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410 articles for “drug development”
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Design and Evaluation of Extended-Release Tablet Compositions Containing Oxaprozin: Integrating Concepts from Bioinformatics
Abstract: The procured sample of Oxaprozin was tested for its identification. The manufacturer also was confirmed of quality and purity of sample. The sustained release tablets of Oxaprozin were prepared by wet granulation method, They were evaluated for weight variation, drug content, friability, hardness, and thickness for all batches (T-1 – T-10). The release of Oxaprozin from sustained release tablet of various formulations varied according to the ratio and degree of …
Published in Research and Reviews: A Journal of Toxicology · Vol. 11, Issue 1, 2024 · pp. 39–45 Read article
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Stress Urinary Incontinence (Salasulul-Baul): A Review of The Unani Concept
Abstract: Greco-Arabic medicine, a rich repository of knowledge on various bodily ailments, offers significant insights into managing and treating numerous health conditions. Among these, urinary incontinence (UI) stands out as a frequently overlooked, underreported, and untreated medical issue that profoundly affects the quality of life for women across all age groups. Salasul baul, a term used in Greco-Arabic medicine, describes this distressing condition characterized by an inability to control urine, significantly …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 11, Issue 3, 2024 · pp. 30–33 Read article
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Unveiling Nature’s Potential: In Silico Exploration and Identification of Herbal Remedies for Major Depressive Disorder Through Molecular Interaction Studies
Abstract: Major depressive disorder (MDD), a globally discussed mental health condition, has drawn significant attention because of its unique and intricate nature. This is marked by the enduring presence of negative emotions stemming from a lack of interest, diminished self-esteem, and excessive rumination. Despite the widespread availability of various antidepressant medications, their effectiveness is hindered by low response rates, prolonged treatment durations, and the prevalence of side effects, such as headaches, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 54–62 Read article
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Development and Assessment of Levetiracetam Microspheres Utilizing Synthetic and Natural Polymers: A Biomedical Engineering Perspective
Abstract: In the present study, comparative study of Levetiracetam loaded microspheres using Ethyl cellulose as synthetic and Sodium alginate as natural polymers was done. Solvent evaporation and ionic gelation technique has been successfully employed to produce Levetiracetam loaded ethyl cellulose and sodium alginate microspheres with optimal drug encapsulation that sustained the drug release over a period of time. Based on the pre-formulation studies E1 to E4 and S1 to S4 batches …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 1–18 Read article
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HPTLC Method Development and Validation for Rabeprazole Sodium in Pharmaceutical Formulation
Abstract: Background: The most common medication for acid related disorders stands as Proton pump inhibitor (PPI) Rabeprazole Sodium. The pharmaceutical formulations require essential quality control of Rabeprazole Sodium through reliable analytical methods to maintain reliability. HPTLC provides a cost-effective rapid method for drug quantification compared to conventional HPLC methods so how HPTLC stands as an appropriate method for drug determination. Objective: The emphasis of this research project involves developing and validating …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 18–24 Read article
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Analytical Method Development and Validation of Simultaneous Estimation of Natural Active Constituents Andrographolide and Piperine by UV Method.
