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156 articles for “Mechanisms of Action”
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Design, Synthesis, and Spectroscopic Elucidation of 3-Methyl-1-Phenylpyrazol-5-One: A Cheminformatics-Aided Approach to Heterocyclic Drug Scaffolds
Abstract: Pyrazolone, a notable heterocyclic compound, has drawn increasing interest due to its broad pharmacological profile and structural versatility. The synthesis, characterisation, and biological assessment of new pyrazolone derivatives are examined in this work. A comprehensive review of existing synthetic strategies is presented, emphasizing green and efficient methodologies. Novel derivatives were synthesized using varied starting materials and catalytic systems, followed by structural confirmation through spectroscopic analyses, including NMR, IR, and mass …
Published in International Journal of Cheminformatics · Vol. 3, Issue 1, 2025 · pp. 29–40 Read article
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Automatic Bluetooth Controlled Shutter System Using Microcontroller and Mobile Application
Abstract: Automation has become an essential part of modern engineering system. Manual shutter systems used in shops, garages, and industries require physical effort and time. To overcome these limitations, wireless control systems using Bluetooth technology have been developed. Bluetooth-based automation systems allow communication between smartphones and embedded systems. These systems are widely used due to their low cost, low power consumption, and ease of integration. This paper focuses on designing a …
Published in International Journal of Electronics Automation · Vol. 4, Issue 2, 2026 Read article
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Zinc Oxide Nanoparticles from Murayya koenigii: Antibacterial Potential Review
Abstract: Nanoparticles (NPs) display unique characteristics in contrast to conventional physico-chemical synthesis methods, and they are utilized in various life science fields including surface coating, catalysis, food packaging, corrosion prevention, environmental cleanup, electronics, biomedical applications, and antimicrobial purposes. Metal NPs synthesized through green methods, particularly from plant origins, have garnered significant interest because of their inherent traits such as environmental friendliness, quick production, and cost efficiency. Over the past few years, …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 14, Issue 1, 2024 · pp. 54–67 Read article
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Immune Dysregulation and Cytokine Circuitry in Genital Endometriosis: Mechanistic Insights and Next-Generation Immunotherapeutic Strategies
Abstract: Genital endometriosis is increasingly recognized as an immune-mediated inflammatory disorder driven by complex interactions between dysregulated immune cells, cytokine hubs, and microbiome-derived modulators. This review introduces a novel “immune–cytokine circuitry” framework that unifies innate and adaptive immune abnormalities with key cytokine loops sustaining chronic inflammation, angiogenesis, neuroinflammation, and immune tolerance. Within this circuitry, macrophage polarization, dendritic cell immaturity, NK-cell anergy, Treg expansion, Th17 amplification, and B-cell–mediated autoimmunity converge to establish …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 06–16 Read article
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Strategic Integration of Machine Learning in Polymer Composite Development: A Framework for R&D Portfolio Management and Technological Adoption
Abstract: The progress of advanced polymer composites is slow, costly and unpredictable due to traditional methods of trial-and-error research. As materials informatics and data-driven modeling speed up the process of discovering technology, there exists a huge disconnect between computational predictions on one hand and strategic decision-making on the other in research and development (R&D). To solve this issue, this paper presents the Agile Materials-Intelligence (AMI) Framework, a systematic combined methodology that …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1272–2286 Read article
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Impact of Urbanization and Policy Interventions on Carbon Emissions Towards Achieving SDG 13
Abstract: Climate change remains a major threat to ecosystems and human society. This undermines efforts to achieve Sustainable Development Goal 13 (SDG 13), which aims to take immediate action to address climate change and its impacts. This study provides an overview of the wide-ranging impacts of climate change. It focuses on the increasing frequency, intensity and uncertainty of extreme weather events such as droughts, famines, landslides and heat waves, and impacts …
Published in Journal of Alternate Energy Sources & Technologies · Vol. 16, Issue 1, 2025 · pp. 18–29 Read article
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COVID-19: Nija or Agantuj Roga, Ayurvedic Perspective
