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474 articles for “clinical studies”
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Knowledge and awareness of final years dental and medical students towards management. and clinical outcomes of maxillary sinus squamous cell carcinoma 2021
Abstract: Background: - study aimed to assess dental and medical students' knowledge on managing and clinical outcomes of maxillary sinus squamous cell carcinoma, a preventable and treatable cancer, and to address delays in referral and treatment.. objective: -To assess a knowledge and awareness of management and clinical outcomes of maxillary sinus squamous cell carcinoma among final years dental students and medical students at university of Khartoum Materials and Methods: A cross-sectional …
Published in Research and Reviews: A Journal of Dentistry · Vol. 16, Issue 1, 2025 · pp. 10–17 Read article
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Leveraging Genome-Wide Association Studies for Precision Medicine in Cardiovascular Diseases
Abstract: Cardiovascular diseases (CVDs) are the leading cause of death globally, with complex etiologies involving genetic, environmental, and lifestyle factors. Genome-wide association studies (GWAS) have significantly advanced the understanding of genetic underpinnings of CVDs by identifying numerous risk loci and variants associated with various cardiovascular conditions. This review explores the potential of GWAS to drive precision medicine in cardiovascular diseases by linking genetic data with clinical outcomes, providing insights into disease …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 1, 2025 · pp. 35–39 Read article
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Bridging the Theory-Practice Gap in Nursing Education in India: Exploring the Role of Simulation-Based Learning and AI-Driven Education
Abstract: The theory-practice gap in nursing education is a persistent issue that hinders the effective application of theoretical knowledge in clinical practice, ultimately affecting the clinical competence and decision-making skills of nursing graduates. This study explores the factors contributing to the theory-practice gap in nursing education in India and evaluates the potential of simulation-based learning (SBL) and artificial intelligence (AI)-driven education in bridging this gap. A mixed-methods approach was employed, involving …
Published in Journal of Nursing Science & Practice · Vol. 15, Issue 2, 2025 Read article
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A Study on the Prevalence and Causative Factors of Anemia in Patients Undergoing Maintenance Hemodialysis
Abstract: Anemia is a common and serious issue in individuals with chronic kidney disease (CKD) who are on maintenance hemodialysis (MHD), greatly affecting their overall health and quality of life (QoL). Despite advancements in treatment, anemia remains a challenging issue in this population. This study investigates the prevalence of anemia and identifies the contributing factors in CKD patients on MHD with the aim of enhancing clinical management strategies. This study focused …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 1, 2024 · pp. 73–89 Read article
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A Systematic Review of the Herbal Medicinal Plants With Anti-Obesity Potential
Abstract: Obesity is a chronic, multifactorial metabolic condition characterized by abnormal fat accumulation. It is mainly driven by the intricate influence of genetic, environmental, hormonal, metabolic and lifestyle determinants. The burden of obesity has risen considerably over the past few years, making it one of the major health concerns in both developed and developing countries alike. The rapid increase globally in obesity prevalence is linked with numerous health complications such as …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 2, 2026 Read article
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Kisunla (Donanemab): A Novel Breakthrough Illuminating a Path to Better Alzheimer’s Outcomes
Abstract: Background: Alzheimer’s disease (AD) is a progressive neurodegenerative condition marked by cognitive decline, memory loss, and loss of independence. Despite decades of extensive research, disease-modifying treatments have been limited in success. Recent therapeutic advancements have led to the development of monoclonal antibodies targeting amyloid-beta (Aβ) plaques, particularly the pyroglutamate-modified variant, a key pathological hallmark of AD. Objectives: This review aims to explore the therapeutic potential of Donanemab (Kisunla), a novel …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 3, 2025 · pp. 37–45 Read article
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Evaluation of Drug Utilization Patterns and Prescription Trends in Patients with Hypothyroidism and Hyperthyroidism in a Tertiary Care Hospital
