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182 articles for “gene therapy”
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Stem Cell Therapy: Advancements, Applications, and Future Prospects in Regenerative Medicine
Abstract: Stem cell therapy has come up as a revolutionary technique in regenerative medicine living up to the promise in treating numerous diseases and injuries. The latest discoveries made in the field of stem cell research such as the introduction of gene editing technology like CRISPR and the creation of the 3D bioprinting process have increased the accuracy and efficacy of stem cell-based therapies. Examples include cardiac regeneration and repair of …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 1, 2026 Read article
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The Rising Burden of Heart Attacks: Causes, Trends, and Prevention Strategies
Abstract: Heart attacks, or myocardial infarctions, remain a leading cause of morbidity and mortality worldwide, with their incidence rising steadily across diverse populations. This review explores the increasing prevalence of heart attacks, emphasizing traditional risk factors, such as poor diet, physical inactivity, smoking, and medical conditions like hypertension, diabetes, and hyperlipidemia. It also highlights emerging risk factors, such as chronic infections, pollutants, substance abuse, and the lasting cardiovascular effects of COVID-19. …
Published in Research and Reviews : Journal of Surgery · Vol. 14, Issue 2, 2025 · pp. 1–11 Read article
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Drug Induced Immune Mediated Nephritis: Molecular Mechanism , Pathways and Clinical Implications
Abstract: Drug-induced immune-mediated nephritis (DI-IMN) has become a more widely known cause of acute kidney injury (AKI), with the potential for development to chronic kidney disease if not detected and treated promptly. T-cell hypersensitivity to pharmaceuticals, such as antibiotics, proton pump inhibitors, nonsteroidal anti-inflammatory drugs, and immunological drugs, are the major causes for it. Beyond clinical burden, DI-IMN reflectsintricate molecular interactions that sustain interstitial inflammation and tubular injury. These interactions include …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 13–29 Read article
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Sequence analysis, DNA Methylation and Molecular therapy of Oral cancer caused by Human Papilloma Virus
Abstract: DNA methylations with oral cancer are been associated with high-risk Human Papillomavirus (HPV) and Epstein-Barr Virus (EBV) onco-proteins interactions may cooperate to increase disease severity. The work focused on human papillomavirus strain 16, a high-risk, sexually transmitted responsible for 95% of all cervical cancers and a large portion of oropharyngeal cancers. The prediction of genes from has shown seven genes from HPV16 strain. Based on gene identification studies, Human papilloma …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 2, 2026 · pp. 1–9 Read article
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Impact of Pre-Operative Nebulized Lidocaine–Dexmedetomidine Combination Versus Monotherapy on Incidence, Severity, and Patient Comfort Scores of Post-Operative Sore Throat: A Randomized Controlled Clinical Trial
Abstract: Post-operative sore throat (POST) is a common issue after endotracheal intubation and can reduce patient comfort and hinder recovery. This randomized, double-blind clinical study investigated how effective pre-operative nebulized lidocaine, dexmedetomidine, and their combination are in minimizing POST. Eligible adult patients classified as ASA I–II and scheduled for elective surgery under general anesthesia were randomly assigned to three groups. Nebulization was administered 15–20 minutes before induction using standardized dosing and …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 4, Issue 1, 2026 · pp. 29–35 Read article
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Inhibition of PI3K/Akt/mTOR Signaling Pathway by Vitis Vinifera Phytocompounds: A Promising Strategy for Supressing Colorectal Cancer Growth and Metastasis
Abstract: Objectives: Colorectal cancer was not typically identified a few decades ago. Today, with almost 900 000 fatalities each year, it is the fourth most dangerous cancer in the world. Colorectal cancer is responsible for about 10% of all cancer diagnoses annually and cancer-related deaths worldwide. It is the second most common type of cancer in women and the third most common type in men. Incidence and death are roughly 25% …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 64–75 Read article
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COVID-19 Resurgence in 2025: India’s Continuing Public Health Challenge
Abstract: The year 2025 has witnessed the resurgence of COVID-19, reigniting concerns at both global and national levels regarding the persistent threat posed by SARS-CoV-2. In early 2025, India witnessed a moderate resurgence of COVID‑19, characterized by the emergence of Omicron sub-variants and a rise in mild-to-moderate infections. As of mid-June, active COVID‑19 cases in India totaled approximately 6,000–7,400, with hotspots in Kerala (~2,100 cases), Delhi (~600), Maharashtra (~500), and several …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 2, 2025 · pp. 16–23 Read article
