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166 articles for “drug response”
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Impact of Various Front-line Hypertensive medication on Blood Pressure Control During Maximum Exercise Testing in Coronary Artery Disease Patients
Abstract: It has long been known that blood pressure (BP) and cardiovascular morbidity are related. It is acknowledged that blood pressure during activity may serve as a more reliable indicator than resting blood pressure, which might not accurately reflect blood pressure at other times. Goals: 1) To assess how blood pressure behaves during physical activity in individuals with coronary artery disease (CAD) whose hypertension is managed with first-line antihypertensive medications. 2) …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 2, 2024 · pp. 37–41 Read article
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Emerging Digital Trends in Virology Software: Optimizing Viral Discovery, Surveillance,and Patient Management.
Abstract: Virology and antiviral therapeutics are being reshaped by rapid advances in computational tools, automation platforms, and virus-focused digital health applications. Software systems now span the entire virology value chain, from in silico viral target identification and antigen design, to AI-supported clinical trial management for vaccines and antivirals, to post-marketing pharmacovigilance and patient-facing mobile tools. This review examines current and emerging software trends relevant to virus studies, emphasizing applications in viral …
Published in International Journal of Virus Studies · Vol. 3, Issue 1, 2026 · pp. 29–38 Read article
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Nanotechnology meet phytomedicine towards smarter drug delivery system.
Abstract: Using bioactive substances derived from plants, or phytomedicine, has long shown promise in treating a variety of illnesses with fewer adverse effects than synthetic medications. Nevertheless, a lot of phytochemicals have issues with inadequate targeting in vivo, low bioavailability, poor solubility, and chemical instability. By enabling encapsulation, controlled release, targeted delivery, and stimuli responsive behavior, nanotechnology provides effective tools to get around these restrictions. This review examines the intersection of …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 46–53 Read article
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Advanced Techniques in Filler Layering for the Malar Region: Implications for Cellular Integrity and Long-Term Outcomes
Abstract: Objective: This review investigates advanced filler layering techniques for the malar region, focusing on cellular integration, collagen remodeling, hydration dynamics via aquaporin channels, genetic responses, and filler performance over time. Emphasis is placed on high-density HA fillers (Lyft, Voluma, Volift, and Volux), examining cellular-level mechanisms, genetic interactions, and the role of key pathways (TGF-β, ERK/MAPK, AQP3) in long-term outcomes. Methods: A systematic review was conducted, focusing on genetic, cellular, and …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 1, 2025 · pp. 10–19 Read article
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Histological Effects of the Antibiotic Gentamicin on the Ovarian Tissue of Female White Laboratory Rats
Abstract: This study aimed to evaluate the histological alterations induced by Gentamicin in the ovarian tissue of white laboratory rats. A total of 12 adult female rats were used and randomly divided into two groups, with each group consisting of six animals. The experimental group received Gentamicin at a dose of 120 mg/kg body weight administered as an injection once daily, while the control group received an equivalent volume of normal …
Published in International Journal of Antibiotics · Vol. 3, Issue 1, 2026 · pp. 1–8 Read article
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IoT-Based Real-Time Monitoring System for Temperature and Humidity Control in Pharmaceutical Manufacturing
Abstract: Environmental conditions, especially temperature and humidity, play a vital role in pharmaceutical manufacturing processes. Even minor fluctuations in these parameters can significantly influence the stability, potency, and overall effectiveness of drug formulations. In many cases, uncontrolled environmental variations may lead to chemical degradation, reduced shelf life, contamination risks, and substantial financial losses for manufacturers. Therefore, maintaining precise and consistent environmental conditions is essential to ensure product quality, regulatory compliance, and …
Published in International Journal of Mobile Computing Technology · Vol. 4, Issue 1, 2026 · pp. 32–37 Read article
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Comprehensive Strategies for the Prevention and Management of Genital Thrush in Males and Females: A Public Health Approach in Punjab (September 2024 to February 2025)
