Research and Reviews: A Journal of Pharmaceutical Science Review Article
A Review of Nanotechnology Application in Pharmaceutical and Health Care
Abstract
Nano drug and nano delivery systems are a fairly new but fleetly developing wisdom where accoutrements in the nanoscale range are employed to serve as means of individual tools or to deliver remedial agents to specific targeted spots in a controlled manner. Nanotechnology provides numerous advantages in treating chronic diseases by enabling precise, site-specific, and targeted drug delivery. Recently, there have been several remarkable applications of nanomedicine, including chemotherapeutic agents, natural agents, immunotherapeutic agents, and more, in the treatment of various conditions. This review presents an updated overview of the recent advancements in nanodrugs and nanomedicine delivery systems, offering a comprehensive analysis of the discovery and utilization of nanomaterials to enhance the efficacy of both new and existing medicines (such as natural products), as well as enabling selective diagnosis through disease marker molecules. The opportunities and challenges of nanomedicines in drug delivery—ranging from synthetic and natural sources to clinical applications—are also discussed. Furthermore, this review includes insights on the emerging trends and future perspectives in the field of nanomedicine.
Keywords
References (29)
- Pandey R, Khuller GK. Nanotechnology based drug delivery system (s) for the management of tuberculosis, Indian Journal of Experimental Biology Vol. 44, May 2006, pp. 357-366
- N.K.Jain,Pharmaceutical Nanotechnology, Sagar,Dr.Hari Singh Gour University,2007.
- Ali Mansoori G, Bastami TR, Ahmadpour A, Eshaghi Z. Environmental application of nanotechnology. Annual review of nano research. 2008:439-93.
- . Peng Liu, Nano-crystal formulation for poorly soluble drugs, Finland, Helsinki University Printing House, 2013.
- D'Mello SR, Cruz CN, Chen ML, Kapoor M, Lee SL, Tyner KM. The evolving landscape of drug products containing nanomaterials in the United States. Nature Nanotechnology. 2017;12(6):523-529. doi:10.1038/nnano.2017.67
- Nguyen VP, Le Trung H, Nguyen TH, Hoang D, Tran TH. Synthesis of Biogenic Silver Nanoparticles with Eco‐Friendly Processes Using Ganoderma lucidum Extract and Evaluation of Their Theranostic Applications. Journal of Nanomaterials. 2021;2021(1):6135920.
- A. Di Paolo, “Liposomal anticancer therapy: pharmacokinetic and clinical aspects, “Journal of chemotherapy, vol. 16, supple-mint 4, pp. 90–93, 2004
- Tyner KM, Zheng N, Choi S, Xu X, Zou P, Jiang W, et al. How Has CDER Prepared for the Nano Revolution? A Review of Risk Assessment, Regulatory Research, and Guidance Activities. The AAPS Journal. 2017;19(4):1071-1083. doi:10.1208/s12248-017-0084-6
- Meng E, Hoang T. Micro- and nano-fabricated Implantable drug-delivery Systems. Therapeutic Delivery. 2012;3(12):1457-1467. doi:10.4155/tde.12.132
- Sridhar R, Ramakrishna S. Electrosprayed nanoparticles for drug delivery and pharmaceutical applications. Biomatter. 2013;3(3). doi:10.4161/biom.24281
- Stevenson CL, Santini JT, Langer R. Reservoir-based drug delivery systems utilizing microtechnology. Advanced Drug Delivery Reviews. 2012;64(14):1590-1602. doi:10.1016/j.addr.2012.02.005
- Zhang Y, Chan HF, Leong KW. Advanced materials and processing for drug delivery: The past and the future. Advanced Drug Delivery Reviews. 2013;65(1):104-120. doi:10.1016/j.addr.2012.10.003
- Wilczewska AZ, Niemirowicz K, Markiewicz KH, Car H. Nanoparticles as drug delivery systems. Pharmacological reports. 2012 Sep 1;64(5):1020-37.BAWARSKIW.E.(2008)‘Nanomedicine’,Nanotechnology, Biology and Medicine, Vol.4, pp.273–282.
- Zhang L, Gu F, Chan J, Wang A, Langer R, Farokhzad O. Nanoparticles in Medicine: Therapeutic Applications and Developments. Clinical Pharmacology & Therapeutics. 2007;83(5):761-769. doi:10.1038/sj.clpt.6100400
- Jain KK. The role of nanobiotechnology in drug discovery. Drug Discovery Today. 2005;10(21):1435-1442. doi:10.1016/s1359-6446(05)03573-7
- Pankaj Khuspe et al., A Comprehensive Review on Novel Pharmaceutical Nanotechnology and Its Applications, Indo Am. J. P. Sci, 2017; 4(12).
- RANGASAMY,M. (2011) ‘Nano Technology: A Review’ ,Journal of Applied Pharmaceutical Science, Vol. 1(2), pp. 8-16
- C.S.S.R.Kumar Nanomaterials for Medical Diagnosis and Therapy, Wiley-VCH(2007)
- Nanotechnology 2008: Life Sciences, Medicine & Bio Materials – Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, Volume 2 – TechConnect Briefs [Internet]. Techconnect.org. 2024 [cited 2025 Apr 11]. Available from: https://briefs.techconnect.org/books/nanotechnology-2008-life-sciences-medicine-bio-materials-technical-proceedings-of-the-2008-nsti-nanotechnology-conference-and-trade-show-volume-2/
- Stern E, Klemic JF, Routenberg DA, Wyrembak PN, Turner-Evans DB, Hamilton AD, et al. Label-free immunodetection with CMOS-compatible semiconducting nanowires. Nature. 2007;445(7127):519-522. doi:10.1038/nature05498
- Mansour M.Amiji, Nanotechnology for Drug Delivery: An Overview.Northeastern Boston,2006.
- Saurabh Bhatia,Nanotechnology and Its Drug Delivery Applications,2016.
- MarshallN.J.,GoodwinC.J.,HoltS.J.Acritical assessmen to ftheuse of microculture tetrazolium assays to measure cell growth and function. Growth Regul. 1995;5:69–84.
- HussainS.M.,FrazierJ.M.Cellular toxicity of hydrazinein primary rathepatocytes. Toxicol. Sci. 2002;69:424–432. doi:10.1093/toxsci/69.2.424.
- Gelperina S, Kisich K, Iseman MD, Heifets L (2005) The potential advantages of nanoparticle drug
- delivery systems in chemotherapy of tuberculosis. Am J Respir Crit Care Med 172(12):1487–1490.
- Goyal R, Macri LK, Kaplan HM, Kohn J (2016) Nanoparticles and nanofibers for topical drug delivery. J Control Release 240:77–92.
- Hashemi Goradel N, Ghiyami-Hour F, Jahangiri S, Negahdari B, Sahebkar A, Masoudifar A, Mirzaei H (2018) Nanoparticles as new tools for inhibition of cancer angiogenesis. J Cell Physiol 233(4):2902–2910.
- Bobo D, Robinson KJ, Islam J, Thurecht KJ, Corrie SR (2016) Nanoparticle-based medicines: a review of FDA-approved materials and clinical trials to date. Pharm Res 33(10):2373–2387.