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240 articles for “binding”
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Development and Characterization of Bottom Ash–Fly Ash–GGBS-Based Geopolymer Composites for Sustainable Applications
Abstract: The growing demand for sustainable construction materials has spotlighted geopolymer concrete (GPC) as an environmentally viable substitute for conventional cement-based systems. This study presents an innovative dual-waste valorization approach, integrating pulverized bottom ash (BA) and ground granulated blast furnace slag (GGBS) as binders while replacing sodium silicate (Na₂SiO₃) in the alkaline activator with treated textile effluent. Unlike prior works that focus solely on solid waste incorporation, this research pioneers the …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 32–42 Read article
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In Silico Screening of Terminalia chebula Phytocompounds as Potential Inhibitors of NTCP and DDB1 in Hepatitis B Virus Infection
Abstract: Hepatitis B virus (HBV) infection is a major global health concern, and chronic carriers are at risk of developing cirrhosis, hepatocellular carcinoma (HCC), and even death. Existing treatments can effectively inhibit viral replication, but they achieve little eradication of the virus because of covalently closed circular DNA (cccDNA) retention. In this investigation, bioactive compounds of Terminalia chebula, a plant known for its hepatoprotective and antiviral properties in traditional medicine, were …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 1, 2026 · pp. 33–44 Read article
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Unlocking Novel Drug Targets and Therapeutic Advancements Against RNA Viruses: Insights from HMPV and SARS-CoV-2
Abstract: Re-emerging RNA viruses pose a significant epidemiological welfare threat due to their high mutation rates, potential for zoonotic transmission, and capacity to cause widespread outbreaks such as Human Metapneumovirus (HMPV), Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Influenza, etc. The rapid evolution and re-emergence of these viruses necessitate the development of novel drug targets and therapeutic strategies to combat existing and future outbreaks. This study focuses on structural as well …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 3, 2025 · pp. 54–86 Read article
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Biophysical Properties and Spin Transport in Hemoglobin, Heme Along the Easy Magnetic Fe-N Symmetric Axis
Abstract: Many physical processes that take place in human and animal hemoglobin are associated with a transport of minerals, air, charge carriers, ions, and spin. They are greatly influenced by external electric and magnetic fields, the concentration of mineral intake, pH value, thermal conditions, and the structure of hemoglobin. In this research, emphasis is given to spin transport in hemoglobin, where a weak spin transport is noticed. In order to clarify …
Published in Research & Reviews : Journal of Physics · Vol. 14, Issue 3, 2025 · pp. 45–62 Read article
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Molecular Docking-Based Analysis of Rauvolfia serpentina Alkaloids Targeting HPV E1 and L1 Proteins for Antiviral Therapeutic Potential
Abstract: Human papillomavirus (HPV) is a major cause of cervical cancer and other epithelial cancers. E1 and L1 proteins are crucial to the virus's lifespan. E1 is a viral helicase that is needed for HPV DNA replication, and L1 is the main structural capsid protein that builds the virion and infects target cells. Going after these proteins is a good way to stop viruses from spreading. In this case, Rauvolfia serpentina, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 100–113 Read article
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Hierarchical Computational Modeling of Physical Structure Across Quark, Nuclear, and Atomic Scales
Abstract: We present a modular, multi-scale computational framework that integrates physical modeling and visualization across quark, nuclear, and atomic scales within a unified pipeline. Developed to address the traditional fragmentation between sub-nucleonic, nuclear, and electronic representations, the system provides a continuous data flow and visualization bridge spanning from femtometers to ångströms. The framework consists of three primary modules: a particle-level module illustrating nucleons as confined quark-triplets with effective flux-tube geometries; a …
Published in Research & Reviews : Journal of Physics · Vol. 15, Issue 1, 2026 Read article
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Computational Exploration of Aristolochia indica Bioactive Compounds Against Snake Venom Proteins Using Docking and Dynamics Simulations
