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166 articles for “ADME analysis”
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Valeton Phytoconstituents from Curcuma Phaeocaulis as Prion Protein Mutant V210I Inhibitors: A Computational Docking and Virtual Screening Study
Abstract: Objective: Creutzfeldt-Jakob disease (CJD), a neurological disorder that is sporadic, fatal, communicable, and worsens rapidly, is caused by abnormal folding of prion proteins. Identifying and assessing the potential of phytocompounds from the Curcuma phaeocaulis Valeton plant as a new therapeutic candidate aimed at the treatment of CJD is the objective of this research article. Methods: In this experiment, we assessed outcomes following an in-silico assessment to design a new oral …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 2, 2023 · pp. 1–16 Read article
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Contextualising health-disaster risk reduction pillars for under-resourced rural secondary schools in Limpopo Province, South Africa
Abstract: School communities in under-resourced rural settings face a disproportionate burden of health-related disasters, including outbreaks, water and sanitation failures, food insecurity and compound events that disrupt learning and wellbeing. Yet school based disaster risk reduction (DRR) evidence in Southern Africa is uneven with limited empirically guidance tailored to the organisational and infrastructural realities of disadvantaged schools. Drawing on the Comprehensive School Safety Framework and the World Health Organization's Health Emergency …
Published in International Journal of Education Sciences · Vol. 3, Issue 1, 2026 · pp. 124–135 Read article
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Molecular Pharmacokinetics and Structural Docking of Phenolic Acids for Targeting NF-κB Pathway Components in Inflammation and Fibrosis: A Computational Approach Toward Therapeutic Discovery
Abstract: Inflammation and Fibrosis are critical pathological processes associated with various chronic diseases, often mediated by the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. This study investigates the therapeutic potential of phenolic acids as modulators of the NF-κB pathway, aiming to identify novel ligands that can effectively interact with key components of this signaling cascade. A comprehensive computational approach was employed, utilizing molecular docking, pharmacological screening, and post-docking …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 14–31 Read article
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Sentiment Analysis of X (Formerly Twitter) Using Machine Learning
Abstract: Sentiment analysis is a methodology to determine the nature and behavior of each and every user for the content posted on the social media platform in the form of post and feed. Consumers of the online platform are encouraged to post reviews of the product that they purchase. Little attempt is created by Amazon to confine or limit the content of these reviews. The number of reviews for various merchandise …
Published in Journal of Software Engineering Tools & Technology Trends · Vol. 11, Issue 2, 2024 · pp. 28–37 Read article
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The Clean Water Act: Legal Analysis and Implementation Challenges
Abstract: The Clean Water Act is one of the most far-reaching environmental laws in the United States; it was enacted with express purposes for the protection and restoration of the country's waters. For many years, though, numerous logistical, administrative, and legal challenges have beset its implementation. This paper will undertake a detailed legal review of the CWA, discussing its foundational principles, major amendments, and evolving interpretations by courts. It does so …
Published in Journal of Water Pollution & Purification Research · Vol. 12, Issue 1, 2025 · pp. 1–9 Read article
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Inhibition of PI3K/Akt/mTOR Signaling Pathway by Vitis Vinifera Phytocompounds: A Promising Strategy for Supressing Colorectal Cancer Growth and Metastasis
Abstract: Objectives: Colorectal cancer was not typically identified a few decades ago. Today, with almost 900 000 fatalities each year, it is the fourth most dangerous cancer in the world. Colorectal cancer is responsible for about 10% of all cancer diagnoses annually and cancer-related deaths worldwide. It is the second most common type of cancer in women and the third most common type in men. Incidence and death are roughly 25% …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 64–75 Read article
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Modern Approaches in Lung Cancer Management from Herbal Nanomedicine to Artificial Intelligence
Abstract: Lung cancer continues to be a major global health concern and one of the leading causes of cancer-related mortality worldwide. Despite significant advancements in therapy, there is still a pressing need for safer and more effective therapeutic alternatives; problems such drug resistance, side effects, metastasis, and recurrence continue to impact patient outcomes and quality of life. Examining current advancements in the use of herbal drug-loaded nanoparticles as a novel approach …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 Read article
