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238 articles for “Clinical Safety”
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Qualitative and Quantitative Effects of Non-Thermal Atmospheric Pressure Plasma and ErCr: YSGG Laser Activation on Surface Remineralization and Fluoride Release of Three Different Fluoride Varnishes
Abstract: Dental caries remains a prevalent oral health concern worldwide, prompting ongoing research into innovative approaches for caries prevention and management. This experimental investigation endeavors to conduct a comparative assessment of the bioactivity, fluoride release kinetics, shear bond strength, and compressive strength of glass ionomer cement (GIC) augmented with three distinct types of inorganic bioactive nanoparticles. Bioactive nanoparticles have garnered interest in dental materials for their potential to enhance material properties …
Published in Journal of Polymer & Composites · Vol. 12, Issue 5, 2024 · pp. 292–303 Read article
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Prime Editing and Base Editing in Human Hematopoietic Stem Cells Toward Scarless Correction of Monogenic Blood Disorders
Abstract: Monogenic hematological disorders – such as sickle cell disease (SCD), β-thalassemia, and X-linked chronic granulomatous disease (X-CGD) – affect >400, 000 newborns worldwide each year, with a considerable burden in low-resource settings . Although donor-derived allogeneic hematopoietic stem-cell transplantation (HSCT) is widely regarded as curative, its application is limited due to issues of donor availability and graft-versus-host disease (GVHD) and conditioning-related toxicity. DSB-based conventional CRISPR-Cas9 strategies are limited by inefficient …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 4, Issue 1, 2026 · pp. 15–22 Read article
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From Clinic Formulation to Development of Acebrophylline
Abstract: Acebrophylline, a commonly utilized bronchodilator with anti-inflammatory properties, has become a key therapeutic option for managing respiratory conditions like asthma, chronic obstructive pulmonary disease (COPD), and chronic bronchitis. This review explores the journey of Acebrophylline from its clinic formulation to its development and commercialization, focusing on the key aspects of formulation strategies, pharmacological properties, and regulatory considerations. The drug’s dual mechanism of action, which involves both bronchodilation and anti-inflammatory effects, …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 35–48 Read article
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The Safety of Dental X-ray Machine against the Deoxyribonucleic Acid (DNA): In Vitro Model Explores the Effects of Chlorine Free Radical, Duration of Exposure and the Doses of Irradiation
Abstract: Background: Patients attended to the dental clinics are referred to X-ray which may arise the possibility of adverse reactions upon oral mucosa. X-ray-induced oral mucosa damage is related to the generation of the free radicals in the aqueous media of the cells. Objectives: This study aimed to clarify the safety of dental X-ray exposure by utilizing an in vitro experimental model of calf-thymus double strands DNA (ctdsDNA) molecule exposed to …
Published in Research and Reviews: A Journal of Dentistry · Vol. 10, Issue 2, 2019 · pp. 23–28 Read article
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An Evaluation of the Efficacy and Safety Profile of Inula Racemosa in Patients of Restrictive Lung Diseases
Abstract: In this paper, we explain the procedure to evaluate the efficacy and safety profile of Inula racemosa in patients of restrictive lung diseases. The patients included in this study were selected from the outpatient clinic of a tertiary care hospital in North India. The present study was initiated on 45 patients suffering from restrictive lung diseases, 31 of these patients were followed up for 6 weeks. Remaining patients did not …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 4, Issue 3, 2015 · pp. 18–21 Read article
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Toxicological Profiling and Safety Assessment of NASAT 2.0: A Conceptual Framework for Adaptive Nanoparticle Therapy in Rabies
Abstract: Rabies, caused by the highly neurotropic Rabies lyssavirus, remains one of the most enigmatic and universally lethal infectious diseases known to modern medicine. Once clinical symptoms manifest following successful neuroinvasion, the fatality rate approaches absolute certainty (approximately 99.9%), a staggering statistic that has remained largely unchallenged despite massive, concurrent advances in modern virology, critical care medicine, and cellular immunology. Current late-stage therapeutic protocols, most notably the widely debated Milwaukee Protocol, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 2, 2026 · pp. 1–19 Read article
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Pharma Tech: Leveraging Software for Drug Development & Clinical Research
