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336 articles for “Chemical compounds”
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In Silico Molecular Docking Studies of Phytoconstituents Identified in Curcuma zedoaria Rosc. on Acetylcholinesterase: An Enzyme Target for Anti Alzheimer’s Activity
Abstract: Alzheimer’s disease (AD) is a chronic, progressive and disabling organic brain disorder characterized by disturbances of multiple cortical functions. Acetylcholinesterase (AChE) inhibition is thought to be a promising approach towards the treatment of AD. The aim and objective of the present study is to perform in-silico docking analysis of the major active constituents identified in Curcuma zedoaria Rosc. against AChE for anti-Alzheimer’s activity. In this perspective, phytoconstituents like bisdemethoxy curcumin, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 3, 2019 · pp. 9–14 Read article
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Induction of Genetic Damage in Peripheral Erythrocytes of the Fish, Anabas testudineus Exposed to Sublethal Concentration of Acid Orange 7
Abstract: Acid orange 7, a synthetic organic compound, generally considered as pollutant, released from the process of chemical textile finishing process was exposed to the freshwater fish Anabas testudineus at sublethal concentration i.e., 0.27 gl-1 for 24, 72 and 96 h, maintaining ten animals per group along with the control. The median lethal concentration of acid orange 7 determined by Probit analysis was 2.7 gl-1 concentration. Sublethal exposure to the azo …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 2, 2019 · pp. 83–96 Read article
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In Silico Tau Protein Kinase I Inhibitory Activity of Some Commercially Available Flavonoids
Abstract: Molecular docking is a frequently used tool in computer-aided structure-based rational drug design. Flavonoids are a group of natural products which exhibits various biological and pharmacological activities. The primary objective of this study was to investigate the tau protein kinase I inhibitory activity of flavonoids using in silico docking studies. Memantine, a known neuro-receptor antagonist is currently used in the treatment of Alzheimer’s disease (AD). In silico docking studies were …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 2, Issue 1, 2015 · pp. 6–12 Read article
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Ethanolic Extract of Hemigraphis Colorata Leaves: Extraction, Phytochemical Screening, and in Vitro Evaluation of Antiulcer Activity
Abstract: This study aims to extract the phytochemical constituents and in-vitro evaluation of antiulcer activity of Hemigraphis colorata (Acanthaceae) Commonly known as red flameivy, belongs to the family Acanthaceae. Used to advance pee, checkhemorrhage, stopdysentery, treat veneral sicknesses and to recuperate hemorrhoids. Preliminary phytochemical screening revealed the presence of the leaves contain flavonoids, polyphenols, tannins, high potassium and low sodium levels; stem contains saponins and tannins, roots contain flavonoids and polyphenols. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 13, Issue 1, 2022 · pp. 1–6 Read article
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Thermal Behavior of Biomass Ashes with the Influence of Additives: A Critical Review
Abstract: The gasification of biomass is undoubtedly one of the most promising processes for sustainable energy and heat production. The formation of low-melting ashes can compromise the proper functioning of plants. To address potential risks of ash fusion and agglomerate formation in high-temperature zones that may occur in downdraft reactor configurations, a detailed literature review on the use of additives to counteract the risk of ash formation and deposition has been …
Published in Journal of Alternate Energy Sources & Technologies · Vol. 14, Issue 3, 2024 · pp. 1–11 Read article
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Degradation of Phenol, an Innovative Biological Approach
Abstract: A bacterial strain capable of utilizing phenol as a sole carbon source was isolated from the soil samples, collected at a vicinity of industrial wastewater treatment plant of phenol manufacturing unit. Based on the biochemical tests and 16S rRNA sequencing results the organism was identified as Serratia marcescens. The organism is capable of degrading the highly toxic phenolic compound to an optimum concentration of 2500 mgL-1 in 120 h at …
Published in Journal of Water Pollution & Purification Research · Vol. 5, Issue 3, 2018 · pp. 1–6 Read article
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A Review Article on Spice up the Solution of Inflammation Through Phytomedicines
