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173 articles for “Organic molecules”
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Uncovering the Comparative Efficacy of Antiviral Drugs and Caricapapaya Phytocompound as VP2H inhibitors in Ebola virus: An Insilico Molecular Docking Analysis
Abstract: The Ebola virus is a fatal disease that transmits from wild animals to humans. Infected individuals' body fluids such as spit, blood, perspiration, faeces, blood, saliva, breast milk, sperm, or fomites can transmit Ebola. Adhesion to cell membranes and penetration into the host organism are essential aspects in viral growth. The presence of VP24, as well as nucleoproteins and structural proteins, is necessary for nucleocapsid formation and integration. The inhibition …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 62–78 Read article
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Cadmium Toxicity: Oxidative Stress and Organ Dysfunction
Abstract: Due to continued anthropogenic mobilization, cadmium accumulation in the environment causes various health problems because of its diverse toxic effects, extremely lingering biological half life (20–30 years), low rate of excretion from the body and storage predominantly in soft tissue primarily liver and kidney. Cadmium is known to have numerous noxious effects, including nephrotoxicity, hepatoxicity, osteoporosis, cardiovascular toxicity, lung toxicity, and reproductive toxicity. The biologically significant ionic form of cadmium, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 4, Issue 2, 2014 · pp. 14–31 Read article
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Identification of Hub Genes and Enriched Gene Ontology & Pathways in Idiopathic Pulmonary Fibrosis Through Bioinformatics Approaches
Abstract: Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease marked by aberrant remodeling of lung tissue and excessive extracellular matrix deposition, ultimately leading to respiratory failure. Despite ongoing research, the molecular mechanisms underlying IPF remain incompletely understood. This research aims to uncover differentially expressed genes (DEGs) and related biological pathways through an integrated analysis of microarray data. Two publicly available datasets, GSE110147 and GSE53845, were obtained from the Gene …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 1, 2026 · pp. 1–13 Read article
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Emerging Engineered Nanoweapons for Tumors
Abstract: Cancer is a type of disease characterized by abnormal growth of cells which tend to proliferate in uncontrolled manner. It occurs at molecular level when genes undergo genetic alterations. The malignant growth of tumor cells results in non-functioning of the concerned organ. Over the years, cancer targeting technique has greatly improved by new approaches based on nanotechnology. Nanotechnology is helpful in development of new therapies against cancer. Nanotechnology is a …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 1, Issue 2, 2012 · pp. 1–6 Read article
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3D-QSAR and Molecular Docking Studies of Triazol-Cycloalkanol Derivatives Used as Potent 3-Dehydroquinase II Inhibitors Against Mycobacterium tuberculosis
Abstract: Tuberculosis is a life threatening infectious disease caused by gram positive bacteria mycobacterium tuberculosis. Emergence of drug resistance, multi drug resistance and extensively drug resistance strain of mycobacterium make the situation more worst. It increases the mortality rate of tuberculosis patient, time duration and cost of treatment. Various inhibitors and drug molecules are designed to combat this fatal disease. Enzymes of shikimate pathway are responsible for production of essential amino …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 5, Issue 3, 2015 · pp. 18–28 Read article
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Occupational Infections and Preventive Measures: An Update
Abstract: There are many infections which are closely associated with certain occupations, whereby the workers are put at a higher risk of being contracted with certain infections in the work setup. Occupational hazards are classified as being either physical (high temperature or pressure) or chemical (organic solvents and chemicals) or biological (virus, bacteria, fungi) hazard. Sometimes the prevalent occupation-associated life-style results in higher risk of exposure to the infections. These hazards …
Published in Research and Reviews: A Journal of Medicine · Vol. 1, Issue 1, 2011 · pp. 88–97 Read article
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Exploration of Diverse Epoxy-Based Surface Coating Methods for Enhancing Anticorrosion Characteristics
