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268 articles for “discovery”
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A Review Article on the Human Blood Groups in Relation to Healthy Longevity
Abstract: After significant discovery of the ABO blood groups of human beings by Karl Landsteiner, a number of works have been carried out on different types of blood groups like MN type, Q types, etc. and in the same time, number of researches were also carried regarding different aspects of blood groups like its genetic analysis, its inheritance, its role in paternity test, its role in blood transfusion and general physiology …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 3, 2024 · pp. 1–5 Read article
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Exploring Potential Phytochemicals for Myasthenia Gravis Treatment: A Molecular Docking and ADME Analysis Approach
Abstract: Objective: Muscle feebleness and exhaustion derived from a disruption in neuromuscular transference are hallmarks of the crippling autoimmune disease myasthenia gravis (MG). The drawbacks of the current MG therapy options are frequently partial efficacy and adverse effects. To investigate the potential of phytochemicals in MG control, in this work we integrated molecular docking with ADME (absorption, distribution, metabolism, and excretion) analysis using a computer method. We identified molecules exhibiting favorable …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 1–13 Read article
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Molecular Docking of Saraca asoca (Ashoka) Phytocompounds for Ovarian Cancer Therapy
Abstract: Objective: One of the top five cancers that causes death in women is ovarian cancer, with increases awareness till date the rate of survival is unpredictable. Even though there are advance treatments introduced, chemotherapy is most suggested to the ovarian cancer patients but the rate of relapses increased and the tumors get resistant towards the drugs. This present study is to evaluate the interaction of phytocompounds from Saraca asoca an …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 27–35 Read article
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Exploring the Therapeutic Potential of Grapeseed Phytoconstituent Through Molecular Docking Analysis for Multiple System Atrophy Treatment
Abstract: Objective: Alpha-synuclein (α-Syn) aggregates are a common neurodegenerative disorder associated with Parkinson’s disease and multiple system atrophy (MSA). As a fruit that is extensively grown, grapes have several pharmacological advantages when it comes to reducing oxidative stress. Research has indicated that grape seed phytoconstituents have a major effect on α-Syn. The objective of this study is to inquire into the pharmacological characteristics and potential therapeutic applications of grape seed derivatives …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 14–26 Read article
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Exploring the Role of Ginkgo biloba in Investigating 7L1X in Triple-Negative Breast Cancer Through Integrative Bioinformatics
Abstract: Objectives: Triple-negative breast cancer is a very dangerous form of cancer that affects mostly Hispanic and African American women above the age of 40. It represents approximately 15–20% of the global cancer incidence. This experiment aims to investigate the use of Gingko biloba in the treatment of the disease triple-negative breast cancer. Methods: We use a variety of online tools, and websites, including the Indian Medicinal Plants, Phytochemistry, and Therapeutics …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 2, 2024 · pp. 1–10 Read article
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Strategies for Increasing User Engagement in Academic Libraries
Abstract: Traditionally viewed as repositories of books, libraries are now evolving into dynamic community hubs. But even with this change, many libraries are dealing with a drop in patronage in a world that is becoming more digital.libraries face declining user engagement in an increasingly digital world. This research investigates effective strategies to revitalise library engagement and ensure its enduring relevance. Drawing from professional experience in an educational institution's library, it is …
Published in International Journal of Sustainability · Vol. 1, Issue 2, 2024 · pp. 1–5 Read article
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Microbial Symphony: Understanding Biochemical Pathways for Precision Medicine and Beyond
Abstract: The human microbiome, an intricate ecosystem of microorganisms inhabiting the body, is a key regulator of host biochemistry and physiology. This review delves into the complex biochemical pathways influenced by the microbiome, spotlighting critical metabolites like short-chain fatty acids, bile acids, and tryptophan derivatives, which impact immune regulation, energy metabolism, and neurobehavioral functions. By examining interactions between the microbiome and the host, including the influence of genetic factors and metabolite-driven …
