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114 articles for “in silico characterization”
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In Silico Identification of Therapeutic Agents for Dengue Virus by Molecular Docking
Abstract: The dengue virus causes serious health issues and a loss of quality of life. Dengue poses a yearly threat to half of the world’s population. The drugs that are based on allopathy are expensive and also exhibit toxic effects on tissues and biological activities. It is also generally accepted that most pharmacologically active drugs, including those derived from medicinal plants, are isolated from natural sources. The present study is directed …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 · pp. 01–14 Read article
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Optimization and Analysis of InGaAs Vertical Nanowire Transistor for Memory Array Applications
Abstract: In this paper, we present a cylindrical gate all around In 0.53 Ga 0.47 As Vertical Nanowire Transistor (VNWT) on silicon at ultra-shortchannel gate length 14nm by numerical simulation approach. The In 0.53 Ga 0.47 As VNWT device dimensions like diameter, source and drainextension length and channel doping are taken as critical process parameters and optimized for better performance. The proposed device isscalable up-to 10nm with a maximum On-current of …
Published in Journal of VLSI Design Tools and Technology · Vol. 13, Issue 2, 2023 · pp. 32–44 Read article
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Significance of Composite Materials for Making Better Future Society
Abstract: Since in the beginning of human history, Materials had been started in use. We can't imagine our world without materials. In fact, Materials has taken centre position in many developed and developing countries. The materials that humans have chosen to use for engineering projects throughout history, including the Stone, Iron, and Silicon ages. However, in order to meet today's difficulties, new materials must be discovered and developed with the necessary …
Published in International Journal of Advance in Molecular Engineering · Vol. 1, Issue 2, 2023 · pp. 56–62 Read article
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Fabrication and Analysis of Al 7075 Based Metal Matrix Composites - A Review
Abstract: Aluminium 7075 alloys are extensively used in aerospace, marine, aviation, and automotive industries due to their superior mechanical properties, high strength-to-weight ratio, and low density. However, to further enhance their performance, aluminium-7075 metal matrix composites (AMMCs) are developed by incorporating various reinforcements. This paper focuses on the influence of reinforcements on the mechanical, tribological, and corrosion behavior of AMMCs. The study examines fabrication techniques, particularly the stir casting method, which …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 1–12 Read article
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First Insights into Whole Genome Sequencing of the Mycobacterium tuberculosis Complex: Molecular Diversity and Drug Susceptibility Patterns in Senegal
Abstract: Background: We conducted a bibliographic analysis of the Mycobacterium tuberculosis complex (MTBC) in sub-Saharan Africa, which included the analysis of 8,139 genomic sequences from 34 of the 49 sub-Saharan African countries. Notably, only one complete sequence from Senegal was identified, which had been generated in the United States. Our primary objective was to utilize whole genome sequencing (WGS) to detect resistance in anti-tuberculous strains of the MTBC in Senegal. This …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 1, 2025 · pp. 1–14 Read article
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Exploration of Mechanical Characteristics and Microstructural Analysis of Copper Matrix Composites with Hybrid Reinforcements via Muffle Furnace Sintering
Abstract: Metal Matrix Composites (MMCs) have drawn a lot of interest in the area of innovative materials because of how widely they may be used. Due to their extraordinary qualities, such as high thermal conductivity, higher temperature endurance, improved corrosion resistance, and great weldability, copper matrix composites stand out among them. These qualities make them desirable and promising materials for uses including heat exchangers, automotive parts, and electrical components. In this …
Published in Journal of Polymer & Composites · Vol. 11, Issue 12, 2023 · pp. 119–126 Read article
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A Review of Fire Retardants for Commercially Important Polyurethane Foams
Abstract: The review covers various additive and reactive fire retardants used to render flexible and rigid polyurethane foams fire retardant. Literature sources are mostly from technical publications, patents, books and handbooks since 1962. Various fire retardants such as phosphorus-containing compounds, halogen-containing compounds, nitrogen-containing additives, silicone-containing products and miscellaneous organic and inorganic additives have been used to render polyurethane foams fire retardant. Some heatresistant groups such as carbodiimide, isocyanurate and nitrogen-containing heterocycles …
