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1951 articles for “structure” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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An Efficient Synthesis of Some Novel Benzo Coumarin Derivatives Under Solvent Conditions from 2-acetyl-benzo[f]chromen-3-one
Abstract: The synthesis of the target compounds began with the preparation of 2-[3-dimethylamino[acryloyl-3H-benzo[f]chromen-3-one. This intermediate was obtained through the reaction of 2-acetylbenzo[f]coumarin-3-one with N,N-dimethylformamide dimethyl acetal [DMFDMA[ under reflux conditions in xylene. The enaminone thus formed was subsequently reacted with 6-aminothiouracil in acetic acid, leading to the formation of 2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one. This compound served as a pivotal intermediate for the synthesis of a series of pyridotriazolopyrimidinones. These derivatives were synthesized by reacting …
Published in International Journal of Cheminformatics · Vol. 2, Issue 2, 2024 · pp. 33–46 Read article
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Role of Carboxylesterases in Xenobiotic Metabolism and Detoxification: Insights for Cheminformatics Approaches
Abstract: Xenobiotics, which include a wide range of environmental pollutants, food additives, drugs, and carcinogens, are foreign chemical entities that enter the human body and may accumulate, leading to toxic effects. Phase I and phase II metabolic responses are among the detoxification procedures that are necessary to lessen these negative consequences. This review highlights the pivotal role of carboxylesterases (CES), enzymes involved in the hydrolysis of ester, amide, and thioester bonds …
Published in International Journal of Cheminformatics · Vol. 2, Issue 2, 2024 · pp. 9–17 Read article
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In Silico Exploration of Podophyllum Hexandrum-Derived Phytocompounds as Potential Therapeutics Against Small Cell Lung Cancer (SCLC): A Molecular Docking Approach
Abstract: Small Cell Lung Cancer (SCLC) is a fast-growing and aggressive type of lung cancer that spreads quickly strongly associated with smoking. It is characterized by symptoms, such as persistent cough, breathing difficulties, or hoarseness, though it can sometimes be asymptomatic which makes early detection challenging. The tumor suppressor gene TP53 is critical in regulating the cell cycle and preventing uncontrolled cell division. Mutations in TP53 result in the loss of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 1–11 Read article
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Comparative Evaluation of the Pozzolanic Activity of Artificial Pozzolans: Steel Slag, Fly Ash, and GGBFS
Abstract: Evaluating the pozzolanic activity of specific industrial waste is crucial given the growing demand for cementitious materials. This research aims to expand the possibilities of incorporating pozzolanic waste such as Steel Slag (SS) as additives to cement. SS is a byproduct of the steel production process. A byproduct of the steelmaking process, slags have long been used as aggregates in building materials like concrete and roads. A closed-loop structure and …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 341–361 Read article
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Computational Investigation of Phytochemicals Targeting AKT1 for Major Depressive Disorder: A Molecular Docking and ADMET Study
Abstract: Major depressive disorder (MDD) is a prevalent neuropsychiatric condition affecting approximately 280 million individuals worldwide, with women exhibiting a 50% higher likelihood of diagnosis than men. Despite significant advancements in treatment, MDD remains a chronic and relapsing disorder, necessitating the exploration of novel therapeutic interventions. This study focuses on the AKT1 gene, a key player in neuropsychiatric disorders, and investigates its interactions with natural phytochemicals as potential alternatives to conventional …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 2, 2025 Read article
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The Effect of Vitamin A Dose For Different Periods On The Spleen of White Rats: A Histological Study
Abstract: There are many detrimental effects of hypervitaminosis (A) on immune system function, growth, and reproduction. The main objective of the study was to evaluate the histological changes in the spleen of white rats given an excessive amount of vitamin A. The study was conducted from October 21, 2022, to December 12, 2022, at the College of Education's Animal House. (40) adult male albino rats, weighting between 200 and 220 grams …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 15, Issue 2, 2025 Read article
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Western Indian Ocean and Impacts of SDG14: Life Below Water
Abstract: The SDGs outline a sustainable and inclusive global future. This paper discusses progress toward SDG 14 within the WIO, emphasizing four targets that were set for achievement by 2020. Given that current methods of evaluation of policy-informing lack precision, in this region, little headway has been made toward meeting the set targets, and the attainment of SDG 14 by 2030 does not seem possible. SDG 14.2 and 14.5: Moving at …