Abstract: The pharmaceutical sector is progressively adopting software solutions to enhance the drug development process and optimize clinical research results. Drug development is a time-consuming, expensive, and intricate process that traditionally requires extensive laboratory research, preclinical testing, and several stages of clinical trials. Software tools are revolutionizing these stages by improving efficiency, minimizing errors, and speeding up timelines. During preclinical testing, predictive software tools are used to model toxicological effects and …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 11–19 Read article
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COSMECEUTICAL: The Intersection Between Beauty and Science
Abstract: The intersection of beauty and science has given rise to the rapidly growing field of cosmeceuticals—products that blend cosmetic and pharmaceutical elements to improve both the appearance and health of the skin. As consumers increasingly seek advanced, evidence-based skincare solutions, the demand for cosmeceuticals has surged. These products typically contain bioactive ingredients that go beyond simple aesthetic enhancement, offering therapeutic benefits backed by scientific research. The article explores the evolving …
Published in Recent Trends in Cosmetics · Vol. 2, Issue 1, 2025 · pp. 17–31 Read article
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A Research on the Additives and Regulatory Requirements for Pediatric Formulation
Abstract: These days, pediatric considerations are incorporated early on in the creation of new medications. The guidelines and policies of European drug regulatory bodies served as the foundation for our investigation. The review comprehensively outlines excipients commonly found in pediatric medicine formulations. It identifies potentially harmful compounds flagged by scientific literature, stressing the necessity of rigorous safety checks, often involving toxicity studies. Excipients included in pediatric databases, like the STEP database, …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 1, 2024 · pp. 28–45 Read article
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Exploring Phytomedicine: Innovations, Efficacy and Future Directions
Abstract: The use of plant-derived substances for therapeutic purposes has long been a cornerstone of traditional medicine systems worldwide. With increasing interest in natural remedies, the field of phytomedicine is experiencing a revival, marked by innovations in research, formulation, and application. This review article explores recent advancements in phytomedicine, highlighting novel extraction technologies, and the efficacy of plant-based treatments in clinical settings. The review also addresses the challenges faced in phytomedicine …
Published in Research & Reviews : Journal of Botany · Vol. 14, Issue 2, 2025 · pp. 32–50 Read article
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AI-Driven Pharmacogenomics and Precision Medicine: Future of Personalized Therapy
Abstract: Pharmacogenomics and artificial intelligence (AI) are emerging as important drivers of precision medicine, enabling healthcare systems to adopt individualized therapeutic approaches. Pharmacogenomics examines how genetic variations influence drug response, efficacy, metabolism, and toxicity, while AI provides advanced computational tools for analyzing complex genomic and clinical data. This review highlights the integration of AI-driven pharmacogenomics in personalized therapy and its potential to improve treatment outcomes. Machine learning, deep learning, natural language …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 2, 2026 · pp. 1–12 Read article
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SAR Radar: The Future of Radar Systems
Abstract: The first radar was invented 110 years ago. In the meantime, implementations have become various and the device principles for accessible technologies have been adopted. Main examples include speed control, air traffic control and synthetic radar, airborne and space borne flights, military applications and remote sensing. Work on clinical radar technology is well underway for the identification of breast cancer and the localization of tumors. Automotive safety and autonomous driving …
Published in Research & Reviews : Journal of Space Science & Technology · Vol. 9, Issue 2, 2020 · pp. 21–25 Read article
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Review of Atorvastatin As A Potent Drug For Cardio-Vascular Disease(CVD)
Abstract: Cardiovascular disease (CVD), particularly atherosclerosis, remains the leading cause of death worldwide, significantly burdening public health, especially in Western societies. Metabolic syndrome and arrhythmic complications further exacerbate cardiovascular morbidity and mortality. Among restorative specialists, statins particularly atorvastatin have gotten to central in both the essential and auxiliary anticipation of coronary heart infection (CHD) due to their strong lipid-lowering properties and additional pleiotropic impacts. Atorvastatin, a selective HMG-CoA reductase inhibitor, not …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 8–18 Read article
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Evaluation of the efficacy and safety of Unani Medicine Tukhm-e-Karafs (Apium graveolans Linn) and Tukhm-e- Duqu (Peucedanum grande) in patients with urolithiasis by assessing the symptomatic relief, reduction/expulsion of urinary stones and urinary biochemical parameters.