Abstract: Snakebite envenoming is a neglected health threat impacting millions of people each year especially in tropical and subtropical countries. Ethnomedicinal plants are sources of various bioactive compounds and have been utilised by several tribes across the world for centuries. Aristolochia indica is a perennial herb mentioned in the Indian Ayurveda with a long history of use against snake venom, scorpion venom, fevers, rheumatic arthritis, liver ailments, leishmaniasis etc. The major …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 1, 2026 Read article
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A Comprehensive Review of Green Hybrid Polymer–Inorganic Composite Systems Incorporating Palm Tree Ash and Titanium Dioxide
Abstract: The increasing requests on sustainable and high performance systems have motivated extensive investigations on polymer-based hybrid systems with bio-derived and/or functional inorganic fillers. In this review, the importance of palm tree ash (PTA) and titanium dioxide (TiO₂) as synergistic fillers for polymer–inorganic hybrid composites, particularly about structure–property relations, interfacial adhesion and durability performance, is discussed. Agricultural waste-derived palm tree ash (PTA) plays as a silica-rich filler which not only aids …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1811–1820 Read article
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In Silico Identification of Therapeutic Agents for Dengue Virus by Molecular Docking
Abstract: The dengue virus causes serious health issues and a loss of quality of life. Dengue poses a yearly threat to half of the world’s population. The drugs that are based on allopathy are expensive and also exhibit toxic effects on tissues and biological activities. It is also generally accepted that most pharmacologically active drugs, including those derived from medicinal plants, are isolated from natural sources. The present study is directed …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 · pp. 01–14 Read article
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Optimized Utilization of Kota Stone Slurry Waste in Fly Ash–Based Geopolymer Mortar: A Taguchi-Driven Approach
Abstract: The large-scale generation of stone-processing wastes presents a critical sustainability challenge and an opportunity for value-added reuse in construction materials. This study develops a high-performance fly ash geopolymer mortar by partially replacing Class F fly ash with Kota stone slurry waste (KSSW) and optimizing the key mix parameters using a Taguchi design framework. Five governing factors—binder replacement level, NaOH molarity, sodium silicate–to–sodium hydroxide ratio (SS/SH), curing temperature, and alkaline solution-to-binder …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 426–445 Read article
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Molecular Docking Analysis of Phytocompounds from Ficus hispida Aagainst Epidermal Growth Factor Receptor Kinase Domain
Abstract: The Epidermal Growth Factor Receptor (EGFR) kinase domain plays a key role in cancer, as it promotes tumour growth and helps cancer cells survive, making it an important focus for developing treatments. Through comprehensive computational analysis, this study investigates the anticancer potential of phytocompounds from Ficus hispida, a medicinal plant renowned for its diverse bioactive compounds, as novel EGFR inhibitors. Molecular docking techniques using Py Rx software were employed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 Read article
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Molecular Docking Analysis of Phytocompounds from Ficus hispida Against Epidermal Growth Factor Receptor Kinase Domain
Abstract: The Epidermal Growth Factor Receptor (EGFR) kinase domain plays a key role in cancer, as it promotes tumour growth and helps cancer cells survive, making it an important focus for developing treatments. Through comprehensive computational analysis, this study investigates the anticancer potential of phytocompounds from Ficus hispida, a medicinal plant renowned for its diverse bioactive compounds, as novel EGFR inhibitors. Molecular docking techniques using Py Rx software were employed to …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 48–62 Read article
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Neuro-Symbolic Agentic AI for Autonomous Scientific Discovery: Integrating Deep Reinforcement Learning, Quantum Simulation, and XAI-Audited LLM Hypothesis Generation in Drug Target Identification
Abstract: The exponential growth of multi-omics data and the increasing complexity of disease-associated protein interactomes have rendered conventional drug target identification pipelines computationally and epistemologically inadequate. This paper presents the Neuro-Symbolic Agentic AI for Scientific Discovery (NS-AASD) framework, a unified architecture that cohesively integrates deep reinforcement learning (DRL) exploration strategies, variational quantum simulation (VQS) of protein conformational dynamics, and XAI-audited large language model (LLM) hypothesis generation within an autonomous scientific discovery …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 2, 2026 Read article