Abstract: A simple, accurate, precise, and robust UV-Visible spectrophotometric method was developed and validated for the simultaneous estimation of Andrographolide and Piperine in bulk and combined pharmaceutical dosage forms. Preformulation studies confirmed favorable physicochemical properties for both drugs, including acceptable solubility profiles, melting points, pH values, and partition coefficients. The method development involved determination of λmax values at 224 nm for Andrographolide and 288 nm for Piperine using ethanol as solvent. …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 3, 2025 · pp. 33–41 Read article
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The Dual Crisis: Antibiotic Resistance and the Discovery Void – A Review of Novel Therapeutic Strategies and Non-Traditional Approaches
Abstract: The global rise of antimicrobial resistance (AMR) has emerged as one of the most critical public health challenges of the 21st century, threatening to undermine decades of therapeutic success and rendering conventional antibiotic regimens increasingly ineffective. Parallel to the escalating resistance rates is a profound “discovery void,” characterised by a steep decline in the development of new antibiotic classes since the late 20th century. Together, these two interconnected crises create …
Published in International Journal of Antibiotics · Vol. 3, Issue 1, 2026 · pp. 47–65 Read article
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Biodegradable and Natural Fiber-Reinforced Polymer Composites for Antimicrobial Coatings in Biomedical Applications
Abstract: Since they make medical equipment more biocompatible and practical, biomedical polymers are quite crucial for the advancement of medical technologies. One of the most exciting applications for biomedical polymers is their possible use as protective drug coatings for devices. These coatings aim to limit bacterial binding and biofilm growth, two key causes of illnesses acquired after implantation. Scientists are searching for fresh approaches to combat microorganisms as the issue of …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 392–405 Read article
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Innovations in Tuberculosis Management: Advancements in Drug-Resistant TB Treatment and Rapid Diagnostics
Abstract: Tuberculosis (TB) remains one of the deadliest infectious diseases worldwide, exacerbated by the increasing prevalence of drug-resistant strains, such as multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB). Despite advancements in first-line and second-line treatments, resistance to conventional antibiotics has complicated therapeutic strategies, necessitating novel approaches. This mini review explores emerging advancements in TB treatment, including gene editing technologies, such as CRISPR, which offer potential for precise targeting of drug-resistant bacterial …
Published in International Journal of Antibiotics · Vol. 2, Issue 2, 2025 · pp. 1–7 Read article
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AI: Revolutionizing Pharmacy Practice and Enhancing Patient Care and Safety
Abstract: The use of artificial intelligence (AI) in pharmacy is transforming medication management, improving patient care, and boosting safety. By leveraging cutting-edge technologies, such as machine learning, natural language processing, and predictive analytics, AI enables pharmacists to develop personalized treatment plans and anticipate possible adverse drug reactions. AI-driven systems enhance operational efficiency by streamlining inventory management, prescription processing, and administrative duties, allowing pharmacists to devote more time to patient care. Additionally, …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 12, Issue 1, 2025 · pp. 13–20 Read article
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Biopolymer-Based Nanoparticles: Advances in Fabrication, Characterization, and Biomedical Applications
Abstract: The emergence of biopolymer-based nanoparticles, particularly those composed of proteins and polysaccharides, has significantly transformed the landscape of biocompatible and biodegradable materials. These nanoparticles offer immense potential due to their ability to facilitate encapsulation and targeted delivery of bioactive compounds, enhancing therapeutic efficacy while minimizing side effects. This review explores the various fabrication techniques, including emulsification, desolvation, coacervation, and electrospray drying, emphasizing their advantages and limitations. The characterization of nanoparticles …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 3, Issue 1, 2025 · pp. 38–46 Read article
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A Review on Phytochemical and Pharmacological Properties of Anacyclus Pyrethrum (Akarkara)
Abstract: The wild species Anacyclus pyrethrum, or A. pyrethrum, is a member of the Asteraceae family. It is commonly known as Akarkara. It originated in Spain, Morocco, and Algeria, and has since spread to Sri Lanka, India, Ukraine, Germany, Myanmar, France, and Poland. It is the benefits of bioactive compounds of plant found the chemical makeup, analgesic, anti-inflammatory, and wound-healing effects of hydroalcoholic extracts of A. pyrethrum’s roots, seeds, leaves, and …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 1, 2025 · pp. 102–110 Read article
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Advancements in Polymer Chemistry for Biomedical Applications: A Focus on Injection Guides
