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175 articles for “Lead compound.”
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Relevance of Unani Medicine (Greco-Arab Medicine) in Management of Bawāsῑr (Hemorrhoids): An Updated Review
Abstract: Hemorrhoids is a prevalent anorectal disease with substantial compromise in quality of life, and various important factors are implicated in its causation. Increased abdominal pressure, excessive straining and hard stool lead to the venous engorgement of the hemorrhoidal plexus clinically characterized by per rectal bleeding, thrombosis and symptomatic prolapse of haemorrhoidal mass. In Unani System of medicine, the primary cause for the development of hemorrhoidal disease is focal retention of …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 7, Issue 2, 2020 · pp. 20–27 Read article
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Silkworm Growth and Silk Yield under Changing Climatic Conditions: Challenges and Adaptations
Abstract: Climate change is emerging as a critical factor affecting agriculture and sericulture industries worldwide. Rising global temperatures, shifting rainfall patterns, and the growing frequency of extreme weather events present ever challenges to the growth and productivity of silkworms (Bombyx mori L.). Silkworms are extremely sensitive to environmental conditions like temperature, humidity, and photoperiod, all altered by climate change. Higher temperatures can accelerate silkworm metabolism, reduce silk yield, and increase susceptibility …
Published in International Journal of Insects · Vol. 1, Issue 2, 2024 · pp. 1–5 Read article
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Exploring Phytochemicals from Ricinus Communis for Potential Therapeutic Applications in Rheumatoid Arthritis: An in-Silico Approach
Abstract: Aim: Rheumatoid arthritis (RA) is a long-term autoimmune condition characterized by the immune system mistakenly attacking the joints, leading to swelling, discomfort, and joint deformities. Current management strategies include anti-rheumatic drugs and biologics, which have limitations. This study aims to explore the therapeutic potential of Ricinus communis (castor bean plant) phytochemicals as plant-based therapies for autoimmune conditions, like RA. Methods: Phytochemicals from Ricinus communis were retrieved using the IMPPAT database, …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 32–41 Read article
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Investigation of Annonaceae Acetogenins for Inhibition of Dengue Viral Protease using in silico Docking Studies
Abstract: Dengue viruses (DENVs) cause severe and widespread epidemics of diseases such as dengue fever and dengue hemorrhagic fever/dengue shock syndrome. Unfortunately, there is at present neither prophylaxis nor specific treatment to cure the disease and thus it is need of the hour to develop new antiviral therapeutic agents to combat diseases caused by DENV. Non-structural protein NS3 play a major role in the processing of polyprotein and replication of the …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 1, 2019 · pp. 47–52 Read article
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Creating Awareness on Toxic Nature of Cadmium
Abstract: Every day, we come into touch with hundreds of harmful compounds, both natural and manmade. A dangerous heavy metal that is widely present in nature is Cadmium. There have been several reports of cadmium poisoning throughout the world. It is well known that all forms of cadmium are harmful to the environment and to living things. It is a widespread issue with world health that, in some situations, can lead …
Published in Research & Reviews : Journal of Ecology · Vol. 11, Issue 2, 2022 · pp. 28–31 Read article
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A Review on Toxic Effects of an Organophosphate Pesticide Chlorpyrifos in Fish
Abstract: AbstractOne of the most potentially harmful toxic chemical is pesticides that are introduced into the environment and used in extensive agriculture practices to defense against disease and pest. Though human welfare have been contributed considerably to them, the adverse effects of pesticides on the non-target organisms like fish are extremely significant. Through impairment of metabolism pesticides hampers health of fish, sometimes leading to death of fish. Among the different group …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 9, Issue 1, 2020 · pp. 19–31 Read article
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Enhancing the Bioavailability of Polyphenols: A Comprehensive Review