Abstract: Background: Genital thrush, a common fungal infection caused mainly by Candida albicans, affected both men and women, leading to itching, discomfort, and recurrent infections. In Punjab, high humidity, poor hygiene awareness, excessive antibiotic use, and limited access to healthcare contributed to its widespread occurrence. Without effective prevention and management strategies, the condition significantly impacted quality of life. Addressing this issue through a public health approach was essential for reducing its …
Published in Research and Reviews: A Journal of Medicine · Vol. 15, Issue 3, 2025 Read article
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Artificial Intelligence for Improved Healthcare: A Case Study and Applications
Abstract: Artificial intelligence (AI) in healthcare ushers in a revolutionary period of innovation, but it also brings with it significant ethical dilemmas. This paper explores the complex relationship between AI and healthcare, emphasizing both its useful applications and the moral conundrums that arise. Ethical issues span a wide range, including patient privacy, transparency, accountability, and the unintentional reinforcement of biases in AI algorithms. Privacy concerns take center stage as healthcare providers …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 12, Issue 1, 2025 · pp. 1–12 Read article
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Nano-Therapeutics in Diabetes Mellitus: Revolutionizing Diagnosis, Treatment, and Drug Delivery
Abstract: Diabetes mellitus is a chronic metabolic disorder in which blood glucose concentration remains high over an extended duration, resulting in significant lethal complications, including neuropathy, nephropathy and cardiovascular diseases. However, conventional diabetes management strategies, including insulin therapy and oral hypoglycemic agents, rarely exhibit poor bioavailability, high doses, off target delivery, etc. Nanotechnology has brought the rise of diabetes treatment revolution, by overcoming the challenges present in standard treatment, owing to …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 08–19 Read article
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Exploring the Therapeutic Potential of Phytochemicals in Aloe Barbadensis Miller Through Molecular Docking for Ulcerative Colitis Management
Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by mucosal inflammation of the colon, often associated with immune dysregulation and oxidative stress. Natural compounds have gained significant attention as alternative therapeutic agents due to their efficacy and minimal side effects. Quercetin, a flavonoid abundantly found in Allium cepa (onion), has demonstrated potent anti-inflammatory and antioxidant properties. This study employs an in silico approach to evaluate the therapeutic potential …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 1, 2026 · pp. 06–12 Read article
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Advancements in Polymer Chemistry for Biomedical Applications: A Focus on Injection Guides
Abstract: Polymers have revolutionized biomedical applications, offering versatility, biocompatibility, and cost-effective manufacturing. This paper explores the role of polymer chemistry in the development of an advanced injection guide for precise drug delivery, aiming to enhance both safety and efficiency in clinical settings. Emphasis is placed on polymer selection, structural design, and functional modifications to improve injection procedures. By leveraging biodegradable and biocompatible polymers, the guide minimizes adverse tissue reactions while ensuring …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 129–136 Read article
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Nano‑Enabled CT for Cancer Imaging: From Molecular Targeting to Image‑Guided Therapy
Abstract: Nano‑enabled computed tomography (CT) exploits high‑atomic‑number (high‑Z) nanomaterials engineered with targeting ligands and therapeutic payloads to enhance contrast, enable molecular imaging, and support image‑guided interventions in oncology. Tumor‑specific nanoprobes such as RGD‑modified gold nanorods, polymer‑coated bismuth nanoparticles, and peptide, antibody, or aptamer‑functionalized platforms can intensify tumor conspicuity, allow early lesion detection and staging, and provide real‑time treatment monitoring. Integration of CT visibility with photothermal, photodynamic, chemo‑, radio‑, and immunotherapeutic functions …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 1, 2025 · pp. 40–49 Read article
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Formulation and Evaluation of Aqueous Azadirachta indica Phytosome
Abstract: A phytosome is a complex created through the union of a natural compound, typically a plant extract, with a phospholipid. Phospholipids play a crucial role in cell membranes, possessing a structure comprising a hydrophilic (water-attracting) head and hydrophobic (water-repelling) tails. This distinctive structure enables phospholipids to construct lipid bilayers, fundamental elements of cell membranes. Phytosome increases the bioavailability, and absorption of active chemical constituents in the extract with the help …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 1, 2024 · pp. 17–30 Read article