Abstract: which is explained under name Janapadodhwamsa or Maraka, It is explained in detail as an independent chapter in various classical texts. As per description Ayurvedic literature described their mechanism of Aetiology (Nidana), various factors affecting severity and actions complicating illnesses along with their management and preventive method. In this article,An attempt is made to describe it as per our classical science, which assert the superiority of host susceptibility (Nija) over …
Published in Research and Reviews: A Journal of Health Professions Read article
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From Waste to Strength: Hybrid Binder Approach for Sustainable M25 Concrete
Abstract: The growing demand for concrete in infrastructure development has led to increased cement consumption, raising serious environmental concerns due to high energy use and carbon dioxide emissions correlated with cement manufacturing. In this context, the use of industrial residues as partial substitutions for cement has achieved deep focus as a sustainable construction strategy. The current investigations experimentally explore the strength and quality performance of concrete produced using a hybrid binder …
Published in Journal of Construction Engineering, Technology & Management · Vol. 16, Issue 1, 2026 · pp. 24–32 Read article
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Design and Implementation of an IoT-Based Power Theft Detection System Using Sensor Networks
Abstract: With the increasing demand for efficient energy distribution and consumption monitoring in smart grid systems, the need for robust power theft detection mechanisms becomes paramount. This project proposes an IoT-based solution utilizing energy metering to detect instances of power theft within different segments of the distribution network. The system employs three types of energy meters: Distribution Point (DP), Pole, and Domestic meters. Every meter is positioned thoughtfully to track the …
Published in Journal of Semiconductor Devices and Circuits · Vol. 11, Issue 2, 2024 Read article
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The State of Air Quality: Pollution Sources, Health Implications, and Future
Abstract: Air quality is a critical component of environmental health, significantly affecting human well-being and ecological balance. Poor air quality has been related to a variety of health issues, including respiratory and cardiovascular disorders, and it is a major cause of early death worldwide. Understanding the origins, kinds, and impacts of air pollutants is critical for establishing effective pollution-reduction initiatives. This review focuses on the principal pollutants that affect air quality, …
Published in International Journal of Atmosphere · Vol. 1, Issue 2, 2024 · pp. 1–4 Read article
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Role of ion Regulation in Heartbeat Initiation
Abstract: The heart can beat quite 2 billion times in normal life, but the mechanism by which the guts beats is that the subject of intense research. Since the invention of pacemaker currents in 1978, several studies have shown that rhythmic changes in membrane tension (the "membrane tension clock") underlie the mechanism of automation. It's the depolarizing current activated during hyperpolarization. Therefore, when the guts cells recover, it's activated, the cell …
Published in Research and Reviews: A Journal of Medicine Read article
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Antibiotic Resistance: Molecular Mechanisms of Resistance
Abstract: Antibiotics are called as ‘Wonder Drugs’, the miracles of modern sciences. They help combat bacteria and prevent their growth. But due to unmonitored and uncontrolled consumption of these antibiotics, there is an emergence of antibiotic resistance. This has led to a series of downfall in the therapeutic potency and efficacy of many drugs. More and more bacteria are becoming Multi-Drug Resistant (MDR); such highly resistant strains of certain bacteria are …
Published in Research and Reviews: A Journal of Microbiology and Virology Read article
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Characterization of Glass Fiber/Epoxy Laminates Modified with MWCNT–Al₂O₃ Hybrid Nanofillers
Abstract: Enhancing the performance of fibre-reinforced polymer composites increasingly involves the integration of nanoscale additives that can improve strength, toughness, and overall durability. In the present investigation, woven E-glass/epoxy laminates were modified using a hybrid nanofiller system consisting of multi-walled carbon nanotubes (MWCNTs) and aluminium oxide (Al₂O₃) nanoparticles. The two nanomaterials were combined in a 2:4 proportion and introduced into the epoxy matrix at total loadings of 1%, 3%, and 5% …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 350–368 Read article
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Exploring The Multitarget Pharmacological Mechanism of Diabex for T2dm by Combining Network Pharmacology and Molecular Docking Techniques
