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162 articles for “formulation design”
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Polymer-Coated Composite Granules of Clarithromycin: Design, Characterization, and Functional Evaluation for Taste Masking and Antibacterial Performance
Abstract: Background: Masking the unpleasant taste of clarithromycin is essential to improve patient adherence, especially among pediatric and elderly groups. However, enhancing palatability while maintaining its antibacterial effectiveness remains a significant formulation challenge. This study focused on developing polymer-coated clarithromycin granules (B1–B10) using novel non-sugar-based polymers and assessing their antibacterial activity against Staphylococcus aureus Methods: Clarithromycin granules were produced using a fluidized bed coating technique with non-saccharide polymers, specifically Eudragit E-100 …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1042–1050 Read article
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Analysis of Field Distribution in Optical Fibre Using FEM Method
Abstract: The application of the linear Finite Element Method (FEM) to the analysis of the field distribution in optical fibres is examined in this work. Characterizing fibre characteristics like mode profiles, propagation constants, and dispersion, all of which are critical for maximizing fibre performance in a variety of applications like sensing and telecommunications, requires an understanding of the distribution of electric and magnetic fields. In order to accurately determine the modal …
Published in Trends in Opto-electro & Optical Communication · Vol. 15, Issue 2, 2025 · pp. 31–40 Read article
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Polyurethane: Chemistry, Production, Applications, and Future Prospects—An Overview
Abstract: Polyurethane (PU), a class of versatile polymers, has emerged as one of the most significant materials in modern industry owing to its remarkable mechanical strength, elasticity, durability, and resistance to abrasion, chemicals, and environmental degradation. Its wide range of tunable properties has made PU indispensable across multiple sectors, including fashion, automotive, manufacturing, biomedical, coatings, and construction. This review emphasizes the diverse applications of polyurethane and explores how its unique chemistry …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 12, Issue 3, 2025 · pp. 17–25 Read article
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Development of a Novel Analytical Framework for Investigating Non-Symmetric Deformation Behavior in Strip Rolling
Abstract: In recent years, the asymmetrical rolling process has attracted considerable research attention due to its ability to induce non-uniform deformation characteristics within metallic workpieces. In this context, the present study introduces a novel analytical framework for asymmetrical cold rolling based on an enhanced slab method, specifically designed to overcome the inherent limitations of existing analytical models when applied to a wide range of asymmetric rolling conditions. A newly developed mathematical …
Published in Journal of Experimental & Applied Mechanics · Vol. 17, Issue 1, 2026 · pp. 1–21 Read article
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Child Friendly Innovation: A New Era in Pediatrics Drug Delivery Systems
Abstract: Pediatric formulations are becoming more and more popular as a result of advancements in pharmaceutical delivery technology. For young patients, there isn't a safe and effective drug delivery system in place. Since children's pharmacokinetics and pathophysiologic profiles differ from those of adults, it is imperative to design and develop an innovative and appropriate delivery system to provide accurate and dependable medicine administration to pediatric patients. Discussions will be held under …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article
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Simulation And Analysis of Radio Frequency Energy Harvesting System Operating at 2.45 GHz Frequency
Abstract: — This paper proposed study of an RF energy harvesting system at 2.45 GHz using a rectifier and an antenna so called rectenna. Inset-fed micro-strip rectangular patch antenna array is fabricated. The rectifier circuit, employing Schottky diodes (HSMS-2850), converts AC power from the antenna to DC for RF detection. Analysis of the antenna's design and parameters such as directivity, return loss, gain, and VSWR is done using high-frequency simulator software …
Published in Journal of Microwave Engineering and Technologies · Vol. 11, Issue 1, 2024 · pp. 7–15 Read article
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Intuitionistic Fuzzy Hypergraph Laplacians and Dominating Transversals for Resilient Discrete Network Design
Abstract: This manuscript develops a discrete mathematical framework for resilience analysis on networks whose interactions are polyadic, uncertain, and partially conflicting. Classical graphs compress multi-way coordination into pairwise edges, while ordinary fuzzy graphs often ignore the non-membership information that becomes critical in emergency logistics, infrastructure interdependence, and cyberphysical coordination. We therefore formulate an intuitionistic fuzzy hypergraph in which each vertex hyperedge incidence carries membership, non-membership, and hesitation, and we construct a …