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Medical Tourism in India: Analyzing Benefits, Risks, and Regional Trends
Abstract: Background: India’s medical tourism industry has emerged as a global hub, generating approximately US$9 billion annually and attracting over 2 million patients seeking cost-effective, high-quality treatments and wellness therapies. Objective: To evaluate the benefits, risks, and regional disparities in medical tourism experiences among patients and providers across five Indian states. Methods: A mixed-methods study was conducted involving 850 international patients and 150 healthcare providers. Quantitative data were gathered through structured …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 15, Issue 1, 2026 · pp. 12–16 Read article
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Pharmacovigilance: Enhancing Drug Safety Through Technology
Abstract: The research and practices surrounding the identification, evaluation, and avoidance of hazardous medication responses in people are known as pharmacovigilance. Pharmacovigilance has been defined as a kind of ongoing observation of side effects and other safety-related features of medications that have previously been introduced to the market. Pharmacovigilance has been shown to be crucial in promoting the sensible use of medications by disseminating knowledge about the negative effects that pharmaceuticals …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 38–44 Read article
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Advances In HIV Research: Epidemiology, Pathogenesis, And Emerging Therapeutic Strategies
Abstract: Human Immunodeficiency Virus (HIV) remains a critical global health concern, infecting millions of individuals each year. The introduction of antiretroviral therapy (ART) has markedly improved disease outcomes by suppressing viral replication, restoring immune function, and extending patient longevity. Despite these advances, the complete eradication of HIV is hindered by the persistence of viral reservoirs, the emergence of drug-resistant strains, and disparities in healthcare accessibility. This review summarizes key developments in …
Published in International Journal of Pathogens · Vol. 3, Issue 1, 2026 · pp. 1–5 Read article
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Immune Dysregulation and Cytokine Circuitry in Genital Endometriosis: Mechanistic Insights and Next-Generation Immunotherapeutic Strategies
Abstract: Genital endometriosis is increasingly recognized as an immune-mediated inflammatory disorder driven by complex interactions between dysregulated immune cells, cytokine hubs, and microbiome-derived modulators. This review introduces a novel “immune–cytokine circuitry” framework that unifies innate and adaptive immune abnormalities with key cytokine loops sustaining chronic inflammation, angiogenesis, neuroinflammation, and immune tolerance. Within this circuitry, macrophage polarization, dendritic cell immaturity, NK-cell anergy, Treg expansion, Th17 amplification, and B-cell–mediated autoimmunity converge to establish …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 06–16 Read article
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Impact of Topical Pure Honey Application on Radiation-induced Oral Mucositis in Patients Receiving Radiation Therapy
Abstract: This quasi-experimental study assessed the effects of pure honey on radiation-induced oral mucositis in patients with head and neck cancer undergoing radiation therapy in Kottayam. The primary objectives were to evaluate the severity of oral mucositis in both experimental and control groups, determine the effectiveness of honey in alleviating symptoms, and examine the relationship between mucositis severity and selected demographic variables. Utilizing Bertalanffy’s General System Model as a conceptual framework, …
Published in International Journal of Oncological Nursing and Practices · Vol. 2, Issue 2, 2024 · pp. 14–18 Read article
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Clinical Medicine Done with Clinical Accuracy
Abstract: The advancement of clinical medicine has progressively underscored the significance of accuracy in diagnosis and therapy. This article examines the concept of "Clinical Medicine Administered with Clinical Precision," emphasising how innovations in diagnostics, data analytics, and personalised treatments are transforming the healthcare environment. Clinicians can provide therapy that is not only successful but also personalised to each patient's requirements by combining evidence-based practices with patient-specific factors including genetic profiles, comorbidities, …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 1, 2026 · pp. 6–19 Read article
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Paediatric Epilepsy: Current Advances in Diagnosis and Management
