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216 articles for “Insulin/IGF1-AKT-mTOR”
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Polycystic Ovary Syndrome: A Current Update from Literature
Abstract: PCOS (polycystic ovary syndrome) is an endocrine condition that affects women of reproductive age and can have catastrophic consequences. Menstrual irregularities, hirsutism, evidence of hyperandrogenism, and insulin resistance are all indicators of PCOS. PCOS individuals are more likely to suffer reproductive, metabolic, and cardiovascular problems. The pathogenesis of PCOS is complicated by a number of factors, including genetics, environmental factors, hormonal imbalances, obesity, ovarian dysfunction, and hypothalamus pituitary malformations. Despite …
Published in Research and Reviews: A Journal of Health Professions · Vol. 12, Issue 3, 2022 · pp. 1–21 Read article
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Study of Polycystic Ovary Syndrome (PCOS) with Special Reference to Candidate Genes
Abstract: The PCOS (polycystic ovary syndrome) has become a worldwide concern as progression of PCOS in the age group of adolescence to postmenopausal women is increasing. In India, sudden rapid growth in PCOS is observed in the range of 3.7–22.5%. Effects of PCOS are not only on the reproductive and metabolic systems, but the whole body’s metabolism gets affected; ultimately, it leads to different life- style diseases like type 2 diabetes …
Published in Research and Reviews: A Journal of Health Professions · Vol. 13, Issue 1, 2023 · pp. 49–55 Read article
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A short review on scenario of Type 1 diabetes in Australia
Abstract: Type 1 diabetes (T1D) is caused by an autoimmune attack on pancreatic beta cells that leads to insulin deficiency. The incidence of T1D in Australia has doubled over the past 20 years. T1D treatment focuses on physiological insulin replacement, aiming for near-normal blood glucose levels. Morbidity and mortality result in hypoglycemia in T1D. Better results can be achieved by following some of the new technologies which includes insulin pumps, continuous …
Published in Research and Reviews : A Journal of Immunology · Vol. 9, Issue 2, 2019 · pp. 1–5 Read article
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FACTORS OF DIABETES MELLITUS
Abstract: AbstractDiabetes mellitus (DM) is one of the most common non-communicable diseases (NCDs) globally. Diabetes mellitus is also known as prameha or madhumeha. It is most commonly found in many economically developing and newly industrialized countries. Diabetes mellitus is a disorder that affects the body’s ability to make or use insulin. Insulin is a hormone produced in the pancreas that helps transport glucose (blood sugar) from the bloodstream into the cells …
Published in Research and Reviews: A Journal of Medicine · Vol. 10, Issue 2, 2020 · pp. 19–25 Read article
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Computational Identification of Protein Tyrosine Phospatase-1B (PTP-1B) Inhibitors for Checking Type II Diabetes
Abstract: Protein tyrosine phosphatases (PTPs) are a family of enzyme that comprises of about 100 proteins which catalyze dephosphorylation of phosphotyrosine residues in protein substrates. Phosphotyrosine is a central element in cell signaling, and its activity is essential for cellular homeostasis and for appropriate responses to extracellular signals. PTP-1B antagonizes insulin signaling by reducing the activation state of the insulin receptor kinase, thereby inhibiting post-receptor signaling in insulin responsive tissue. The …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 6, Issue 3, 2017 · pp. 21–25 Read article
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An Overview on the Management cum Treatment of Nephropathy in Type-1 Diabetes Mellitus
Abstract: The motive of this review is to keep updated with the medical nonfictions, the projected early natural arrangement of diabetic nephropathy, the theories behind the root of its pathogenesis pathophysiology, diagnosis and its supervision. Type 1 diabetes is an autoimmune disease characterized by advanced destruction of pancreatic beta cells by genetic and environmental factors which primes to an absolute necessity of insulin for survival and conservation of health; while Diabetic …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 9, Issue 3, 2020 · pp. 19–38 Read article
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Comparative Study of Supervised Learning Techniques
Abstract: AbstractDiabetes is an incessant ailment that happens either when the pancreas does not deliver enough insulin or when the body cannot adequately utilize the insulin it produces. Insulin is a hormone that manages glucose. Hyperglycaemia, or raised glucose, is a typical impact of uncontrolled diabetes and after some time prompts genuine harm to huge numbers of the body's frameworks, particularly the nerves and veins. In 2014, 8.5% of grown-ups matured …