Published in International Journal of Antibiotics · Vol. 2, Issue 1, 2025 · pp. 28–43 Read article
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Investigation of Residual Stress, and corrosion behavior of AA6082/Al 2 O 3 /C/ Si 3 N 4 Composite Material
Abstract: The main objective of the current study was to create AA6082/ Al2O3/C/Si3N4 Composite Material by the use of stir casting. The properties of the AA6082/ Al2O3/C/ Si3N4 Composite Material shown a significant improvement, with a micro-hardness rise of 13.5% and a residual stress decrease of 60%. As the testing parameters were increased, the residual stress of the AA6082/ Al2O3/C/ Si3N4 Composite Material rapidly decreased from -65MPa to -15MPa. An electromagnetic …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 1104–1109 Read article
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Techniques of Atomic Structure Orbit Potential of The Frequency Characteristics of Silicon Element
Abstract: This study explores the technological applications and material integration of semiconductor materials, with a focus on their electronic properties and practical implementations. The investigation primarily addresses four key objectives: analyzing the electronic band structure and density of states (DOS) of semiconductor materials, evaluating the band alignment in heterojunctions, and integrating these materials into practical technological applications. Using a simplified tight-binding model, we compute and plot the electronic band structure of …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 11, Issue 3, 2024 · pp. 16–32 Read article
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Alzheimer’s Disease Detection Using ML Algorithm
Abstract: A degenerative neurological state of affairs, Alzheimer's disease (AD) gradually impairs cognitive and functional capacities, especially in people over 65. Early AD detection is crucial for efficient management and treatment prep. This study delves into novel approaches for the early detection of AD using non-invasive methods. We've implemented a blend of neuroimaging data analysis and machine learning algorithms to pinpoint markers indicative of the disease during its initial phases. Our …
Published in Journal of Experimental & Applied Mechanics · Vol. 15, Issue 3, 2024 · pp. 53–57 Read article
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Exploring The Therapeutical Potential Of Pongamia Pinnata For Herpes Simplex Virus Type 1 (HSV-1)
Abstract: Objective: Pongamia pinnata (L.), commonly known as Indian beech or pongam tree, is a tropical plant renowned for its medicinal properties in traditional medicine systems. Extracts derived from various parts of Pongamia pinnata have demonstrated antimicrobial, anti-inflammatory, and immunomodulatory activities. Such attributes make it a compelling candidate for exploring its therapeutic potential against HSV infections. Thymidine kinase is the target protein mostly used in the treatment of HSV1 infections. In …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 1, 2025 · pp. 1–9 Read article
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Aerodynamic Influences on Structures with Varied Plan Configurations
Abstract: The wind-induced effects on tall buildings demonstrate a level of unpredictability, attributed to the intricate influence of the building's plan shape on the distribution of wind loads. The oscillations experienced by tall structures, both longitudinally and laterally, are influenced by factors such as wind direction, building configuration, height, and structural characteristics. This investigation is centred around examining the impact of wind on tall buildings featuring diverse plan cross-sectional shapes. The …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 377–388 Read article
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Evaluation of Small Vessel Disease by Advanced Brain Imaging
Abstract: Studying and comprehending brain small vessel disease requires extensive imaging. Recent applications of cutting-edge brain imaging techniques have led to the discovery of several significant results. Diffusion-weighted MRI studies have demonstrated the diagnostic accuracy of using clinical features alone or in combination with CT scan results to identify small vessel disease as the underlying cause is suboptimal in patients with acute lacunar syndromes. Acute infarcts caused by small vessel disease …
Published in International Journal of Cheminformatics · Vol. 2, Issue 1, 2024 · pp. 15–19 Read article
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Targeting Homogentisate Dioxygenase Dysfunction in Alkaptonuria: Investigating Curcuma longa’s Therapeutic Potential