Abstract: The polyphenolic compounds are abundantly found in different plant parts including fruits, leaves, stem and seeds, and are known for possessing a wide range of biological activities. These include antioxidant, antimicrobial, anti-inflammatory, anticancer, antidiabetic, cardioprotective, and neuroprotective effects. Their functional relation with their structure highlights the significant therapeutic potential. As a result, the polyphenols are being further being exploited for applications in functional foods, pharmaceuticals, and targeted drug delivery. Despite …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 15, Issue 2, 2026 · pp. 37–51 Read article
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Pharmacological evaluation of Hepatoprotective activity of Indian medicinal plants Cordia Myxa and Canscora diffusa on wistar albino rats
Abstract: Two plants (Cordia myxa and Canscora diffusa), which were claimed to possess hepatoprotective activity, were selected. The Selected plants were authenticated by an expert botanist. In the current study, herbal extraction involving solvents of decreasing polarity (petroleum ether, ethyl acetate, and hydroalcoholic) was used to extract bioactive compounds from the plants of Cordia Myxa and Canscora diffusa in polyherbal preparations. A phytochemical evaluation was performed, including an acute toxicity study …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 31–44 Read article
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Study the Effect of Certain Plant Extracts in Blood Coagulation
Abstract: Blood is an essential component in human and other animals that deliver necessary substance such as nutrients and oxygen to cells and transport metabolic waste from cells. Blood performs much important function within body including supply of oxygen to tissues and supply of nutrients. During haemorrhage or bleeding the components of blood may lose which leads to severe illness to patient or sometimes death. Blood loss outside the body is …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 5, Issue 1, 2018 · pp. 13–19 Read article
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A Spectrum of Psychoactive Drugs in Ayurveda
Abstract: We are in the 21st century, to fulfill minimum requirements like food, shelter, clothing etc; we are struggling day by day in the stressful atmosphere where demand and supply ratio is improper, so that the people are trying to overcome the stressful situation that may be financial or social aspect, but after lot of struggle few of them able to get their appropriate job and lot of people compromise what …
Published in Research & Reviews : Journal of Herbal Science · Vol. 4, Issue 2, 2015 · pp. 16–20 Read article
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Review on Spirulina ( Green Alage)
Abstract: Spirulina is an edible blue-green algae that is a plant protein source. In recent years, its health benefits have attracted scientific attention, including micro-level examinations of the algae's bioactive components. As proof of concept, investigations conducted in vitro, in vivo, and ex vivo have shown how spirulina works and how it affects immunity. Spirulina has been used as a whole food and as a nutritional supplement for many years. It …
Published in International Journal of Pathogens · Vol. 1, Issue 1, 2024 · pp. 33–37 Read article
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The Nutritional Value of Moringa Plant as a Superfood: A Comprehensive Review
Abstract: Moringa oleifera, commonly known as the "miracle tree," has garnered global attention for its rich nutritional profile and diverse medicinal properties. This review article comprehensively explores the nutritional composition and health benefits of Moringa, highlighting its potential as a superfood. The plant is rich in essential nutrients, including proteins, vitamins, minerals, and bioactive compounds, such as flavonoids and phenolic acids. These constituents contribute to its antioxidant, anti-inflammatory, antimicrobial, and anti-cancer …
Published in International Journal of Sustainability · Vol. 1, Issue 2, 2024 · pp. 20–23 Read article
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DESIGNING OF COUMARIN ANALOGS: A NEW INSIGHT AS ENOL ACYL CARRIER PROTEIN REDUCATSE INHIBITORS
Abstract: Tuberculosis was almost certainly the leading cause of death in Europe and the United States in recorded history, although because of the multifarious forms of the disease. Based on literature we have designed coumarin linked with thiadiazole derivatives as antitubercular agents. To determine structural requirements, we carried out molecular docking study in which we found that our designed molecule have similar binding with enoyl acyl carrier protein reductase (InhA). The …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 2, 2019 · pp. 1–5 Read article
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An Overview on Formulation and Development of Herbal Creams for Treatment of Acne/Pimple