Published in International Journal of Marine Life · Vol. 2, Issue 1, 2025 · pp. 32–39 Read article
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Advanced Composite Materials for Electric Vehicle Charging Stations: A Comprehensive Study
Abstract: EV chargers are thought to be a major determinant in the adoption of EVs in present transport systems. The performance and durability of these charging stations highly depend on the materials applied in the construction of these charging stations because these materials should be very reliable, durable and efficient. The current paper reviews the current literature on advanced composite materials relevant in the construction of the EV charge station. Recognitions …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 401–415 Read article
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Solid Lipid Nanoparticles in Medicine: Formulation, Characterization and Future prospects
Abstract: An alternative to conventional colloidal carriers such liposomes, polymeric nanoparticles, and emulsions, solid lipid nanoparticles (SLNs) were created in the early 1990s. Benefits include targeted medicine distribution, controlled drug release, and improved stability. An extensive review of the excipients utilized, the production techniques, including the membrane contractor approach, and the possible advantages and disadvantages of SLNs is given in this work. It investigates secondary stabilization techniques like freeze-drying and spray-drying, …
Published in International Journal of Membranes · Vol. 2, Issue 1, 2025 · pp. 1–15 Read article
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Au@Sio2@PVP-DCMD Membranes: A Breakthrough in Heavy Metal Removal and Antibacterial Defense
Abstract: This study investigates the development and characterization of multifunctional gold-doped silica (Au@SiO₂) membranes for water distillation and antibacterial applications. The manufacturing process integrated gold nanoparticles into silica matrices using sol-gel techniques. Structural analysis was conducted using SEM (showing uniform pore distribution with an average pore size of 40-50 nm), FTIR (confirming Si-O-Si and Si-Au-Si bonding peaks at 525 cm⁻¹ and 1310 cm⁻¹ respectively), EDX (revealing gold nanoparticle content of 1.5 …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 13–27 Read article
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Advancements In Metal-Fiber Composites for Aerospace and Defense Applications: A Comprehensive Review
Abstract: This paper provides a comprehensive review of fiber-reinforced composites, focusing specifically on the utilization of metal-fiber composites in aerospace such as metal surface preparation prior to bonding, resin selection, and detailed examination of mechanical testing and impact studies. The significance of metal surface preparation for establishing strong bonding, which is a crucial initial step in composite fabrication, is discussed. Additionally, the prevalent use of epoxy resins and their importance in …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 96–108 Read article
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Numerical Investigation on Medium Velocity Impact Response of Hybrid Metal Matrix Composite Laminate
Abstract: The current investigation centers on examining the numerical analysis of a hybrid metal matrix composite laminate resulting from impacts inflicted by diverse projectiles on the composite structure. Composite materials are chosen based on their inherent properties and compatibility in terms of bonding with other materials, forming the layers for the hybrid metal matrix composite. The fiber taken for the research paper was Kevlar and Sisal because they both bear good …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 346–358 Read article
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Assessment of Differential Global Positioning System (DGPS Technology for Generating Accurate Topographic Maps and Controls: A Case Study of Farin-Lamba to Kwali College Area"
Abstract: This study investigates the application of Differential Global Positioning System (DGPS) for topographic mapping and control point establishment in Farin-Lamba to Kwali College Area. The second order Survey controls extension are critical indices for ensuring structural and border control mechanisms in environmental development projects. However, creating these controls using traditional ways presents major obstacles. Most modern techniques are improvements on ancient approaches, which raises the possibility of environmental dangers and …
Published in International Journal of Land · Vol. 2, Issue 1, 2025 · pp. 11–23 Read article
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Performance of GFRP Bars in Flexural Members: A Comparative Study with Metal Bars Using FEA and Experimental Study