Published in Research & Reviews: Discrete Mathematical Structures · Vol. 13, Issue 2, 2026 · pp. 15–21 Read article
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Kinematic and Dynamic Modelling of a 6-DOF Robotic Manipulator for Industrial Applications
Abstract: The rapid evolution of industrial automation has intensified the need for highly accurate, flexible, and intelligent robotic systems capable of operating in dynamic and demanding environments. Among these systems, six-degree-of-freedom (6-DOF) robotic manipulators have emerged as a versatile solution due to their superior dexterity, large workspace, and human-arm-like motion capabilities. This research focuses on the comprehensive kinematic and dynamic modelling of a 6-DOF robotic manipulator designed for various industrial tasks …
Published in International Journal of Robotics and Automation in Mechanics · Vol. 3, Issue 2, 2025 · pp. 27–32 Read article
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Enhancing Energy Efficiency in HVAC Systems: A Comprehensive Study of EC+ Fans, VFDs, and AI Integration
Abstract: This research paper explores the integration of EC+ fans with Variable Frequency Drives (VFDs) and Permanent Magnet (PM) motors to enhance energy efficiency and operational performance in heating, ventilation, and air conditioning (HVAC) systems. An extensive energy audit was conducted at the BidP plant in Bangalore, focusing on air handling units (AHUs) in Hangar 101. The audit revealed substantial variations in fan efficiency, secondary fan performance, power consumption, and airflow …
Published in Trends in Machine design · Vol. 11, Issue 3, 2024 · pp. 44–54 Read article
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Optimizing Mechanical and Durability Properties of Eco-Friendly Composite Materials Using Recycled Fillers and ML Techniques
Abstract: The increasing demand for sustainable construction materials has intensified the exploration of recycled fillers as partial or full replacements for natural aggregates in composite materials. This study investigates the mechanical and durability performance of polymer matrix composites incorporating processed recycled fillers derived from construction and demolition (C&D) waste. Three distinct processing methods were employed to prepare the recycled fillers: untreated (URF), single processed (SPRF), and double processed (DPRF), with replacement …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 269–309 Read article
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pH-Triggered In-Situ Nasal Gel Systems for Migraine Therapy: A Review
Abstract: Intranasal drug delivery has gained considerable attention as a non-invasive route for delivering drugs to both systemic circulation and the central nervous system, particularly for the treatment of migraine. Traditional nasal formulations such as sprays and drops often show poor therapeutic performance due to rapid mucociliary clearance and limited retention within the nasal cavity. To overcome these challenges, in-situ gel systems have been designed, which transform from a liquid to …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article
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Gastro Retentive Drug Target System: Its Needs, Advantages, Limitation and Approaches
Abstract: Background: Gastro retentive drug delivery systems (GRDDS) address limitations of oral therapy for drugs with poor solubility, instability at intestinal pH, or narrow absorption windows by prolonging gastric residence and increasing contact with the gastric mucosa. Objectives: To review GRDDS approaches—floating systems, mucoadhesive systems, and super porous hydrogels—with emphasis on formulation strategies and polymer–excipient selection to enhance gastric retention, modulate buoyancy/swelling/adhesion, and ultimately improve oral bioavailability and therapeutic outcomes for …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article
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Prediction of Mechanical Properties for Advanced Engineering Applications utilizing Polymer Composite Materials by Machine Learning
Abstract: Polymer composites show great promise as engineering materials because of their mechanical performance, resistance to corrosion, lightweight nature, and adaptability in design. Aerospace, automotive, biomedical, maritime, and civil engineers all rely on mechanical property prediction to cut down on trial expenses, expedite product development, and optimize material selection. Speedy design optimization is not possible using traditional numerical and experimental methods due to the high costs associated with material characterisation, computational …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 Read article
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Differential Model of Wave Vibration on Strings and Rods