Abstract: Background: Endocrine disorders affecting the thyroid gland represent some of the most frequently encountered conditions globally, necessitating prolonged therapeutic intervention and vigilant clinical surveillance. The evaluation of Drug utilization patterns (DUE) serves an essential function in examining prescriptive behaviours and promoting appropriate pharmaceutical management. Objective: To evaluate drug utilization patterns, prescribing trends, and rationality of therapy in patients with hypothyroidism and hyperthyroidism. Methods: A prospective, cross-sectional observational investigation was performed …
Published in Research and Reviews: A Journal of Medicine · Vol. 16, Issue 2, 2026 · pp. 1–5 Read article
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Interfacial Performance and Structural Stability of Repaired vs. Replaced Polymer-Based Composites: A 3-Year Retrospective Analysis of 'Patch-up' Restorative Engineering
Abstract: Objective: This retrospective study aimed to evaluate the clinical longevity and interfacial success of repairing aged polymer-based composites versus complete replacement, focusing on the integration between the existing polymer matrix and the new restorative material. Materials and Methods: A retrospective clinical audit was conducted on 50 cases (n = 50) of posterior restorations with localized defects. The sample was categorized into: Group A (n = 25), where defective sites were …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 180–187 Read article
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Exploring Challenges in Clinical Learning and the Impact of Structured Teaching on Infection Control Knowledge and Attitudes Among Nursing Students
Abstract: Living a healthy lifestyle is essential for preventing chronic diseases and maintaining physical, psychological, and social well-being. The present study, titled “Exploring Challenges in Clinical Learning and the Impact of Structured Teaching on Infection Control Knowledge and Attitudes among Nursing Students” aimed to address key challenges faced by nursing students and evaluate the impact of a structured teaching program. The study employed a quantitative research approach using a pre-experimental design …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 1, 2025 · pp. 42–47 Read article
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Comparative Efficacy and Safety of Safinamide and Rasagiline in the Treatment of Parkinson’s Disease: A Meta-Analysis and Systematic Review
Abstract: Background: Recent studies have suggested Rasagiline and Safinamide monotherapy as potential management options for Parkinson’s disease. Parkinson’s disease, a neurological disorder characterized by tremors and movement difficulties, necessitates treatments aimed at managing clinical symptoms. Levodopa remains the primary effective treatment for Parkinson’s disease symptoms; however, its long-term use often leads to motor complications in many patients. Additional therapeutic drugs, such as dopamine agonists and monoamine oxidase B inhibitors, including Safinamide …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 74–91 Read article
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Health-Seeking Behavior among Women Living in Internally Displaced Persons Camp in Kagara, Niger State
Abstract: This study investigates health-seeking behavior among women in the Internally Displaced Persons (IDP) camp in Kagara, Niger State. Using a cross-sectional design, the study surveyed 400 women to understand factors influencing their health-seeking practices, including barriers to accessing healthcare. The findings of this study reveal that a combination of financial constraints, deeply ingrained cultural beliefs, logistical hurdles, and a general lack of awareness among internally displaced persons (IDP) women significantly …
Published in Research and Reviews: A Journal of Health Professions · Vol. 15, Issue 1, 2025 · pp. 19–28 Read article
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SGLT2 Inhibitors in Heart Failure and Chronic Kidney Disease: Expanding Therapeutic Horizons beyond Glycemic Control
Abstract: Heart failure (HF) and chronic kidney disease (CKD) are closely related clinical diseases that significantly increase morbidity and death worldwide. The co-occurrence of both conditions is frequently referred to as the "cardio-renal syndrome," in which the failure of one organ hastens the decline of the other. The original purpose of sodium–glucose cotransporter-2 (SGLT2) inhibitors was to treat type 2 diabetic mellitus (T2DM) by reducing blood sugar levels. Nevertheless, new data …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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A Study on the Comparative Changes in Nutritional Status in Follow-Up of End Stage Renal Disease Patients
Abstract: Dialysis Disequilibrium Syndrome (DDS) is a rare but serious neurological complication associated with hemodialysis, particularly during the initiation phase or in patients with high metabolic derangements. It is characterized by a range of neurological symptoms resulting from rapid shifts in plasma osmolality, leading to cerebral edema. Despite advancements in dialysis techniques, DDS continues to pose a clinical challenge due to its unpredictable nature and potential for severe outcomes. The present …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 16, Issue 1, 2026 · pp. 9–13 Read article
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Interpretable Skin Cancer Detection via Optimized CNN Models for Smart Healthcare Solutions
