Search
1593 articles for “strategy”
-
Formulation Challenges in Long-acting Injectable Small Molecules: Emerging Strategies and Perspectives
Abstract: Long-acting injectable (LAI) formulations represent a transformative approach in pharmacotherapy, particularly for conditions demanding sustained drug exposure over weeks to months. Although biologics have dominated this space historically, the adaptation of LAI technology to small molecules presents a distinct and complex set of challenges rooted in physicochemical properties, manufacturing scalability, and regulatory expectations. This review systematically addresses the principal formulation barriers encountered in developing LAI small-molecule products, including aqueous solubility …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article
-
Mental Health Nursing Interventions in Schizophrenia Care: Effectiveness of Nurse-Led Strategies in Managing Schizophrenia Disorder
Abstract: Schizophrenia is a chronic and severe mental disorder characterized by disturbances in thought, perception, emotion, and behavior that significantly impair an individual’s functioning and quality of life. Mental health nurses play a pivotal role in the management of schizophrenia through comprehensive, patient-centered, and evidence-based interventions. This article critically examines the effectiveness of nurse-led strategies in managing schizophrenia disorder, focusing on pharmacological support, psychosocial interventions, psychoeducation, therapeutic communication, relapse prevention, and …
Published in Journal of Nursing Science & Practice · Vol. 16, Issue 1, 2026 Read article
-
Structural Optimization of FDM-Processed ASA Polymer Frames through Acetone Solvent Welding, Variable Infill Strategy, and Layer Orientation: Experimental Validation via Quadcopter Flight Testing
Abstract: Acrylonitrile styrene acrylate (ASA) is an amorphous terpolymer with superior UV resistance compared to acrylonitrile butadiene styrene (ABS), as its acrylate rubber phase lacks photodegradation-prone carbon–carbon double bonds. This study proposes acetone solvent welding as a polymer joining method to produce monolithic structures from FDM-processed ASA components, addressing three processing challenges: achieving structural continuity through polymer chain interdiffusion at solvent-wetted interfaces, correcting thermal warping via post-print geometric correction during welding, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 689–703 Read article
-
Intelligent Power Quality Enhancement Strategies for PV-Integrated Smart Distribution Networks: A State-of-the-Art Review
Abstract: The rapid integration of photovoltaic (PV) systems into modern power distribution networks has introduced significant challenges related to power quality. Issues such as voltage fluctuations, harmonic distortion, flicker, and reactive power imbalance arise due to the intermittent and nonlinear nature of solar energy generation. This paper presents a concise literature review of various power quality enhancement techniques employed in PV-integrated networks. Key approaches include the use of active power filters …
Published in International Journal of Electrical Power and Machine Systems · Vol. 4, Issue 1, 2026 · pp. 30–53 Read article
-
Non-Small Cell Lung Cancer: Types, Pathogenesis, Diagnosis, and Novel Therapeutic Strategies
Abstract: Non-small cell lung cancer (NSCLC) is the most prevalent type of lung cancer, accounting for over 85% of all cases globally. It remains one of the primary causes of cancer-related death due to its rapid progression, few early symptoms, and late detection. The three main forms of non-small cell lung cancer (NSCLC) are adenocarcinoma, squamous cell carcinoma, and giant cell carcinoma; each has a unique histology, prognosis, and response to …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
-
Personalized Medicine: the impact of ferrofluids, clinical procedures, strategies, applications,challenges, current trends, and reseach opportunities.
