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1680 articles for “BCS Class II/IV drugs”
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Molecular Docking Studies of Wildtype P53 with Damnacanthal and Scopoletin- Phytochemicals Derived from Morinda Citrifolia
Abstract: Cancer is a prominent cause of mortality globally, and it has the potential to impact any region of the body. The tumor suppressor protein P53 plays a significant role in inhibiting tumor growth by regulating DNA repair, inducing cell cycle arrest, promoting senescence, and triggering apoptosis when confronted with genotoxic stress. P53 is found mutated in 50% of cancers where it loses its tumor suppressive properties and gains oncogenic properties …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 20–31 Read article
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Detection of Pneumonia in COVID-19 Patients Using X-ray Images
Abstract: This study explores the use of chest X-ray image analysis and deep learning methods to identify pneumonia in COVID-19 patients. Due to the pandemic, Proper as well as immediate examination of COVID-19 is now essential for patient care and disease control. This study proposes a novel approach that uses convolutional neural networks (CNNs) to automatically predict pneumonia in COVID-19 patients using chest X-ray images. In this study, an X-ray of …
Published in International Journal of Radio Frequency Innovations · Vol. 1, Issue 1, 2023 · pp. 13–23 Read article
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An AAV Vector for Inducible Gene Expression Preferentially in Muscles
Abstract: Adeno associated viral (AAV) vectors has been used widely in gene therapy and efforts have been made to improve their utility by adding genetic elements that would enable targeting transgene expression to particular cells or tissues of interest and permitting on/off regulation of expression. In this study, we designed a recombinant AAV9 variant PHP.eB vector with muscle creatine kinase (Mck)-derived enhancers, a synthetic muscle-expression promoter, in combination with a third-generation …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 46–61 Read article
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Design of Automated Student Permission System using RFID and NodeMCU
Abstract: Automated Student Permission System is a system that can be used to automate the process of monitoring students attendance and granting permission to students to leave college early. The system works by having a sign-out sheet placed at the college's entrance that students can access using their college ID. When a student wants to leave the college early, they log in to the electronic sign-out sheet using their college ID. …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 1, Issue 1, 2023 · pp. 23–31 Read article
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Valeton Phytoconstituents from Curcuma Phaeocaulis as Prion Protein Mutant V210I Inhibitors: A Computational Docking and Virtual Screening Study
Abstract: Objective: Creutzfeldt-Jakob disease (CJD), a neurological disorder that is sporadic, fatal, communicable, and worsens rapidly, is caused by abnormal folding of prion proteins. Identifying and assessing the potential of phytocompounds from the Curcuma phaeocaulis Valeton plant as a new therapeutic candidate aimed at the treatment of CJD is the objective of this research article. Methods: In this experiment, we assessed outcomes following an in-silico assessment to design a new oral …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 2, 2023 · pp. 1–16 Read article
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Effectiveness of Sensitization Program on Knowledge of School Children Regarding Refractive Errors
Abstract: The human eyes are portals of absorbing divine knowledge from the surrounding world. These two precious pearls need to take proper care throughout to taste life. The eye care starts right from birth onward and becomes keenly required in children's school age as they use these gifts for intense learning. The neglected care in the initial years may trouble them with various visual disorders and disturb their studies too. Well-structured …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 1, 2024 · pp. 13–20 Read article
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Nutraceutics: Opening the Debate for a Framework for the Safety and Efficacy of Nutraceuticals Formulations
Abstract: As of right now, there is no precise definition for nutraceuticals that distinguishes them from other food-based categories such herbal products, dietary supplements, pre- and probiotics, functional foods, and fortified foods. Several studies have shed light on the possible mechanisms of action of pharmaceutically active ingredients in food, emphasizing their ability to improve health, lower the risk of disease, and promote general wellbeing. However, Nutraceuticals confront difficulties in substantiating safety …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 1, 2024 · pp. 27–33 Read article
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Clinical Profile of Dengue Patients who had a Prior Infection with the Covid 19 Virus in a Tertiary Care Centre
Abstract: This cross-sectional analytical study conducted in a tertiary care center aims to investigate the clinical profile of Dengue virus-infected patients with a prior history of COVID-19 within the last three years. Dengue, a prevalent tropical disease, ranges from mild fever to severe conditions like hemorrhagic fever and shock syndrome. The study utilizes the World Health Organization's 2009 classification for Dengue and delineates the febrile, critical, and recovery phases of infection. …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 1, 2024 · pp. 34–38 Read article
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Zero Trust Security Governance by Utilizing Identity and Access Management
Abstract: The Zero Trust Paradigm, a more stringent approach to network security, operates on the fundamental concept of “Never Assume, Always Authenticate.” It is currently being implemented in different countries to align with their national cybersecurity and access management governance policies. The differentiation of these Zero Trust systems is contingent upon factors such as awareness, infrastructure, expenses, and security demand. Additionally, the identity-based access management models within the Zero Trust system …
Published in International Journal of Mobile Computing Technology · Vol. 1, Issue 2, 2023 · pp. 6–17 Read article
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A Study to Assess the Effectiveness of Home-based Stretching Exercises on Joint Pain Among Clients with Osteoarthritis in Selected Old Age Home, Rajkot City, Gujarat
Abstract: Osteoarthritis (OA) is a commonly encountered condition in middle-aged and older individuals, marked by its slow development. Strengthening exercises targeting the quadriceps muscles, situated in the front thigh, can mitigate knee pain, and reduce disability associated with OA. The musculoskeletal system encompasses the bones of the skeleton, the joints where these bones connect, and the muscles responsible for enabling and regulating movement. The knee, the largest and most complex joint, …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 1, Issue 2, 2023 · pp. 24–28 Read article