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Exploring the Role of Advanced Shell Scripts for Malware Threat Detection
Abstract: This study investigates the application of advanced shell scripts in detecting malware threats within computer systems. As cyber-attacks become more sophisticated, traditional detection methods frequently prove inadequate, highlighting the need for innovative approaches. The research highlights the effectiveness of shell scripting in automating the monitoring and analysis of system behavior, file integrity, and network traffic. By leveraging patterns and signatures of known malware, the scripts can identify anomalies indicative of …
Published in Journal of Advances in Shell Programming · Vol. 11, Issue 3, 2024 · pp. 6–16 Read article
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Synthetic Highs in Urban India: A Quantitative Study of Synthetic Drug Use Among Youth in Maharashtra’s Metropolitan Cities
Abstract: Background: The increasing prevalence of synthetic drug use among urban youth is emerging as a serious public health issue in cities like Mumbai and Pune. The transition from traditional drugs to more modern ones, such as MDMA, LSD, and meth, is indicative of deeper global shifts fueled by urbanization, increased access to the internet, and peer pressure. There is an abundant increase in reports about the availability of synthetic drugs, …
Published in Research and Reviews: A Journal of Health Professions · Vol. 16, Issue 1, 2026 · pp. 6–12 Read article
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ECO Report Analys Achieving SDG 15
Abstract: This project creates automated data processing tool Eco Data Analyser for ecological data analysis for SDG 15: Life on Land conservation and biodiversity. File_picker, Excel, and CSV are used in the Flutter and Dart based cross-platform solution to assist environmental organizations in handling ecological data. Uploading ecological datasets, verifying data, classifying biodiversity indicators, and producing summary reports helps Eco Data Analyser to make conservation data accessible and valuable. User-defined parameters …
Published in International Journal of Land · Vol. 2, Issue 2, 2025 · pp. 1–10 Read article
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Evaluating Delay Impacts: From Root Cause Analysis to Dispute Resolution
Abstract: Construction projects inherently involve complex coordination among multiple stakeholders, interdependent tasks, and unpredictable external challenges, which frequently cause schedule overruns and disputes. Traditional contractual mechanisms—such as extensions of time (EoT), liquidated damages, and force majeure clauses—serve to define responsibilities, allocate risk, and establish formal dispute pathways when delays arise. For example, EoT provisions protect contractors from penalties when delays are beyond their control, provided proper notice and evidence are submitted …
Published in Journal of Structural Engineering and Management · Vol. 12, Issue 3, 2025 · pp. 11–25 Read article
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e-learning Platforms in Higher Education: An Analysis of Institutional Planning, Implementation and Evaluation Strategies
Abstract: This quantitative study investigates the impact of e-learning platforms on student learning outcomes in higher education, focusing on institutional planning, implementation, and evaluation strategies. A descriptive-correlational research design was employed, surveying 100 administrators, faculty, and students from various higher education institutions. The results show significant positive correlations between platform organization, user-friendliness, instructor feedback, technical support, and student motivation. Well-structured platforms with clear communication of learning objectives, quality technical support, and …
Published in International Journal of Education Sciences · Vol. 2, Issue 2, 2025 · pp. 41–49 Read article
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Prediction of Molecular Targets for Anthraquinone and Its Analogs for Treatment of Good Pasteur Syndrome
Abstract: Objective: In order to find prospective molecular targets for the treatment of Good Pasteur Syndrome (GPS), a rare autoimmune disease that affects the kidneys and other organs, computational methods and network pharmacology were applied in this work. The goal of the study is to identify particular human proteins that might interact with anthraquinone and its analogues as well as to uncover potential mechanisms of action by which these drugs might …
Published in International Journal of Bioinformatics and Computational Biology Read article
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Anticancer Activity of Calotropis procera by Molecular Docking Analysis
