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98 articles for “controlled drug release”
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AI in Healthcare: Drug Delivery in Tuberculosis
Abstract: Tuberculosis (TB) , mainly caused by Mycobacterium tuberculosis, remains a major global health burden, accounting for millions of new infections and deaths each year. Although progress has been made in diagnosis and treatment, the growing threat of multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB makes disease control increasingly difficult. Conventional diagnostic approaches such as chest X-rays, sputum smear microscopy, and culture methods continue to play an important role, but they …
Published in Trends in Drug Delivery · Vol. 13, Issue 1, 2026 · pp. 9–17 Read article
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Synthesis and Characterization of Polymer-Based Benzamide Derivatives with Potential Biomedical Applications
Abstract: The present study explores the synthesis and characterization of polymer-supported benzamide derivatives, focusing on their potential biomedical applications. The use of polymer-supported synthesis offers several advantages, including improved reaction efficiency, ease of purification, and reusability of the support material, making it an environmentally friendly and cost-effective approach. The synthesis involved a stepwise reaction sequence, with polymeric supports facilitating controlled functionalization and ensuring high product purity. These materials have been widely …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 Read article
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Nanotechnology In Herbal Medicine
Abstract: Herbal medicine has been widely used for centuries as a natural and holistic approach to health care. However, many herbal compounds face challenges such as low solubility, low bioavailability, instability, and the lack of targeted delivery, which affect their efficacy. The integration of nanotechnology into herbal medicine has emerged as a promising strategy to overcome these challenges and enhance the pharmacological potential of plant-derived compounds. Nanocarriers such as liposomes, solid …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 1, 2025 · pp. 50–69 Read article
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Nanotechnology meet phytomedicine towards smarter drug delivery system.
Abstract: Using bioactive substances derived from plants, or phytomedicine, has long shown promise in treating a variety of illnesses with fewer adverse effects than synthetic medications. Nevertheless, a lot of phytochemicals have issues with inadequate targeting in vivo, low bioavailability, poor solubility, and chemical instability. By enabling encapsulation, controlled release, targeted delivery, and stimuli responsive behavior, nanotechnology provides effective tools to get around these restrictions. This review examines the intersection of …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 46–53 Read article
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Polymer-Coated Composite Granules of Clarithromycin: Design, Characterization, and Functional Evaluation for Taste Masking and Antibacterial Performance
Abstract: Background: Masking the unpleasant taste of clarithromycin is essential to improve patient adherence, especially among pediatric and elderly groups. However, enhancing palatability while maintaining its antibacterial effectiveness remains a significant formulation challenge. This study focused on developing polymer-coated clarithromycin granules (B1–B10) using novel non-sugar-based polymers and assessing their antibacterial activity against Staphylococcus aureus Methods: Clarithromycin granules were produced using a fluidized bed coating technique with non-saccharide polymers, specifically Eudragit E-100 …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1042–1050 Read article
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Microsphere and Nanoparticle Drug Delivery Systems: Role of Polymers in Pharmacology
Abstract: Microsphere and nanoscale drug delivery methods have changed the field of pharmacology by making treatment agents more bioavailable, more targeted, and easier to manage. These delivery systems, which are mostly made up of polymers, look like a good way to get around the problems that traditional drug formulations have, like not dissolving well, clearing quickly, and spreading in different places. Plastics are very important in the creation of these improved …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 420–432 Read article
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Exploring Recent Advancements in Nanomedicine for Tumor Microenvironmental Tissue Engineering
Abstract: The combination of tissue engineering and nanomedicine is transforming cancer treatment by offering creative ways to get around problems with conventional therapies. Recent developments in nanomedicine are examined in this review, with an emphasis on how they might be used to comprehend and control the tumor microenvironment (TME), a dynamic and complex environment that has a major impact on the course of cancer and the effectiveness of treatment. Targeted interactions …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 122–136 Read article
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Bioconjugates and Biohybrid Polymers: Intricate Cellular Integration Methods and Sophisticated Biofunctionalization Techniques for Tailored Properties in Medical Contexts
Abstract: Bioconjugates are made when biological molecules are covalently linked to manufactured polymers. They can be used in many ways for imaging, diagnosis, and specific drug delivery. Getting perfect cellular fusion is very important for how well they work. Biomolecules can be attached to polymer scaffolds in a controlled way using techniques like click chemistry and site-specific conjugation. This makes sure that the molecules connect optimally with their biological targets. Using …
Published in Journal of Polymer & Composites · Vol. 12, Issue 3, 2024 · pp. 227–243 Read article
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Harnessing Polymer Chemistry for Pharmaceutical Technology
Abstract: Polymer chemistry has emerged as a cornerstone of modern pharmaceutical technology, offering unprecedented control over drug formulation, delivery, and therapeutic performance. This review highlights the pivotal role of polymers—both synthetic and natural—in revolutionizing drug delivery systems across various routes, including oral, parenteral, transdermal, ocular, nasal, and pulmonary administration. Special emphasis is placed on the structural and functional versatility of polymers, which allows for tailored drug release profiles, enhanced bioavailability, and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1–6 Read article
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Clone-Specific Drug Delivery Systems: Targeted Approaches and Future Clinical Applications