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Growth of Individual House Builders (IHB) in Raigad Districts
Abstract: The study delves into the dynamic landscape of individual house builders (IHBs) in Raigad district, exploring the substantial growth within the real estate industry and its related sectors. The emphasis is on residential structures, ranging from bungalows to row houses and small individual buildings, designed to accommodate diverse family structures. This surge in construction activities is attributed to factors such as the abundant availability of land, improved connectivity, burgeoning employment …
Published in International Journal of Rural and Regional Development · Vol. 1, Issue 2, 2023 · pp. 15–23 Read article
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Unresolved and misdiagnosed of floating sensation in young man
Abstract: Persistent Postural-Perceptual Dizziness (PPPD) stands out as a prevalent peripheral vestibular disorder, earning its recognition in the International Classification of Vestibular Disorders in 2017. Characterized by chronicity, this condition manifests symptoms persisting for more than three months, encompassing a disconcerting array such as a floating sensation, unsteadiness, and dizziness. Notably, individuals afflicted with PPPD often report symptom exacerbation following prolonged standing, self-initiated motion, or exposure to dynamic visual stimuli. This …
Published in International Journal of Brain Sciences · Vol. 1, Issue 1, 2024 · pp. 1–4 Read article
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Optimizing Antibiotic Analysis: A Comprehensive Guide to HPLC Process of Assessment and Quantification
Abstract: The history and uses of chromatography are thoroughly covered in this work, with an emphasis on the use of High-Pressure Liquid Chromatography (HPLC) in pharmaceutical analysis. Since its discovery by Russian botanist Mikhail Tswett in the 19th century, chromatography has undergone tremendous developments that have given rise to a variety of chromatography types and applications. The story follows the evolution historically, emphasizing Tswett's groundbreaking breakthrough in plant color classification and …
Published in International Journal of Antibiotics · Vol. 1, Issue 2, 2024 · pp. 27–44 Read article
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Grid based docking study of some 2-(4-methylsulfonyl phenyl) pyrimidine derivatives (designed after QSAR studies) with Cyclooxygenase
Abstract: Molecular docking helps in studying drug/ligand or receptor/ protein interactions by identifying the suitable active sites in protein, obtaining the best geometry of ligand-receptor complex and calculating the energy of interaction for different ligands to design more effective ligands. In Grid based docking, after unique conformers of the ligand are generated, the receptor cavity of interest is chosen and a grid is generated around the cavity. Cavity points are found …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 23–41 Read article
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Zymomonas isolated from different States of Mexico: limited producers of ethanol
Abstract: The microbial synthesis of ethanol is conventionally by yeast, however the bacterial genus Zymomonas has an interesting capacity to synthesize ethanol, currently it is an ecological alternative, for the global demand for fuels other than oil. The objectives of this work were: i) to isolate Zymomonas that synthesize ethanol from natural sources ii) to select Zymomonas natural amounts for ethanol synthesis. The results show a wide distribution of Zymomonas in …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 1, 2024 · pp. 1–9 Read article
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Effect of Calcination Condition and Cooling Method on Reactivity of Lime Sludge
Abstract: In this Experimental Study, Raw Lime sludge from the Paper industry was characterized by XRD and TGA techniques. Lime Sludge was calcined for a temperature range of 550–7500C for 2 h and cooled by air cooling. The effect of calcination temperature on the reactivity of resultant Sludge was investigated by various indirect and direct methods of pozzolanic activity assessment such as the Strength Activity Test(SAI), Lime reactivity test, XRD, TGA, …
Published in Journal of Polymer & Composites · Vol. 11, Issue 10, 2023 · pp. 36–48 Read article
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Risk Return Analysis Of Pharmaceuticals Companies During Covid-19
Abstract: An unknown disease (COVID-19) is spreading globally, impacting people and economies very negatively. The virus, which was first discovered in a small part of China in December 2019, has since grown fast across more than 175 countries. The virus is very contagious, thus in order to stop it, certain measures have been put in place, such as a national shutdown, air traffic control, and the wearing of masks, avoidance of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 1, 2024 · pp. 1–6 Read article
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Overview of Virulence Factor of Staphylococcus sp.
Abstract: Staphylococcus is a highly virulent genus of bacteria that can cause a range of infections in humans and animals. The production of toxins, enzymes, and biofilms contributes to its ability to establish infections and evade host defenses. Understanding the characteristics and virulence factors of Staphylococcus is crucial for the development of effective prevention strategies and treatment options. Staphylococcus aureus is a significant etiological agent of nosocomial infections on a global …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 1, 2024 · pp. 25–31 Read article
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Vyanga, Present-Day Challenge: Insights from Toxicological Standpoint
Abstract: The condition of Vyanga can have significant repercussions, as facial disfigurement not only impacts an individual's psychological and social well- being but also hampers their overall contribution to society. This can result in reduced productivity, impaired social functioning, and diminished self-esteem. In classical Ayurvedic texts, Vyanga is categorized under Kshudrarogas, representing minor disorders with straightforward causes and symptoms. However, in certain instances, these conditions can lead to noticeable cosmetic impairments, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 1, 2024 · pp. 11–16 Read article
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Assessment of Diuretic Activity of Hydroalcoholic Extract of Matricaria Chamomilla (Linn.) and Its Phytochemical Analysis with Emphasis on Toxicology
Abstract: While the traditional medicines are derived from medicinal plants, minerals and organic matter, the herbal drugs are prepared from medicinal plants only. This current research work will be very beneficial in figuring out the Matricaria chamomilla leaves extract diuretic effect by determining the ions and electrolyte excreted by the animals using ion selective channel inhibition. The phytochemical screening results revealed that the after which it was observed whether the alkaloids …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 1, 2024 · pp. 1–10 Read article