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1260 articles for “CTLA-4”
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In Silico Analysis and Docking Study of the Active Phytocompounds of Bacopa monnieri Against Alzheimer Disease
Abstract: Objective: Alzheimer’s is a neurodegenerative disease and is the cause of 60–70% of cases of dementia. It infected a million people worldwide. An effort was undertaken to explore the potential of natural compounds found in Bacopa monnieri, a plant renowned for its extensive medicinal properties in Indian Ayurveda, to combat the disease. This was achieved through molecular docking studies, evaluation of drug-likeness, and comprehensive ADME (absorption, distribution, metabolism, and excretion) …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 1–13 Read article
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NPSB Fertilizer Effect on Yield of Wheat (Triticum aestivum L.) At Wolaita Zone Sodo Zuria Woreda, South Ethiopia
Abstract: Wheat (Triticum aestivum) is one of most important cereal crop in Ethiopia. The major obstacle for farmer to produce wheat in Ethiopia was low soil fertility status and nutrient imbalance. The experiment was conduct during 2019 and 2020 ‘meher’ cropping season at Kokate substation of Areka agricultural research center at sodo zuria woreda wolaita zone south Ethiopia with objectives of evaluating the effect of NPSB fertilizers rate on yield and …
Published in Research & Reviews : Journal of Botany · Vol. 13, Issue 3, 2024 · pp. 46–52 Read article
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Stilbenes: A Molecular Docking and ADMET Analysis Approach on an Emerging Resource for Scavenging Reactive Oxygen Species in the Field of Colon Malignancy
Abstract: Objective: Colon malignancy, also referred to as colon cancer, originates as precancerous polyps in the colon or rectum, which have the potential to thrive and progress into cancerous tumors over time. This study delves into various bioactive compounds (from natural sources like plants) to assess their potential efficacy in inhibiting colon malignancy as compared to conventional methods. Methods: The objective of this study was to employ computational methodologies to evaluate …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 3, 2024 · pp. 29–38 Read article
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Removal of Lead (II) ions from Water by using green nanoTrimanganese Tetroxide
Abstract: Inorganic pollutants like heavy metal ions and organic pollutants like pesticides and dyes are the main causes of water pollution. These contaminants cause serious issues for the environment and public health when they are present. To get rid of these contaminants from water bodies, several methods are employed.Due to its ease of use, great efficiency, abundance of adsorbents, and low sludge creation, adsorption is the most advantageous method for purifying …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 691–700 Read article
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Realtime Life Cycle Assessment, Synthesizing Life Cycle Inventory with Business Process Management, Sustainable Growth in the Fourth Industrial Revolution
Abstract: A prevalent methodology for evaluating the ecological impacts of processes and products throughout their entire life cycle is known as Life Cycle Assessment (LCA). This approach involves scrutinizing each phase, encompassing the extraction of raw materials, manufacturing, utilization, and disposal. Nevertheless, conventional LCA methods often fail to account for the dynamic nature of industrial processes and are deficient in real-time data. The Life Cycle Inventory (LCI), a pivotal component of …
Published in International Journal of Industrial and Product Design Engineering · Vol. 2, Issue 2, 2024 · pp. 1–9 Read article
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Drying Characteristics of Moringa (Moringa oleifera) Leaves
Abstract: Moringa oleifera belongs to Moringaceae family whose leaves carries bundles of nutrients and vitamins. In this study, moringa leaves were dried and quality was evaluated under different drying temperatures viz, 40, 50, 60, & 70ºC. The initial moisture content of the fresh moringa leaf was found to be 73.20 % on a wet basis or 273.0% on dry basis. In tray drying the final moisture content of dried moringa leaves …
Published in Research & Reviews : Journal of Herbal Science · Vol. 14, Issue 1, 2025 · pp. 15–23 Read article
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Screening Some Sorghum (Sorghum Bicolor L. Moench) Genotypes for Yield and Resistance Against Stem Borer (Sesamia Calamistis) in Nigeria
Abstract: Sorghum is a staple crop with global significance, scientifically it’s known as Sorghum Bicolor, stands as one of the most important cereal crops globally, particularly in regions with arid and semi-arid climates. Sorghum remains a cornerstone of agricultural economies worldwide with its widespread cultivation and diverse applications; however, its production is often hindered by various biotic stresses, with stem borer (Sesamia calamistis) infestation being a significant concern. The stem borer …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 15, Issue 1, 2025 · pp. 50–55 Read article