Published in Journal of Construction Engineering, Technology & Management · Vol. 3, Issue 3, 2013 · pp. 1–36 Read article
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Microbially Modified Sustainable Cementitious Composites Using Industrial Ash Fillers
Abstract: The growing demand for sustainable, durable construction materials has driven the development of bio-engineered cementitious composites incorporating industrial by-products and self-healing mechanisms. This study investigates a microbially modified cementitious composite that integrates industrial ash fillers with bacteria-based self-healing technology to enhance mechanical performance and microstructural integrity while reducing cement consumption. Cement was partially replaced with industrial ash at 20%, 30%, and 40% replacement levels, and a uratolytic bacterial strain (Bacillus …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 331–350 Read article
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An Analysis of Machining Parameters for Metal Matrix Composite
Abstract: The electro-discharge machining analysis of hybrid Composite is presented in this work. Variables are chosen for the input process parameters. The material removal rate is acknowledged as an output parameter, together with the current, graphite and silicon carbide percentage and pulse on time. We used the Taguchi Method to conduct our experiments. To create the theoretical model and look into how process parameters affect the rate at which material is …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 76–85 Read article
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A Study On Mems Piezoresistive Pressure Sensor Design And Its Applications
Abstract: Easier and faster means of Pressure measurement is in utmost demand in Industries. MEMS piezoelectric pressure sensors can meet the claim due to its compactness and lightweight. The pressure measurement is purely application specific. The number of steps required to fabricate the MEMs sensor can be condensed if a proper selection of sensor is done. Based on the type of the piezoelectric materials used in the design, the shape of …
Published in Recent Trends in Electronics Communication Systems · Vol. 8, Issue 1, 2021 · pp. 18–23 Read article
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Fabrication and Optimization of Process Parameters for Friction Stir Welding AA7075+10%wt.SiC Composite by Taugchi Method
Abstract: Aluminium alloy 7075 as matrix and silicon carbide (SiC) as reinforcement has been widely used in aircrafts and space industries because of high strength to weight ratio. Fusion welding of this Aluminium Metal Matrix Composite (MMC) will lead to many problems such as porosity, micro-fissuring and hot cracking. However, friction stir welding (FSW) can be used to weld this MMC without above mentioned defects. Objective of this investigation are fabrication …
Published in Journal of Experimental & Applied Mechanics · Vol. 9, Issue 3, 2018 · pp. 102–112 Read article
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In Silico Analysis and Docking Study of the Active Phytocompounds of Bacopa monnieri Against Alzheimer Disease
Abstract: Objective: Alzheimer’s is a neurodegenerative disease and is the cause of 60–70% of cases of dementia. It infected a million people worldwide. An effort was undertaken to explore the potential of natural compounds found in Bacopa monnieri, a plant renowned for its extensive medicinal properties in Indian Ayurveda, to combat the disease. This was achieved through molecular docking studies, evaluation of drug-likeness, and comprehensive ADME (absorption, distribution, metabolism, and excretion) …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 1–13 Read article
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Targeting PTPN22 in Arthritis: Molecular Docking and Pharmacokinetic Evaluation of Artemisia vestita Compounds
Abstract: Rheumatoid arthritis (RA) is a long-term autoimmune condition characterized by inflammation of the synovial membrane, commonly resulting in swelling, pain, stiffness, and overall fatigue. Protein tyrosine phosphatase non-receptor type 22 (PTPN22) has been identified as a risk factor linked to various autoimmune diseases, including RA. In the PTPN22 gene, two missense Single nucleotide polymorphisms (SNPs) are associated with autoimmune conditions. The R620W (C1858T, rs247660) variant in exon 14 has been …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 20–31 Read article
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In Silico Assessment of Drug like Properties of Some Thiadiazole and Oxadiazole Derivatives as HDAC Inhibitors
Abstract: Purpose: To investigate in silico the drug-like properties of some thiadiazole and oxadiazole derivatives as HDAC inhibitors. Methods: We used Chemdraw Ultra 11.0 to redraw all chemical structures. Furthermore, some applications, such as Bio-Loom for Windows - version 1.5, Molinspiration Property Calculator, and ACD/I-LAB, were used to forecast the drug-like properties of thiadiazole and oxadiazole derivatives, including relative molecular mass (MW), partition coefficient log P (cLog P), number of hydrogen …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 9, Issue 2, 2022 · pp. 1–13 Read article