Abstract: In recent years, GFRP bars have been introduced as a replacement for metal bars as reinforcement in flexural members. This study evaluates the use of GFRP bars as the main reinforcement in flexural members such as beams through computer simulations and experimental work. A 4-meter beam from a sample structure, analyzed as per IS 875 (1987) Part 2, was considered for the study. This beam was designed considering both metal …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 262–267 Read article
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An Evaluation of the Effectiveness of a Self-Instructional Module on First Aid and Safety Measures for School Children (Aged 11–14 years) at PDR VVP Vidyalaya, Loni
Abstract: Background: School children are active youngsters. India is home to nearly 500 million young individuals, with approximately 370 million being children under 15 years old, highlighting their crucial role as the future of the country. Young children often exhibit naughty, defiant, and impulsive behavior. According to the World Health Organization’s Global report, in the South-East Asia Region, road traffic accidents, drowning, burns, and other injuries are leading causes of child …
Published in Journal of Nursing Science & Practice · Vol. 15, Issue 1, 2025 · pp. 17–22 Read article
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Analysis of Health Benefits Associated with Exclusive Breastfeeding Among Lactating Mothers in Maiduguri Metropolis, Borno State, Nigeria for Sustainable National Development
Abstract: Exclusive breastfeeding, which involves feeding an infant only breast milk for the first 6 months of life, offers numerous health benefits for both the baby and the breastfeeding mother. Despite the well-established advantages, global rates of exclusive breastfeeding remain lower than ideal, and this is also the case in Maiduguri Metropolis, Borno State, Nigeria. This study aims to explore the health benefits of exclusive breastfeeding for lactating mothers in Maiduguri …
Published in International Journal of Women's Health Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 1–8 Read article
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Pregnancy-Induced Post-Natal Back Pain
Abstract: Pregnancy-induced post-natal back pain (PNBP) is a common condition that affects many women following childbirth, significantly impacting their quality of life and physical functioning. The physiological and anatomical changes during pregnancy, such as weight gain, altered posture, and hormonal changes, contribute to the onset of back pain. As the body prepares for delivery, the pelvis and spine undergo structural shifts that can strain the muscles and ligaments supporting the lower …
Published in International Journal of Women's Health Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 25–31 Read article
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Human-Robot Interactions and Social Robotics in Legal, Ethical, and Social Dimensions
Abstract: Human-robot interaction and social robotics have emerged as transformative fields, reshaping human engagement with intelligent machines. This evolution brings profound legal, ethical, and social challenges that demand critical exploration. Also, legal firms often struggle to keep pace with the advancements, raising questions about liability, accountability, and privacy in human-robot interaction. However, social robots, designed to operate in dynamic human environments, present ethical dilemmas around autonomy, trust, and preserving human dignity. …
Published in Journal of Advancements in Robotics · Vol. 12, Issue 1, 2025 · pp. 09–11 Read article
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Breaking the Cycle: The Impact of Hygiene Deficiencies on the Health of the Poor
Abstract: Poor sanitation and hygiene present significant health risks, particularly for individuals in low- income communities. Inadequate sanitation systems increase the likelihood of exposure to harmful microorganisms found in contaminated water, food, and environments. This exposure contributes to the spread of waterborne diseases such as cholera, dysentery, and typhoid, along with various gastrointestinal illnesses. Limited access to clean water and soap for handwashing exacerbates these risks, particularly for children, who are …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 1, 2025 · pp. 22–39 Read article
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An overview of Nanocrystalline Hydrogenated Silicon Thin film Transistor
Abstract: This article elaborates and comprehends an overview on nc-Si:H TFT's, detailing and highlighting the topics like fabrication methodology, properties/stability, modelling, characterization techniques, challenges and futuristic scope/applications.With the growing demands in commercialization of Solar Cells (low-cost photo voltaic devices), Large Area Displays (like OLED’s), Thin film electronics (FPD applications), pixel switches, wearable/flexible electronics and so on, has prompted researchers to develop nc-Si:H TFT's (an alternative solution) which can out perform the …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 27, Issue 2, 2025 · pp. 1–23 Read article