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268 articles for “discovery”
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Molecular Docking and Interaction of Anthocyanin Derivatives in Regulating Hippo-taz Pathway for Renal Injuries
Abstract: Introduction: The Hippo pathway plays a pivotal role in renal disease, with Yes-associated protein (YAP) exhibiting promise for combined treatments. The crucial evaluation of YAP-targeted drug safety and efficacy through preclinical studies is imperative. Additionally, α-SMA and SMAD3 emerge as potential therapeutic targets in renal fibrosis, driving ongoing research toward innovative interventions. Materials and Methods: In the systematic identification of therapeutic secondary metabolites, Anthocyanin derivatives were methodically retrieved from the …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 23–38 Read article
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Universities in Ancient Bharat
Abstract: Our country was very much rich in respect of scientific, spiritual, literature and medical knowledge and even also in gross domestic product in comparison to any other country of the world. In single sentence, Bharat (India) was the leader in many respects in the world. Frequent Muslim aggressions started from 711 A.D., looting, burning and killing the intelligent persons by the Muslim in Bharat and destroyed not only physical wealth …
Published in Recent Trends in Social Studies · Vol. 1, Issue 1, 2024 · pp. 01–12 Read article
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Tobacco Use Among Government and Public School Students in the Sangam Vihar Area of South Delhi
Abstract: The most fundamental right inherent to all human beings, as recognized in international law, is the right to health. Men and women worldwide prioritize good health as their top aspiration when asked to rank their desires. Currently, one of the most significant global challenges to achieving this desire is the widespread epidemic of tobacco use. This exceptional epidemic is notable not just for its magnitude but also for its characteristics. …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 1, 2024 · pp. 1–5 Read article
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Evolution of War Technology
Abstract: The continued evolution of combat technology is examined in this research study, which also discusses recent trends, historical developments, and possible future developments in this important area. Throughout history, the quest for military superiority has propelled considerable advancements in warfare technology. This study provides a succinct examination of this evolutionary process, shedding light on historical turning points, modern cutting-edge technologies, and expected future developments in combat. Important advances in the …
Published in Journal of Advancements in Robotics · Vol. 11, Issue 1, 2024 · pp. 25–32 Read article
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A Machine Learning Based Artificial Intelligence Model for Detecting Heart Illness
Abstract: This study centers around the improvement of an artificial intelligence- and computerized reasoning-based heart sickness determination framework. We exhibit how AI can help with foreseeing whether an individual will get cardiovascular infection. In this review, a Python-based application for medical care research is created since it is more reliable and helps track and lay out many kinds of well-being observing applications. We show information handling, which incorporates working with all …
Published in Journal of Computer Technology & Applications · Vol. 15, Issue 1, 2024 · pp. 50–58 Read article
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Long non-coded RNA, cancer, immune cells, tumor micro-environment, immuno-oncology, immune escape, cancer-immune cycle, lncRNA signature
Abstract: Developing data from current research reveals fresh insights into the roles played by long non-coding RNAs (lncRNAs) in immuno-oncology. Long non-coding RNAs (lncRNAs) not only influence the aggressiveness of cancer cells but also play a crucial role in controlling different immune cells and stromal cells, which in turn changes the tumor micro-environment and impacts anti-tumor immunity. The significance of predictive indicators derived from long non-coding RNAs (lncRNAs) is underscored by …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 1, 2024 · pp. 7–26 Read article
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Advancing Library Systems: The Impact of OPACs on Research and Learning
Abstract: The Online Public Access Catalogue (OPAC) has emerged as a transformative tool in library science, reshaping the landscape of information access and retrieval. This abstract explores the historical evolution, functionalities, and broader implications of OPAC systems in modern libraries. Initially conceived as digital replacements for traditional card catalogs, OPACs have undergone significant advancements, leveraging internet technologies to offer users unprecedented access to library collections. From basic search functionalities to sophisticated …