Abstract: Polymers have revolutionized biomedical applications, offering versatility, biocompatibility, and cost-effective manufacturing. This paper explores the role of polymer chemistry in the development of an advanced injection guide for precise drug delivery, aiming to enhance both safety and efficiency in clinical settings. Emphasis is placed on polymer selection, structural design, and functional modifications to improve injection procedures. By leveraging biodegradable and biocompatible polymers, the guide minimizes adverse tissue reactions while ensuring …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 129–136 Read article
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Biodegradable and Natural Fiber-Reinforced Polymer Composites for Sustainable Biomedical Applications
Abstract: Liposomal drug delivery has evolved into a viable approach in modern pharmacology thanks to its enhanced bioavailability, reduced systemic toxicity, and targeted drug release. Conventional liposomes have limited stability, medicine leakage, and short circulation times among other problems. Overcoming these limits, the inclusion of nano-polymers into liposomal formulations has transformed medication delivery. Thorough research has been done on the potential of nano-polymers including chitosan, hyaluronic acid, polyethylene glycol (PEG), and …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 420–432 Read article
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Design and Evaluation of Thermo-Responsive Poly(N-isopropylacrylamide)-Based Polymeric Nanoparticles for Temperature-Triggered Intratumoral Release of Doxorubicin in Solid Tumors
Abstract: Thermo-responsive polymeric systems have emerged as promising platforms for targeted intratumoral drug delivery in cancer therapy. This study aimed to develop and evaluate poly(N-isopropylacrylamide) (PNIPAM)-based polymeric nanoparticles as intelligent carriers for temperature-responsive delivery of doxorubicin (DOX) to solid tumors. Nanoparticles were synthesized via free radical polymerization using N-isopropylacrylamide as a thermoresponsive monomer and N,N′-methylenebisacrylamide as a crosslinker, forming a stable network with a tunable lower critical solution temperature (LCST).The optimized …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 159–168 Read article
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Revolutionizing Gastro-retentive Drug Delivery: Exploring Innovative Formulation Strategies and Mechanisms in Floating in Situ Gel Raft Forming System
Abstract: An in-depth exploration of the transformative shift underway in gastro-retentive drug delivery, spotlighting the utilization of Floating Drug Delivery Systems (FDDS) and specifically honing in on the innovative formulation strategies and mechanisms inherent in Floating In Situ Gel Raft Forming Systems. FDDS present a promising avenue for revolutionizing drug delivery efficacy by capitalizing on buoyancy to float atop the gastric fluid surface, thereby extending gastric residence time and improving drug …
Published in Trends in Drug Delivery · Vol. 11, Issue 1, 2024 · pp. 9–21 Read article
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A Brief Review on Herbal Excipients
Abstract: Natural or herbal excipients are significantly more advantageous than their synthetic equivalents because they are readily available, non-toxic, and less expensive. The pharmaceutical industries are becoming more interested in using these herbal excipients – mainly polymers of natural origin – in formulation development because of growing knowledge of them. The purpose of this study is to provide light on the possibility of using natural excipients, which are biocompatible and able …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 12, Issue 2, 2025 · pp. 5–14 Read article
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Polymer Chemistry and Its Applications in Pharmaceutical Composite Formulations
Abstract: Polymer chemistry plays a critical role in pharmaceutical formulations, particularly in enhancing drug stability, bioavailability, and controlled release. Polymers are widely utilized in drug delivery systems. Polymers are widely used in pharmaceutical sciences for drug delivery, controlled release, and stability enhancement. This paper explores the role of polymers in the extraction and formulation of glycyrrhetinic acid from Glycyrrhiza glabra, a bioactive compound. Various polymer-based extraction and purification techniques are discussed, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 216–221 Read article
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Formulation, Evaluation, and Stability Studies of a Topical Clotrimazole and Zinc Oxide Suspension with Enhanced Skin Protective Properties
Abstract: Background: Clotrimazole is a well-known antifungal agent frequently used in the treatment of various superficial fungal infections, while Zinc Oxide is a widely accepted skin protectant with soothing, astringent, and antimicrobial properties. Combining these agents in a topical suspension offers a dual therapeutic approach, enhancing both antifungal efficacy and skin protection. Objective: The objective of this study was to formulate, evaluate, and conduct stability studies on topical suspensions containing Clotrimazole …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 3, 2025 · pp. 22–31 Read article
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A Review of Nanotechnology Application in Pharmaceutical and Health Care
Abstract: Nano drug and nano delivery systems are a fairly new but fleetly developing wisdom where accoutrements in the nanoscale range are employed to serve as means of individual tools or to deliver remedial agents to specific targeted spots in a controlled manner. Nanotechnology provides numerous advantages in treating chronic diseases by enabling precise, site-specific, and targeted drug delivery. Recently, there have been several remarkable applications of nanomedicine, including chemotherapeutic agents, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 07–17 Read article