Abstract: The increasing demand for natural skincare products has spurred the development of herbal creams for the treatment of common dermatological conditions, particularly acne and pimples. Acne is a complex skin condition that predominantly affects teenagers but can continue into adulthood. Traditional treatments for acne often have undesirable side effects, leading to a growing interest in herbal remedies. Plant-based creams are becoming increasingly popular because they are considered safer and more …
Published in Research & Reviews : Journal of Herbal Science · Vol. 14, Issue 2, 2025 · pp. 1–12 Read article
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Pathways in Drug Discovery and Development: From Molecular Targets to Market Approval
Abstract: A complicated, multidisciplinary, and resource-intensive process, the discovery and development of new pharmacological drugs is essential to the advancement of contemporary medicine. Finding and optimising lead chemicals comes after a disease-relevant biological target has been identified and validated. Through preclinical research in animal models, these leads are thoroughly assessed for toxicity, pharmacokinetics, safety, and efficacy. Clinical trials, which are carried out in several stages to evaluate safety, efficacy, ideal dosage, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 01–04 Read article
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Rosemary: A Natural Way to Improve Brain Health and Cognitive Function
Abstract: Cognitive decline is a common consequence of aging, often leading to diminished quality of life. Although conventional drug treatments, such as anticholinesterase inhibitors, are available for managing cognitive decline, they are not always effective in older adults and may even induce adverse effects. As a result, there has been growing interest in natural alternatives, particularly traditional herbal medicines, for their potential cognitive-enhancing properties. Among these, Rosmarinus officinalis (Rosemary) has gained …
Published in International Journal of Brain Sciences · Vol. 2, Issue 1, 2025 · pp. 30–36 Read article
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Impacts of Climate Change on Land Degradation: A Review of Mitigation
Abstract: Land degradation has emerged as one of the most pressing environmental challenges globally, significantly impacted by the multifaceted and escalating effects of climate change. The degradation of land, including soil erosion, nutrient depletion, deforestation, and desertification, directly threatens food security, biodiversity, and human livelihoods. As climate change leads to increasingly erratic weather patterns, including prolonged droughts, intense rainfall, and extreme temperatures, land degradation has become more pronounced and widespread, exacerbating …
Published in International Journal of Land · Vol. 2, Issue 1, 2025 · pp. 6–10 Read article
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Heterogeneous vs. Homogeneous Catalysis: Comparative Insights and Breakthroughs
Abstract: Catalysis, a pivotal process in chemical reactions, can be classified into two main types: heterogeneous and homogeneous catalysis. This comparative analysis delves into the distinctions, advantages, and breakthroughs in both domains. Heterogeneous catalysis, involving catalysts in a different phase than the reactants, is characterized by ease of separation and catalyst recovery, making it industrially favorable. Conversely, homogeneous catalysis, where catalysts and reactants share the same phase, offers superior selectivity and …
Published in Journal of Catalyst & Catalysis · Vol. 10, Issue 3, 2023 · pp. 1–7 Read article
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Exploring Abies grandis phytocompounds potential by in silico analysis targeting on the 5P9J Protein
Abstract: Blood Cancer, also popular with name ‘Hematologic cancer’ have variety of types: Leukaemia, Lymphoma, Myeloma, uncontrolled multiplication of blood cells mainly affecting to bone marrow and blood cells (White Blood Cells). Lymphoma, originating from lymphatic system resulted in uncontrolled growth and instead of normal apoptosis development of tumor. Myeloma, uncontrolled formation of malignant plasma cells leads disrupting production of healthy blood cells. This situation creates variety of diseases like anaemia, …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 · pp. 1–12 Read article
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TRACING PLANT POTENTIAL FOR CONTROLLING DIABETES: A COMPREHENSIVE STUDY
Abstract: Diabetes mellitus is a chronic metabolic non- communicable condition characterized with elevated or raised blood sugar or glucose levels for a prolonged period of time. The high level of blood sugar leads to development of specific symptoms like polyuria, polydipsia and polyphagia. The other symptoms include abnormal weight loss, fatigue, poor wound healing, infections, altered mental state and blurry vision. Exploring alternative treatments for diabetes, particularly those derived from medicinal …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 12, Issue 3, 2023 · pp. 34–41 Read article