been studied. The Electron Spin Resonance (ESR) technique was used to study radical generation and behavior under different conditions. The ESR spectra of PTFE irradiated at low or very high doses of irradiation were doublets, characteristic of peroxy radicals. Similarly spectra at different temperatures are also doublets. In order to study nature of free radicals, the …
Published in Research & Reviews : Journal of Physics · Vol. 8, Issue 1, 2019 · pp. 104–114 Read article
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Studies on Biological Degradation of 4-Bromophenol Using Anaerobic, Anoxic and Aerobic Bioreactors
Abstract: The present study investigates biodegradation of 4-Bromophenol (4-BP) and simultaneous removal of COD in anaerobic, anoxic and aerobic moving bed bioreactors. Cow dung slurry was used as a source of microbial consortium for acclimatization in moving bed reactors in batch mode. The acclimated microbial consortium was able to degrade various concentrations such as 5, 10 and 15 mg/l of 4-BP within specific time period. Biodegradation was evaluated by determining total …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 7, Issue 1, 2016 · pp. 37–41 Read article
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Study on the Degradation of Total Petroleum Hydrocarbon (TPH) by Water Hyacinth Co-composts
Abstract: AbstractThis study was carried out to investigate the rate of total petroleum hydrocarbon (TPH) by water hyacinth co-compost at the Teaching and Research Farm, Faculty of Agriculture, Delta State University (DELSU), Asaba Campus. Five (5) kg of soils was collected from the school farm and measured into eighty-four (84) experimental pots and the treatments were arranged in 4×7 factorial experiment in a completely randomized design replicated three (03) times. The …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 8, Issue 3, 2019 · pp. 20–26 Read article
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Study of Crude Oil Degradation Using Bio-stimulant: The Concept of Remediation Application
Abstract: The Total Petroleum Hydrocarbon (TPH) degradation was monitored in a batch reactor with the addition of bio-stimulants of palm oil processed waste water (POPWW) and NPK fertilizer in contaminated clay soil medium. The comparative study on the performance of both bio-simulants revealed that the NPK fertilizer was more effective than the palm oil processed waste water (POPWW). This study is based on the overview on the degradation of petroleum hydrocarbon …
Published in Journal of Petroleum Engineering & Technology · Vol. 13, Issue 2, 2023 · pp. 13–23 Read article
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Spectroscopic, Thermal and Morphological Properties of Pa6 Copolymers
Abstract: Spectroscopic, thermal and morphological properties of PA6/PA12 copolymers have been reported in the present study. FTIR studies indicate the chemical interaction occurring between PA6 and PA12 homopolymers. Thermal properties of copolymers have been investigated by DTA technique. Among the PA6 copolymer, hydrolyzed PA6 has more Tg and Tm then the copolymer. Thermal degradation of copolymer is studied by TGA and DTG technique. The studies suggest that hydrolyzed PA6 has more …
Published in Research & Reviews : Journal of Physics · Vol. 7, Issue 3, 2018 · pp. 56–62 Read article
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Formulation and Characterization of Bilayer Tablet of Anti-hyperlipidemic BCS Class II drug
Abstract: The main objective of work was to formulate co-loaded bilayer tablets of atorvastatin (ATV) and ezetimibe(EZM).ATV loaded in the immediate-release (IR) layer is an HMG CoA reductase inhibitor, while EZM, added in the immediate-release (IR) layer, is a lipid-lowering agent. The immediate release of BCS class II drugs atorvastatin and Ezetimibe, in a bilayer approach was achieved by wet granulation and fluid bed granulation followed by compression. The Preformulation studies …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 14, Issue 1, 2023 · pp. 1–18 Read article
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From Knowledge to Action: Contribution of Environmental Studies in Sustainable Development
Abstract: In the contemporary era, most developing and underdeveloped nations across the world are striving to achieve rapid economic growth. However, it is essential to recognize that this unplanned and indiscriminate pursuit of development has resulted in significant environmental degradation. Increasing urbanization, industrialization, population growth, and excessive exploitation of natural resources have caused serious adverse impacts on the environment. As a result, sustainable development and environmental protection have emerged as major …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 16, Issue 1, 2026 · pp. 1–8 Read article
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Study on Photocatalytic Cement Concrete for the Degradation of Textile Dyes
Abstract: This process is developed in the way that low level usage of chemical such as Titanium-di-oxide and urea along with the cement concrete structure for the photocatalytic activity under sunlight. When the cement concrete structure is introduced the sustainability of the process is increased so the efficient use of the reactant is achieved. From this study we obtained that the photocatalytic way of separation of waste ions can increase the …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 8, Issue 1, 2017 · pp. 32–35 Read article
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Photo-Catalytic Degradation of Rhodamine-B by using UV/TiO2 and Nb2O5 Process: A Kinetic Study
Abstract: The photo-catalytic degradation of Rhodamine-B (RB) in aqueous solution with titanium dioxide (TiO2) and niobium pentaoxide (Nb2O5) as photocatalyst in slurry form has been carried out using UV-A light (254 nm). The effect of various parameters such as catalyst loading, pH and initial concentration of the RB dye on degradation have been determined. An attempt has been made to study the effect of process parameters through concentration of dye, amount …