Published in International Journal of Electronics Automation · Vol. 1, Issue 2, 2023 · pp. 8–19 Read article
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Strength and Compressibility Behaviours of Expansive Soil Treated with Coffee Husk Ash and Xanthan Gum
Abstract: The strength of the sub-grade, the caliber of the subbase and base course, the surrounding conditions, and the characteries of the soil utilized are some of the variables that might impact how long a road lasts. Because expansive soil swells and shrinks in response to variation in moisture content, roads constructed on it are especially vulnerable to early deterioration. Buildings with black cotton soils have experienced different settlement due to …
Published in Journal of Polymer & Composites · Vol. 12, Issue 2, 2024 · pp. 80–90 Read article
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Advancements in Antiviral Therapeutics: Strategies and Challenges in the Development of Drugs and Vaccines for Viral Diseases
Abstract: Viral infections continue to pose a significant threat to global health, leading to high rates of illness, death, and economic burden. The constantly evolving nature of viruses, along with the rise of drug-resistant strains, underscores the need for continuous advancements in antiviral treatments. This review highlights the pivotal role of antiviral drugs and vaccines in mitigating the impact of viral infections, showcasing recent breakthroughs and exploring emerging technologies. Key advancements …
Published in International Journal of Virus Studies · Vol. 1, Issue 1, 2024 · pp. 32–36 Read article
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A Review of Different Polymer and Plasticizers
Abstract: Plasticizer and polymer are essential components in the pharmaceutical industry, especially when creating both cutting-edge and conventional drug delivery systems. The differences between synthetic, semi-synthetic, and all-natural polymers are examined in this review to highlight their diverse qualities and uses. When designing drug delivery systems to target areas, the choice of polymer is crucial. Because of their repeatability and adaptability, synthetic polymers are widely used in the creation of precision …
Published in International Journal of Membranes · Vol. 1, Issue 1, 2024 · pp. 1–7 Read article
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Exploring Glucagon-like peptide-1 as a Target Protein for Diabetes Mellitus Treatment: Molecular Docking and Pharmacokinetic Analysis of Phytocompounds from Momordica charantia
Abstract: Objective: This study aimed to use molecular docking techniques to explore the potential of GLP-1 (glucagon-like peptide-1) as a target protein for the treatment of diabetes mellitus, a chronic metabolic disease marked by elevated blood glucose levels. Given its crucial role in maintaining insulin secretion and glucose homeostasis, GLP-1 may serve as a future target for diabetes therapy. Method: The study employed a multi-phase method. Initially, protein extraction was carried …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 8–20 Read article
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Using Multitarget Molecular Docking to Examine the Antiviral Potential of Clerodendrum Phlomidis against Measles
Abstract: Objective: Measles, a viral disease caused by a member of the Paramyxoviridae virus family, is highly contagious and characterized by a respiratory illness and a maculopapular rash on the skin. Children are the main victims of the illness. In the context of drug development, this study investigates the efficacy of phytocompounds derived from Clerodendrum phlomidis against the target protein of the measles virus. Methods: The 7SKS protein was retrieved from …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 32–42 Read article
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Plants Disease Detection Using TensorFlow and OpenCV
Abstract: Growing healthy and productive crops is crucial in the global battle for food security. To minimize crop losses and apply timely control measures, early and precise diagnosis of plant diseases is essential. Conventional illness detection techniques are subjective, labor-intensive, and complicated; they frequently rely on eye inspection. The TensorFlow and OpenCV libraries are used in this study to explore the use of Convolutional Neural Networks (CNNs) for plant disease discovery. …
Published in Journal of Electronic Design Technology · Vol. 15, Issue 1, 2024 · pp. 31–38 Read article
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Computational Exploration of Bhrijraj-derived Phytochemicals as Potential Anti-inflammatory Agents: A Molecular Docking Study with Cyclooxygenase-II Complex