Published in Recent Trends in Parallel Computing · Vol. 6, Issue 3, 2019 · pp. 23–28 Read article
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Initiatives of Nanotechnology to Combat Diabetes Mellitus
Abstract: Diabetes is the single most important metabolic disease which can affect approximately every organ system in the body. It has been projected that 300 million individuals would be affected with diabetes by the year 2025. In India, it is estimated that presently 19.4 million individuals are affected by this deadly disease, which is likely to go up to 57.2 million by the year 2025. It is imperative that effective monitoring …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 3, Issue 2, 2013 · pp. 38–47 Read article
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Comparative Study between Aspirin and Vanadium-Aspirin Complex against Nicotine Exacerbated Diabetic Cataract in Rodents
Abstract: Aspirin is one the most common nonsteroidal anti-inflammatory drug (NSAID) used for the management of various disorders. In the 2254 various previous studies, it was found out that aspirin had a positive correlation in the management of diabetes as well as the cataract. Vanadium is well known metal complex that had an insulin mimetic property and had a significant anti-cataract action. Current work is done with rationale of evaluating the …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 4, Issue 3, 2017 · pp. 18–36 Read article
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Dipeptidyl peptidase-IV (DPP-IV) Inhibitors – a promising oral anti-diabetic drug
Abstract: Dipeptidyl-peptidase IV (DPP-4) inhibitors inhibit the degradation of the incretins i.e glucagon-like peptide1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). Incretins augment the insulin release by a blood glucose-dependent mechanism. Generally DPP-IV enzyme is responsible for inactivating incretins and this enzyme inhibition will prolong and enhance the activity of GLP-1 and GIP. DPP-IV inhibitors increase post prandial insulin secretion, decreases glucagon secretion and seems to have beneficial effect on cardiovascular system, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 11, Issue 3, 2020 · pp. 1–6 Read article
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Herbal Drug Used in the Treatment of Diabetes: A Review
Abstract: Background: Diabetes mellitus is a chronic disease that occurs at the point when the pancreas is not able to produce insulin, or when the body cannot utilize the insulin it produces. Diabetes mellitus is a complex metabolic disorder that affects various systems of body such as visual, circulatory, renal and nervous system. Human beings depend upon plants for their various needs such as food, fodder, fuel, timber, fibres, dyes, gums, …
Published in Research & Reviews : Journal of Herbal Science · Vol. 9, Issue 4, 2020 · pp. 27–34 Read article
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Inhibition of PI3K/Akt/mTOR Signaling Pathway by Vitis Vinifera Phytocompounds: A Promising Strategy for Supressing Colorectal Cancer Growth and Metastasis
Abstract: Objectives: Colorectal cancer was not typically identified a few decades ago. Today, with almost 900 000 fatalities each year, it is the fourth most dangerous cancer in the world. Colorectal cancer is responsible for about 10% of all cancer diagnoses annually and cancer-related deaths worldwide. It is the second most common type of cancer in women and the third most common type in men. Incidence and death are roughly 25% …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 64–75 Read article
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In Situ Investigation of Hemidesmus indicus Phytocompound Extracts as a Therapeutic Target for Acute Myeloid Leukemia
Abstract: Objective: Acute myeloid leukemia (AML) is an apoptotic condition in the hematopoietic system induced by the differentiation and maturation of stem cells into erythrocytes, and leukemic cell proliferation is suppressed as the PI3K-Akt-mTOR pathway is pharmacologically targeted with certain inhibitors. As a result, in silico molecular docking of compounds against AML receptors, CTMP, was used in computational research on Hemidesmus indicus to uncover therapeutic phytochemicals for AML. Thus, this study …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 38–53 Read article
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Assessing the Clinical Efficacy and Safety of Semaglutide: A Comprehensive Study
