Search
176 articles for “side effects”
-
CB₁ Reverse Agonists: A Cheminformatic and Patent Landscape Study
Abstract: The endocannabinoid system plays a crucial role in numerous physiological functions, making cannabinoid receptor 1 (CB1) an attractive target for therapeutic development. This review provides a systematic analysis of patent filings from 2019 to 2023 that focus on small-molecule CB1 reverse agonists. It begins with an overview of the endocannabinoid system, highlighting CB1’s involvement in energy balance, pain regulation, and neuroinflammatory processes The main section of the review examines fifteen …
Published in International Journal of Cheminformatics · Vol. 3, Issue 2, 2025 · pp. 33–36 Read article
-
Formulation and Evaluation of Herbal Face Pack Using Moringa
Abstract: In the global market herbal cosmetics have a growing demand. Many cosmetics are being manufactured by pharmaceutical companies. Since ancient times, people have utilized herbal cosmetics, which are natural cosmetics. Since herbal cosmetics have lesser side effects than synthetic ones, they are more prevalent. Over 80% of people on the planet rely on herbs. These herbs not only treat the diseases but also are used in the form of cosmetics. …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 1, 2026 · pp. 1–5 Read article
-
An Integrative Review of Male Sexual Disorders and the Therapeutic Role of Unani Aphrodisiacs
Abstract: Sexual health is a vital component of overall well-being, encompassing physical, emotional, and psychosocial dimensions. Male sexual dysfunction – including conditions, like erectile dysfunction, premature ejaculation, and low libido – can significantly impact quality of life and intimate relationships. Aphrodisiacs, derived from the Greek goddess Aphrodite, are substances that stimulate sexual desire and performance. Historically, natural aphrodisiacs have been used in various cultures and include plant-based substances such as Yohimbine, …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 12, Issue 3, 2025 · pp. 8–15 Read article
-
Nanoformulation Strategies: Emerging Innovations in Drug Delivery Systems
Abstract: Nanotechnology is significantly advancing the pharmaceutical industry by introducing nanosystems that improve drug delivery, therapeutic efficacy, and patient outcomes. Various nanosystems-such as liposomes, dendrimers, polymeric nanoparticles, solid lipid nanoparticles, carbon nanotubes, and metallic nanoparticles-offer benefits like enhanced bioavailability, targeted delivery, improved stability, and reduced side effects. Innovative formulation strategies, including surface functionalization, particle size optimization, and use of biodegradable carriers, support controlled and sustained drug release. Additionally, production in non-aqueous …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 54–67 Read article
-
Nanotechnology In Herbal Medicine
Abstract: Herbal medicine has been widely used for centuries as a natural and holistic approach to health care. However, many herbal compounds face challenges such as low solubility, low bioavailability, instability, and the lack of targeted delivery, which affect their efficacy. The integration of nanotechnology into herbal medicine has emerged as a promising strategy to overcome these challenges and enhance the pharmacological potential of plant-derived compounds. Nanocarriers such as liposomes, solid …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 1, 2025 · pp. 50–69 Read article
-
Plant Bioactive Metabolites and Their Role in the Prevention and Control of Dental Diseases and Infections.