Abstract: Paediatric epilepsy is one of the most common chronic neurological disorders of childhood, characterised by recurrent unprovoked seizures resulting from abnormal neuronal activity. Accurate diagnosis is essential and is based on a detailed clinical history, seizure semiology, neurological examination, and electroencephalography (EEG), with neuroimaging such as magnetic resonance imaging (MRI) used to identify structural abnormalities. Classification according to seizure type and underlying aetiology genetic, structural, metabolic, immune, infectious, or unknown—guides …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 53–68 Read article
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Decompensated Liver Failure and Acute Renal Failure in a Patient with Chronic HBV,HCV, and HIV Infections
Abstract: This case study focuses on a 30-year-old male patient suffering from decompensated liver failure and acute renal failure, complicated by chronic hepatitis B (HBV), hepatitis C (HCV), and HIV/AIDS. Presenting with severe abdominal pain, nausea, and general weakness, the patient had a history of alcohol and intravenous drug use, leading to chronic liver disease and acute renal failure. Despite aggressive interventions, including intravenous antibiotics and fluid therapy, his condition worsened …
Published in International Journal of Pathogens · Vol. 2, Issue 1, 2025 · pp. 17–23 Read article
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Biodegradable and Natural Fiber-Reinforced Polymer Composites for Advanced Controlled Drug Delivery Systems
Abstract: Polymer-gel forms have gained popularity in medicine as means of medication delivery over the skin. This is so since they enable medications pass the skin more readily. These products allow medicine to be administered without surgery and provide continuous active ingredient supply. They are excellent for long-term therapy for managing conditions that keep resurfacing. From tiny synthetic ones to huge biological ones, polymer gels can store a wide spectrum of …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 271–284 Read article
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Strengthening Neurological and Familial Interventions: Adult Coping Following Pediatric Brain Injury and Comorbidity
Abstract: Background: Pediatric traumatic brain injury (PTBI) contributes to long-term physical, cognitive, and emotional difficulties and is a major cause of mortality and disability in children. An estimated 200,000 fatalities in India each year are attributed to traumatic brain injuries, with PTBI accounting for a significant share of these cases. Accidents, abuse, and sports injuries are just a few of the causes of post-traumatic brain injury (PTBI), which can result in …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 2, Issue 2, 2024 · pp. 7–15 Read article
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Phosphorescence of Carbon Nanodots – The Phenomena and the Applications
Abstract: Photoluminescence has emerged as a fundamental phenomenon in modern biomedical science, enabling advanced diagnostic, therapeutic, and theranostic applications through light–matter interactions at the nanoscale. The ability of photoluminescent materials to absorb electromagnetic radiation and emit light at distinct wavelengths has been widely exploited in bioimaging, biosensing, drug delivery tracking, and photodynamic therapy. Among various photoluminescent nanomaterials, carbon nanodots have attracted significant attention due to their strong emission intensity, tunable fluorescence, …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 4, Issue 1, 2026 · pp. 01–05 Read article
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Stiff Person Syndrome: Advances in Understanding, Diagnosis, and Treatment of a Rare Autoimmune Disorder
Abstract: Stiff Person Syndrome (SPS) is a rare and complex autoimmune neurological disorder characterized by progressive muscle stiffness, rigidity, and painful spasms. This chapter provides a comprehensive overview of SPS, exploring its pathophysiology, clinical presentation, diagnostic challenges, and current treatment approaches. We discuss the latest research findings, including the role of autoantibodies, genetic factors, and environmental triggers in the development of SPS. The chapter examines various diagnostic methods, emphasizing the importance …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 35–43 Read article
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A Comprehensive Analysis of Novel Liposomes: Categorization, Approach, Description, and Present Formulations
Abstract: Liposomes have gained attention as a promising drug delivery system, which come with the advantages of biocompatibility, ability to load hydrophilic and hydrophobic drugs, and they can function for targeted drug delivery. In this regard, this paper offers a comprehensive overview on novel liposomes, including classification, formulation strategies, detailed structures, and current pharmaceutical applications. Recent advances in liposomal drug delivery systems includes, new liposomal architectures (i.e. stealth, targeted, stimuli-responsive, hybrid …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 15–20 Read article