Abstract: Vibration, as a physical phenomenon, plays a multifaceted role in both natural and engineered systems. Beyond its essential contribution to communication through sound and speech, it finds critical application in various technological domains. For instance, in the design of stringed musical instruments such as violins and guitars, precise manipulation of string vibrations defines tonal quality and musical resonance. Similarly, metal rods in tuning forks exhibit vibrational properties that are finely …
Published in Research & Reviews : Journal of Physics · Vol. 14, Issue 1, 2025 · pp. 17–21 Read article
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Toxicological Optimization and Assessment of Buccal Films Containing Felodipine Co-crystals to Enhance Bioavailability
Abstract: The preformulation study of felodipine was carried out and it was found that the drug is poorly water soluble. The co-crystals were prepared using three different co-formers sorbitol, ascorbic acid and oxalic acid. The solublity enhancement was observed in combination with sorbitol compared to other co-formers used. The characterization of co crystals was performed like PXRD, FTIR, SEM Analysis. XRD results indicates the amorphous form of the drug. The co-crystals …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 10–29 Read article
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Using Artificial Intelligence for The Design of Polymeric Drug Delivery Systems
Abstract: AI is cost effective and time efficient process. Artificial intelligence is a method which uses high speed calculation, the improvement regarding algorithm along with collection about biological and chemical features in pharmaceutical exploration and development .Present day because continuous progress towards machine learning (ML),Artificial intelligence an effective statistics analysing technology might have been broadly utilized in drug design .In pharmaceutical exploration and research employ of AI in target identification, compound …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 1018–1027 Read article
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Crystallographic Studies on The Stability of Pharmaceutical Compound
Abstract: Crystallographic studies provide detailed insights into the molecular structure and intermolecular interactions within a crystal lattice, which are key determinants of a compound's stability. By analyzing crystal structures, researchers can identify potential polymorphs, solvates, and hydrates that may impact the physical and chemical stability of the drug. This knowledge helps in optimizing formulation strategies, predicting shelf life, and ensuring consistent drug performance. Advanced techniques like X-ray diffraction and neutron diffraction …
Published in International Journal of Crystalline Materials · Vol. 1, Issue 1, 2024 · pp. 38–42 Read article
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Advances in Polymeric In Situ Drug Delivery and Soft Biosensors: Innovations in Biochemical Sensing and Personalized Healthcare
Abstract: Advanced healthcare and personalized medicine are undergoing a transformation thanks to in situ medication delivery systems and biochemical sensor technology. Polymeric in situ drug delivery systems form gels upon administration, releasing medications in a controlled manner and providing benefits such as ease of administration and enhanced patient compliance. Similarly, advancements in soft electronics, including flexible and stretchable biosensors, enable continuous, in situ biochemical monitoring, conforming to complex biological environments like …
Published in International Journal of Cheminformatics · Vol. 2, Issue 1, 2024 · pp. 27–32 Read article
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An Overview of Examination of Some Basic Raw Materials for Adsorbent on Approach of Pollutant Mitigation and Treatment
Abstract: This research showcases the basic parameters that are required to produce bio-adsorbent suitable for adsorption process and their important role on treatment of contaminated water environment. The overview of the physicochemical parameters of the raw materials used for the production of the adsorbents, the particle size and the mix ratio were identified as a contributing factor to the rate of contaminants mitigation in the system. The effect of water pollution …
Published in Journal of Petroleum Engineering & Technology · Vol. 14, Issue 2, 2024 · pp. 01–16 Read article
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A Mathematical Perspective on Recent Cloud-Computing Trends for Scalable and Secure Social-Media Platforms
Abstract: Cloud computing underpins modern social-media platforms by providing elastic compute, storage, and data-processing pipelines capable of absorbing highly bursty workloads. This paper surveys recent cloud-native trends—serverless and event-driven design, container orchestration, edge/CDN offload, streaming analytics, and privacy-enhancing security controls—and formalizes their impact through a compact mathematical model. We express workload volatility using arrival-rate functions, use queueing-based capacity sizing to derive auto-scaling rules, and formulate an optimization objective that balances cost …
Published in Recent Trends in Mathematics · Vol. 3, Issue 2, 2026 · pp. 35–40 Read article