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222 articles for “therapeutic strategies”
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DMARDs, Biologic Agents and Novel Experimental Strategies in The Treatment of Rheumatoid Arthritis
Abstract: An inflammatory and autoimmune disease, rheumatoid arthritis (RA) causes severe pain and inflammation in affected areas of the body. According to the report, there is no known cure for RA. Therefore, reducing discomfort and halting future harm must be the goals of present therapy. For the purpose of prevention and to reduce disease activity in RA patients, significant success has been achieved with the continued development of disease-modifying antirheumatic drugs …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 1, 2024 · pp. 14–24 Read article
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Advancements in Photocatalysis: Applications in Environmental Remediation
Abstract: The study of radioluminescence, a phenomenon where materials emit light upon exposure to ionizing radiation, has expanded significantly in recent years, finding applications in various fields, including environmental remediation, radiation detection, and dosimetry. This paper reviews recent advancements in radioluminescent technologies, particularly focusing on Radioluminescent Isotope Cells (RLICs) and semiconductor colloidal quantum dots (cQDs). The use of RLICs, particularly those based on 63Ni, demonstrates enhanced energy conversion efficiency through optimized …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 2, Issue 2, 2024 · pp. 39–44 Read article
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Pharmacodynamics and Drug–Receptor Interactions: Integrating PK/PD Modeling with Modern Drug Development
Abstract: Understanding drug action requires an integrated perspective of pharmacodynamics and pharmacokinetics, which together determine therapeutic efficacy and safety. This review provides a comprehensive overview of the mechanisms underlying drug action, with particular emphasis on drug–receptor interactions and their role in modulating physiological responses. Drugs exert their effects primarily through interactions with specific biological targets, including receptors, enzymes, ion channels, and transporters, resulting in a spectrum of desired and adverse outcomes. …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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Enhancing the Bioavailability of Polyphenols: A Comprehensive Review
Abstract: The polyphenolic compounds are abundantly found in different plant parts including fruits, leaves, stem and seeds, and are known for possessing a wide range of biological activities. These include antioxidant, antimicrobial, anti-inflammatory, anticancer, antidiabetic, cardioprotective, and neuroprotective effects. Their functional relation with their structure highlights the significant therapeutic potential. As a result, the polyphenols are being further being exploited for applications in functional foods, pharmaceuticals, and targeted drug delivery. Despite …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 15, Issue 2, 2026 · pp. 37–51 Read article
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The Role of Pyruvate Dehydrogenase in Non-Alcoholic Fatty Liver Disease: Therapeutic Insights and Future Directions
Abstract: Non-alcoholic fatty liver disorders (NAFLD) are defined by the accumulation of excess fat in the liver that has no other cause, such as drinking alcohol. Pyruvate dehydrogenase has been established as an alternative treatment for this disorder. NAFLD pathogenesis is complex and includes oxidative stress inflammatory processes and mitochondrial dysfunction. Impaired liver fatty acid oxidation and glucose oxidation are significant individuals in developing NAFLD, and strategies to reverse these defects …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 44–51 Read article
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Anti-hyperglycemia Effects of Plant Secondary Metabolites Towards PKA/CREB Pathway Activation in Diabesity
Abstract: Objective: Diabesity, the amalgamation of diabetes and obesity, presents a significant global health challenge. This research carefully examines how plant secondary metabolites influence glucose regulation in diabetes using the PKA/CREB pathway, paying particular attention to diabesity—the combination of diabetes and obesity. Understanding the complex ways in which these metabolites affect metabolic health will help to identify new treatment approaches for managing diabetes and its associated problems. By conducting a thorough …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 33–50 Read article
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Utilize Nature’s Power: Nutraceuticals in the Fight Against Dengue
Abstract: As dengue fever continues to surge across tropical and subtropical regions, the exploration of novel therapeutic approaches is crucial. Nutraceuticals, natural bioactive compounds derived from food sources, are emerging as promising adjuncts in the fight against this viral disease. Unlike conventional treatments that primarily target symptoms, nutraceuticals offer a complementary strategy by enhancing the body’s immune defense and addressing key complications. This review highlights the diverse potential of nature’s remedies, …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 1, 2025 · pp. 19–27 Read article