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Immunological Biomarkers and Epidemiological Evaluation of Lymphatic Filariasis Elimination Efforts in Osun State, Nigeria
Abstract: Lymphatic filariasis (LF) remains a neglected tropical disease affecting millions globally, despite extensive elimination efforts. While the interruption of transmission is a key goal, the long-term immunological effects on individuals with existing complications like elephantiasis remain poorly understood. This study assessed the current transmission status of LF and the haematological profiles of infected individuals across selected Local Government Areas (LGAs) in Osun State, Nigeria. A total of 7,388 individuals from …
Published in International Journal of Tropical Medicines · Vol. 3, Issue 1, 2026 · pp. 22–30 Read article
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The Role of Natural Products in Antiviral Drug Discovery: Insights into Mechanisms and Therapeutic Potential
Abstract: Drug discovery has always relied heavily on natural sources, especially when it comes to creating antiviral medications. This review explores the therapeutic potential of various natural products, including plant extracts, marine compounds, and microbial metabolites, in the fight against viral infections. We examine the mechanisms of action by which these natural compounds exert their antiviral effects, including direct inhibition of viral replication, modulation of host immune responses, and interference with …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 36–47 Read article
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Integration of Raspberry Pi and Arduino for an Intelligent Medicine Dispensing System in Healthcare Facilities
Abstract: "Automatic Medicine Dispenser Using QR Code" revolutionizes healthcare service delivery by minimizing queue-related inconveniences. Our project created a vending machine using QR code technology in response to the evolving healthcare and technological landscape. The system is powered by an Arduino Mega 2560 and includes key components like a DC gear motor, L298N motor driver, infrared sensor, HC05 Bluetooth module, and a 12V power supply for drug delivery. The project comprises …
Published in International Journal of Electrical Power and Machine Systems · Vol. 2, Issue 2, 2024 · pp. 33–45 Read article
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Prevalence and Risk Factors of Neglected Tropical Diseases Among Women and Children in Rural Liberia: A Regional Perspective
Abstract: Neglected Tropical Diseases (NTDs) remain a critical public health challenge in Liberia, disproportionately affecting women and children in rural regions due to systemic inequities in water, sanitation, and healthcare access. This cross-sectional study assessed the prevalence and risk factors of NTDs among 1,000 participants (600 children above 15 years and 400 women aged 15–49) in rural Liberia using stratified and cluster sampling. Laboratory diagnostics, including Kato-Katz stool analysis, urine filtration, …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 2, 2025 · pp. 1–7 Read article
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Drug Screening Using Stem Cell Technology
Abstract: Stem cell technology in drug screening has transformed the research and development sector of pharmaceuticals. Although stem cells imitate their human counterparts in terms of both safety and potential, it is a new paradigm for mimicking diseases of humans and scale measuring for toxicity. These tissues will, therefore, be more predictive of what will happen in humans during clinical situations, compared to conventional cell lines or animal models, since they …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 42–51 Read article
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Pharmacophore mapping, 3D QSAR, docking, and ADME prediction studies of novel Benzothiazinone derivatives
Abstract: Background Tuberculosis is a major public health concern worldwide which is caused by Mycobacterium tuberculosis. DprE1 (Decaprenyl Phosphoryl Ribose 2’- Epimerase) is the most challenging target for development of novel anti- tubercular agents because it is a small protein and located into cytoplasmic membrane. So, novel anti-TB drugs did not bound effectively with it. DprE1 catalyzes the oxidation of the 2’ hydroxyl group of DPR (Decaprenyl Phosphoryl D- Ribose) …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 59–82 Read article
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Bioconjugates and Biohybrid Polymers: Intricate Cellular Integration Methods and Sophisticated Biofunctionalization Techniques for Tailored Properties in Medical Contexts
Abstract: Bioconjugates are made when biological molecules are covalently linked to manufactured polymers. They can be used in many ways for imaging, diagnosis, and specific drug delivery. Getting perfect cellular fusion is very important for how well they work. Biomolecules can be attached to polymer scaffolds in a controlled way using techniques like click chemistry and site-specific conjugation. This makes sure that the molecules connect optimally with their biological targets. Using …
Published in Journal of Polymer & Composites · Vol. 12, Issue 3, 2024 · pp. 227–243 Read article