Abstract: Skin cancer is a common and potentially life-threatening condition, highlighting the importance of reliable and efficient diagnostic techniques. Recently, convolutional neural networks (CNNs) have demonstrated significant potential in automating the classification of skin cancer using thermoscopic images. Despite these advancements, the lack of interpretability in these models poses a barrier to their widespread use in clinical settings. In this study, we propose an interpretable CNN architecture optimized for skin cancer …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 12, Issue 1, 2025 · pp. 41–45 Read article
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GenChrome-ML: A Machine Learning Framework for Early Detection of Chromosomal Disorders Using Genomic Data
Abstract: The increasing burden of chronic disease and cancer demands innovative, more rapid and effective diagnostic tools in the field of healthcare. The majority of current diagnostic tools are dependent upon clinical symptomology and manual evaluation, leading to delays in early detection and treatment. The development of artificial intelligence (AI) and machine learning (ML), in recent years, has offered opportunities for the enhancement of disease prediction, diagnosis and personalization of treatment …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 2, 2026 Read article
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Phytotherapeutic Potential of Melaleuca: An Integrative Review of Phytochemistry and Antimicrobial, Antifungal, Antioxidant, and Antiviral Mechanisms
Abstract: Melaleuca alternifolia and other species of the Melaleuca genus stand out for the broad spectrum of pharmacological properties attributed to their bioactive compounds, such as monoterpenes, sesquiterpenes, flavonoids, and polyphenols. This study aimed to critically review and analyze scientific evidence produced between 2005 and 2025 regarding the antimicrobial, antifungal, antioxidant, and antiviral activities of Melaleuca, correlating its phytochemistry with molecular mechanisms of action. For this purpose, an integrative literature review …
Published in Research & Reviews : Journal of Herbal Science · Vol. 15, Issue 2, 2026 Read article
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Diabetes Prediction Using ML Techniques
Abstract: Diabetes mellitus, commonly referred to as diabetes, denotes a cluster of prevalent endocrine disorders characterized by persistent elevated levels of blood sugar. Diabetes is classified into two main types: type 1 and type 2. Type 1 diabetes arises when the body is unable to produce insulin, while type 2 diabetes involves either insulin resistance or insufficient insulin production. Early detection and intervention are essential to reduce its harmful impacts. The …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 3, 2024 · pp. 1–9 Read article
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Impact of Diabetes on Quality of Life of Patient with Diabetes in West Tripura
Abstract: Throughout the new millennium, diabetes mellitus is on the rise everywhere. According to IDF, the prevalence of diabetes in worldwide was 537 million in 2021; this number is anticipated to climb to 643 million by 2030 if no effective preventative measures are introduced. According to an IDF research, one in three households has diabetic patients, and one in seven adult diabetics worldwide lives in India. India's percentages were 9.3% in …
Published in Journal of Nursing Science & Practice · Vol. 15, Issue 2, 2025 · pp. 17–28 Read article
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Association of Metabolic Syndrome with Cholelithiasis in Female Patients and Its Impact on Clinical Management and Surgical Outcome
Abstract: Background: Metabolic syndrome (MetS) is associated with obesity, insulin resistance, dyslipidemia, and hypertension, which may predispose to gallstone formation. This study aimed to evaluate the association between MetS and cholelithiasis in female patients and to assess its impact on clinical presentation, surgical difficulty, and postoperative outcomes. Methods: A prospective observational study was conducted on 88 female patients with ultrasonography-confirmed cholelithiasis. Patients were divided into two groups: MetS (n=44) and non-MetS …
Published in Research and Reviews : Journal of Surgery · Vol. 14, Issue 3, 2025 · pp. 1–7 Read article
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A Review: Homeopathic Remedies and Their Potential Neurological Implications in Depression and Asthma
Abstract: Homeopathy, based on the principle “like cures like”, has gained popularity as a complementary treatment for chronic diseases, including depression and asthma. Both health conditions have a profound impact on the quality of life of individuals and are often treated with pharmacological interventions such as antidepressants and bronchodilators. This review reviews homeopathic remedies used to treat depression and asthma, evaluating the available clinical evidence. Although some studies suggest that homeopathy …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 1, 2025 · pp. 15–20 Read article