Abstract: Background: - Karafs(Apium graveolans Linn) and Duqu (Peucedanum grande) are some of the main plants whose seeds are used in Unani System of Medicine from ancient times for a number of problems of urinary system like urinary retention, kidney and bladder stones , and other kidney diseases like nephrits, etc.Aim of the study: - To evaluate the efficacy and safety of Unani Medicine Tukhm-e-Karafs (Apium graveolans Linn) and Tukhm-e- Duqu …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 9, Issue 3, 2022 · pp. 22–27 Read article
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A Review of Telepharmacy: Advancements, Challenges, and Future Directions
Abstract: Like telemedicine, telepharmacy is a relatively new term that describes the delivery of pharmacological services. While tele comes from the Greek word “Telos,” which means from a distance, medicine comes from the Latin word “Meden,” which means to heal. The National Association of Boards of Pharmacy defines telepharmacy as the use of information and communication technology to provide patients with pharmaceutical treatment from a distance. Clinical pharmacy services are provided …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 34–42 Read article
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CRISPR-Cas9: Revolutionizing the Genetic Frontier
Abstract: The rapid development of CRISPR/CRISPR-associated enzyme (Cas) technology has enabled truly customised treatment of human genetic disorders, paving the way for recent developments in the field of gene therapy. Because CRISPR/Cas can accurately target and edit individual genes within a genome, it has established itself as a formidable tool for genetic manipulation. CRISPR/Cas9 technology allows for precise editing of specific DNA sequences in an organism's genome. This method uses three …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 2, 2025 Read article
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Recent Advancements in Nanobiocomposite-Based Wound Healing and Tissue Regeneration
Abstract: Haemostasis, inflammation, proliferation, remodeling, and other highly coordinated cellular and molecular activities are all part of the complex biological processes of wound healing and tissue regeneration. Following an injury, these stages cooperate to restore tissue integrity and function. However, this normal process is disturbed in many clinical circumstances, especially chronic wounds such diabetic ulcers, burns, and pressure sores. Prolonged inflammation, chronic microbial infection, diminished angiogenesis, and impaired extracellular matrix production …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 297–318 Read article
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Orthodontics during the COVID-19 Times: Fight or Flight-A Literature Review
Abstract: The corona virus (SARS-CoV-2) a Nano-sized entity has led to a halt in our existence, confining and isolating the mankind. In spite of the regional and national lockdown being prevailed in most of the countries there still is a surge and swell in the number of cases and the graph is being increased continuously. New normality can be covered under three phases, starting with the preparatory phase which covers the …
Published in Research and Reviews: A Journal of Dentistry · Vol. 12, Issue 2, 2021 · pp. 1–9 Read article
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A Literature Review on Future Perspective of Metformin use for Chemotherapy
Abstract: The emergence of metformin as a potential anticancer and cancer-preventive therapeutic tool is exciting. More recently, metformin has been associated with decreased cancer incidence and mortality in diabetic patients and the insulin-lowering effects of metformin are integral to its anticancer properties. With the added benefits of being readily available, economical, and easily tolerated with good safety profile, it can be effortlessly transitioned from bench to bedside for cancer therapy. So, …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 3, 2020 · pp. 1–9 Read article
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Cosmetic Topical Formulations: Design Strategies, Skin Interaction Mechanisms, Clinical–Cosmetic Applications, and Emerging Trends
Abstract: Cosmetic topical products are central to modern skin care, as they deliver active ingredients directly to the skin surface and upper layers to improve appearance, texture, and function. By acting locally on the epidermis and adnexal structures, these preparations help manage dryness, photoaging, pigmentation, acne, and sensitive-skin conditions while minimizing systemic exposure. A wide range of dosage forms—creams, lotions, gels, ointments, serums, sprays, and transdermal-inspired cosmetic patches—are engineered to modulate …
Published in Recent Trends in Cosmetics · Vol. 3, Issue 1, 2026 · pp. 39–47 Read article