Abstract: Epoxy-based polymers, commonly referred to as polyepoxides, constitute one of the most versatile and widely adopted categories of polymeric materials due to their exceptional structural, mechanical, and chemical characteristics. Their unique macromolecular framework enables strong interfacial bonding, high mechanical stability, and superior resistance to environmental and chemical degradation, positioning them as advanced alternatives to many traditional organic corrosion inhibitors that often fail under prolonged exposure to aggressive conditions When polyepoxides …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 167–177 Read article
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An Overview on Nuclear Imaging Scans (Diagnostic Nuclear Medicine) in Breast Cancer Diagnosis
Abstract: Nuclear medicine has major role in clinical oncology specially in tumor imaging. Under this, specific organs are evaluating or to detect presence of tumor in entire body. Nuclear medicine used to evaluate the extent of tumor at initial stage. Molecular imaging helps doctor to diagnose the accuracy of cancer. This study represents the types of nuclear medicine scan and molecular imaging in breast cancer diagnosis.Keywords: breast cancer, nuclear imaging scan, …
Published in Journal of Nuclear Engineering & Technology · Vol. 8, Issue 3, 2018 · pp. 12–17 Read article
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Flavonoid Contents and Antioxidant Activity of an Endophytic Bacteria Associated with Medicinal Plant Humulus lupulus
Abstract: Endophytes are symbiotic microorganisms, most often bacteria or fungi, that reside and multiply within plant tissues without inducing visible signs of disease or negatively affecting the host plant. Endophytic bacteria contribute to plant development by stimulating growth, strengthening defence mechanisms, enhancing tolerance to both abiotic and biotic stresses, and facilitating improved nutrient uptake. Endophytic bacteria serve as an important reservoir of bioactive compounds, notably antioxidant molecules, that play a crucial …
Published in Research & Reviews : Journal of Herbal Science · Vol. 14, Issue 3, 2025 · pp. 1–6 Read article
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InSilico Analysis and Homology Modeling of Tetrahydroprotoberberine Oxide involved in the Berberine Biosynthesis
Abstract: Objective: Berberine, a bioactive compound found in various plant species, exhibits diverse pharmacological properties with potential applications in pharmaceutical research. The biosynthesis of berberine involves several enzymatic steps, with (S)-tetrahydroprotoberberine oxidase playing a pivotal role. This study aimed to elucidate the structural and functional characteristics of (S)-tetrahydroprotoberberine oxidase to better understand its role in berberine biosynthesis and its potential biotechnological applications. Methods: Using bioinformatics tools and computational methods, the physicochemical …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 1, 2024 · pp. 7–26 Read article
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Health Hazards of Nanoparticles and Environmental Pollutants
Abstract: The exponential growth in the use of nanoparticles and the prevalence of environmental pollutants have raised significant concerns regarding their health hazards. Nanoparticles, owing to their unique physicochemical properties—such as small size, high surface areatovolume ratio, and chemical reactivity—can penetrate biological barriers, including the bloodbrain barrier, and interact at the cellular and molecular levels. This can lead to oxidative stress, inflammation, and cellular dysfunction, ultimately resulting in potential toxicity. Similarly, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 1–9 Read article
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Acoustical and Thermodynamical Studies of L- Glycine in Buffer Solution of Different pH at 298.15 K
Abstract: The volumetric, viscometric, and acoustical studies are used to investigate the exchange of L-Glycine in a buffer solvent system of different pH at 298.15K within a concentration range of 0.02 to 0.10 molal. L-glycine, being the simplest amino acid, serves as an important model compound for understanding molecular exchanges in biological systems. The effect of pH on the physicochemical properties of amino acid solutions is of considerable significance, as it …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 17, Issue 2, 2026 · pp. 48–58 Read article
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Molecular Identification of Common Bacterial Infection in Chronic Otitis Media in an Outpatient Department of Tertiary Care Hospital
Abstract: Chronic otitis media (COM) is a chronic inflammation of the mucoperiosteum of the middle ear left which leads to profuse discharge from the ear and hearing impairment that may have a serious long-term effect on language, auditory and cognitive development and on educational progress. In the present study, the prevalence of culture-positive cases of an active mucosal variety of COM was 92.65%. Pseudomonas aeruginosa (41.2%) was the predominant aerobic bacterial …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 8, Issue 1, 2019 · pp. 18–24 Read article
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QSAR Modeling of a Novel Series of Methoxylated Chalcones as Antioxidant Agents Against Gram-Positive Bacteria Staphylococcus aureus