Abstract: The molecular docking analysis was meticulously conducted using state-of-the-art computational tools, notably Chimera and Python. These tools were employed to unravel the complex interactions between the identified phytochemicals from Bhrijraj and the target protein, COX-II. The 3D structures of the phytochemicals were prepared with precision using ChemSketch, ensuring accuracy in the subsequent molecular docking simulations. This rigorous approach enhances the reliability and validity of the findings. This research aims to …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 31–37 Read article
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Computational Screening of Vitex negundo Compounds for Potential Arthritis Therapies in India
Abstract: Objective: Arthritis is a pervasive medical condition that manifests as inflammation and discomfort within the joints. As of September 2021, arthritis has affected an estimated 180 million people in India, making it a substantial public health concern with a considerable impact on individuals' quality of life and healthcare systems. Therefore, using molecular docking, drug-likeness prediction, and ADME analysis, an effort was made to identify natural compounds from Vitex negundo, which …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 01–18 Read article
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In Situ Investigation of Hemidesmus indicus Phytocompound Extracts as a Therapeutic Target for Acute Myeloid Leukemia
Abstract: Objective: Acute myeloid leukemia (AML) is an apoptotic condition in the hematopoietic system induced by the differentiation and maturation of stem cells into erythrocytes, and leukemic cell proliferation is suppressed as the PI3K-Akt-mTOR pathway is pharmacologically targeted with certain inhibitors. As a result, in silico molecular docking of compounds against AML receptors, CTMP, was used in computational research on Hemidesmus indicus to uncover therapeutic phytochemicals for AML. Thus, this study …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 38–53 Read article
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Impact of Diet and Certain Functional Foods in Type-II Diabetes Management
Abstract: Global health is greatly challenged by type 2 diabetes mellitus (T2DM), whose management mostly depends on dietary and lifestyle changes. This review study looks at how important diet and certain functional items are for managing type 2 diabetes. It offers a thorough summary of current scientific discoveries and clinical investigations that emphasize the contribution of dietary decisions and functional foods to better glycemic control, increased insulin sensitivity, and decreased risk …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 13, Issue 1, 2024 · pp. 9–15 Read article
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Breaking Boundaries: A Comprehensive Review of Screenless Display Technology
Abstract: This review explores new ways of showing images without traditional screens. We cover technologies like holography, where images appear to float in space, and retinal projection, which projects images directly onto your eye. We also discuss virtual retinal displays, which draw images on your retina using lasers, and augmented reality (AR), which overlays digital content onto your real-world view.Visual picture, Synaptic interface, Virtual Retinal Display. This primarily elucidates and illustrates …
Published in International Journal of Optical Innovations & Research · Vol. 1, Issue 2, 2023 · pp. 34–40 Read article
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Healthcare, Medicines, and the Advancement in Robotics: Pitch the Vision of Smart Public Health
Abstract: Robots are revolutionizing medical procedures, optimizing supply delivery and disinfection processes, and allowing healthcare providers to dedicate more time to patient care and interaction. Intel offers a diverse array of technology solutions designed specifically for the advancement of medical robots, encompassing surgical aids, customizable modules, and self-governing mobile robots. Social robots are human-to-human communicators that may be used to monitor and socialize with patients in long-term care settings. They lessen …
Published in Journal of Advancements in Robotics · Vol. 11, Issue 2, 2024 · pp. 26–29 Read article
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Challenges in the Commercialization of Lithium (Li)–Sulphur (S) Batteries †
Abstract: Li-S batteries can be used in drones owing to their high gravimetric energy density (2600 Wh/kg of sulphur) as well as the high theoretical specific capacity values (1674 mAh/g) values. Most of the ground breaking inventions in energy sources occurred during war time (1st September 1939-2nd September 1945), including the discovery of the famous nuclear fission process that lead to the origin of the little boy and the fat man. …
Published in International Journal of Advance in Molecular Engineering · Vol. 1, Issue 2, 2023 · pp. 26–36 Read article