Abstract: The oral diseases, including dental caries and periodontitis, affect masses worldwide, and have historically been managed with synthetic antimicrobials that cause deleterious side effects, leading to mounting bacterial resistance. Consequently, contemporary dentistry is rapidly shifting toward phytomedicine using plant bioactive molecules, such as polyphenols, terpenes, anthraquinones (berberin, eugenol, curcumin, catechins, allicin, and azadirachtin. These compounds offer potent antimicrobial, anti-inflammatory, and tissue-regenerative properties that are crucial for preventing and curing dental …
Published in Emerging Trends in Metabolites · Vol. 3, Issue 1, 2026 · pp. 47–66 Read article
-
Preoperative Use of Midazolam vs Dexmedetomidine for Anxiolysis in Day-Care Surgery
Abstract: Surgical procedures trigger significant fear and anxiety that can adversely affect physiological responses and recovery outcomes. This prospective, randomized, double-blinded clinical trial compared the anxiolytic efficacy and safety of intravenous midazolam and dexmedetomidine in 60 patients undergoing day-care surgery. Primary outcomes included anxiety scores measured by STAI and sedation assessed by the OAAS scale at multiple perioperative time points. Secondary outcomes assessed in the study included detailed evaluation of hemodynamic …
Published in Research and Reviews: A Journal of Medicine · Vol. 16, Issue 1, 2026 · pp. 7–12 Read article
-
GLP-1 Receptor Agonists: A Dual Therapeutic Strategy for the Management of Type 2 Diabetes Mellitus and Obesity
Abstract: For the treatment of obesity and type 2 diabetes mellitus (T2DM), glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become a revolutionary class of pharmaceutical drugs. These drugs were first created as glucose-lowering treatments, but they have now shown other advantages, such as notable weight loss, better cardiovascular results, and general metabolic control. The objective of this narrative review is to assess the pharmacological mechanisms, clinical efficacy, safety profile, and therapeutic …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 69–75 Read article
-
Immunological Mechanisms Underlying Autoimmune Disorders: Recent Advances and Therapeutic Implications
Abstract: A diverse range of illnesses known as autoimmune disorders are typified by dysregulated immune responses against self-antigens, which result in tissue damage and persistent inflammation. Understanding the genetic, epigenetic, and environmental variables that contribute to autoimmune pathogenesis has advanced significantly during the last ten years. Current disease models have been transformed by new understandings of immunological tolerance mechanisms such as the functions of regulatory T cells, cytokine networks, and the …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 1, 2026 · pp. 21–25 Read article
-
A Comprehensive Review of Ethnobotanical Studies on Traditional Indian Herbal Plants for Lung Cancer Management
Abstract: Lung cancer is a leading cause of cancer-related deaths in the world. Current therapies for lung cancer are often limited by many side effects. This review compiles and evaluates ethnobotanical evidence and modern scientific findings of Indian herbal plants traditionally used for respiratory and tumor-related disorders, with a focus on their relevance to lung cancer management. Herbal phytochemicals and how they show their potent activities were also listed in this …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 1, 2026 · pp. 1–7 Read article
-
Molecular Dynamics and Therapeutic Architectures of Cannabinoid Receptors: A Comprehensive Review
Abstract: Expanding on these foundations, recent structural biology studies using cryo-electron microscopy have provided high-resolution insights into the conformational dynamics of CB₁ and CB₂ receptors. These findings have enabled a more precise understanding of ligand–receptor interactions, particularly how agonists, antagonists, and reverse agonists stabilize distinct receptor states. Such knowledge is critical for rational drug design, allowing researchers to selectively modulate downstream signaling pathways. For instance, CB₁ receptors primarily couple to Gi/o …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 36–40 Read article
-
Advances in Stimuli-Responsive Smart Drug Delivery Systems: A Systematic Review
Abstract: Imagine a world where medicines work smarter, not harder. Stimuli-responsive drug delivery systems (SRDDS) are transforming healthcare by releasing therapeutic agents in response to specific triggers. These triggers can be internal, like changes in pH or temperature, or external, like light or magnetic fields. By leveraging these triggers, SRDDS can optimize treatment and minimize side effects. The potential applications of SRDDS are vast, from cancer treatment to gene delivery and …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article
-
A Review on Poly Herbal Anti-Dandruff Shampoo with Bay and Betel Leaves
Abstract: Dandruff is one of the most common scalp problem it is mainly caused by the abnormal growth of yeast Malassezia species. It can lead to itching, irritation, excessive shedding of dead skin. Most of the anti-dandruff shampoos are made up of chemical based which are available in the market, they may give quick results but their long-term use will show side effects like hair dryness, damage, irritation, frizziness. To overcome …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 2, 2026 Read article
-
Assessment of Knowledge, Attitudes and Practice of Family Planning among Women of Reproductive Age in Northern Nigeria: A Sociological Study
Abstract: Family planning is a very vital element of reproductive health that enables individuals and couples to decide on how many and how far they would have their children. It is important in enhancing maternal health, child health, alleviating poverty and enhancing sustainable development. Although family planning services are available in Nigeria, their use has been low in most regions in the country especially Northern Nigeria. The paper evaluated the KAP …
Published in International Journal of Behavioral Sciences · Vol. 3, Issue 1, 2026 · pp. 45–64 Read article
-
A Review on Formulation and Evaluation of Polyherbal Face Sheet Mask.