Abstract: Background: Chalcones are aromatic ketones belonging to the flavonoid family. They are plant-based compounds and are widely found in nature. For centuries, these bioactive molecules have been utilized in various traditional medicines for the treatment of several ailments. Chalcones have antibacterial, antiviral, antimalarial, antifungal, antioxidant, and antileishmanial properties. They are also used to treat inflammation and cancer. Chalcones act as angiogenesis inhibitors, an important factor in cancer progression and metastasis. …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 1, 2025 · pp. 28–34 Read article
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Analysis of Natural Pigments and its Application on Various Fields towards the Eco-Friendly Environment
Abstract: The pigments that are found naturally in the environment are most likely to be said as "earth colour" or "earth pigment". The traditional pigments are observed to have all the substances that are available on the natural environment and are of more economic values. The pigments as a natural dye are observed to be safe, highly efficient and eco- friendly. These organic colorants are observed to contain oxygen, carbon with …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 9, Issue 3, 2019 · pp. 9–19 Read article
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A study on Bridging Chemical Transformation and Climate Feedbacks in the Earth System
Abstract: The atmosphere operates as a vast and complex chemical reactor, where minute-scale transformations exert profound influence on planetary-scale climate stability. This research investigates the multi-scale coupling between reactive tropospheric chemistry and large-scale climate feedbacks, challenging traditional modeling approaches that often divorce chemical kinetics from dynamic processes. By integrating high-resolution chemical transport models (CTMs) with comprehensive Earth System Models (ESMs), we map the flow of energy and matter from the molecular …
Published in International Journal of Climate Conditions · Vol. 2, Issue 2, 2025 · pp. 1–8 Read article
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Integrative Network Biology Analysis of GSE6011 Uncovers Molecular Signatures in Duchenne Muscular Dystrophy
Abstract: Duchenne muscular dystrophy (DMD) is a rare, severe neuromuscular disorder demonstrated by progressive skeletal muscle deterioration and premature mortality. Despite advances in supportive care, no definitive cure exists, highlighting the need to explore novel molecular targets. The current study aimed to uncover key dysregulated genes and molecular pathways in DMD through a dataset-specific network biology approach. Publicly available microarray data (GSE6011) from DMD quadriceps muscle biopsies of 22 patients and …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 3, 2025 · pp. 36–48 Read article
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Breeding and Genetics of Disease Resistance in Poultry and Farm Animals: A Review
Abstract: Disease resistance is one of the most essential parameters that is now getting consideration in the animal selection along with production traits. Development and rearing of genetically disease resistant stocks is the newer face of animal husbandry at present. The increasing microbial resistance, increased drug residues in animal products, ever increasing cost of therapeutic treatment, and consumer’s preference towards organic products are all giving bright signal to the development of …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 10, Issue 1, 2021 · pp. 1–7 Read article
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Diverse microRNAs Expressed in Five Prominent Cancers Worldwide
Abstract: MicroRNA being a small RNA molecule plays an important role in the process of transcription of gene to mRNA. The importance of several numbers of microRNAs has been studied till date. They are capable of aiding in normal functioning of an organism. At the same time, their expression can have serious effects in different diseases. Many numbers of miRNAs has been reported to play vital roles in progression as well …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 5, Issue 1, 2018 · pp. 1–9 Read article
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Screening of Pharmaceutically Significant Methioninase-Producing Fungi from the Satpura Range of Hoshangabad District and Its Large-Scale Production
Abstract: L-methioninase, an enzyme with notable anticancer properties, has emerged as a promising therapeutic agent due to its ability to selectively degrade methionine, a critical amino acid for the survival of methionine-dependent cancer cells. Methionine dependency, observed in many tumor cells, is a metabolic vulnerability that can be exploited for targeted cancer therapy. The Satpura Range in the Narmadapuram District, India, with its diverse microbial ecosystems, offers a rich reservoir for …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 12, Issue 2, 2025 · pp. 33–43 Read article