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1929 articles for “sign” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Molecular Docking studies of Benzodiazepine Derivatives With GABA(B) Receptor
Abstract: Benzodiazepines (BZDs) are pharmacologically significant compounds that act by binding to GABA A neurotransmitter receptors, subsequently augmenting GABA-induced chloride ion flux, consequently inducing neuronal hyperpolarization. Benzodiazepines are commonly used in the treatment of sleep disorders, anxiety, muscle spasms, seizure disorders, and some forms of depression. The primary inhibitory neurotransmitter, GABA, functions on two types of receptors: the ligand-gated GABA A/C receptors and the G protein-coupled GABA B receptors. These neurotransmitters …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 2, 2024 · pp. 1–14 Read article
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Exploring the properties and extraction of neem leaves
Abstract: Neem (Azadirachta indica) is a versatile medicinal plant, for its diverse therapeutic properties. This abstract provides a comprehensive overview of recent research focusing on phytochemical analysis, biochemical characterization, and antimicrobial susceptibility testing of Neem extracts. Utilizing the different from of chemical used in it, phytochemical analysis identified a plethora of secondary metabolites within Neem, including alkaloids, flavonoids, terpenoids, steroids, saponin, tannins, quinone, and phenolic compounds, indicative of its complex chemical …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 2, 2024 · pp. 32–39 Read article
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Drug abuse in Teenagers
Abstract: Teenage drug abuse is a significant public health concerns with far - reaching consequences. This abstract provides on overview of the prevalence, contributing Factor and consequences of drug abuse among adolescents. Drug abuse remains persistence and multifaceted issue globally, affecting individual’s families and society. Factors that influence the teenagers to experiment with drugs, including peer pressure, family dynamics and predisposition. The abstract also describes the various substance abused by teenagers, …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 2, 2024 · pp. 15–25 Read article
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Role of JIPMER Burn Progress Proforma
Abstract: Burn injuries represent a significant contributor to mortality rates in developing nations such as India. While critical care ICUs commonly utilize progress proformas, those specifically tailored for burns are less prevalent. Recognizing this gap, a modified burn progress proforma has been developed to encompass comprehensive details for both acute management and rehabilitation strategies. In a country like India, where burns can have severe consequences, the need for a specialized progress …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 1, 2024 · pp. 6–10 Read article
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Role of Dried Allogenic Amniotic Membrane in Second degree Scald Burns
Abstract: Burn injuries represent a significant portion of common injuries, stemming from thermal, scalding, or electrical incidents. Among these, scald injuries stand out as the predominant type in children under five years old, constituting a majority, with over 65% of cases falling under this category. Currently, various scaffolds are employed to enhance the healing process and mitigate scar formation. Collagen plays a crucial role as a scaffold, facilitating tissue regeneration and …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 1, 2024 · pp. 25–30 Read article
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Design and Evaluation of Extended-Release Tablet Compositions Containing Oxaprozin: Integrating Concepts from Bioinformatics
Abstract: The procured sample of Oxaprozin was tested for its identification. The manufacturer also was confirmed of quality and purity of sample. The sustained release tablets of Oxaprozin were prepared by wet granulation method, They were evaluated for weight variation, drug content, friability, hardness, and thickness for all batches (T-1 – T-10). The release of Oxaprozin from sustained release tablet of various formulations varied according to the ratio and degree of …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 1, 2024 · pp. 39–45 Read article
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Microneedles and the paradigm shift in the field of dentistry: A Review Article
Abstract: Needle-based instruments are advancing as a promising tool for both diagnosis and treatment within the medical realm. They possess versatility, being capable of drug delivery and fluid extraction, catering to both systemic and local requirements. Unlike traditional drug delivery methods, which necessitate repeated dosing in the oral cavity due to saliva presence, there's a growing demand for delivery systems like needle-based devices that can offer sustained drug release orally. These …
Published in Research and Reviews: A Journal of Dentistry Read article
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Comparative Evaluation of Variable Thicknesses of Vacuum-formed Retainers
Abstract: Since the commencement of this orthodontic specialty, it is a grueling and portentous task to maintain the orthodontically treated teeth in their corrected and desired position. Retention of what has been achieved is the goal and the most clamant phase of any orthodontic treatment as well as the orthodontist. To maintain the stomatognathic system's esthetics, function, and stability, orthodontic retainers play a vital role in precluding post-treatment tooth movement. The …
Published in Research and Reviews: A Journal of Dentistry · Vol. 15, Issue 1, 2024 · pp. 12–16 Read article
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Design and Evaluation of Extended-Release Tablet Compositions Containing Oxaprozin: Integrating Concepts from Bioinformatics
Abstract: The procured sample of Oxaprozin was tested for its identification. The manufacturer also was confirmed of quality and purity of sample. The sustained release tablets of Oxaprozin were prepared by wet granulation method, They were evaluated for weight variation, drug content, friability, hardness, and thickness for all batches (T-1 – T-10). The release of Oxaprozin from sustained release tablet of various formulations varied according to the ratio and degree of …
Published in Research and Reviews: A Journal of Toxicology · Vol. 11, Issue 1, 2024 · pp. 39–45 Read article
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Zolmitriptan Mouth Dissolving Tablets: Development of Formulas and Invitro Evaluation
Abstract: Pharma Burst ODT super disintegrants were used in different concentrations to manufacture Zolmitriptan fast dissolving tablets by a direct compression method. With a 28° angle of repose, there is good flow. The densities for bulk and tapped materials are 0.410 (g/ml) and 0.500 (g/ml), respectively. The compressibility index and Hausner ratio have values of 19.05 and 1.24, correspondingly. According to IP standard, weight variation test results range from 121.4 mg …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 2, 2024 · pp. 1–15 Read article