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Evaluation of Medication Adherence in Patients with Type 2 Diabetes Mellitus: A Mixed- Methods Approach
Abstract: Background: Medication adherence refers to how closely an individual follows the prescribed medication regimen. It is essential for achieving desired therapeutic outcomes and improving patient health. Inadequate adherence can result in the deterioration of health conditions, higher mortality rates, and increased healthcare expenses. Diabetes mellitus, being a chronic condition, demands ongoing medical care not only to prevent the onset of serious complications but also to manage them effectively once they …
Published in International Journal of Community Health Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 28–35 Read article
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Development and evaluation of multigrain pasta
Abstract: Pasta is one of the most consumed food among the food products prepared from cereals due to low cost, ease in preparation along with pleasant textural and sensory characteristics. This study was performed to prepare multigrain pasta by utilising the numerous health benefits of wheat, chickpea, kodo and ragi flour. Each ingredient was selected according to unique nutritional attributes which will be incorporated in pasta to make it more nutritious …
Published in International Journal of Nutritions · Vol. 2, Issue 2, 2025 · pp. 34–47 Read article
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Effects of Tendon Gliding Exercises on the Speed of Handwriting Among Female UG Students: Pilot Study
Abstract: Background: Handwriting is an intricate function which requires the combination of fine motor skills, visual and motor coordination abilities, and concentration. Handwriting involves two main movements: horizontal wrist motion and vertical finger movements, along with a rightward translation of the entire arm. Handwriting speed is an important factor in a student’s academic performance, particularly in fields such as statistics. The strength and flexibility of hand muscles can significantly influence writing …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 1–6 Read article
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A Role of Ergonomics in Advanced Manufacturing Systems: A Harmonious Blend of Human and Machine
Abstract: The integration of human and machine elements in advanced manufacturing systems (AMS) necessitates a careful consideration of ergonomic principles to ensure the well-being and performance of the workforce. This paper explores the critical role of ergonomics in AMS, focusing on physical, cognitive, and organizational aspects. By optimizing the interaction between humans and technology, ergonomics aims to reduce musculoskeletal disorders, improve worker satisfaction, and enhance overall system efficiency. The paper delves …
Published in International Journal of Manufacturing and Production Engineering · Vol. 3, Issue 1, 2025 · pp. 1–7 Read article
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Enhancement of Thermo-hydraulic Properties of a Novel Composite-Based Spiral Fin Tube Heat Exchanger: An Experimental Investigation
Abstract: It is now crucial for engineers to enhance procedures and boost heat exchanger efficiency. Heat exchanger performance can be significantly enhanced by a variety of methods. Composite-based fins or enlarged surfaces are frequently utilized to increase the air-side heat transfer rate in a variety of heat transfer applications. Because composite materials are lightweight, highly thermally conductive, and resistant to corrosion, they were used. A composite based fin's efficiency is influenced …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 238–251 Read article
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Investigation, Fabrication and Testing of Spur Gear Using Composite Material
Abstract: Composite materials constitute one of the favorable, efficacious material zones for tomorrow’s sustainable future through identification of materials with higher strength to weight ratio. A composite material is combination of two or more different materials with varied qualities that work together to create a material that is better than the sum of its parts. Therefore, finding some alternative material for various mechanical applications to accelerate the Indian composite industry is …
Published in Journal of Experimental & Applied Mechanics · Vol. 16, Issue 2, 2025 · pp. 1–8 Read article
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An Ultraviolet-Curable Nano Cerium Oxide Coating and Its Anti Ultraviolet /Blue Light Properties