Abstract: Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has emerged as a versatile therapeutic agent with significant potential in managing a range of diseases. Extensive research has demonstrated its efficacy in treating obesity, type 1 and type 2 diabetes, and even neurodegenerative disorders like Parkinson’s disease. This comprehensive review examines the principal outcomes derived from clinical trials that incorporate semaglutide alongside other GLP-1 agonists, with particular emphasis on the mechanisms underlying …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 96–104 Read article
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Exploring Type-II Diabetes Potential of Phyto-Derived Carbon Dots
Abstract: The integration of phytoconstituents with carbon dots (C-dots) presents a novel and sustainable approach to the development of nanotherapeutics for type 2 diabetes mellitus (T2DM). C-dots, zero-dimensional carbon-based nanomaterials, exhibit unique physicochemical properties including high fluorescence, tunable surface chemistry, biocompatibility, and low toxicity. Their ability to enhance the solubility, bioavailability, and targeted delivery of poorly soluble phytochemicals renders them highly suitable for biomedical applications. This study explores the synthesis of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 08–25 Read article
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In silico analysis of Abrus precatorius L. as a potential agonist of PPARγ : A novel approach to the treatment of diabetes
Abstract: Diabetes mellitus is a chronic disorder that is characterized by a lack of insulin secretion by the pancreas or a defect in insulin action, or both. If diabetes is not controlled, over time it can cause damage to blood vessels and nerves, leading to life-threatening complications such as, kidney damage, heart disease and vision impairment. It can also weaken the immune system, making patients more prone to infection. Although treatments …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 · pp. 13–24 Read article
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Vitamin D Mitigates Inflammation and Downregulates Importin α3 in Non-Alcoholic Fatty Liver Disease (NAFLD)
Abstract: Background: Pro-inflammatory cytokines, such as TNF-α, IL-1β, IL-6, and IL-8, seem to play a crucial role in the progression of NAFLD as they activate the transcription factor NF-кB. The activated NF-кBp50/RelA subunits are translocated to the nucleus by Importin α3 and Importin α4. Numerous studies have indicated a negative association between NAFLD and vitamin D levels. Low vitamin D levels have been correlated with histological severity, necro-inflammation, and fibrosis in …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 1–16 Read article
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The Effectiveness of Curry Leaves in Reducing the Blood Glucose Level in Subjects with Type-2 Diabetes Mellitus
Abstract: Type 2 diabetes mellitus occur when body is unable to resist insulin normal effect on cells which is called as insulin resistance. A pre experimental study was conducted to see effectiveness of curry leaves in decreasing the blood glucose level among subjects with diabetes mellitus type 2. The objectives of study were; (1) To assess the blood glucose level among subjects with diabetes mellitus type 2. (2) To see the …
Published in Journal of Nursing Science & Practice · Vol. 12, Issue 2, 2022 · pp. 26–31 Read article
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Screening of Obesity and its Associated Biochemical Markers in North Indian Population
Abstract: The aim of the present study was to explore out the prevalence of biochemical markers, and their connection with obesity in north Indian population. The sample size was 300, between the ages of 10 and 60 years old from all the ethics of north India. The obesity was calculated by body mass index based on the World Health Organization standard. We collected venous blood for biochemical markers investigation (total cholesterol, …
Published in Research and Reviews: A Journal of Health Professions · Vol. 8, Issue 3, 2018 · pp. 51–54 Read article
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A Review on Binge Eating Disorder in Youth with Diabetes Mellitus
Abstract: The repetitive scenes of voraciously consuming food without normal compensatory conduct, for example, regurgitating or purgative maltreatment are portrayed as binge dietary issue. It is exceptionally regular in the fat gathering, yet it is not restricted to those individuals. Many empirical studies and reports suggest that about 58% of young women (aged 18–30 years) with insulin-dependent diabetes mellitus (IDDM) may be at high risk of developing eating disorders. Binge disorder …
Published in Research and Reviews: A Journal of Health Professions · Vol. 11, Issue 1, 2021 · pp. 1–10 Read article