Abstract: Clone-specific drug delivery systems represent a transformative frontier in personalized medicine, addressing the longstanding challenge of clonal heterogeneity within diseases such as cancer, infectious diseases, and autoimmune disorders. Traditional drug delivery platforms often fail to discriminate between pathogenic and healthy cells, leading to systemic toxicity and reduced therapeutic efficacy. In contrast, clone-specific systems aim to selectively target and eliminate disease-driving cellular clones based on unique molecular signatures, thereby improving treatment …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 21–29 Read article
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Pharmaceutical Syrup Formulation Enhancing Bioavaibility and Patient Compliance
Abstract: Pharmaceutical syrup formulations are crucial for drug delivery, especially in pediatric and geriatric populations. However, challenges, such as bioavailability, stability, and patient compliance due to factors, like taste and viscosity, must be addressed. Strategies to enhance bioavailability include solubility enhancers, nanoparticle systems, and advanced techniques like solid dispersions and emulsions. Palatability plays a critical role in patient compliance, with flavoring agents, sweeteners, and texture modifications improving acceptability. Innovations, like controlled-release …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 1–6 Read article
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Fabrication and Characterization of Diacerein Loaded Nanosponge for Topical Delivery
Abstract: Diacerein, an anti-inflammatory drug, which comes under BCS class II, commonly used in treatment of osteoarthritis has limited by its poor solubility and bioavailability when administered topically. This study aimed to develop and evaluate diacerein-loaded nanosponges gel using varying concentrations of ethyl cellulose and polyvinyl alcohol (PVA) to enhance its delivery. Nanosponges were prepared using an emulsion solvent evaporation technique, with different ratios of ethyl cellulose (0.05-0.250%) and PVA (0.2-0.3%). …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 26–46 Read article
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Phyto-Entrapped Carbon Dots as Emerging Nanomaterials for Anti-Cancer Activity
Abstract: Phytoconstituent-loaded carbon dots (C-dots) represent an innovative approach in targeted cancer therapy, combining the therapeutic power of plant-derived compounds with the advanced capabilities of nanotechnology. These ultra-small, biocompatible nanostructures offer excellent fluorescence, tunable surface chemistry, and low toxicity, making them ideal for drug delivery, bioimaging, and theranostic applications. Traditional phytochemicals often face challenges like poor solubility, low bioavailability, and high first-pass metabolism barriers that C-dots help overcome. C-dots synthesized through …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 51–63 Read article
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To Rule Out the Efficacy of Haridradi Drugs in Respiratory Allergic Disorders in the Childrens.
Abstract: Allergic diseases in children have increased significantly in recent years and they are a major cause of morbidity in the children. Although there is a genetic predisposition, exposure to allergens i.e pollens, irritants, infections, diets and inhalant will determine the sensitization. At present, the best approach to the children who are at high risk for the development of allergies is to introduce environmental and dietary control and adopt early measures …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 13, Issue 2, 2024 · pp. 53–60 Read article
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Biomedical Coatings: Surface Engineering for Enhanced Biocompatibility and Performance
Abstract: Biomedical coatings have become essential in modern healthcare, significantly improving the performance, durability, and biocompatibility of medical implants and devices. These coatings serve multiple functions, including reducing infection risks, enhancing osseointegration, promoting tissue integration, and enabling localized drug delivery. Advances in surface engineering have led to the development of innovative coatings with superior properties such as antimicrobial resistance, bioactivity, and controlled biodegradation. Various materials are employed in biomedical coatings, including …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 12, Issue 1, 2025 · pp. 8–15 Read article
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Polymer Nanocomposites As Emerging Platforms in Pharmaceutical Nanotechnology
Abstract: Nanotechnology allows the handling of materials in the 1–100 nm range, where distinct physicochemical phenomena, including quantum effects and higher surface-to-volume ratio, enable disruptive uses in pharmaceuticals and biomedicine. Significant challenges in solubility, stability and targeted biodistribution of therapeutics can be overcome by incorporating nanostructured polymers and polymer-based composites into drug delivery systems. PLGA nanoparticle and other nanocarriers, such as PLGA micelles, dendrimers, and hydrogels, have revealed promising effects on …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 268–278 Read article
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Digital Enablers of Nanomedicine: Pharmaceutical Software Across the Lifecycle of Nanotechnology‑Based Drug Products
Abstract: Nanotechnology‑based drug products have rapidly evolved from laboratory concepts to clinically relevant therapies, yet their development is constrained by complex design variables, stringent quality requirements, and emerging regulatory expectations specific to nanomaterials. Pharmaceutical software now plays a central role in the nanomedicine lifecycle, enabling in silico design of nano‑carriers, simulation of nano–bio interactions, control of nanoscale quality attributes during manufacturing, and systematic tracking of safety signals in real‑world use. Integrated …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 1, 2025 · pp. 11–16 Read article
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Emerging Therapies for Diabetes Mellitus: Efficacy and Safety of USFDA-Approved Drugs and Late-Stage Clinical Trials
Abstract: This review provides a comprehensive analysis of drugs approved by the U.S. Food and Drug Administration (USFDA) for managing diabetes mellitus (DM) from 2013 to 2022, including emerging treatments from phase 3 clinical trials during this period. Over the past decade, the treatment landscape for diabetes has evolved significantly, with new therapies not only improving blood sugar control but also targeting broader health outcomes like heart and kidney health. In …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 2, 2025 · pp. 11–23 Read article