Abstract: An ultraviolet (UV)-curable nano cerium oxide (CeO2) coating with enhanced blue light and UV shielding properties, prepared using an ultrasonic blending method, is presented. This study systematically investigated the optimal synthesis conditions for nano CeO2, as well as the effects of UV intensity and CeO2 concentration on the curing kinetics and blue/UV light shielding performance of the UV-curable nanocomposite. The results indicate that the synthesized nano CeO2 exhibited improved mechanical …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 306–324 Read article
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The Role of Indigenous Knowledge Systems in Cultural Heritage Preservation under NEP 2020
Abstract: In Introduction, This study explores the roles of India’s National Education Policy (NEP) 2020 in cultural heritage preservation through indigenous knowledge systems. These include traditional arts, crafts, ecological practices, and languages. It also includes perspectives through gender and regional lenses on this integration. In Methodology, Confirming the study, a survey was held with 2,300 participants, with an equal split of male, female and non-binary, from rural and urban settings. The …
Published in International Journal of Trends in Humanities · Vol. 2, Issue 2, 2025 · pp. 22–30 Read article
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Integrating Genetic Algorithms with Lean Manufacturing for Enhanced Production Efficiency
Abstract: Lean manufacturing is a well-established philosophy focusing on the systematic reduction of waste and the ongoing development of value supplied to the customer. It emphasizes efficiency, quality, and adaptability through ideas such as just-in-time production, continuous improvement (Kaizen), and value stream optimization. However, the increased complexity of modern production systems, driven by global rivalry, product variety, and rapid technology innovation, has shown the limitations of classic lean tools in achieving …
Published in Journal of Production Research & Management · Vol. 15, Issue 3, 2025 · pp. 38–43 Read article
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Novel approaches to the Design and Optimization of Universal Shift Register with Reversible logic
Abstract: Reversible logic is gaining importance in new multi-disciplinary fields, such as quantum computing, low-power computing, and even nanotechnology. The study of reversible gates has quickly evolved as a distinctive area of research as a result of the new developments aimed at fully utilizing resources and performing operations without any loss of information. With chip integration, these USRs, or Universal Shift Registers, have now become fundamental sequential components needed in various …
Published in Journal of VLSI Design Tools and Technology · Vol. 15, Issue 3, 2025 · pp. 21–28 Read article
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Impact of Diabetes on Quality of Life of Patient with Diabetes in West Tripura
Abstract: Throughout the new millennium, diabetes mellitus is on the rise everywhere. According to IDF, the prevalence of diabetes in worldwide was 537 million in 2021; this number is anticipated to climb to 643 million by 2030 if no effective preventative measures are introduced. According to an IDF research, one in three households has diabetic patients, and one in seven adult diabetics worldwide lives in India. India's percentages were 9.3% in …
Published in Journal of Nursing Science & Practice · Vol. 15, Issue 2, 2025 · pp. 17–28 Read article
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Next-Generation mRNA Therapeutics: Self-Amplifying, Thermostable and Personalized mRNA Vaccines in the Era of Precision Medicine
Abstract: Messenger RNA (mRNA) technology has brought a major change in modern medicine, especially after its successful use in COVID-19 vaccines. However, early mRNA vaccines faced several problems such as low stability, strict cold storage requirements, and lack of personalized treatment. To overcome these challenges, next-generation mRNA technologies have been developed, including self-amplifying mRNA (saRNA), thermostable mRNA vaccines, and personalized mRNA vaccines. This article discusses the development of mRNA therapeutics, the …
Published in International Journal of Vaccines · Vol. 2, Issue 2, 2025 · pp. 38–54 Read article
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Emerging Digital Trends in Virology Software: Optimizing Viral Discovery, Surveillance,and Patient Management.
Abstract: Virology and antiviral therapeutics are being reshaped by rapid advances in computational tools, automation platforms, and virus-focused digital health applications. Software systems now span the entire virology value chain, from in silico viral target identification and antigen design, to AI-supported clinical trial management for vaccines and antivirals, to post-marketing pharmacovigilance and patient-facing mobile tools. This review examines current and emerging software trends relevant to virus studies, emphasizing applications in viral …
Published in International Journal of Virus Studies · Vol. 3, Issue 1, 2026 · pp. 29–38 Read article