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Deciphering Th-Related Gene Interactions in Chronic Spontaneous Urticaria: Bioinformatics Insights and Drug Affinity Exploration
Abstract: Objective: There has been a great deal of interest in how inflammatory dermatosis and The cell interact, but the etiopathogenesis of chronic spontaneous urticaria (CSU) is still inadequately comprehended. Through bioinformatics techniques, the purpose of this work is to elucdate the molecular mechanism underlying Th-related genes in CSU and seeks to find the highest affinity drug. Methods: The CSU RNA expression profiling dataset provided the basis for the investigation. The …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 1–15 Read article
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A study conducted among young women living in specific locations of Honavar, Uttara Kannada, to evaluate their attitudes and knowledge about women abuse. With a view to organize a Mass Health Education Programme
Abstract: Worldwide and regional projections of violence against women indicate More than 25% of women in relationships between the ages of 15 and 49 report having experienced physical or sexual abuse at least once in their lifetime (since they were 15). Up to 38% of all female killings globally are the result of intimate relationship violence. Apart from domestic violence, 6% of women worldwide report experiencing sexual assault at the hands …
Published in International Journal of Brain Sciences · Vol. 1, Issue 1, 2024 · pp. 5–12 Read article
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Identification and Categorization of Brain Tumors
Abstract: Brain tumors are a serious and aggressive disease that can lead to a reduced life expectancy. Strategic and well-thought-out treatment planning significantly contributes to improving a patient's overall quality of life. Many different imaging techniques, such as Magnetic Resonance Imaging (MRI), Computed Tomography (CT) and also ultrasound are used to evaluate tumors in different parts of the body, with a focus on using MRI images for brain tumors. It is …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 1, Issue 2, 2023 · pp. 32–37 Read article
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Innovative Use of Pressure Relieving Foam Based Garment for Lumbar Pressure Sore
Abstract: Pressure ulcers, stemming mainly from friction and shear forces, manifest as chronic wounds that worsen over time. They commonly afflict individuals who are bedridden or have limited mobility. Our investigation involved a 62-year-old male with a hypertrophic scar on his back resulting from the excision of a carbuncle. Subsequently, he developed a lumbar pressure sore at the scar site. To address this issue, adjustments were made to his pressure garment, …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 52–56 Read article
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Optimizing Concrete Strength and Sustainability: Quarry Dust and Copper Slag Powder Additives
Abstract: This research investigates the potential of quarry dust and copper slag powder additives to enhance the strength and performance of concrete. Compressive strength tests were conducted on mortar cubes at 7 and 28 days to evaluate the effects of these additives. The results indicate significant improvements in compressive strength over time, with Mix A4 achieving a remarkable 43.42% increase in strength at 28 days. Other mixes also demonstrated substantial strength …
Published in Journal of Construction Engineering, Technology & Management · Vol. 14, Issue 1, 2024 · pp. 1–6 Read article
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Comprehensive Review of Recycled Aggregate Concrete in Construction: Suitability, Properties, and Sustainable Practices
Abstract: Concrete production, integral to construction and demolition processes, generates substantial waste. This waste can be repurposed as recycled aggregates in new concrete production, offering sustainable solutions and addressing resource management and environmental concerns. This literature review explores the utilization of construction and demolition waste as aggregates in recycled aggregate concrete (RAC), with a focus on key areas, including the suitability of RAC, its fresh properties, mix design, mechanical characteristics, and …
Published in Recent Trends in Civil Engineering & Technology · Vol. 14, Issue 1, 2024 · pp. 1–8 Read article
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Empowering Concrete: Enhancing Strength and Durability with Coal Bottom Ash
Abstract: The utilization of coal bottom ash, an industrial waste byproduct, as a sustainable alternative to river sand in concrete production has gained increasing attention due to environmental concerns and the need for resource optimization. This study examines how incorporating coal bottom ash into concrete mixtures, either partially or entirely replacing river sands, affects different properties. These properties include the workability of fresh concrete, as well as its compressive strength, splitting …
Published in Recent Trends in Civil Engineering & Technology · Vol. 14, Issue 1, 2024 Read article
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A Case Study on Ayurvedic Management of Psoriasis.
Abstract: Psoriasis is non-contagious, chronic autoimmune disease which causes inflammation and hyper-proliferation of the skin. It is characterized by erythematous plaques that are clearly defined and associated with severe itching and silvery scaling, especially on extensor surfaces, scalp and nails. At times, it may manifest as localized or generalised pustular eruption which usually follows relapses and remissions pattern. Psoriasis may lead to other autoimmune diseases like psoriatic arthritis. In Ayurveda, Variety …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 13, Issue 1, 2024 · pp. 18–22 Read article
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Green Human Resource Management: Trends in Sustainable and Agile Human Resources Research in SMEs
Abstract: Small and medium-sized enterprises (SMEs) collectively have a significant environmental impact, despite each individual SME having a relatively small footprint. To mitigate this impact, the implementation of green human resource management practices is crucial for effective workforce management within SMEs. However, SMEs face challenges in executing these strategies and ensuring long-term business continuity. This study aims to establish a theoretical framework for a business model that can assist SMEs in …
Published in International Journal of Environmental Noise and Pollution Control · Vol. 1, Issue 2, 2023 · pp. 9–33 Read article
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What Does Location of Abdominal Pain Say, Anatomically and Homoeopathically
Abstract: Background and justification for the study: Every symptom is an indication of bodily derangements which a patient feels when sick. The medical personal has to recognize these derangements only by symptomatic study of the disease without making any hypothetical theories. Therefore, examining symptoms is the sole correct method for determining the presentation of a disease. In Homoeopathy, a complete symptom is that which covers location, sensation, modalities and concomitant symptoms. …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 11, Issue 1, 2024 · pp. 14–19 Read article