Abstract: Personalized medicine has shown progressive development and evolution in health care systems. It is considered as transformative emerging medicine encorporating advanced technologies including genomics, AI as thinking partner, and nanotechnology in a greater extent. The quest for painless injection, lesstoxicity, rapid cell separation, and gene sequencing make ferrofluid the focus of personalized medicine. Currently, magnetic nanoparicles and ferrofluides are becoming driving force of personalized medicine. However, contronlling and managing nanoscale …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 2, 2026 Read article
-
Strategies for the Development and Optimization of Orally Disintegrating Tablets (ODTs) to Improve Bioavailability and Patient Compliance
Abstract: Background: Pharmaceutical scientists have developed Orally Disintegrating Tablets (ODTs) to advance patient drug acceptance and biological system availability through simplified medi-cation delivery especially for children and senior citizens and people who cannot swallow pills regularly. The oral disintegrating tablets dissolve in the mouth within thirty seconds or less (USP 701) while needing no additional liquid thus making them suitable for both emergency treatments. Objective: The research examines ODT development strategies …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article
-
Host Invasion to Immune Evasion: Emerging Concepts in Pathogen Virulence Strategies
Abstract: The interaction between hosts and pathogens represents a continuous evolutionary struggle, shaping both microbial virulence and host immunity. Pathogens employ diverse strategies to evade immune surveillance, ranging from antigenic variation and molecular mimicry to hijacking of host immune checkpoints. Simultaneously, hosts refine innate and adaptive immune mechanisms to counteract infection and limit damage. This reciprocal adaptation, known as host–pathogen coevolution, influences pathogen persistence, transmission, and fitness, while also sculpting immune …
Published in International Journal of Pathogens · Vol. 3, Issue 1, 2026 Read article
-
Study on the Response of Strengthening Strategies for Masonry-infilled Open Ground Storey Framed Building
Abstract: The strengthening of reinforced concrete (RC) frame buildings with masonry infill wall and with open ground storey is a very timely and significant topic because of the poor performance against seismic action. The absence of infill walls in the ground storey makes the ground storey less stiff and weaker than the all upper storys which results in a poor performance against lateral loads. Soft storey mechanism prevails in these cases …
Published in Journal of Structural Engineering and Management Read article
-
Development of Game Theory Strategy for Estimating Mobility Variety in Approaching Wireless Networks
Abstract: Game theory designed with a set of structured tools with an evaluation tool for the tedious interaction among logical players. This theory approaches for analyzing of communication networks, which functions with autonomous structured networks and the designed network devices can take rational decisions according to network congestion. The proposed structure consists of mixture frame for channel allocation for random probability for accessing channel. The main objective of this work is …
Published in Recent Trends in Electronics Communication Systems Read article
-
A Security Investigation Survey of Ransomware Detection and Avoidance Strategies for IoT Networks
Abstract: The internet of things (IoT) refers to the interconnection of a large number of distinct physical objects, which in turn makes possible a variety of services and applications. Because the IoT sector is developing at such a rapid rate, ensuring its safety ought to be a high concern. At this time, ransomware attacks constitute the biggest danger to IoT posed by cyberattacks. Ransomware is software that blocks access to or …
Published in International Journal of Information Security Engineering · Vol. 1, Issue 2, 2023 · pp. 14–23 Read article
-
Inhibition of PI3K/Akt/mTOR Signaling Pathway by Vitis Vinifera Phytocompounds: A Promising Strategy for Supressing Colorectal Cancer Growth and Metastasis
Abstract: Objectives: Colorectal cancer was not typically identified a few decades ago. Today, with almost 900 000 fatalities each year, it is the fourth most dangerous cancer in the world. Colorectal cancer is responsible for about 10% of all cancer diagnoses annually and cancer-related deaths worldwide. It is the second most common type of cancer in women and the third most common type in men. Incidence and death are roughly 25% …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 64–75 Read article
-
Review on Algae Biodiesel Production: A Strategy to Enhance Future
Abstract: The quest for cleaner and renewable energy sources has propelled the interest in the production of biodiesel from algae. Algae, due to their high oil content and fast growth rate, present a promising feedstock for the production of biodiesel, especially since they can be cultivated on non-arable land and with seawater or wastewater. Algae biodiesel offers the advantage of being compatible with current diesel engines without any need for modification, …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 2, 2023 · pp. 23–30 Read article