Abstract: This research focuses on the formulation and evaluation of a polyherbal face sheet mask developed using natural herbal ingredients to address common skin concerns such as acne, dullness, pigmentation, sun damage, dark spots, and uneven skin tone. With the increasing demand for safe, eco-friendly, and chemical-free skincare products, herbal-based cosmetic formulations have gained significant attention due to their therapeutic properties, minimal side effects, and enhanced consumer acceptance. Face sheet masks …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 2, 2026 Read article
-
Thermo-Hydraulic Enhancement of Annular Finned Shell-and-Tube Heat Exchangers Using Epoxy-Based Polymer Composites: A Material–Geometry Coupled CFD Investigation
Abstract: Shell-and-tube heat exchangers remain a backbone of industrial thermal systems, yet their performance is often limited by relatively low shell-side heat transfer and the weight and cost associated with conventional metallic components. In this context, the integration of polymer composite materials offers a promising pathway toward lightweight, corrosion-resistant, and performance-tunable heat exchanger designs. The present study investigates the thermo-hydraulic performance of a straight-tube shell-and-tube heat exchanger equipped with annular fins, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 669–684 Read article
-
Cardanol Glycidyl Ether in Advanced Materials: Recent Progress, Synthetic Strategies, and Future Perspectives
Abstract: Cardanol glycidyl ether (CGE), a bio-based precursor and epoxy derived product has been emerged as a promising sustainable alternative to conventional petroleum-based epoxy materials. Due to the presence of a phenolic hydroxyl group and an unsaturated aliphatic side chain, cardanol can be effectively undergoes glycidylation to produce reactive epoxy monomers that has excellent flexibility, hydrophobicity, low viscosity, and notably good chemical resistance. In recent years, CGE-based systems have attracted remarkable …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 Read article
-
A Study to Evaluate the Effectiveness of a Structured Teaching Program on the Knowledge and Practice of Road Traffic Accident Prevention Measures Among Teenagers
Abstract: An investigation to evaluate the impact of a structured educational program on the understanding and implementation of strategies for preventing road traffic accidents among teenagers. Introduction: Accident is an accidental injury, passing or property harm happening in a grouping of occasions. Accidents don't simply occur; they are neglectfulness, indiscretion, carelessness, and flashing absence of focus. Accidents have turned into a significant reason for dismalness and mortality, particularly among the grown-ups …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 1, Issue 1, 2023 · pp. 29–40 Read article
-
Market Architecture, an Effect of Roadside Trading in Port Harcourt Metropolis. A Case Study of Rumu-Woji Market, Rivers State, Nigeria
Abstract: The challenges of road side trading along major market roads in Port Harcourt Metropolis has brought about certain menace to the city. The efforts put in place by the Rivers State government to eradicate the act of roadside trading along market roads have been proven abortive. Various means employed by the government to stop the act of roadside trading have not been successful such as, relocation of traders, barricading market …
Published in International Journal of Urban Design and Development · Vol. 3, Issue 1, 2025 · pp. 36–46 Read article
-
Enhancing Power Quality and Harmonics Control via Integration of PV, Wind, and Battery Systems with Three-level Inverter in DC Micro grid Management
Abstract: The primary goal of this research is to develop a multi-level inverter-based energy management approach for a smart DC-micro grid. An electric micro grid is created in this project by combining photovoltaic (PV), wind, and batteries. Solar and wind power can be efficiently extracted, and the quality of power can be improved by using FOPID control for source-side converters (SSC) and load-side converters controlled by multilevel inverters. To make the …
Published in Journal of Power Electronics and Power Systems · Vol. 14, Issue 1, 2024 · pp. 18–27 Read article