Abstract: Inflammation is a complex, protective immune response essential for healing and combating infection. However, prolonged inflammation is associated with chronic diseases, such as arthritis, cardiovascular disorders, diabetes, and neurodegenerative conditions. Traditional nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids can exhibit adverse effects, particularly with chronic administration. This challenge has encouraged the exploration of natural alternatives. Among various natural anti-inflammatory agents, spices, such as ginger, garlic, turmeric, cardamom, and black pepper have …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 1, 2025 · pp. 1–10 Read article
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Psychoactive and Physiological Homogeneity of Cannabis: A Literature Review: Actions of the Medical Plant that Takes Care of Itself
Abstract: Naturally occurring plants like Cannabis and the biologically ubiquitous alkaloids (e.g., morphine, quinine, and atropine) are composed of mostly physiological and psychoactive compounds. Extracts of the Cannabis plant are not alkaloid substances nor are they not related chemically to alkaloids, having no component nitrogen in their structures. Three species of Cannabis (marijuana) are recognized in scientific classifications: Cannabis sativa, Cannabis indicus and Cannabis ruderalis. Cannabis sativa is the species that …
Published in Research and Reviews : A Journal of Immunology · Vol. 7, Issue 2, 2017 · pp. 1–4 Read article
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An in-silico toxicity study of the phytocompounds found in Pongamia pinnata leaves using the ProTox-II web server
Abstract: The aim of the current study was to determine the Insilco toxicity of the phytocompound present in the leaves of Pongamia pinnata. The leaves of Pongamia pinnata have long been used in traditional medicine for their therapeutic properties. Nowadays, herbal toxicity is a common problem caused by incorrect dosage. The FDA reviews the safety and effectiveness of herbal products only in response to patient or health care provider complaints—problems with …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 13, Issue 1, 2024 Read article
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QSAR Modeling Techniques A Comprehensive Review of Tools and Best Practices
Abstract: Quantitative Structure–Activity Relationship (QSAR) modeling has become an essential tool in drug discovery, toxicity assessment, and environmental chemistry. By correlating chemical structure with biological activity or toxicity, QSAR enables the prediction of compound behavior without extensive experimental testing. This approach not only saves time and resources but also supports ethical practices by reducing reliance on animal studies. The evolution of QSAR from basic linear models to advanced machine learning and …
Published in International Journal of Cheminformatics · Vol. 3, Issue 1, 2025 · pp. 56–63 Read article
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Molecular Docking of Arjuna Tree Phytocompounds for Ischemic Heart Disease
Abstract: Heart disease is a serious condition that can be caused by several lifestyle changes and sometimes genetic problems. The primary protein component of apolipoprotein is the LDL receptor, which indicates that a reduction in LDL levels can reduce the risk of ischemic heart disease. Apolipoprotein levels are associated with increased levels of ischemic heart disease. Using ADMET analysis, drug likelihood prediction, and molecular docking, this work attempted to find natural …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 42–52 Read article
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In Silico Assessment of Demethoxycurcumin: Molecular Docking and Computational Insights into its various therapeutic Potential
Abstract: Natural compounds are increasingly explored for their therapeutic potential in medical research. Here, we focused on demethoxycurcumin (DMC), a polyphenolic bioactive compound extracted from Curcuma longa, commonly found in turmeric. DMC, with a chemical formula of C20H18O5 and a molecular weight of 340 g/mol, possesses two aromatic ring systems, each featuring a β-diketone moiety connected by a seven-carbon chain. This unique structure allows DMC to engage in tautomerism, which is …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 9–15 Read article
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Estimation of the Total Phenol Contents of the Stem of the Anogeissus pendula
Abstract: Plants are the greatest gift to human kinds; they are the sources of various kinds of metabolites of known as well as unknown composition. Secondary metabolites are the compounds which are non-nutrient and are rich sources of other activity in the plants. Plant phenolics are the compounds which have phenyl ring in them in addition to two or more hydroxyl rings; they perform variety of function in plants such as …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 5, Issue 3, 2018 · pp. 5–7 Read article
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Evaluation of Inhibition Effect of Nanohybrid Curcumin (Cur-ZnO) and Cur-free Against Some Types of Bacteria