-
Navigating the Depths of Cancer Stem Cells: Unraveling Resistance Mechanisms and Emerging Therapeutic Strategies
Abstract: In the past few decades, comprehensive evidence has convincingly established the presence of cancer stem cells (CSCs) as a minor subset within tumors, contributing to an unusually elevated level of cellular diversity within the malignancy. CSCs are functionally identified by their capacity for self-renewal and differentiation, frequently influenced by signals from their surrounding microenvironment. The interconnected transcriptional, post-transcriptional, metabolic, and epigenetic regulatory networks govern the biological characteristics of CSCs. CSCs …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 14–18 Read article
-
Exploring Inclusivity: Challenges, Strategies, and Impact
Abstract: Inclusivity is a cornerstone which aims to create environments, products and systems that meet the diverse needs and abilities of all people. This research paper provides a comprehensive study of inclusivity and sheds light on its role in building a just and accessible world. It continues to trace the historical development of universal design, revealing key milestones and their impact on the pursuit of inclusivity. In addition, the article examines …
Published in International Journal of Rural and Regional Development · Vol. 1, Issue 2, 2023 · pp. 24–36 Read article
-
Exploring Decarbonization Strategies and Sustainable Alternatives for Cement
Abstract: As one of the most evolving economic sectors, building construction creates wealth and income while making a significant contribution to global development. Almost 40% of all carbon emissions, both direct and indirect, come from this industry. It is crucial to lower emissions from the manufacture of cement to mitigate climate change. The cement industry must be made less carbon-based. The need to address the environmental effects of traditional cement production, …
Published in International Journal of Manufacturing and Production Engineering · Vol. 1, Issue 2, 2023 · pp. 1–8 Read article
-
Review of Control Strategies in Lower Extremity Exoskeleton
Abstract: Personal mobility is one of the biggest challenges for ensuring the quality of rehabilitation in the lives of Persons with Locomotor Disabilities (PwLDs) and old aged persons. In order to ensure effective orthotic rehabilitation, there is need to design and develop more and more automated aids and appliances. In order to know the status of research a study has been made on the controllers of lower limb exoskeleton (LLE). In …
Published in International Journal of Robotics and Automation in Mechanics · Vol. 1, Issue 2, 2023 · pp. 9–21 Read article
-
Vaccination in the Era of Precision Medicine: Tailoring Immunization Strategies for Individual Risk Profiles
Abstract: The introduction of precision medicine has caused a paradigm change in the vaccine landscape. Conventionally, vaccination programmes have been homogeneous, targeting immunity at the population level without taking into consideration the individual differences in immune response and vulnerability to diseases that can be prevented by vaccination. However, a more individualised approach to immunisation has been made possible by current developments in genetics, immunology, and data analytics. Within the context of …
Published in International Journal of Vaccines · Vol. 1, Issue 2, 2024 · pp. 32–47 Read article
-
Unveiling Insights and Strategies for Cognitive Mental Acuity
Abstract: This comprehensive review focuses on the intricate facets of cognition, emphasizing its multifaceted nature rooted in thought, experience and sensory perception. The role of key brain regions, such as the prefrontal cortex, temporal lobes, parietal cortex, occipital cortex and cerebellum, is elucidated in shaping various mental functions. The pathophysiology of cognitive decline is examined, linking specific impairments to damage in distinct brain regions. The study delves into pharmacological and non-pharmacological …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 14, Issue 1, 2024 · pp. 1–10 Read article
-
Advancements in Antiviral Therapeutics: Strategies and Challenges in the Development of Drugs and Vaccines for Viral Diseases
Abstract: Viral infections continue to pose a significant threat to global health, leading to high rates of illness, death, and economic burden. The constantly evolving nature of viruses, along with the rise of drug-resistant strains, underscores the need for continuous advancements in antiviral treatments. This review highlights the pivotal role of antiviral drugs and vaccines in mitigating the impact of viral infections, showcasing recent breakthroughs and exploring emerging technologies. Key advancements …
Published in International Journal of Virus Studies · Vol. 1, Issue 1, 2024 · pp. 32–36 Read article