Abstract: Objective: Hyperglycemia brought on by an absolute or relative absence of insulin synthesis or action characterises a set of illnesses known as diabetes mellitus. Chronic hyperglycemia in diabetes mellitus has been linked to organ damage, heart, and blood vessels. The persistent metabolic condition Diabetes is a severe global issue with negative social, health, and economic effects. It is a type of metabolism disorder that interferes with food digestion in the …
Published in International Journal of Bioinformatics and Computational Biology Read article
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Unveiling the Veil of Black Money Understanding Its Impact on Economic Stability and Policy Formulation in India
Abstract: The issue of black money has emerged as a critical concern for India, undermining economic stability and challenging the effectiveness of policy formulation. Black money, generated through unaccounted income and tax evasion, exerts a detrimental influence on multiple facets of the economy, including resource allocation, income distribution, and public trust in governance. This study examines the multifaceted impact of black money on India’s economic framework, highlighting its role in distorting …
Published in Recent Trends in Social Studies · Vol. 2, Issue 2, 2025 · pp. 1–10 Read article
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Corrosion Testing and Evaluation of Inhibitors Performance
Abstract: Choosing test methods that will analyze specific needs, like film barrier strength that real field settings is essential for the proper evaluation and development of inhibitors. The flowing loop and the bubble test are two examples of the first and second, respectively. Corrosion is measured by gravimetric, electrical noise, alternating-current impedance, potentiodynamic measurement, linear polarization and gravimetric. The inhibitors action can be analyzed in different corrosive environments. Their performance is …
Published in Journal of Materials & Metallurgical Engineering · Vol. 16, Issue 1, 2026 · pp. 82–88 Read article
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A Review on Automatic Railway Gate Control System
Abstract: Railway transportation is one of the most efficient and widely used modes of transport; however, safety at level crossings remains a critical issue, especially at unmanned or manually operated gates. A significant number of accidents happen as a result of human carelessness, insufficient coordination, and postponed gate operations. To address these issues, the Automatic Railway Gate Control System has been created as a viable solution to improve safety and minimize …
Published in Journal of Control & Instrumentation · Vol. 17, Issue 2, 2026 Read article
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IoT Sensors to Monitor Pipeline Pressure and Flow Rate Combined with ML-Algorithms to Detect Leakages
Abstract: In the field of fluid mechanics, pipelines are the lifeblood of industries, transporting everything from natural gas and oil to water and chemicals. Maintaining their integrity is paramount for safety, economic efficiency, and environmental protection. Traditional leak detection methods explained in fluid mechanics can be slow, expensive, and sometimes fail to identify small leaks early enough to prevent significant damage. However, the convergence of Internet of Things (IoT) and Machine …
Published in Recent Trends in Fluid Mechanics · Vol. 12, Issue 2, 2025 · pp. 40–48 Read article
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Mystery of Grass milk: A Deeper Dive into Quality, Quantity and Economics of Grass-milk in Dairy Cows
Abstract: Consumers perceive ‘grass-fed milk’ as healthier than conventional ones since grass-fed milk contains higher levels of beneficial fatty acids and lower levels of omega-6. The study highlights the nutritional benefits of feeding green grass, in terms of quality, quantity, and farm economics emphasizing its specific influence on the fatty acid profile of milk, including enrichment of omega-3 fatty acids and conjugated linoleic acids. It also delves into the environmental benefits …
Published in International Journal of Nutritions · Vol. 2, Issue 2, 2025 Read article
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Farmer Producer Organizations as Catalysts of Rural Transformation: A Multidimensional Framework from Punjab, India
Abstract: Farmer Producer Organizations (FPOs) have evolved as an important institutional mechanism for resolving the socio-economic challenges of small and marginal farmers by fostering collective action, expanding market access, and boosting bargaining power. In the broader context of sustainable rural development, FPOs are increasingly acknowledged as catalysts of rural transformation by contributing to numerous dimensions of farmer well-being. However, current study has generally analyzed FPOs through economic and operational indicators, with …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 15, Issue 3, 2026 Read article