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Microsphere-Based Drug Delivery: A Critical Review of Innovations and Applications
Abstract: Microspheres have emerged as a revolutionary approach in pharmaceutical sciences, offering controlled and targeted drug delivery with improved bioavailability, stability, and patient compliance. These spherical carriers, ranging from nanometers to micrometers in size, can encapsulate both hydrophilic and hydrophobic drugs, enabling sustained and site-specific release. The development of microspheres has been significantly driven by the need to enhance drug efficacy while minimizing systemic side effects. This review provides a comprehensive …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 52–59 Read article
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Influence of Antibiotic Promotion Practices on Pharmacovigilance and Resistance Reporting Patterns
Abstract: The global escalation of antimicrobial resistance (AMR) has emerged as a critical public health crisis, undermining decades of therapeutic advancements. While inappropriate prescribing and misuse of antibiotics are widely acknowledged contributors, the role of pharmaceutical promotion practices remains underexplored in influencing prescribing behaviors and downstream pharmacovigilance systems. This review critically examines how antibiotic promotion strategies – ranging from direct physician engagement to digital marketing – affect adverse drug reaction (ADR) …
Published in International Journal of Antibiotics · Vol. 3, Issue 2, 2026 · pp. 1–11 Read article
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Nutritional Status, Bioactive Properties & Therapeutic Efficacy of Omega-3 Polyunsaturated Fatty Acids Obtained by Green Synthetic Routes
Abstract: Polyunsaturated fatty acids (PUFAs), particularly omega-3 (n-3) fatty acids like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are crucial for human health. They support structural brain development, visual acuity, and cardiovascular function, while also exhibiting potent anti-inflammatory, antioxidant, and antimicrobial properties. Historically, marine fish oil has been the primary dietary source of these essential fatty acids. However, escalating concerns regarding ecological environmental impacts, the oceanic bioaccumulation of heavy metal contaminants, …
Published in International Journal of Nutritions · Vol. 3, Issue 2, 2026 Read article
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Exploring Malaria Fever (Vishama Jwara) Through an Ayurvedic Lens: A Comprehensive Review
Abstract: Malaria fever, known as Vishama Jwara in Ayurveda, is a significant global health challenge caused by the Plasmodium species transmitted via Anopheles mosquitoes. While conventional medicine has advanced in diagnosing and treating malaria, exploring it through the Ayurvedic perspective offers valuable insights into its holistic understanding and management. Ayurveda describes Vishama Jwara as a fever with irregular patterns, aligning with the cyclical febrile episodes seen in malaria. This review delves …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 13, Issue 3, 2024 · pp. 47–53 Read article
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A Study on accelerating threat of Emerging Infectious Diseases (EIDs) and imperative for a proactive, interdisciplinary Global Health Security Framework
Abstract: Emerging Infectious Diseases (EIDs) represent one of the most critical and persistent threats to global health security in the 21st century. Driven primarily by the synergy of unprecedented human encroachment into wild habitats, climate change-induced ecological disruption, accelerated international travel, and antimicrobial resistance, the frequency and severity of zoonotic spillover events are rapidly increasing. Traditional, reactive public health measures—focused on containment after an emergence—have repeatedly proven insufficient, leading to catastrophic …
Published in International Journal of Tropical Medicines · Vol. 3, Issue 1, 2026 · pp. 8–21 Read article
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Crispr Cas – Revolutionizing Modern Therapies and Beyond
Abstract: CRISPR-Cas technology has emerged as a transformative tool in modern molecular biology, revolutionizing both fundamental research and clinical applications. This RNA-guided gene-editing system enables precise and efficient genomic modifications, offering unprecedented potential for addressing genetic disorders, infectious diseases, and oncological conditions through innovative therapeutic interventions. The inherent specificity and programmability of CRISPR-Cas systems have facilitated breakthroughs in diverse fields, including precision medicine, regenerative therapies, and immuno-oncology. Beyond its therapeutic applications, …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 25–38 Read article
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From Clinic Formulation to Development of Acebrophylline