Abstract: Cyclin-dependent kinase 2 (CDK2) is a protein synthesized by Calotropis procera. It is known to be responsible for causing cancer in the human body. Studies have presented the significance of the phytochemicals to inhibit the CDK2 protein. Adsorption, distribution, metabolism, and excretion (Swiss ADME) and PubChem were the pharmacological tools which were used to check molecular weight, which should be less than 500D, acceptors less than 10, and donors less …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 01–07 Read article
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Comparative Evaluation of GPBB and CK-MB in Early Diagnosis of Acute Myocardial Infarction in Diabetic and Non-Diabetic Patients
Abstract: Background: Acute myocardial infarction (AMI) continues to be a leading cause of morbidity and death among people worldwide. To lower the risk of problems, early and precise diagnosis is essential, particularly for diabetes patients. The study investigates the diagnostic value of Glycogen Phosphorylase BB (GPBB), a potential early biomarker of myocardial necrosis, and compares it with CK-MB, a widely used cardiac marker, in AMI diagnosis. Inflammatory markers (hs-CRP, IL-6, TNF-α) …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 33–37 Read article
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Unveiling Nature’s Potential: In Silico Exploration and Identification of Herbal Remedies for Major Depressive Disorder Through Molecular Interaction Studies
Abstract: Major depressive disorder (MDD), a globally discussed mental health condition, has drawn significant attention because of its unique and intricate nature. This is marked by the enduring presence of negative emotions stemming from a lack of interest, diminished self-esteem, and excessive rumination. Despite the widespread availability of various antidepressant medications, their effectiveness is hindered by low response rates, prolonged treatment durations, and the prevalence of side effects, such as headaches, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 54–62 Read article
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QSAR Modeling of a Novel Series of Methoxylated Chalcones as Antioxidant Agents Against Gram-Positive Bacteria Staphylococcus aureus
Abstract: Background: Chalcones are aromatic ketones belonging to the flavonoid family. They are plant-based compounds and are widely found in nature. For centuries, these bioactive molecules have been utilized in various traditional medicines for the treatment of several ailments. Chalcones have antibacterial, antiviral, antimalarial, antifungal, antioxidant, and antileishmanial properties. They are also used to treat inflammation and cancer. Chalcones act as angiogenesis inhibitors, an important factor in cancer progression and metastasis. …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 1, 2025 · pp. 28–34 Read article
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Spectral Mapping and Tracking Error of MBOC signal and Wavelet based GNSS receiver
Abstract: This research paper delves into the historical evolution and contemporary state of the art in navigation technologies, emphasizing the paramount importance of reliable positioning systems. Tracing the journey from ancient primitive methods to the present-day Global Navigation Satellite Systems (GNSS), with a focus on the Global Positioning System (GPS), the paper explores the diverse instruments and methods developed by civilizations throughout history to determine location and navigate effectively. The main …
Published in Current Trends in Signal Processing · Vol. 16, Issue 1, 2026 Read article
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A Pre-experimental Evaluation of a Structured Educational Program on Awareness of Mosquito-borne Diseases in Senior Secondary School Students in Punjab
Abstract: Introduction: Mosquitoes constitute the most important single family of insects from the standpoint of human health. They are found all over the world. The four important groups of mosquitoes in India that are related to disease transmission are the Anopheles, Culex, Aedes, and Mansonia. Aims: The aims of the study are to assess the effectiveness of structured teaching program on knowledge regarding mosquito-borne diseases among students of senior secondary schools …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 2, Issue 1, 2024 · pp. 7–14 Read article
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A Study on the Knowledge of Arterial Blood Gas (ABG) Analysis Among Staff Nurses in a Rural Hospital Setting
Abstract: To evaluate the comprehension of Arterial Blood Gas (ABG) analysis among staff nurses in a designated Rural Hospital, this study aimed to assess their knowledge level and correlate it with specific demographic variables. Utilizing a descriptive approach, the study encompassed all staff nurses within the Rural Hospital, with a sample of 50 individuals meeting the inclusion criteria: completion of either a Diploma in Nursing and Midwifery (GNM) or a Degree …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 2, 2024 · pp. 1–21 Read article