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Assessing the Influence of Aggregates and Cement Type on the Properties of Roller-compacted Concrete
Abstract: Roller-compacted concrete (RCC) pavement is suitable for heavy traffic and harsh environment. In the present investigation, RCC slab samples have been prepared using two types of aggregates (crushed and rounded), and two types of cement binder (ordinary Portland and sulphate resistant). Cubes and beam specimens have been extracted from the slab samples with the aid of diamond saw. Specimens were tested for bulk density, ultrasound pulse velocity, compressive and flexural …
Published in Trends in Transport Engineering and Applications Read article
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Eco-friendly Azadirachta Indica Ash and Miscanthus Fiber Brick for Carbon Neutrality Environment
Abstract: Naturally grown fiber are not utilized properly they are neglected as wastes. These resources are thrown away due to insufficient research being conducted to discover viable uses for naturally existing fibres. These byproducts have a wide variety of applications in the manufacturing sector, notably in the construction sector. The prospective applications of miscanthus fibre, which may be found growing wild in uncultivated places, are investigated in this research. The production …
Published in Journal of Polymer & Composites Read article
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Development of Zinc Gluconate Vitamin C Effervescent Tablet for Immunity Improvement and Management of Corona Virus Disease (COVID-19)
Abstract: The global pandemic of coronavirus disease- 2019 (COVID-19) continues to pose a threat to people, societies, and economic and healthcare systems. COVID-19s progression and lethality are determine by the host immune system, as is the case with many other diseases. revolutionary idea that has been used to treat other diseases is the control of inflammatory response and cytokine production based on immunonutrition. Some COVID-19 clinical trials are now using zinc, …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 1, 2024 Read article
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In Silico Drug Design for Mycobacterium tuberculosis and Development of Host–Pathogen Interaction Network and Molecular Docking Procedures
Abstract: Objective: A leading cause of illness is the contagious disease tuberculosis (TB), this infection with Mycobacterium tuberculosis complex (MTBC) particularly M. tuberculosis and M. africanum, is what causes tuberculosis. Diverse receptor proteins (mycobacterial proteins) with various 3D structures and functions were evaluated to access the multi-domain antimycobacterial action of ligands. The specific receptor proteins PDB ID: 3PTY, PDB ID: 4OW8, PDB ID: 5KWA, and PDB ID: 3ZXR, were opted for …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 1–19 Read article
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Preparing Chitosan Hybrid Nanocomposites by Novel Additives for Wound Healing
Abstract: Biomaterials made from chitosan have been discovered to be particularly unique marine polysaccharides (or polycarbohydrates) with a wide range of physico-chemical and biological characteristics suitable for biomedicine field. Due to net positive charge of chitosan, it is essentially capable of chemically binding with negatively charged surfaces A biodegradable blend of chitosan nanoparticles (CHT), poly vinyl alcohol (PVA) and polyethylene glycol (PEG) hybridized with metal oxides nanopowders were prepared and used …
Published in Journal of Polymer & Composites · Vol. 11, Issue 2, 2023 · pp. 9–23 Read article
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Uncovering the Comparative Efficacy of Antiviral Drugs and Caricapapaya Phytocompound as VP2H inhibitors in Ebola virus: An Insilico Molecular Docking Analysis
Abstract: The Ebola virus is a fatal disease that transmits from wild animals to humans. Infected individuals' body fluids such as spit, blood, perspiration, faeces, blood, saliva, breast milk, sperm, or fomites can transmit Ebola. Adhesion to cell membranes and penetration into the host organism are essential aspects in viral growth. The presence of VP24, as well as nucleoproteins and structural proteins, is necessary for nucleocapsid formation and integration. The inhibition …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 62–78 Read article
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Analysis of Fibre Reinforced Beams
Abstract: There has been research into the flexural behaviour of composite beams with a variety of fibre layer depths, all of which were designed using the balancing section and the limit state design idea. The fibre depth is estimated to be 112 mm (d = 112 mm), with the first three dimensions being 94.44 mm (d1 = 94.44 mm), 46.12 mm (d2 = 22.35 mm), and 22.35 mm (d3) respectively. The …
Published in Journal of Polymer & Composites · Vol. 11, Issue 4, 2023 · pp. 53–59 Read article