Abstract: Acebrophylline, a commonly utilized bronchodilator with anti-inflammatory properties, has become a key therapeutic option for managing respiratory conditions like asthma, chronic obstructive pulmonary disease (COPD), and chronic bronchitis. This review explores the journey of Acebrophylline from its clinic formulation to its development and commercialization, focusing on the key aspects of formulation strategies, pharmacological properties, and regulatory considerations. The drug’s dual mechanism of action, which involves both bronchodilation and anti-inflammatory effects, …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 35–48 Read article
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A Review on Applications of Artificial Intelligence (AI) in Parkinsons’s Disease Diagnosis and Treatment and Its Future Challenges
Abstract: Parkinson’s disease (PD) is a long-term, progressive neurodegenerative disorder that mainly occurs in people older than 60 years, affecting nearly 1% of this population. It is chiefly marked by the loss of dopaminergic neurons in the substantia nigra, a crucial brain region responsible for controlling motor functions. The resultant dopamine deficiency significantly disrupts motor control, manifesting in clinical symptoms such as tremors, bradykinesia, muscle rigidity, and postural instability. While PD …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 3, 2025 · pp. 1–15 Read article
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Management of Varicose Veins: A Review of Literature
Abstract: Lower extremities venous insufficiency is a frequent disorder that can cause a variety of symptoms, such as ulceration, soreness, swelling, and bulging leg veins. Whereas there is many other treatment choices, the more recent endovascular treatments are simple, safe, rapid, and very effective at reducing symptoms. Foam sclerotherapy, thermal ablation, and mechanical chemical ablation are minimally invasive endovascular techniques commonly used in the treatment of varicose veins. This review article …
Published in Research and Reviews : Journal of Surgery · Vol. 14, Issue 1, 2025 · pp. 17–21 Read article
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STRUCTURAL–EPIGENOMIC ATLAS: CNV/SV- DRIVEN PROGNOSTIC REFINEMENT ACROSS CANCERS
Abstract: Structural genomic alterations, including copy number variations (CNVs) and structural variants (SVs), play a central role in cancer initiation and progression. These alterations extend beyond gene dosage effects and interact dynamically with epigenomic mechanisms such as DNA methylation, histone modifications, and three-dimensional chromatin organization. Recent pan-cancer studies have demonstrated that CNV burden and SV signatures reflect key oncogenic processes including chromothripsis, homologous recombination deficiency, enhancer hijacking, and extrachromosomal DNA (ecDNA) …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 1, 2026 Read article
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Review on Formulation and Evaluation of Herbal Gel of Moringa oleifera and Aloe vera for management of acne
Abstract: Acne vulgaris is a prevalent chronic inflammatory disorder of the pilosebaceous units, characterized by excessive sebum production, follicular hyperkeratinization, bacterial colonization, and inflammation. Conventional therapies often result in side effects and the development of drug resistance, prompting the exploration of natural alternatives. This review highlights the potential of Moringa oleifera and Aloe vera in acne management via topical drug delivery systems (TDDS). Moringa oleifera is rich in bioactive compounds such …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 1, 2026 · pp. 10–16 Read article
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Tsetse Flies and African Trypanosomiasis: Biology, Epidemiology, and Integrated Vector Control.
Abstract: Tsetse flies (Glossina spp.) are hematophagous dipterans confined to sub-Saharan Africa and serve as cyclical vectors of human African trypanosomiasis (HAT) and African animal trypanosomiasis (AAT), with major implications for human health, livestock productivity, and rural development. An integrated understanding of tsetse biology, parasite transmission, climate, and land–use–driven distribution shifts, and the comparative performance of control tools—especially insecticides and sterile insect technique (SIT)—is essential for designing sustainable elimination strategies. HAT …
Published in International Journal of Insects · Vol. 3, Issue 1, 2026 · pp. 21–28 Read article
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What Nurses Should Know About New Ways to Treat Muscle Pain
Abstract: Muscle discomfort is a common clinical concern that can significantly limit mobility, functional ability, and overall quality of life. Recent advancements in assessment and management strategies have enabled nurses to deliver more precise, evidence-based care for patients experiencing muscular pain. Emerging diagnostic approaches now include enhanced screening scales that offer greater sensitivity in identifying pain patterns, as well as digital monitoring tools that allow continuous evaluation of symptoms across care …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 3, Issue 2, 2025 · pp. 12–17 Read article