Published in Journal of Catalyst & Catalysis · Vol. 1, Issue 3, 2014 · pp. 12–24 Read article
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High-Performance Liquid Chromatographic Assay of Nateglinide and its Stability Study
Abstract: Nateglinide (NTG) is a D-phenylalanine derivative used in the treatment of type-2 diabetes mellitus. An accurate, sensitive and reproducible high-performance liquid chromatographic (HPLC) method has been developed and validated for the quantification of NTG in pharmaceutical samples. The drug was eluted from Inertsil ODS 3V (150×4.6 mm; 5 µm particle size) column at 30á´¼C with a mobile phase consisting of phosphate buffer of pH 3.3 and methanol (70:30 v/v). The …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 7, Issue 3, 2016 · pp. 41–52 Read article
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Development and Validation of a New Stability-Indicating HPLC Method for the Determination of Rosiglitazone in Tablets
Abstract: Rosiglitazone (ROS) is an antidiabetic drug belonging to the thiazolidine class. A new stability-indicating high-performance chromatographic (HPLC) method was developed for the determination of ROS in pharmaceuticals, and validated for its suitability following the ICH guidelines. Chromatography was performed on a Chromatopack (250×4.6 mm; 5 µm particle size) column using phosphate buffer of pH 3.2 and methanol (70:30 v/v) as mobile phase pumped at a flow rate of 1 ml …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 1, 2017 · pp. 1–9 Read article
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Synthesis and Characterisation of Ceria Doped Titania Catalyst for the Degradation of Methylene Blue
Abstract: Photocatalytic degradation of Methylene Blue (MB) dye using synthesized ceria doped titania catalyst was performed and results were interpreted. The photocatalyst was prepared by incipient wet impregnation method, using cerium nitrate and titanium dioxide as the starting materials. The synthesized catalyst was characterized by powder X-ray diffraction (XRD), Vibrating sample magnetometer analysis (VSM), UV-Vis Diffuse reflectance measurements (DRS-UV) and UV analysis. The XRD pattern indicated that the sample has a …
Published in Journal of Water Pollution & Purification Research · Vol. 7, Issue 3, 2020 · pp. 26–33 Read article
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Climate Change and Soil Degradation: Its Economic Impact on Cassava Production in Ondo State: A Case Study of Akoko North West Local Government
Abstract: AbstractThis paper, presents an empirical analysis of climate change and soil degradation, its economic impact on cassava product in Ondo State with special reference to Akoko North West local government area. Data used for this study is from primary source. The data consists of 300 respondents selected from ten towns/villages in the study area using purposive sampling technique; only 280 cases were useful. Structured interview guide were used to collect …
Published in Research & Reviews : Journal of Ecology · Vol. 4, Issue 3, 2015 · pp. 1–5 Read article
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Stability-Indicating Rp-Hplc Development and Validation for the Estimation of Lercanidipine Hydrochloride Content in Tablet Dosage Form
Abstract: A sensitive, stability-revealing, and easy reverse-phase high-performance liquid chromatographic (RP-HPLC) technique was developed and rationalized to be in a position to determine Lercanidipine hydrochloride in ingested dosing preparations. It was separated by chromatography on a C 18 column using a mobile phase containing 10 mM potassium dihydrogen phosphate buffer and methanol (20:80, v/v; pH 4.0) at a flow rate of 1.0 mL/min and UV detected at 258 nm. The retention …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 1, 2026 · pp. 17–26 Read article
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Quantitative Image-Based Assessment of Degradation Patterns in Polymer-Based Medical Implants
Abstract: Polymer-based medical devices are widely used in clinical practice, where long-term material degradation can compromise performance and patient safety. Traditional polymer degradation studies predominantly rely on laboratory-based experiments, which often fail to capture real-world operational and usage conditions. In this study, a multimodal, data-driven framework is proposed for the quantitative assessment of degradation patterns in polymer-based medical devices using publicly available clinical failure data. Structured operational parameters, including cumulative usage …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1510–1518 Read article
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HPLC Method Development and Validation for Simultaneous Estimation of Succinic Acid and Succinylmonocholine in Succinylcholine Chloride Injection
Abstract: Succinylcholine chloride injection USP is a sterile, non-pyrogenic solution to be used as a short-acting, depolarizing, skeletal muscle relaxant. The injection is administered as IM or IV use. Succinylcholine chloride, USP is chemically designated C14H30N2O4 and its molecular weight is 290.399. Succinylcholine chloride has three known impurities: (1) Doublet peak, (2) Succinic acid and (3) Succinylmonocholine chloride. Out of these impurities, succinic acid and succinylmonocholine chloride are degradation impurities, whereas …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 2, Issue 3, 2015 · pp. 52–60 Read article
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Microwave Aided Ecological Forced Degradation Method for the Rapid Exploration of the Drug Impurity: Literature Investigated UP TO the Time Point
Abstract: The drug development life cycle is a time-consuming process, which also involves lots of efforts in the testing of the chemical stability of the drug molecules and possible impurity and degradation product of the drug before it comes in the form of a stable formulation. The Forced degradation and stability testing involves the major time portion in researching the chemistry of the molecules. With the aim of getting a green …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 7, Issue 3, 2020 · pp. 23–27 Read article