Abstract: This study aimed to prepare an efficient nanohybrid food preservative by loading curcumin on zinc oxide. The prepared compound was characterized using microscopy and spectral methods. Fourier transform infrared spectrum of the nanohybrid curcumin showed a shift in the frequencies of some chemical groups towards high and low frequencies. X-ray diffraction (XRS) spectrum also revealed the emergence of new diffraction planes in the nanohybrid compound, Compared with the carrier spectrum …
Published in Journal of Polymer & Composites · Vol. 11, Issue 2, 2023 · pp. 68–79 Read article
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Fruit Adulteration Detection Utilizing Machine Learning Methods
Abstract: A device utilizing Internet of Things (IoT) technology was developed for the identification of fruit adulteration through machine learning methods, specifically targeting formalin content assessment. The identification of the fruits based on their extracted traits has been accomplished using a variety of machine-learning techniques. The formalin concentration can be detected as an estimate of the generated voltage of any fruit via an Arduino Uno board 3 and a volatile compound …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 1, Issue 1, 2023 · pp. 32–45 Read article
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Corrosion inhibitors of steel applicable by green but toxics
Abstract: Inhibitors in detergent and alkali based chemicals are used in various media for steels. Toxicity has induced pharmaceutical compounds as better inhibitors to restrict pollutant gases emissions after reaction with alkaline inhibitors. Green in origin inhibitors are toxin free to use with detergents for inhibition of both pollutant gases and corrosion of processing machineries made of metals. Eco-friendly inhibitors have appeared for steel corrosion being embedded in concrete i.e. alkaline …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 6, Issue 2, 2019 · pp. 38–47 Read article
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Development and Applications of a Simple Chalcone- Based Low Molecular Weight Ligand for Treating Nosocomial Infections due to Staphylococcus aureus and Escherichia coli
Abstract: Abstract Inspired from the available biological data of several imperative therapeutic scaffolds in several medicinal chemistry databases, thiophene-containing chalcone compounds were identified and the molecule was designed for treating various nosocomial infections. In one of the recent rational exploration, (E)-3-(4-methoxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one was synthesized in a single-step reaction, characterized comprehensively by using a few sophisticated spectroscopic instruments such as FT-IR spectroscopy, mass spectroscopy, and 1H-NMR spectroscopy, as well as CHN analyzer, and …
Published in Research and Reviews: A Journal of Medicine · Vol. 10, Issue 2, 2020 · pp. 14–18 Read article
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A Novel Approach for Extraction of Polyphenols
Abstract: Polyphenols are class of compounds which are found in fruits, vegetables, walnuts, olives, tea leaves and many more. Polyphenols are antioxidant phyto-chemicals that prevent or neutralize the damaging effects of free radicals. They are secondary metabolites of plants and are generally involved in defence against ultra-violet radiation or aggression against pathogens. Polyphenols are various alcoholic compounds containing two or more benzene rings that each has at least one hydroxyl group …
Published in Emerging Trends in Chemical Engineering · Vol. 1, Issue 1, 2014 · pp. 31–36 Read article
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Interaction of Bioactive Component of Aframomum melegueta on Molecular Docking
Abstract: Computational mimicry of the structure of large complexes created by di- and poly-interaction of molecules has been termed molecular docking. The purpose of molecular docking is the prediction of the three-dimensional structures of interest, this is due to that docking only produces plausible candidate structures. The docking was carried out between the bioactive compounds against 5α-reductase, 3β-hydroxy-steroid dehydrogenase, and 17β-hydroxy-steroid dehydrogenase of returned binding energy, BE (kcal/mol) between -5.9 and …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 51–60 Read article
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Studies on Mechanical, Electrical and Thermal Properties of Compatibilized PLA/ABS Blends Reinforced with Wood Flour
Abstract: AbstractPoly lactic acid (PLA) bio-polymer (60%) was blended with acrylonitrile butadiene styrene (ABS) (40%) and filled with wood flour (0, 10, 20%) using a twin screw compounding extruder and a suitable compatibilizer i.e., glycerol, is also incorporated into that mixture at a percentage of 4% respectively. Test specimens were prepared by using an injection molding machine for mechanical, electrical and thermal properties as per ASTM standards and the properties were …
Published in Journal of Polymer & Composites · Vol. 3, Issue 3, 2015 · pp. 20–26 Read article