Abstract: Objectives: Alkaptonuria is known to have a faulty gene HGO in the metabolic process. In the present research work, the focus is towards investigating the therapeutic capabilities of the Curcuma longa upon the faulty Homogentisate dioxygenase gene using ligand-protein binding, which would assist in the corrective tyrosine metabolism. Methods: This study is based on the computational approach using different phytochemicals for evaluation of the potency against the abnormal Homogentisate dioxygenase …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 2, 2024 · pp. 1–11 Read article
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A Comprehensive Review on Pharmacological Properties of Coumarins
Abstract: Coumarins are a diverse group of secondary metabolites found in a variety of plant species (over 1200 different coumarins have been identified from natural sources, especially plants), as well as in fungi and microorganisms. Coumarin is a simple, widely occurring chemical structure in nature, present in many plants, fungi, and bacteria. In recent years, these natural compounds have attracted growing interest from the scientific community due to their broad spectrum …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 2, 2024 · pp. 12–17 Read article
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Deciphering the Roles of Estrogen Receptors and 27-Hydroxycholesterol in BC Progression
Abstract: Breast cancer (BC) ranks among the top causes of cancer-related deaths in women worldwide. Many risk factors of BC are linked to estrogen. Experiments of Beatson in 1896 show the role of steroid hormones as major determinant in BC. Action of steroid hormones is mediated by their receptors including Estrogen receptors (ERs). ERs are part of a subfamily of ligand-regulated transcription factors. Their primary role is to translate hormone signals …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 18–26 Read article
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Recent Developments in Structural Genomics: Uncovering Cellular Functions
Abstract: Structural genomics has become a groundbreaking field for understanding cellular functions by revealing the three-dimensional structures of proteins and other biomolecules. This field combines advanced methods like X-ray crystallography, nuclear magnetic resonance spectroscopy, cryo-electron microscopy, and computational modeling to explore the molecular structure and behavior of cellular components. Recent advances have significantly accelerated the pace of structure determination, bolstered by high-throughput methods and artificial intelligence tools like AlphaFold. These developments …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 30–35 Read article
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Exploring the Connection: Analyzing the Relationship Between Duqu and Stuxnet
Abstract: Malware computer worms like Stuxnet and Duqu have the ability to take down any computer system in the globe. Although they are extremely similar to one another, Duqu is superior to Stuxnet. Because it comes in two versions, Duqu 1.0 and 2.0, it is also more harmful and dangerous than Stuxnet. The first malware attack to garner international attention was Stuxnet, which was designed to physically harm industrial infrastructure that …
Published in Journal of Telecommunication, Switching Systems and Networks · Vol. 11, Issue 3, 2024 · pp. 11–17 Read article
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Unlocking Microbial Potential: Innovations in Natural Product Biosynthesis and Therapeutic Applications
Abstract: MNPs play a pivotal role in diverse fields, spanning medicine, agriculture, and industry. This review paper synthesizes insights from various discussions on microbial natural products, encompassing their sources, bioactive properties, and applications. We explore microbial diversity contributing to natural product synthesis, emphasizing bacteria and fungi as prolific producers. The methods for isolating and characterizing these compounds underscore the interdisciplinary nature of microbial natural product research utilizing various analytical techniques contributing …
Published in International Journal of Fungi · Vol. 2, Issue 1, 2025 · pp. 18–38 Read article
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Beryllium Mineralogy and Its Strategic Applications in Modern Industries
Abstract: Beryllium, a rare lithophile element, exhibits unique physical and chemical properties that make it indispensable in various high-technology industries, including aerospace, nuclear energy, defense, and telecommunications. This review explores the mineralogy, extraction, applications, and resource distribution of beryllium, highlighting the metallurgical and industrial significance of its primary minerals, beryl and bertrandite. Despite being one of the lightest metals, beryllium boasts high strength, heat resistance, and conductivity, properties that support its …
Published in International Journal of Minerals · Vol. 1, Issue 2, 2024 · pp. 28–33 Read article